메뉴 건너뛰기




Volumn 399, Issue 1-2, 2010, Pages 129-139

Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives

Author keywords

Bioavailability enhancement; High pressure homogenization; Nanocrystals; Poor solubility; SmartCrystals; Solubilization; Targeting

Indexed keywords

2 METHOXYESTRADIOL; APREPITANT; BEVACIZUMAB; BRAIN PROTEIN; BUDESONIDE; BUSULFAN; CALCIUM PHOSPHATE; COSMETIC; DEXMETHYLPHENIDATE; FENOFIBRATE; INSULIN; MEGACE ES; MEGESTROL ACETATE; METHYLPHENIDATE; MORPHINE SULFATE; NANOCRYSTAL; NUCRYST; NUTRACEUTICAL; PACLITAXEL; RAPAMYCIN; SEMAPIMOD; THERALUX; TIZANIDINE; TRIGLIDE; UNCLASSIFIED DRUG;

EID: 77956882799     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.07.044     Document Type: Review
Times cited : (632)

References (79)
  • 1
    • 77956874582 scopus 로고    scopus 로고
    • Apigenin smartCrystals for novel UV skin protection formulations. Eighth European Workshop on Particulate Systems Abstract no. 22., a.
    • Al Shaal, L., Shegokar, R., Müller, R.H., 2010a. Apigenin smartCrystals for novel UV skin protection formulations. Eighth European Workshop on Particulate Systems Abstract no. 22.
    • (2010)
    • Al Shaal, L.1    Shegokar, R.2    Müller, R.H.3
  • 2
    • 77956873927 scopus 로고    scopus 로고
    • Novel UV skin protective antioxidant nanocrystals. First Combined Annual Meeting of the International Pharmaceutical Federation, PSWC and AAPS. Abstract No. 2221., b.
    • Al Shaal, L., Shegokar, R., Müller, R.H., Keck, C.M., 2010b. Novel UV skin protective antioxidant nanocrystals. First Combined Annual Meeting of the International Pharmaceutical Federation, PSWC and AAPS. Abstract No. 2221.
    • (2010)
    • Al Shaal, L.1    Shegokar, R.2    Müller, R.H.3    Keck, C.M.4
  • 4
    • 77951498994 scopus 로고    scopus 로고
    • Nanosuspension technology and its applications in drug delivery
    • Arunkumar N., Deecaraman M., Rani C. Nanosuspension technology and its applications in drug delivery. Asian J. Pharm. 2009, 3:168-173.
    • (2009) Asian J. Pharm. , vol.3 , pp. 168-173
    • Arunkumar, N.1    Deecaraman, M.2    Rani, C.3
  • 5
    • 0032023538 scopus 로고    scopus 로고
    • The function of gelatin in controlled precipitation processes of nanosize particles
    • Auweter H., Andre V., Horn D., Luddecke E. The function of gelatin in controlled precipitation processes of nanosize particles. J. Dispersion Sci. Technol. 1998, 163-184.
    • (1998) J. Dispersion Sci. Technol. , pp. 163-184
    • Auweter, H.1    Andre, V.2    Horn, D.3    Luddecke, E.4
  • 6
    • 77956875547 scopus 로고    scopus 로고
    • Precipitated water-insoluble colorants in colloid disperse form, in US Patent 6,494,924. BASF AG.
    • Auweter, H., Bohn, H., Heger, R., Horn, D., Siegel, B., Siemensmeyer, K., 2002. Precipitated water-insoluble colorants in colloid disperse form, in US Patent 6,494,924. BASF AG.
    • (2002)
    • Auweter, H.1    Bohn, H.2    Heger, R.3    Horn, D.4    Siegel, B.5    Siemensmeyer, K.6
  • 7
    • 0027730863 scopus 로고
    • Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis
    • Blunk T., Hochstrasser D.F., Sanchez J.C., Müller B.W., Müller R.H. Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 1993, 14:1382-1387.
    • (1993) Electrophoresis , vol.14 , pp. 1382-1387
    • Blunk, T.1    Hochstrasser, D.F.2    Sanchez, J.C.3    Müller, B.W.4    Müller, R.H.5
  • 8
    • 77956876186 scopus 로고    scopus 로고
    • Herstellung und Charakterisierung von Nanosuspensionen als neue Arzneiform für Arzneistoffe mit geringer Bioverfügbarkeit. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • Böhm, B.H.L., 1999. Herstellung und Charakterisierung von Nanosuspensionen als neue Arzneiform für Arzneistoffe mit geringer Bioverfügbarkeit. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • (1999)
    • Böhm, B.H.L.1
  • 9
    • 0036967917 scopus 로고    scopus 로고
    • Enhanced ocular anti-inflammatory activity of ibuprofen carried by an Eudragit RS100 nanoparticle suspension
    • Bucolo C., Maltese A., Puglisi G., Pignatello R. Enhanced ocular anti-inflammatory activity of ibuprofen carried by an Eudragit RS100 nanoparticle suspension. Ophthalmic Res. 2002, 34:319-323.
    • (2002) Ophthalmic Res. , vol.34 , pp. 319-323
    • Bucolo, C.1    Maltese, A.2    Puglisi, G.3    Pignatello, R.4
  • 10
    • 70349826235 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy
    • Chiang P.C., Hu Y., Thurston A., Sommers C.D., Guzova J.A., Kahn L.E., Lai Y., Blom J.D. Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy. J. Pharm. Sci. 2009, 98:4354-4364.
    • (2009) J. Pharm. Sci. , vol.98 , pp. 4354-4364
    • Chiang, P.C.1    Hu, Y.2    Thurston, A.3    Sommers, C.D.4    Guzova, J.A.5    Kahn, L.E.6    Lai, Y.7    Blom, J.D.8
  • 11
    • 77956876089 scopus 로고    scopus 로고
    • Parenteral and Oral Formulations of Benzimidazoles. WO/2010/011289.
    • Chow, D.S.L., Gupta, P., Qi, Y., Liang, D., Shah, J., Wisniecki, P., 2010. Parenteral and Oral Formulations of Benzimidazoles. WO/2010/011289.
    • (2010)
    • Chow, D.S.L.1    Gupta, P.2    Qi, Y.3    Liang, D.4    Shah, J.5    Wisniecki, P.6
  • 12
    • 33846783997 scopus 로고    scopus 로고
    • Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals
    • Crisp M.T., Tucker C.J., Rogers T.L., Williams R.O., Johnston K.P. Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals. J. Controlled Release 2007, 117:351-359.
    • (2007) J. Controlled Release , vol.117 , pp. 351-359
    • Crisp, M.T.1    Tucker, C.J.2    Rogers, T.L.3    Williams, R.O.4    Johnston, K.P.5
  • 13
    • 67651172983 scopus 로고    scopus 로고
    • Polymeric ocular nanosuspension for controlled release of acyclovir: in vitro release and ocular distribution
    • Dandagi P., Kerur S., Mastiholimath V., Gadad A., Kulkarni A. Polymeric ocular nanosuspension for controlled release of acyclovir: in vitro release and ocular distribution. Iranian J. Pharm. Res. 2009, 8:79-86.
    • (2009) Iranian J. Pharm. Res. , vol.8 , pp. 79-86
    • Dandagi, P.1    Kerur, S.2    Mastiholimath, V.3    Gadad, A.4    Kulkarni, A.5
  • 14
    • 43449094630 scopus 로고    scopus 로고
    • A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying
    • de Waard H., Hinrichs W.L., Frijlink H.W. A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying. J. Controlled Release 2008, 128:179-183.
    • (2008) J. Controlled Release , vol.128 , pp. 179-183
    • de Waard, H.1    Hinrichs, W.L.2    Frijlink, H.W.3
  • 15
    • 70349084535 scopus 로고    scopus 로고
    • Preparation of drug nanocrystals by controlled crystallization: application of a 3-way nozzle to prevent premature crystallization for large scale production
    • de Waard H., Grasmeijer N., Hinrichs W.L., Eissens A.C., Pfaffenbach P.P., Frijlink H.W. Preparation of drug nanocrystals by controlled crystallization: application of a 3-way nozzle to prevent premature crystallization for large scale production. Eur. J. Pharm. Sci. 2009, 38:224-229.
    • (2009) Eur. J. Pharm. Sci. , vol.38 , pp. 224-229
    • de Waard, H.1    Grasmeijer, N.2    Hinrichs, W.L.3    Eissens, A.C.4    Pfaffenbach, P.P.5    Frijlink, H.W.6
  • 16
    • 77951499718 scopus 로고    scopus 로고
    • Understanding the structure and stability of paclitaxel nanocrystals
    • Deng J., Huang L., Liu F. Understanding the structure and stability of paclitaxel nanocrystals. Int. J. Pharm. 2010, 390:242-249.
    • (2010) Int. J. Pharm. , vol.390 , pp. 242-249
    • Deng, J.1    Huang, L.2    Liu, F.3
  • 17
    • 0028219328 scopus 로고
    • Liposome in Kosmetika und Arzneimitteln
    • Diederichs J.E., Müller R.H. Liposome in Kosmetika und Arzneimitteln. Pharm. Ind. 1994, 56:267-275.
    • (1994) Pharm. Ind. , vol.56 , pp. 267-275
    • Diederichs, J.E.1    Müller, R.H.2
  • 18
    • 0037677616 scopus 로고    scopus 로고
    • Characterization of solidified reverse micellar solutions (SRMS) and production development of SRMS-based nanosuspensions
    • Friedrich I., Müller-Goymann C.C. Characterization of solidified reverse micellar solutions (SRMS) and production development of SRMS-based nanosuspensions. Eur. J. Pharm. Biopharm. 2003, 56:111-119.
    • (2003) Eur. J. Pharm. Biopharm. , vol.56 , pp. 111-119
    • Friedrich, I.1    Müller-Goymann, C.C.2
  • 19
    • 58249109448 scopus 로고    scopus 로고
    • Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery
    • Ganta S., Paxton J.W., Baguley B.C., Garg S. Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery. Int. J. Pharm. 2009, 367:179-186.
    • (2009) Int. J. Pharm. , vol.367 , pp. 179-186
    • Ganta, S.1    Paxton, J.W.2    Baguley, B.C.3    Garg, S.4
  • 20
    • 42549152846 scopus 로고    scopus 로고
    • Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system
    • Gao L., Zhang D., Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J. Nanopart. Res. 2008, 10:845-862.
    • (2008) J. Nanopart. Res. , vol.10 , pp. 845-862
    • Gao, L.1    Zhang, D.2    Chen, M.3
  • 21
    • 41349120910 scopus 로고    scopus 로고
    • Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions
    • Gao L., Zhang D., Chen M., Duan C., Dai W., Jia L., Zhao W. Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions. Int. J. Pharm. 2008, 355:321-327.
    • (2008) Int. J. Pharm. , vol.355 , pp. 321-327
    • Gao, L.1    Zhang, D.2    Chen, M.3    Duan, C.4    Dai, W.5    Jia, L.6    Zhao, W.7
  • 22
    • 42149190687 scopus 로고    scopus 로고
    • Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats
    • Ghosh S., Chiang P.C., Wahlstrom J.L., Fujiwara H., Selbo J.G., Roberds S.L. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic Clin. Pharmacol. Toxicol. 2008, 102:453-458.
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.102 , pp. 453-458
    • Ghosh, S.1    Chiang, P.C.2    Wahlstrom, J.L.3    Fujiwara, H.4    Selbo, J.G.5    Roberds, S.L.6
  • 23
    • 77956871437 scopus 로고
    • Phospholipid-coated microcrystals: injectable formulations of water insoluble drugs. US Patent 5091187.
    • Haynes, D.H., 1992. Phospholipid-coated microcrystals: injectable formulations of water insoluble drugs. US Patent 5091187.
    • (1992)
    • Haynes, D.H.1
  • 24
    • 79952293253 scopus 로고    scopus 로고
    • Overcoming poor aqueous solubility of drugs for oral delivery. In: Stella, V.J., R.T.B., Hageman, M.J., Oliyai, R., Maag. H., Tilley, J.W. (Eds.), Prodrugs, Series - Biotechnology: Pharmaceutical Aspects Springer, New York
    • Heimbach, T., Fleisher, D., Kaddoumi, A., 2007. Overcoming poor aqueous solubility of drugs for oral delivery. In: Stella, V.J., R.T.B., Hageman, M.J., Oliyai, R., Maag. H., Tilley, J.W. (Eds.), Prodrugs, Series - Biotechnology: Pharmaceutical Aspects Springer, New York, pp. 157-215.
    • (2007) , pp. 157-215
    • Heimbach, T.1    Fleisher, D.2    Kaddoumi, A.3
  • 25
    • 33644799822 scopus 로고    scopus 로고
    • Characterization of nebulized buparvaquone nanosuspensions-effect of nebulization technology
    • Hernandez-Trejo N., Kayser O., Steckel H., Müller R.H. Characterization of nebulized buparvaquone nanosuspensions-effect of nebulization technology. J. Drug Target. 2005, 13:499-507.
    • (2005) J. Drug Target. , vol.13 , pp. 499-507
    • Hernandez-Trejo, N.1    Kayser, O.2    Steckel, H.3    Müller, R.H.4
  • 26
    • 77956870407 scopus 로고    scopus 로고
    • Development and characterisation of buparvaquone nanosuspensions for pulmonary delivery in the treatment of Pneumocystis pneumonia. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • Hernandez-Trejo, N., 2006. Development and characterisation of buparvaquone nanosuspensions for pulmonary delivery in the treatment of Pneumocystis pneumonia. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • (2006)
    • Hernandez-Trejo, N.1
  • 27
    • 27644591358 scopus 로고    scopus 로고
    • Research strategies for safety evaluation of nanomaterials, Part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs
    • Holsapple M.P., Farland W.H., Landry T.D., Monteiro-Riviere N.A., Carter J.M., Walker N.J., Thomas K.V. Research strategies for safety evaluation of nanomaterials, Part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs. Toxicol. Sci. 2005, 88:12-17.
    • (2005) Toxicol. Sci. , vol.88 , pp. 12-17
    • Holsapple, M.P.1    Farland, W.H.2    Landry, T.D.3    Monteiro-Riviere, N.A.4    Carter, J.M.5    Walker, N.J.6    Thomas, K.V.7
  • 30
    • 0035910888 scopus 로고    scopus 로고
    • A new approach for targeting to Cryptosporidium parvum using mucoadhesive nanosuspensions: research and applications
    • Kayser O. A new approach for targeting to Cryptosporidium parvum using mucoadhesive nanosuspensions: research and applications. Int. J. Pharm. 2001, 214:83-85.
    • (2001) Int. J. Pharm. , vol.214 , pp. 83-85
    • Kayser, O.1
  • 31
  • 32
    • 28444461830 scopus 로고    scopus 로고
    • Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation
    • Keck C.M., Müller R.H. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur. J. Pharm. Biopharm. 2006, 62:3-16.
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , pp. 3-16
    • Keck, C.M.1    Müller, R.H.2
  • 33
    • 76149089279 scopus 로고    scopus 로고
    • Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystal technology
    • Keck C.M., Kobierski S., Mauludin R., Müller R.H. Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystal technology. Dosis 2008, 2:124-128.
    • (2008) Dosis , vol.2 , pp. 124-128
    • Keck, C.M.1    Kobierski, S.2    Mauludin, R.3    Müller, R.H.4
  • 34
    • 77956882677 scopus 로고    scopus 로고
    • Microprecipitation method for preparing submicron suspensions. US Patent 6869617.
    • Kipp, J.E.W., Joseph, C.T., Doty, M.J., Rebbeck, C.L., 2001. Microprecipitation method for preparing submicron suspensions. US Patent 6869617.
    • (2001)
    • Kipp, J.E.W.1    Joseph, C.T.2    Doty, M.J.3    Rebbeck, C.L.4
  • 35
    • 0029950382 scopus 로고    scopus 로고
    • Cosmetic regulations of the United States, European Union, and Japan
    • Kislalioglu M.S. Cosmetic regulations of the United States, European Union, and Japan. Clin. Res. Regul. Affairs 1996, 13:211-229.
    • (1996) Clin. Res. Regul. Affairs , vol.13 , pp. 211-229
    • Kislalioglu, M.S.1
  • 36
    • 0343051794 scopus 로고    scopus 로고
    • Amphotericin B encapsulated in polyethylene glycolimmunoliposomes for infectious diseases
    • Kohno S., Otsubo T., Tanaka E., Maruyama K., Hara K. Amphotericin B encapsulated in polyethylene glycolimmunoliposomes for infectious diseases. Adv. Drug Del. Rev. 1997, 24:325-329.
    • (1997) Adv. Drug Del. Rev. , vol.24 , pp. 325-329
    • Kohno, S.1    Otsubo, T.2    Tanaka, E.3    Maruyama, K.4    Hara, K.5
  • 37
    • 0030853702 scopus 로고    scopus 로고
    • Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles
    • Kreuter J., Petrov V.E., Kharkevich D.A., Alyautdin R.N. Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles. J. Controlled Release 1997, 49:81-87.
    • (1997) J. Controlled Release , vol.49 , pp. 81-87
    • Kreuter, J.1    Petrov, V.E.2    Kharkevich, D.A.3    Alyautdin, R.N.4
  • 38
    • 77956874760 scopus 로고
    • Pharmaceutical colloidal hydrosols for injection. GB Patent 2200048.
    • List, M., Sucker, H., 1988. Pharmaceutical colloidal hydrosols for injection. GB Patent 2200048.
    • (1988)
    • List, M.1    Sucker, H.2
  • 39
    • 0029080002 scopus 로고
    • Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
    • Liversidge G.G., Cundy K.C. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int. J. Pharm. 1995, 125:91-97.
    • (1995) Int. J. Pharm. , vol.125 , pp. 91-97
    • Liversidge, G.G.1    Cundy, K.C.2
  • 40
    • 77956875893 scopus 로고
    • Surface modified drug nanoparticles. US Patent 5145684.
    • Liversidge, G.G., Cundy, K.C., Bishop, J., Czekai, D., 1992. Surface modified drug nanoparticles. US Patent 5145684.
    • (1992)
    • Liversidge, G.G.1    Cundy, K.C.2    Bishop, J.3    Czekai, D.4
  • 41
    • 77956876004 scopus 로고    scopus 로고
    • Plasmaproteinadsorption als ein möglicher Schlüsselfaktor für eine kontrollierte Arzneistoffappliktion mit partikulären Trägern. Ph.D. Thesis, Freie Universität Berlin.
    • Lück M., 1997. Plasmaproteinadsorption als ein möglicher Schlüsselfaktor für eine kontrollierte Arzneistoffappliktion mit partikulären Trägern. Ph.D. Thesis, Freie Universität Berlin.
    • (1997)
    • Lück, M.1
  • 42
    • 77956877294 scopus 로고    scopus 로고
    • Nanosuspensions of poorly soluble drugs for oral administration. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • Mauludin, R., 2008. Nanosuspensions of poorly soluble drugs for oral administration. Ph.D. Thesis, Freie Universität Berlin, Germany.
    • (2008)
    • Mauludin, R.1
  • 43
    • 61349095957 scopus 로고    scopus 로고
    • Development of an oral rutin nanocrystal formulation
    • Mauludin R., Müller R.H., Keck C.M. Development of an oral rutin nanocrystal formulation. Int. J. Pharm. 2009, 370:202-209.
    • (2009) Int. J. Pharm. , vol.370 , pp. 202-209
    • Mauludin, R.1    Müller, R.H.2    Keck, C.M.3
  • 44
    • 41949100244 scopus 로고    scopus 로고
    • Drug nanoparticles: formulating poorly water-soluble compounds
    • Merisko-Liversidge E.M., Liversidge G.G. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol. Pathol. 2008, 36:43-48.
    • (2008) Toxicol. Pathol. , vol.36 , pp. 43-48
    • Merisko-Liversidge, E.M.1    Liversidge, G.G.2
  • 46
    • 33644820008 scopus 로고    scopus 로고
    • Spray coated pellets as carrier system for mucoadhesive drug nanocrystals
    • Möschwitzer J., Müller R.H. Spray coated pellets as carrier system for mucoadhesive drug nanocrystals. Eur. J. Pharm. Biopharm. 2006, 62:282-287.
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , pp. 282-287
    • Möschwitzer, J.1    Müller, R.H.2
  • 47
    • 34547874107 scopus 로고    scopus 로고
    • Drug nanocrystals of poorly soluble drugs
    • American Scientific Publishers, H.S. Nalwa (Ed.)
    • Müller R.H., Akkar A. Drug nanocrystals of poorly soluble drugs. Encyclopedia of Nanoscience and Nanotechnology 2004, 627-638. American Scientific Publishers. H.S. Nalwa (Ed.).
    • (2004) Encyclopedia of Nanoscience and Nanotechnology , pp. 627-638
    • Müller, R.H.1    Akkar, A.2
  • 48
    • 77956877656 scopus 로고
    • Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution. US Patent 5858410.
    • Müller, R.H., Becker, R., Kruss, K.P., 1992. Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution. US Patent 5858410.
    • (1992)
    • Müller, R.H.1    Becker, R.2    Kruss, K.P.3
  • 49
    • 77956881646 scopus 로고    scopus 로고
    • Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution. US Patent 5858410.
    • Müller, R.H., Becker, R., Kruss, B., Peters, K., 1999. Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution. US Patent 5858410.
    • (1999)
    • Müller, R.H.1    Becker, R.2    Kruss, B.3    Peters, K.4
  • 50
    • 0000595701 scopus 로고    scopus 로고
    • Nanosuspensions-a formulation approach for poorly soluble and poorly bioavailable drugs
    • Marcel Dekker, New York, D.L. Wise (Ed.)
    • Müller R.H., Böhm B.H.L., Grau M.J. Nanosuspensions-a formulation approach for poorly soluble and poorly bioavailable drugs. Handbook of Pharmaceutical Controlled Release 2000, 345-357. Marcel Dekker, New York. D.L. Wise (Ed.).
    • (2000) Handbook of Pharmaceutical Controlled Release , pp. 345-357
    • Müller, R.H.1    Böhm, B.H.L.2    Grau, M.J.3
  • 51
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future
    • Müller R.H., Jacobs C., Kayser O. Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future. Adv. Drug Del. Rev. 2001, 47:3-19.
    • (2001) Adv. Drug Del. Rev. , vol.47 , pp. 3-19
    • Müller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 52
    • 77956884269 scopus 로고    scopus 로고
    • Method for controlled production of ultrafine microparticles and nanoparticles. WO/2001/003670., b.
    • Müller, R.H., Krause, K., Mäder, K., 2001b. Method for controlled production of ultrafine microparticles and nanoparticles. WO/2001/003670.
    • (2001)
    • Müller, R.H.1    Krause, K.2    Mäder, K.3
  • 53
    • 0037177516 scopus 로고    scopus 로고
    • Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability
    • Müller R.H., Jacobs C. Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability. Int. J. Pharm. 2002, 237:151-161.
    • (2002) Int. J. Pharm. , vol.237 , pp. 151-161
    • Müller, R.H.1    Jacobs, C.2
  • 54
    • 77956873057 scopus 로고    scopus 로고
    • Nanoparticles in therapeutics: drug nanocrystals and lipid nanoparticles. NanoTrends, Potsdam, Germany.
    • Müller, R.H., Pardeike, J., Hommoss, A., 2006. Nanoparticles in therapeutics: drug nanocrystals and lipid nanoparticles. NanoTrends, Potsdam, Germany.
    • (2006)
    • Müller, R.H.1    Pardeike, J.2    Hommoss, A.3
  • 55
    • 77956878186 scopus 로고    scopus 로고
    • Positively charged nanostructured lipid carriers (NLC) for drug delivery by adhesion. Ninth International Symposium on 'Advances in Technology and Business Potential of New Drug Delivery Systems' Controlled Release Society-Indian Local Chapter,Mumbai, India,
    • Müller, R.H., Shegokar, R., Singh, K.K., 2009. Positively charged nanostructured lipid carriers (NLC) for drug delivery by adhesion. Ninth International Symposium on 'Advances in Technology and Business Potential of New Drug Delivery Systems' Controlled Release Society-Indian Local Chapter,Mumbai, India, P36.
    • (2009) , pp. 36
    • Müller, R.H.1    Shegokar, R.2    Singh, K.K.3
  • 56
    • 33947487639 scopus 로고
    • The rate of solution of solid substances in their own solutions
    • Noyes A.A., Whitney W.R. The rate of solution of solid substances in their own solutions. J. Am. Chem. Soc. 1897, 19:930-934.
    • (1897) J. Am. Chem. Soc. , vol.19 , pp. 930-934
    • Noyes, A.A.1    Whitney, W.R.2
  • 57
    • 77956870490 scopus 로고    scopus 로고
    • Itraconazole nanosuspension meant for oral use: development of formulation, characterization and in vitro comparison with some marketed formulations
    • Pandey S. Itraconazole nanosuspension meant for oral use: development of formulation, characterization and in vitro comparison with some marketed formulations. Der Pharmacia Lettre 2010, 2:162-171.
    • (2010) Der Pharmacia Lettre , vol.2 , pp. 162-171
    • Pandey, S.1
  • 58
    • 0033965872 scopus 로고    scopus 로고
    • Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine mycobacterium avium infection
    • Peters K., Leitzke S., Diederichs J.E., Borner K., Hahn H., Müller R.H., Ehlers S. Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine mycobacterium avium infection. J. Antimicrob. Chemother. 2000, 45:77-83.
    • (2000) J. Antimicrob. Chemother. , vol.45 , pp. 77-83
    • Peters, K.1    Leitzke, S.2    Diederichs, J.E.3    Borner, K.4    Hahn, H.5    Müller, R.H.6    Ehlers, S.7
  • 59
    • 77956875727 scopus 로고    scopus 로고
    • Nanocrystals for use in topical cosmetic formulations and method of production thereof. US Patent 60/8866233.
    • Petersen, R., 2006. Nanocrystals for use in topical cosmetic formulations and method of production thereof. US Patent 60/8866233.
    • (2006)
    • Petersen, R.1
  • 60
    • 43349108297 scopus 로고    scopus 로고
    • A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium
    • Piao H., Kamiya N., Hirata A., Fujii T., Goto M. A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium. Pharm. Res. 2008, 25:896-901.
    • (2008) Pharm. Res. , vol.25 , pp. 896-901
    • Piao, H.1    Kamiya, N.2    Hirata, A.3    Fujii, T.4    Goto, M.5
  • 61
    • 4544383493 scopus 로고    scopus 로고
    • Nanosuspensions in drug delivery
    • Rabinow B.E. Nanosuspensions in drug delivery. Nat. Rev. Drug. Discov. 2004, 3:785-796.
    • (2004) Nat. Rev. Drug. Discov. , vol.3 , pp. 785-796
    • Rabinow, B.E.1
  • 62
    • 34548044623 scopus 로고    scopus 로고
    • Pharmacokinetics of drugs administered in nanosuspension
    • Rabinow B. Pharmacokinetics of drugs administered in nanosuspension. Discovery Med. 2005, 5:74-79.
    • (2005) Discovery Med. , vol.5 , pp. 74-79
    • Rabinow, B.1
  • 64
    • 77956886428 scopus 로고    scopus 로고
    • In vivo pharmacokinetic studies of albendazole nanoparticulate oral formulations for improved bioavailability
    • Ravichandran R. In vivo pharmacokinetic studies of albendazole nanoparticulate oral formulations for improved bioavailability. Int. J. Green Nanotechnol.: Biomed. 2010, 2:B46-B53.
    • (2010) Int. J. Green Nanotechnol.: Biomed. , vol.2
    • Ravichandran, R.1
  • 66
    • 77956878601 scopus 로고    scopus 로고
    • Development and evaluation of novel drug delivery systems for an anti-HIV Drugs. Ph.D. Thesis, S.N.D.T. Women's University, Mumbai, India.
    • Shegokar, R., 2010. Development and evaluation of novel drug delivery systems for an anti-HIV Drugs. Ph.D. Thesis, S.N.D.T. Women's University, Mumbai, India.
    • (2010)
    • Shegokar, R.1
  • 67
    • 77956871033 scopus 로고    scopus 로고
    • Antiretroviral Nanosuspensions for Latent HIV Reservoir Targeting. 36th Annual Meeting and Exposition of the Controlled Release Society, Copenhagen, Denmark., Abstract No. 588.
    • Shegokar, R., Singh, K.K., 2009. Antiretroviral Nanosuspensions for Latent HIV Reservoir Targeting. 36th Annual Meeting and Exposition of the Controlled Release Society, Copenhagen, Denmark., Abstract No. 588.
    • (2009)
    • Shegokar, R.1    Singh, K.K.2
  • 68
    • 77956870578 scopus 로고    scopus 로고
    • Targeting to Latent HIV reservoirs: production optimization and evaluation of nevirapine nanosuspensions, 69th International Congress of FIP. Istanbul, Turkey. Abstract No. 451.
    • Shegokar R., Singh K.K., Müller R.H., 2009. Targeting to Latent HIV reservoirs: production optimization and evaluation of nevirapine nanosuspensions, 69th International Congress of FIP. Istanbul, Turkey. Abstract No. 451.
    • (2009)
    • Shegokar, R.1    Singh, K.K.2    Müller, R.H.3
  • 69
    • 77956882921 scopus 로고    scopus 로고
    • Apeginin nanocrystal for supportive anticancer treatment. Int. J. Pharm., submitted for publication., a.
    • Shegokar, R., Al Shaal, L., Müller, R.H., Keck, C.M., 2010a. Apeginin nanocrystal for supportive anticancer treatment. Int. J. Pharm., submitted for publication.
    • (2010)
    • Shegokar, R.1    Al Shaal, L.2    Müller, R.H.3    Keck, C.M.4
  • 70
    • 77956883814 scopus 로고    scopus 로고
    • Local anaesthetic nanocrystal as prologed release formulation. First Combined Annual Meeting of the International Pharmaceutical Federation, PSWC and AAPS New Orleans, Louisiana, USA, Abstract no. 2203., b.
    • Shegokar, R., Al Shaal, L., Müller, R.H., 2010b. Local anaesthetic nanocrystal as prologed release formulation. First Combined Annual Meeting of the International Pharmaceutical Federation, PSWC and AAPS New Orleans, Louisiana, USA, Abstract no. 2203.
    • (2010)
    • Shegokar, R.1    Al Shaal, L.2    Müller, R.H.3
  • 71
    • 77956877293 scopus 로고    scopus 로고
    • In-vitro protein adsorption studies on nevirapine nanosuspensions for HIV chemotherapy. Nanomed.: Nanotechnol., Biol. Med., submitted for publication., c.
    • Shegokar, R., Jansch, M., Singh, K.K., Müller, R.H, 2010c. In-vitro protein adsorption studies on nevirapine nanosuspensions for HIV chemotherapy. Nanomed.: Nanotechnol., Biol. Med., submitted for publication.
    • (2010)
    • Shegokar, R.1    Jansch, M.2    Singh, K.K.3    Müller, R.H.4
  • 72
    • 77956870235 scopus 로고
    • Improvements in pharmaceutical compositions. GB Patent 2269536A.
    • Suker, H., Gassmann, P., 1994. Improvements in pharmaceutical compositions. GB Patent 2269536A.
    • (1994)
    • Suker, H.1    Gassmann, P.2
  • 73
    • 77956874859 scopus 로고    scopus 로고
    • US-FDA.
    • US-FDA. http://www.fda.gov/Food/FoodIngredientsPackaging/GenerallyRecognizedasSafeGRAS/default.htm.
  • 74
    • 34547259640 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment. Nanoscale Res. Lett. 2,
    • Wahlstrom, J.L., Chiang, P.C., Ghosh, S., Warren, C.J., Wene, S.P., Albin, L.A., Smith, M.E., Roberds, S.L., 2007. Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment. Nanoscale Res. Lett. 2, 291-296.
    • (2007) , pp. 291-296
    • Wahlstrom, J.L.1    Chiang, P.C.2    Ghosh, S.3    Warren, C.J.4    Wene, S.P.5    Albin, L.A.6    Smith, M.E.7    Roberds, S.L.8
  • 75
    • 77956875808 scopus 로고    scopus 로고
    • weblink1, .
    • weblink1, http://www.wissenschaft-technik-ethik.de/wasser_dampfdruck.html.
  • 76
    • 77956882486 scopus 로고    scopus 로고
    • weblink2, .
    • weblink2, http://www.caelo.de/getfile.html%3Ftype=sdb%26num=3274.
  • 77
    • 77956872372 scopus 로고    scopus 로고
    • weblink3, .
    • weblink3, http://www.europarl.europa.eu/sides/getDoc.do%3Ftype=IM-PRESS%26reference=20090323IPR52331%26language=EN.
  • 78
    • 0032890771 scopus 로고    scopus 로고
    • Lymph node extraction of radiopaque nanoparticulates in the rabbit as measured in vivo with CT
    • Wolf G.L., Shore M.T., Bessin G., McIntire G.L., Bacon E.R., Illig K.J. Lymph node extraction of radiopaque nanoparticulates in the rabbit as measured in vivo with CT. Acad. Radiol. 1999, 6:55-60.
    • (1999) Acad. Radiol. , vol.6 , pp. 55-60
    • Wolf, G.L.1    Shore, M.T.2    Bessin, G.3    McIntire, G.L.4    Bacon, E.R.5    Illig, K.J.6
  • 79
    • 49749102777 scopus 로고    scopus 로고
    • Distribution of an intravenous injectable nimodipine nanosuspension in mice
    • Xiong R., Lu W., Yue P., Xu R., Li J., Chen T., Wang P. Distribution of an intravenous injectable nimodipine nanosuspension in mice. J. Pharm. Pharmacol. 2008, 60:1155-1159.
    • (2008) J. Pharm. Pharmacol. , vol.60 , pp. 1155-1159
    • Xiong, R.1    Lu, W.2    Yue, P.3    Xu, R.4    Li, J.5    Chen, T.6    Wang, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.