Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats

Journal of Ethnopharmacology

Volumn 111, Issue 1, 2007, Pages 29-32

  Graça, Carlos ^a   Freitas, Cristina Setim ^a   Baggio, Cristiane Hatsuko ^a   Dalsenter, Paulo Roberto ^a   Marques, Maria Consuelo Andrade ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Asteraceae; Guaco syrup; Male reproductive toxicology; Mikania laevigata; Wistar rats

Indexed keywords

COUMARIN; HERBACEOUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EXPOSURE; MALE; MALE GENITAL SYSTEM; MEDICINAL PLANT; MIKANIA LAEVIGATA; NONHUMAN; ORGAN WEIGHT; RAT; REPRODUCTIVE TOXICITY; SPERM; SPERMATID; SYRUP; TOXICITY TESTING; TREATMENT DURATION; TREATMENT OUTCOME; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BRAZIL; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; FERTILITY; GENITALIA, MALE; INTUBATION, GASTROINTESTINAL; MALE; MIKANIA; PARASYMPATHOLYTICS; PLANT EXTRACTS; PROSTATE; RATS; RATS, WISTAR; RESPIRATORY SYSTEM AGENTS; SEMINAL VESICLES; SPERM COUNT; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TIME FACTORS;

ANIMALIA; ASTERACEAE; MIKANIA CONGESTA; MIKANIA LAEVIGATA; RATTUS; RATTUS NORVEGICUS;

EID: 34147170529     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.10.039     Document Type: Article

References (23)

1. Amann R.P., Johnson L., Thompson D.L., and Pickett B.W. Daily spermatozoal production. Biology of Reproduction 15 (1976) 586-592
2. Bighetti A.E., Antonio M.A., Kohn L.K., Rehder V.L., Foglio M.A., Possenti A., Vilela L., and Carvalho J.E. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine 12 (2005) 72-77
3. Coimbra, R., 1942. Notas de fitoterapia. Laboratório Clínico Silva Araújo, Rio de Janeiro.
4. Fierro I.M., Silva A.C.B., Lopes C.S., Moura R.S., and Barja-Fidalgo C. Studies on the anti-allergic activity of Mikania glomerata. Journal of Ethnopharmacology 66 (1999) 19-24
5. Leite M.G.R., Souza C.L., Silva M.A.M., Moreira L.K.A., Matos F.J.A., and Viana G.S.B. Estudo farmacológico comparativo de Mikania Glomerata Spreng (guaco). Justicia pectoralis Jacq (anador) e Torresea cearensis Fr. All (cumarú). Revista Brasileira de Farmácia 1 (1993) 12-15
6. Lucas V. Estudo farmacognóstico do guaco Mikania glomerata Sprengel. Revista da Flora Medicinal 9 (1942) 101-132
7. OECD, Organization for Economic Co-operation and Development, 1998. Guideline 408: subchronic oral toxicity, Rodent: 90 days, Paris.
8. Oliveira, F., Alvarenga, M.A., Akisue, G., Akisue, M.K., 1984. Isolamento e identificação de componentes químicos de Mikania glomerata Sprengel de Mikania laevigata Schultz Bip ex Baker. Revista Farmacêutica e Bioquímica da Universidade de São Paulo 2, 169-183.
9. Oliveira, F., Saito, M.L., Garcia, L.O., 1994. Morfologia externa das partes aéreas e anatomia foliar das espécies brasileiras de Mikania secção Globosae Robinson-visão farmacognóstica. LECTA-USF 12, 23-65.
10. Osório, A.C., 2002. Controle de qualidade do extrato fluído e tintura de guaco (Mikania glomerata Sprengel). Ph.D. Thesis. Universidade de São Paulo, São Paulo.
11. Rehder V.L.G., Sartoratto A., Magalhães P.M., Figueira G.M., Montanari Jr. I., and Lourenço C.M. Teor de cumarina em Mikania laevigata Schultz Bip. ex Baker em função do cultivo, colheita e secagem. Anais do, XV., Simpósio de Plantas Medicinais do Brasil. São Paulo (1998) 107
12. Robb G.W., Amann R.P., and Killian G.J. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. Journal of Reproduction and Fertility 54 (1978) 103-107
13. Sá R.C.S., Leite M.N., Reporedo M.M., and Almeida R.N. Evaluation of long-term exposure to Mikania glomerata (Sprengel) extract on male Wistar rat' reproductive organs, sperm production and testosterone level. Contraception 67 (2003) 327-331
14. Santos S.C., Pereira C.I., and Biavatti M.W. Doseamento da cumarina (12 benzopirona) no xarope de guaco (Mikania glomerata Spreng) produzido pelo laboratório de fitoterápicos da UNIVALE. Anais do XV Simpósio de Plantas Medicinais do Brasil. São Paulo (1998) 197
15. Seed J., Chapin R.E., Clegg E.D., Dostal L.A., Foote R.H., Hurtt M.E., Klinefelter G.R., Makris S.L., Perreault S.D., Schrader S., Seyler D., Sprando R., Treinen K.A., Veeramachaneni D.N., and Wise L.D. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation. Reproductive Toxicology 10 (1996) 237-244
16. Silva R.A.D. Pharmacopeia dos Estados Unidos do Brasil (1929), Companhia Editora Nacional, São Paulo p. 1149
17. Soares de Moura R., Costa S.S., Jansen J.M., Silva C.A., Lopes C.S., Bernardo-Filho M., Nascimento da Silva V., Criddli D.N., Portela N.B., Rubenich L.M.S., Araújo R.G., and Carvalho L.C.R.M. Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig trachea. Journal of Pharmacy and Pharmacology 54 (2002) 249-256
18. Suyenaga E.S., Reche E., Farias F.M., Schapoval E.E., Chaves C.G.M., and Henriques A.T. Antiinflammatory investigation of some species of Mikania. Phytotherapy Research 16 (2002) 519-523
19. Thomas J.A. Toxic responses of the reproductive system. In: Klaassen C.D. (Ed). Casarett & Doull's toxicology. The Basic Science of Poisons (1996), McGraw-Hill, New York 547-581
20. Ulubelen A., Ertugrul L., Birman H., Yigit R., Erseven G., and Olgac V. Antifertility effects of some coumarins isolated from Ruta chalepensis and R. chalepensis var. latifolia in rodents. Phytotherapy Research 8 (1994) 233-236
21. Veneziani R.C.S., and Oliveira D.C.R. Constituents of Mikania glomerata Sprengel. Biochemical Systematics and Ecology 27 (1999) 99-102
22. Vilegas J.H.Y., Marchi E., and Lanças F.M. Extraction of low-polarty compounds (with emphasis on coumarin and kaurenoic acid) from Mikania glomerata ("guaco") leaves. Phytochemical Analysis 8 (1997) 266-270
23. Zenick H., and Cleeg E.D. Assessment of male reproductive toxicity: a risk assessment approach. In: Hayes W. (Ed). Principles and Methods of Toxicology (1989), Raven Press, New York 275-309