Carotenoids and cardiovascular risk

Current Pharmaceutical Design

Volumn 18, Issue 34, 2012, Pages 5577-5589

  Giordano, Paola ^a   Scicchitano, Pietro ^a   Locorotondo, Manuela ^a   Mandurino, Cosimo ^a   Ricci, Gabriella ^a   Carbonara, Santa ^a   Gesualdo, Michele ^a   Zito, Annapaola ^a   Dachille, Annamaria ^a   Caputo, Paola ^a   Riccardi, Roberta ^a   Frasso, Giulia ^a   Lassandro, Giuseppe ^a   Di Mauro, Antonio ^a   Ciccone, Marco Matteo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Atherosclerosis; Cardiovascular prevention; Cardiovascular risk; Carotenoids; Oxidative stress

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA CAROTENE; BETA CAROTENE; BIOLOGICAL MARKER; CAROTENOID; LOW DENSITY LIPOPROTEIN; LYCOPENE; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; REACTIVE OXYGEN METABOLITE; XANTHOPHYLL; ZEAXANTHIN;

ANAMNESIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTERIAL WALL THICKNESS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG STRUCTURE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD INTAKE; FOOD PROCESSING; HUMAN; INTESTINE ABSORPTION; LIPID PEROXIDATION; OBESITY; OXIDATIVE STRESS; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RISK REDUCTION; SEX DIFFERENCE; SMOKING;

ANIMALS; ANTIOXIDANTS; CARDIOVASCULAR DISEASES; CAROTENOIDS; DISEASE PROGRESSION; FREE RADICAL SCAVENGERS; HUMANS; LIPOPROTEINS, LDL; OXIDATIVE STRESS; PLAQUE, ATHEROSCLEROTIC; REACTIVE OXYGEN SPECIES; RISK FACTORS;

EID: 84867717544     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212803307527     Document Type: Review

References (73)

1. Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006; 113: e85-151.
2. Rosengren A, Wallentin L, Simoons M, et al. Cardiovascular risk factors and clinical presentation in acute coronary syndromes. Heart 2005; 91: 1141-7.
3. Ciccone MM, De Pergola G, Porcelli MT, et al. Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage? BMC Cardiovasc Disord 2010; 10: 22.
4. Ciccone MM, Marzullo A, Mizio D, et al. Can carotid plaque histology selectively predict the risk of an acute coronary syndrome? Int Heart J 2011; 52: 72-77.
5. Ciccone MM, Miniello V, Marchioli R, et al. Morphological and functional vascular changes induced by childhood obesity. Eur J Cardiovasc Prev Rehabil 2011; 18: 831-5.
6. Ciccone MM, Balbarini A, Porcelli MT, et al. Carotid artery intima-media thickness: normal and percentile values in the Italian population (camp study). Eur J Cardiovasc Prev Rehabil 2011; 18: 650-5.
7. Ciccone MM, Niccoli-Asabella A, Scicchitano P, et al. Cardiovascular risk evaluation and prevalence of silent myocardial ischemia in subjects with asymptomatic carotid artery disease. Vasc Health Risk Manag 2011; 7: 129-34.
8. Wustmann K, Klaey M, Burow A, Shaw SG, Hess OM, Allemann Y. Additive Effect of Homocysteine- and Cholesterol-Lowering Therapy on Endothelium-Dependent Vasodilation in Patients with Cardiovascular Disease. Cardiovasc Ther 2011 doi: 10.1111/j.1755-5922.2011.00272.x. [Epub ahead of print].
9. Diaz MN, Frei B, Vita JA, Keaney JF Jr. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997; 337: 408-16.
10. Marin C, Delgado-Lista J, Ramirez R, et al. Mediterranean diet reduces senescence-associated stress in endothelial cells. Age (Dordr) 2011 Sep 6. [Epub ahead of print].
11. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and metaanalysis. JAMA 2007; 297: 842-57.
12. Paiva SAR, Russell RM. β-Carotene and Other Carotenoids as Antioxidants. J Am College Nutrition 1999; 18: 426-33.
13. Rao AV, Agarwal S. Effect of diet and smoking on serum lycopene and lipid peroxidation. Nutr Res 1998; 18: 713-21.
14. Kontush A, Weber W, Beisiegel U. Alpha- and beta-carotenes in low density lipoprotein are the preferred target for nitric oxideinduced oxidation. Atherosclerosis 2000; 148: 87-93.
15. Dwyer JH, Navab M, Dwyer KM, et al. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation 2001; 103: 2922-7.
16. Hozawa A, Jacobs DR Jr, Steffes MW, Gross MD, Steffen LM, Lee DH. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study. ClinChem 2007; 53: 447-55.
17. Markovits N, Amotz AB, Levy Y. The Effect of Tomato-Derived Lycopene on Low Carotenoids and Enhanced Systemic Inflammation and Oxidation in Severe Obesity. IMAJ 2009; 11: 598-601.
18. Han RM, Zhang JP, Skibsted LH. Reaction Dynamics of Flavonoids and Carotenoids as Antioxidants. Molecules 2012; 17: 2140-60.
19. Palozza P, Serini S, Trombino S, Lauriola L, Ranelletti FO, Calviello G. Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2. Carcinogenesis. 2006; 27: 2383-91.
20. Rissanen T, Voutilainen S, Nyyssönen K, Salonen R, Salonen JT. Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall. Arterioscler Thromb Vasc Biol 2000; 20: 2677-81.
21. Rao AV. Lycopene, Tomatoes, and the Prevention of Coronary Heart Disease. Experimental Biology and Medicine 2002; 227: 908-13.
22. Sies H, Stahl W. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995; 62: 1315S-21S.
23. Goodwin TW. The Biochemistry of the Carotenoids. Vol. 1: "Plants." New York: Chapman and Hall, p 203, 1980.
24. Khachik F, Beecher GR, Goli MB, Lusby WR. Separation, identification, and quantification of carotenoids in fruits, vegetable, and human plasma by high performance liquid chromatography. Pure Appl Chem 1991; 63: 71-80.
25. Olson JA. Absorption, transport, and metabolism of carotenoids in humans. Pure & Appl Chem 1994; 66: 1011-6.
26. Kotake-Nara E, Nagao A. Absorption and Metabolism of Xanthophylls. Mar. Drugs 2011; 9: 1024-37.
27. Stahl W, Schwarz W, Sundquist AR, Sies H. Cis-trans isomers of licopene and β-carotene in human serum and tissue. Arch Biochem Biophys 1992; 294: 173-7.
28. Kaplan LA, Lan JM, Stein EA. Carotenoid composition, concentration and relationship in various human organs. Clin Physiol Biochem 1990; 8: 1-10.
29. Schmitz HH, Poor CL, Wellman RB, Erdman JW. Concentration of selected carotenoids and vitamin A in human liver, kidney and lung tissue. J Nutr 1991; 121: 1613-21.
30. Maiani G, Castón MJ, Catasta G, et al. Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Mol Nutr Food Res 2009; 53: S194-218.
31. Bar-Natan R, Lomnitski L, Sofer Y, Segman S, Neeman I, Grossman S. Interaction between beta-carotene and lipoxygenase in human skin. Int J Biochem Cell Biol 1996; 28: 935-41.
32. Liebler DC Antioxidant reactions of carotenoids Ann NY Acad Sci 1993; 691: 20-31.
33. Beutner F, Bloedorn B, Frixel S, et al. Quantitative assessment of antioxidant properties of natural colorants and phytochemicals: carotenoids, flavonoids, phenols and indigoids. The role of betacarotene in antioxidant functions. J. Sci. Food Agric 2001; 81: 559-68.
34. Stahl W, Nicolai S, Briviba K, et al. Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis 1997; 18: 89-92.
35. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274: 532-8.
36. Brady WE, Mares-Perlman JA, Bowen P, Stacewicz-Sapuntzakis M. Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J Nutr 1996; 126: 129-37.
37. Ford ES, Mokdad AH, Giles WH, Brown DW. The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 2003; 52: 2346-52.
38. Martin KR, Wu D, Meydani M. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis 2000; 150: 265-74.
39. Burton GW, Ingold KU. Beta-carotene an unusual type of lipid antioxidant. Science 1984; 224: 569-73.
40. Zinchuk VV, Khodosovsky MN, Maslakov DA. Influence of different oxygen modes on the blood oxygen transport and prooxidant-antioxidant status during hepatic ischemia/reperfusion. Physiol Res 2003; 52: 533-44.
41. Wang L, Gaziano JM, Norkus EP, Buring JE, Sesso HD. Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. Am J Clin Nutr 2008; 88: 747-54.
42. Khachik F, Bernstein P, Garvalho DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest. Ophthalmol. Visual Sci 1997; 38: 1802-11.
43. Rissanen T, Voutilainen S, Nyyssönen K, Salonen JT. Lycopene, Atherosclerosis, and Coronary Heart Disease. Experimental Biology and Medicine 2002; 227: 900-7.
44. Rissanen TH, Voutilainen S, Nyyssönen K, Salonen R, Kaplan GA, Salonen JT. Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2003; 77: 133-8.
45. Coffey MD, Cole RA, Colles SM, Chisolm GM. In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxideinduced formation of alkoxyl, lipid, and peroxyl radicals. J Clin Invest 1995; 96: 1866-73.
46. Hodis HN, Kramsch DM, Avogaro P, et al. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J Lipid Res 1994; 35: 669-77.
47. Johnstone SR, Kroncke BM, Straub AC, et al. MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation. Circ Res 2012 May 31. [Epub ahead of print].
48. Meensa M, Pfennigera A, Kwaka BR. Risky communication in atherosclerosis and thrombus formation. Swiss Med Wkly 2012; 142: w13553.
49. Agarwal M, Parameswari RP, Vasanthi HR, Das DK. Dynamic Action of Carotenoids in Cardioprotection and Maintenance of Cardiac Health. Molecules 2012; 17: 4755-69.
50. Zou Z, Xu X, Huang Y, et al. High serum level of lutein may be protective against early atherosclerosis: the Beijing atherosclerosis study. Atherosclerosis 2011; 219: 789-93.
51. Karppi J, Kurl S, Laukkanen JA, Rissanen TH, Kauhanen J. Plasma carotenoids are related to intima--media thickness of the carotid artery wall in men from eastern Finland. J Intern Med 2011; 270: 478-85.
52. Hak AE, Stampfer MJ, Campos H, et al. Plasma Carotenoids and Tocopherols and Risk of Myocardial Infarction in a Low-Risk Population of US Male Physicians. Circulation 2003; 108: 802-7.
53. Buijsse B, Feskens EJM, Kwape L, Kok FJ, Kromhout D. Both a- and b-Carotene, but Not Tocopherols and Vitamin C, Are Inversely Related to 15-Year Cardiovascular Mortality in Dutch Elderly Men. J. Nutr 2008; 138: 344-50.
54. Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Wittemen JCM. Serum carotenoids and atherosclerosis: The Rotterdam Study. Atherosclerosis 2000; 148: 49-56.
55. Street DA, Comstock GW, Salkeld RM, Schuep W, Klag MJ. Serum antioxidants and myocardial infarction. Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation 1994; 90: 1154-61.
56. Kohlmeier L, Kark JD, Gomez-Gracia E, et al. Lycopene and Myocardial Infarction Risk in the EURAMIC Study. Am J Epidemiol 1997; 146: 618-26.
57. Polidori MC, Mecocci P, Stahl W, Sies H. Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge. Br J Nutrition 2003; 90: 147-50.
58. Trayhurn P. Adipose tissue in obesity an inflammatory issue. Endocrinology 2007; 146: 1003-5.
59. Maachi M, Piéroni L, Bruckert E, et al. Systemic low-grade inflammation is related to both circulating and adipose tissue TNF-, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord 2004; 28: 993-7.
60. Reitman A, Friedrich I, Ben-Amotz A, Levy Y. Low Plasma Antioxidants and Normal Plasma B Vitamins and Homocysteine in Patients with Severe Obesity. IMAJ 2002; 4: 590-3.
61. Wallström P, Wirfält E, Lahmann PH, Gullberg B, Janzon L, Berglund G. Serum concentrations of β-carotene and α-tocopherol are associated with diet, smoking, and general and central adiposity. Am J Clin Nutr 2001; 73: 777-85.
62. Stryker WS, Kaplan LA, Stein EA, Stampfer MJ, Sober A, Willett WC. The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am J Epidemiol 1988; 127: 283-96.
63. Roidt L, White E, Goodman GE, et al. Association of food frequency questionnaire estimates of vitamin A intake with serum vitamin A levels. Am J Epidemiol 1988; 128: 645-54.
64. Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr 2004; 79: 47-53.
65. Sesso HD, Buring, JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr 2005; 81: 990-7.
66. Thies F, Masson LF, Rudd A, et al. Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. Am J Clin Nutr 2012; 95: 1013-22.
67. Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JAE. Effects of vitamins C and E and b-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial. Am J Clin Nutr 2009; 90: 429-37.
68. Sharma JB, Kumar A, Kumar A, et al. Effect of lycopene on preeclampsia and intra-uterine growthretardation in primigravidas. Int J GynaecolObstet 2003; 81: 257-62.
69. Mercuro G, Bassareo PP, Flore G, et al. Prematurity and low weight at birth as new conditions predisposing to an increased cardiovascular risk. Eur J PrevCardiolog 2012 Jan19. [Epub ahead of print].
70. Ostrea EM Jr, Balun JE, Winkler R, Porter T. Influence of breastfeeding on the restoration of the low serum concentration of vitamin E and beta-carotene in the newborn infant. Am J ObstetGynecol 1986; 154: 1014-7.
71. Gossage CP. Carotenoid composition of human milk during the first month postpartum and the response to b-carotene supplementation. Am J ClinNutr 2002; 76: 193-7.
72. Rubin LP Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants Journal of Perinatology J Perinatol 2012; 32: 418-24.
73. Ford ES, Gillespie C, Ballew C, Sowell A, Mannino DM. Serum carotenoid concentrations in US children and adolescents. Am J ClinNutr 2002; 76: 818-27.