Flavonols and pancreatic cancer risk: The multiethnic cohort study

American Journal of Epidemiology

Volumn 166, Issue 8, 2007, Pages 924-931

  Nöthlings, Ute ^a,b   Murphy, Suzanne P ^a   Wilkens, Lynne R ^a   Henderson, Brian E ^c   Kolonel, Laurence N ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Diet; Flavonols; Pancreatic neoplasms; Prospective studies

Indexed keywords

FLAVONOL DERIVATIVE; KAEMPFEROL; MYRICETIN; QUERCETIN;

CANCER; CHEMICAL COMPOUND; DIET; RISK FACTOR; SMOKING;

ADULT; AGED; ARTICLE; CALCULATION; CANCER INCIDENCE; CANCER RISK; COHORT ANALYSIS; CONFIDENCE INTERVAL; DIET; ETHNICITY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PANCREAS CANCER; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; RISK ASSESSMENT; RISK REDUCTION; TIME SERIES ANALYSIS;

AGED; COHORT STUDIES; CONFIDENCE INTERVALS; DIET SURVEYS; ETHNIC GROUPS; FEMALE; FLAVONOLS; FOLLOW-UP STUDIES; FOOD HABITS; HAWAII; HUMANS; INCIDENCE; LOS ANGELES; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PROPORTIONAL HAZARDS MODELS; QUESTIONNAIRES; RISK; RISK FACTORS; VEGETABLES;

CALIFORNIA; HAWAII [UNITED STATES]; NORTH AMERICA; UNITED STATES;

EID: 34848821940     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwm172     Document Type: Article

References (43)

1. Lambert JD, Hong J, Yang GY, et al. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr 2005;81:284S-91S.
2. Yang CS, Landau JM, Huang MT, et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 2001;21:381-406.
3. Erdman JW Jr, Balentine D, Arab L, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr 2007;137:718S-37S.
4. Yao LH, Jiang YM, Shi J, et al. Flavonoids in food and their health benefits. Plant Foods Hum Nutr 2004;59:113-22.
5. Scalbert A, Manach C, Morand C, et al. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005;45:287-306.
6. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 2004;36:838-49.
7. Dwyer JT, Peterson JJ. Measuring flavonoid intake: need for advanced tools. Public Health Nutr 2002;5:925-30.
8. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005;81(suppl):317S-25S.
9. Neuhouser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 2004;50:1-7.
10. Edwards BK, Brown ML, Wingo PA, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 2005;97:1407-27.
11. Li D, Xie K, Wolff R, et al. Pancreatic cancer. Lancet 2004;363:1049-57.
12. Klein AP, Brune KA, Petersen GM, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res 2004;64:2634-8.
13. Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A, et al. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 2005;92:2076-83.
14. Berrington de Gonzalez A, Sweetland S, Spencer E. A meta-analysis of obesity and the risk of pancreatic cancer. Br J Cancer 2003;89:519-23.
15. Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev 2003;27:87-93.
16. Franke AA, Custer LJAC, Murphy SP. Vitamin C and flavonoid levels of fruits and vegetables consumed in Hawaii. J Food Comp Anal 2004;17:1-35.
17. Kolonel LN, Henderson BE, Hankin JH, et al. A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol 2000;151:346-57.
18. Stram DO, Hankin JH, Wilkens LR, et al. Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol 2000;151:358-70.
19. Nöthlings U, Wilkens LR, Murphy SP, et al. Meat and fat intake as risk factors for pancreatic cancer: the Multiethnic Cohort Study. J Natl Cancer Inst 2005;97:1458-65.
20. Nöthlings U, Wilkens LR, Murphy SP, et al. Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study. Cancer Causes Control 2007;18:165-75.
21. Kipnis V, Subar AF, Midthune D, et al. Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol 2003;158:14-21; discussion 22-6.
22. Nöthlings U, Wilkens LR, Murphy SP, et al. Vegetable intake and pancreatic cancer risk: the Multiethnic Cohort Study. Am J Epidemiol 2007;165:138-47.
23. Knekt P, Järvinen R, Seppänen R, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997;146:223-30.
24. Beecher GR. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 2003;133:3248S-54S.
25. Knekt P, Kumpulainen J, Järvinen R, et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002;76:560-8.
26. Hirvonen T, Virtamo J, Korhonen P, et al. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 2001;12:789-96.
27. Adebamowo CA, Cho E, Sampson L, et al. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int J Cancer 2005;114:628-33.
28. Stefani ED, Boffetta P, Deneo-Pellegrini H, et al. Dietary antioxidants and lung cancer risk: a case-control study in Uruguay. Nutr Cancer 1999;34:100-10.
29. Garcia-Closas R, Agudo A, Gonzalez CA, et al. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Nutr Cancer 1998;32:154-8.
30. Garcia-Closas R, Gonzalez CA, Agudo A, et al. Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes Control 1999;10:71-5.
31. Le Marchand L, Murphy SP, Hankin JH, et al. Intake of flavonoids and lung cancer. J Natl Cancer Inst 2000;92:154-60.
32. Lagiou P, Samoli E, Lagiou A, et al. Flavonoid intake in relation to lung cancer risk: case-control study among women in Greece. Nutr Cancer 2004;49:139-43.
33. Aherne SA, O'Brien NM. Dietary flavonols: chemistry, food content, and metabolism. Nutrition 2002;18:75-81.
34. Mouria M, Gukovskaya AS, Jung Y, et al. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer 2002;98:761-9.
35. Lee LT, Huang YT, Hwang JJ, et al. Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res 2002;22:1615-27.
36. Barotto NN, Lopez CB, Eynard AR, et al. Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. Cancer Lett 1998;129:1-6.
37. Nilsen TI, Vatten LJ. A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trondelag, Norway. Cancer Causes Control 2000;11:645-52.
38. Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002;22:19-34.
39. Chun OK, Chung SJ, Song WO. Estimated dietary flavonoid intake and major food sources of U.S. adults. J Nutr 2007;137:1244-52.
40. Sampson L, Rimm E, Hollman PC, et al. Flavonol and flavone intakes in US health professionals. JAm Diet Assoc 2002;102:1414-20.
41. Hertog MG, Hollman PC, Katan MB, et al. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 1993;20:21-9.
42. Nutrient Data Laboratory, Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture. USDA database for flavonoid content of selected foods. Beltsville, MD: US Department of Agriculture, 2006.
43. Willett W. Nutritional epidemiology; monographs in epidemiology and biostatistics. Oxford, United Kingdom: Oxford University Press, 1998.