-
1
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Albert A. Chemical aspects of selective toxicity. Nature 1958, 182:421-427.
-
(1958)
Nature
, vol.182
, pp. 421-427
-
-
Albert, A.1
-
2
-
-
84906272046
-
-
In: Drug Design and Adverse Reactions, Alfred Benzon Symposium X, Munksgaard
-
Ariens, E.J., Simonis, A.M., 1977. In: Drug Design and Adverse Reactions, Alfred Benzon Symposium X, Munksgaard, pp. 317-330.
-
(1977)
, pp. 317-330
-
-
Ariens, E.J.1
Simonis, A.M.2
-
4
-
-
0026687815
-
(R)-2-(3-mercapto-2(S)-methyl-1-oxo-Propoxy)-3-(methylthio) propanoic acid, the first ultra short acting angiotensin converting enzyme inhibitor
-
Baxter A.J., Carr R.D., Eyley S.C., Fraser-Rae L., Hallam C., Harper S.T., Hurved P.A., King S.J., Meghani P. (R)-2-(3-mercapto-2(S)-methyl-1-oxo-Propoxy)-3-(methylthio) propanoic acid, the first ultra short acting angiotensin converting enzyme inhibitor. J. Med. Chem. 1992, 35:3718-3720.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3718-3720
-
-
Baxter, A.J.1
Carr, R.D.2
Eyley, S.C.3
Fraser-Rae, L.4
Hallam, C.5
Harper, S.T.6
Hurved, P.A.7
King, S.J.8
Meghani, P.9
-
6
-
-
0002622795
-
Designing safer drugs based on soft drug approach
-
Bodor N. Designing safer drugs based on soft drug approach. Trends Pharmacol. Sci. 1982, 3:53-56.
-
(1982)
Trends Pharmacol. Sci.
, vol.3
, pp. 53-56
-
-
Bodor, N.1
-
7
-
-
0021294113
-
The soft drug approach
-
Bodor N. The soft drug approach. Chem. Tech. 1984, 14:28-38.
-
(1984)
Chem. Tech.
, vol.14
, pp. 28-38
-
-
Bodor, N.1
-
8
-
-
0010577935
-
Novel approaches to the design of safer drugs by site specific chemical delivery systems
-
MSR Foundation, Bombay
-
Bodor N. Novel approaches to the design of safer drugs by site specific chemical delivery systems. Adv. Drug Delivery Syst 1985, 111-127. MSR Foundation, Bombay.
-
(1985)
Adv. Drug Delivery Syst
, pp. 111-127
-
-
Bodor, N.1
-
9
-
-
0022270853
-
Targetting of drugs to the brain
-
Bodor N. Targetting of drugs to the brain. Methods Enzymol. 1985, 112:381-396.
-
(1985)
Methods Enzymol.
, vol.112
, pp. 381-396
-
-
Bodor, N.1
-
10
-
-
0023632674
-
Redox drug delivery systems for targeting drugs to the brain
-
Bodor N. Redox drug delivery systems for targeting drugs to the brain. Ann. NY Acad. Sci. 1987, 507:289-306.
-
(1987)
Ann. NY Acad. Sci.
, vol.507
, pp. 289-306
-
-
Bodor, N.1
-
11
-
-
0025170708
-
Prokai L.Site and stereo specific ocular drug delivery by sequential enzymatic bioactivation
-
Bodor N. Prokai L.Site and stereo specific ocular drug delivery by sequential enzymatic bioactivation. Pharm. Res. 1990, 7:723-725.
-
(1990)
Pharm. Res.
, vol.7
, pp. 723-725
-
-
Bodor, N.1
-
12
-
-
0028457169
-
Drug targeting and retro metabolic drug design approaches
-
Bodor N. Drug targeting and retro metabolic drug design approaches. Adv. Drug Delivery Rev. 1994, 14:157-166.
-
(1994)
Adv. Drug Delivery Rev.
, vol.14
, pp. 157-166
-
-
Bodor, N.1
-
13
-
-
0002292012
-
Design of biologically safer chemicals
-
Bodor N. Design of biologically safer chemicals. Chem. Tech. 1995, 25:22-32.
-
(1995)
Chem. Tech.
, vol.25
, pp. 22-32
-
-
Bodor, N.1
-
14
-
-
0033526158
-
Drug targeting and retrometabolic drug design approaches
-
Bodor N. Drug targeting and retrometabolic drug design approaches. Adv. Drug Delivery Rev. 1999, 36:229-254.
-
(1999)
Adv. Drug Delivery Rev.
, vol.36
, pp. 229-254
-
-
Bodor, N.1
-
16
-
-
0031278026
-
Drug targeting via retro metabolic approaches
-
Bodor N., Buchwald P. Drug targeting via retro metabolic approaches. Pharmacol. Ther. 1997, 76:1-27.
-
(1997)
Pharmacol. Ther.
, vol.76
, pp. 1-27
-
-
Bodor, N.1
Buchwald, P.2
-
18
-
-
0033966357
-
Soft drug design: general principles and recent applications
-
Bodor N., Buchwald P. Soft drug design: general principles and recent applications. Med. Res. Rev. 2000, 20:58-101.
-
(2000)
Med. Res. Rev.
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
20
-
-
33747125838
-
Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems
-
Bodor N., Buchwald P. Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems. AAPS J. 2005, 7:E820-E833.
-
(2005)
AAPS J.
, vol.7
-
-
Bodor, N.1
Buchwald, P.2
-
21
-
-
0026045316
-
Improved delivery through biological memberanes. LVI. Pharmacological evaluation of Alprenoxime-A new potential antiglaucoma agent
-
Bodor N., Elkouss A. Improved delivery through biological memberanes. LVI. Pharmacological evaluation of Alprenoxime-A new potential antiglaucoma agent. Pharm. Res. 1991, 8:1389-1395.
-
(1991)
Pharm. Res.
, vol.8
, pp. 1389-1395
-
-
Bodor, N.1
Elkouss, A.2
-
22
-
-
0018908788
-
Soft drugs. 2. Soft alkylating compounds as potential antitumor agents
-
Bodor N., Kaminski J.J. Soft drugs. 2. Soft alkylating compounds as potential antitumor agents. J. Med. Chem. 1980, 23:566-569.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 566-569
-
-
Bodor, N.1
Kaminski, J.J.2
-
23
-
-
77956854345
-
Prodrugs and site specific chemical delivery systems
-
Bodor N., Kaminski J.J. Prodrugs and site specific chemical delivery systems. Annu. Rep. Med. Chem. 1987, 22:303-313.
-
(1987)
Annu. Rep. Med. Chem.
, vol.22
, pp. 303-313
-
-
Bodor, N.1
Kaminski, J.J.2
-
24
-
-
0020332724
-
Soft drugs V: thiazolidine-type derivatives of progesterone and testosterone
-
Bodor N., Sloan K.B. Soft drugs V: thiazolidine-type derivatives of progesterone and testosterone. J. Pharm. Sci. 1982, 71:514-520.
-
(1982)
J. Pharm. Sci.
, vol.71
, pp. 514-520
-
-
Bodor, N.1
Sloan, K.B.2
-
25
-
-
33745609384
-
Soft drugs: labile quaternary ammonium salts as soft antimicrobials
-
Bodor N., Kaminski J.J., Selk S. Soft drugs: labile quaternary ammonium salts as soft antimicrobials. J. Med. Chem. 1980, 23:469-474.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 469-474
-
-
Bodor, N.1
Kaminski, J.J.2
Selk, S.3
-
26
-
-
0019014701
-
Soft drugs. A new class of anticholinergic agents
-
Bodor N., Woods R., Raper C., Kearney P., Kaminski J.J. Soft drugs. A new class of anticholinergic agents. J. Med. Chem. 1980, 23:474-480.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 474-480
-
-
Bodor, N.1
Woods, R.2
Raper, C.3
Kearney, P.4
Kaminski, J.J.5
-
27
-
-
0019843193
-
Site-specific sustained release of drugs to the brain
-
Bodor N., Farag H.H., Brewster M.E. Site-specific sustained release of drugs to the brain. Science 1981, 214:1370-1372.
-
(1981)
Science
, vol.214
, pp. 1370-1372
-
-
Bodor, N.1
Farag, H.H.2
Brewster, M.E.3
-
28
-
-
0023853652
-
Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for beta-adrenergic blocking agents
-
Bodor N., ElKoussi A., Kano M., Nakamura T. Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for beta-adrenergic blocking agents. J. Med. Chem. 1988, 31:100-106.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 100-106
-
-
Bodor, N.1
ElKoussi, A.2
Kano, M.3
Nakamura, T.4
-
29
-
-
0023719851
-
Soft drugs.7. Soft β-blockers for systemic and ophthalmic use
-
Bodor N., el-Koussi A.A., Kano M., Khalifa M.M. Soft drugs.7. Soft β-blockers for systemic and ophthalmic use. J. Med. Chem. 1988, 31:1651-1656.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 1651-1656
-
-
Bodor, N.1
el-Koussi, A.A.2
Kano, M.3
Khalifa, M.M.4
-
31
-
-
0022996140
-
Improved delivery through biological memberanes. XXIV. Synthesis, in vitro studies, and in vivo characterization of brain- specific and sustained progestin delivery systems
-
Brewester E.M., Estes K.S., Bodor N. Improved delivery through biological memberanes. XXIV. Synthesis, in vitro studies, and in vivo characterization of brain- specific and sustained progestin delivery systems. Pharm. Res. 1986, 5:278-285.
-
(1986)
Pharm. Res.
, vol.5
, pp. 278-285
-
-
Brewester, E.M.1
Estes, K.S.2
Bodor, N.3
-
32
-
-
0029072293
-
Dose dependent brain delivery of Zidovudine through the use of a zidovudine chemical delivery system
-
Brewester E.M., Anderson W.R., Helton D.O., Bodor N., Pop E. Dose dependent brain delivery of Zidovudine through the use of a zidovudine chemical delivery system. Pharm. Res. 1995, 12:796-798.
-
(1995)
Pharm. Res.
, vol.12
, pp. 796-798
-
-
Brewester, E.M.1
Anderson, W.R.2
Helton, D.O.3
Bodor, N.4
Pop, E.5
-
33
-
-
0029938744
-
Design and evaluation of soft analogs of Propantheline
-
Brouillette G., Kawamura M., Kumar G.N., Bodor N. Design and evaluation of soft analogs of Propantheline. J. Pharm. Sci. 1996, 85:619-623.
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 619-623
-
-
Brouillette, G.1
Kawamura, M.2
Kumar, G.N.3
Bodor, N.4
-
34
-
-
32344437143
-
Soft quaternary anticholinergics: Comprehensive quantitative structure-activity relationship (QSAR) with a Linerarised Biexponential (LiniBiexp) model
-
Buchwald P., Bodor N. Soft quaternary anticholinergics: Comprehensive quantitative structure-activity relationship (QSAR) with a Linerarised Biexponential (LiniBiexp) model. J. Med. Chem. 2006, 49:883-891.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 883-891
-
-
Buchwald, P.1
Bodor, N.2
-
35
-
-
0032543730
-
L-carnitine esters as soft broad spectrum antimicrobial amphiphiles
-
Calvani M., Critelli L., Gallo G., Giorgi F., Gramiccioli G., Santaniello M., Scafetta N., Tinti M.O., De Angelis F. l-carnitine esters as soft broad spectrum antimicrobial amphiphiles. J. Med. Chem. 1998, 41:2227-2233.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2227-2233
-
-
Calvani, M.1
Critelli, L.2
Gallo, G.3
Giorgi, F.4
Gramiccioli, G.5
Santaniello, M.6
Scafetta, N.7
Tinti, M.O.8
De Angelis, F.9
-
36
-
-
0032563852
-
Strategies to target kyotrophin analogs to the brain
-
Chen P., Bodor N., Wu W.M., Prokai L. Strategies to target kyotrophin analogs to the brain. J. Med. Chem. 1998, 41:3773-3781.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3773-3781
-
-
Chen, P.1
Bodor, N.2
Wu, W.M.3
Prokai, L.4
-
37
-
-
0034677966
-
Drug discovery: a historical perspective
-
Drews J. Drug discovery: a historical perspective. Science 2000, 287(5640):1960-1964.
-
(2000)
Science
, vol.287
, Issue.5640
, pp. 1960-1964
-
-
Drews, J.1
-
38
-
-
0020371621
-
Ultra short acting β-adrenergic receptor blocking agents.2. (Aryloxy) propanolamines containing esters on the aryl function
-
Erhardt P.W., Woo C.M., Anderson W.G., Gorczynski R.J. Ultra short acting β-adrenergic receptor blocking agents.2. (Aryloxy) propanolamines containing esters on the aryl function. J. Med. Chem. 1982, 25:1408-1412.
-
(1982)
J. Med. Chem.
, vol.25
, pp. 1408-1412
-
-
Erhardt, P.W.1
Woo, C.M.2
Anderson, W.G.3
Gorczynski, R.J.4
-
39
-
-
0025769798
-
Design, synthesis and pharmacological evaluation of Ultra short to long acting opioid analgesics
-
Feldman P.L., James M.K., Brackeen M.F., Bilotta J.M., Schuster S.V., Lahey A.P., Lutz M.W., Johnson M.R., Leighton H.J. Design, synthesis and pharmacological evaluation of Ultra short to long acting opioid analgesics. J. Med. Chem. 1991, 34:2202-2208.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2202-2208
-
-
Feldman, P.L.1
James, M.K.2
Brackeen, M.F.3
Bilotta, J.M.4
Schuster, S.V.5
Lahey, A.P.6
Lutz, M.W.7
Johnson, M.R.8
Leighton, H.J.9
-
41
-
-
0018615111
-
Effects of induction of cytochrome P-450 enzymes on concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds
-
Gillette J.R. Effects of induction of cytochrome P-450 enzymes on concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds. Drug Metab. Rev. 1979, 10:59-87.
-
(1979)
Drug Metab. Rev.
, vol.10
, pp. 59-87
-
-
Gillette, J.R.1
-
42
-
-
60049094855
-
1-Malonyl-1, 4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain
-
Hassan H.A., Abdel-Aziz M., Abuo-Rahma Gamal El-Din A.A, Farag H.H. 1-Malonyl-1, 4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain. Bioorg. Med. Chem. 2009, 17:1681-1692.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1681-1692
-
-
Hassan, H.A.1
Abdel-Aziz, M.2
Abuo-Rahma, G.E.D.A.3
Farag, H.H.4
-
43
-
-
0027053957
-
Pharmakokinetic characterization and tissue distribution of the new glucocoid soft drug Loteprednol Etabonate in rats and dogs
-
Hochhaus G., Chen L.S., Ratka A., Druzgala P., Howes J., Bodor N., Derendorf H. Pharmakokinetic characterization and tissue distribution of the new glucocoid soft drug Loteprednol Etabonate in rats and dogs. J. Pharm. Sci. 1992, 81:1210-1215.
-
(1992)
J. Pharm. Sci.
, vol.81
, pp. 1210-1215
-
-
Hochhaus, G.1
Chen, L.S.2
Ratka, A.3
Druzgala, P.4
Howes, J.5
Bodor, N.6
Derendorf, H.7
-
44
-
-
0034692180
-
Soft drugs.12. Design, synthesis and evaluation of soft bufuralol analogs
-
Hwang S.K., Juhasz A., Yoon S.H., Bodor N. Soft drugs.12. Design, synthesis and evaluation of soft bufuralol analogs. J. Med. Chem. 2000, 43:1525-1532.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1525-1532
-
-
Hwang, S.K.1
Juhasz, A.2
Yoon, S.H.3
Bodor, N.4
-
45
-
-
18644377071
-
Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists
-
Jeffrey A.S., Gregory J.P., Richard F.C., Jill R.C., George F.D., Stephen S.G., David K.J., George W.K., Maggie S.M., Jeffrey H.T., Robert P.W., Paul L.F. Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists. Bioorg. Med. Chem. Lett. 2002, 12:3215-3218.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 3215-3218
-
-
Jeffrey, A.S.1
Gregory, J.P.2
Richard, F.C.3
Jill, R.C.4
George, F.D.5
Stephen, S.G.6
David, K.J.7
George, W.K.8
Maggie, S.M.9
Jeffrey, H.T.10
Robert, P.W.11
Paul, L.F.12
-
46
-
-
0017030686
-
N-halo derivatives IV: synthesis of low chlorine potential soft N-chloramine systems
-
Kaminski J.J., Bodor N., Higuchi T. N-halo derivatives IV: synthesis of low chlorine potential soft N-chloramine systems. J. Pharm. Sci. 1976, 65:1733-1737.
-
(1976)
J. Pharm. Sci.
, vol.65
, pp. 1733-1737
-
-
Kaminski, J.J.1
Bodor, N.2
Higuchi, T.3
-
47
-
-
0037136022
-
Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues
-
Katalin P.T., Pá Perjé si, Alevtina D.Z, Xiaoxu L, Laszlo P Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues. Bioorg. Med. Chem. Lett. 2002, 12:2171-2174.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 2171-2174
-
-
Katalin, P.T.1
Pá Perjé si2
Alevtina, D.Z.3
Xiaoxu, L.4
Laszlo, P.5
-
48
-
-
0037468518
-
Synthesis and biological evaluation of novel Cyclosporin A analogues: potential soft drugs for the treatment of autoimmune diseases
-
Lazarova S., Chen J.S., Hamann B., Kang J.M., Homuth-Trombino D., Han F., Hoffmann E., McClure C., Eckstein J., Or Y.S. Synthesis and biological evaluation of novel Cyclosporin A analogues: potential soft drugs for the treatment of autoimmune diseases. J. Med. Chem. 2003, 46:674-676.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 674-676
-
-
Lazarova, S.1
Chen, J.S.2
Hamann, B.3
Kang, J.M.4
Homuth-Trombino, D.5
Han, F.6
Hoffmann, E.7
McClure, C.8
Eckstein, J.9
Or, Y.S.10
-
49
-
-
69549130862
-
Synthesis, radiosynthesis and biological evaluation of 1,4 dihydroquinoline derivatives as new carriers for specific brain delivery
-
Ĺenar̈ig F., Fabienne G., Martine D., Pierre B., Georges D., Jean C., Ahmed A., Francis M., Louisa Barŕe, Vincent L. Synthesis, radiosynthesis and biological evaluation of 1,4 dihydroquinoline derivatives as new carriers for specific brain delivery. Org. Biomol. Chem. 2009, 7:3666-3673.
-
(2009)
Org. Biomol. Chem.
, vol.7
, pp. 3666-3673
-
-
Ĺenar̈ig, F.1
Fabienne, G.2
Martine, D.3
Pierre, B.4
Georges, D.5
Jean, C.6
Ahmed, A.7
Francis, M.8
Louisa Barŕe9
Vincent, L.10
-
50
-
-
0032982918
-
Soft drugs based on hydrocortisone: The inactive metabolite approach and its application to steroidal anti-inflammatory agents
-
Little R.J., Bodor N., Loftsson T. Soft drugs based on hydrocortisone: The inactive metabolite approach and its application to steroidal anti-inflammatory agents. Pharm. Res. 1999, 16:961-967.
-
(1999)
Pharm. Res.
, vol.16
, pp. 961-967
-
-
Little, R.J.1
Bodor, N.2
Loftsson, T.3
-
51
-
-
0006689060
-
-
Marcel Dekker, New York, B. Testa, P. Jenner (Eds.)
-
Mannering G.J. Concepts in drug metabolism 1981, 53-166. Marcel Dekker, New York. B. Testa, P. Jenner (Eds.).
-
(1981)
Concepts in drug metabolism
, pp. 53-166
-
-
Mannering, G.J.1
-
53
-
-
0025824035
-
Solublization and stabilization of a benzyl penicillin chemical delivery system by 2-hydroxylpropyl-β-cyclodextrin
-
Pop E., Loftsson T., Bodor N. Solublization and stabilization of a benzyl penicillin chemical delivery system by 2-hydroxylpropyl-β-cyclodextrin. Pharm. Res. 1991, 8:1044-1049.
-
(1991)
Pharm. Res.
, vol.8
, pp. 1044-1049
-
-
Pop, E.1
Loftsson, T.2
Bodor, N.3
-
54
-
-
0030471676
-
Brain targeted delivery of a leucine-enkaphalin analog by retrometabolic design
-
Prokai T.K., Prokai L., Bodor N. Brain targeted delivery of a leucine-enkaphalin analog by retrometabolic design. J. Med. Chem. 1996, 39:4775-4782.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4775-4782
-
-
Prokai, T.K.1
Prokai, L.2
Bodor, N.3
-
56
-
-
0024372756
-
Esters derivatives of 2,6-bis (1-pyrrolidinylmethyl)-4-benzamidophenol as short acting antiarrythmic agents.1
-
Stout D.M., Black L.A., Barcelon-Yang C., Matier W.L., Brown B.S., Quon C.Y., Stampfli H.F. Esters derivatives of 2,6-bis (1-pyrrolidinylmethyl)-4-benzamidophenol as short acting antiarrythmic agents.1. J. Med. Chem. 1989, 32:1910-1913.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 1910-1913
-
-
Stout, D.M.1
Black, L.A.2
Barcelon-Yang, C.3
Matier, W.L.4
Brown, B.S.5
Quon, C.Y.6
Stampfli, H.F.7
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