Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations

Phytomedicine

Volumn 14, Issue 9, 2007, Pages 587-590

  Matthias, A ^a   Addison, R S ^b   Agnew, L L ^c   Bone, K M ^a,c   Watson, K ^c   Lehmann, R P ^a  

^a MediHerb Research Laboratories   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Bioavailability; Echinacea; Human; Liquid; Pharmacokinetics; Tablet

Indexed keywords

ALCOHOL; AMIDE; ECHINACEA EXTRACT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; ECHINACEA; ECHINACEA ANGUSTIFOLIA; ECHINACEA PURPUREA; HUMAN; HUMAN EXPERIMENT; LIQUID; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; AMIDES; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; ECHINACEA; HUMANS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS;

ECHINACEA ANGUSTIFOLIA; ECHINACEA PURPUREA;

EID: 34547533424     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.12.021     Document Type: Article

References (6)

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2. Dietz B., Heilmann J., and Bauer R. Absorption of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture. Planta Med. 67 (2001) 863-864
3. Lentner, C. (Ed.), 1984. Geigy Scientific Tables. Basel, Switzerland, Ciba-Geigy 3, 65.
4. Matthias A., Blanchfield J.T., Penman K.G., Toth I., Lang C.-S., De Voss J.J., and Lehmann R.P. Permeability studies of alkylamides and caffeic acid conjugates from Echinacea using Caco-2 cell monolayer model. J. Clin. Pharm. Ther. 29 (2004) 7-13
5. Matthias A., Addison R.S., Penman K.G., Dickinson R.G., Bone K.M., and Lehmann R.P. Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion. Life Sci. 77 (2005) 2018-2029
6. Woelkart K., Koidl C., Grisold A., Gangemi J.D., Turner R.B., Marth E., and Bauer R. Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans. J. Clin. Pharmacol. 45 (2005) 683-689