Bile acids and bariatric surgery

Molecular Aspects of Medicine

Volumn 56, Issue , 2017, Pages 75-89

  Albaugh, Vance L ^a   Banan, Babak ^a   Ajouz, Hana ^b   Abumrad, Naji N ^a   Flynn, Charles R ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Bariatric surgery; Bile acids; Metabolic surgery; Metabolism; Obesity; Roux en Y gastric bypass (RYGB); Vertical sleeve gastrectomy (VSG)

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; GLUCOSE; INSULIN; LIPID; STEROID 12ALPHA MONOOXYGENASE; TAUROURSODEOXYCHOLIC ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN;

ANTIMICROBIAL ACTIVITY; BARIATRIC SURGERY; BILE ACID SYNTHESIS; CALORIC RESTRICTION; CLINICAL TRIAL (TOPIC); CONTROLLED CLINICAL TRIAL (TOPIC); EMULSION; ENERGY EXPENDITURE; ENTEROHEPATIC CIRCULATION; FAT INTAKE; FLOW; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; INSULIN SENSITIVITY; INTESTINE FLORA; LIPID HOMEOSTASIS; LIPID METABOLISM; MALABSORPTION; METABOLIC ACTIVATION; MICROBIOME; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; REVIEW; ROUX-EN-Y GASTRIC BYPASS; VERTICAL SLEEVE GASTRECTOMY; WEIGHT REDUCTION; ANIMAL; GASTRECTOMY; GASTRIC BYPASS SURGERY; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; INSULIN RESISTANCE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; RODENT; SIGNAL TRANSDUCTION;

ANIMALS; BILE ACIDS AND SALTS; DIABETES MELLITUS, TYPE 2; ENTEROHEPATIC CIRCULATION; GASTRECTOMY; GASTRIC BYPASS; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION REGULATION; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; OBESITY, MORBID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; RODENTIA; SIGNAL TRANSDUCTION;

EID: 85017429802     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2017.04.001     Document Type: Review

References (249)

1. Abumrad, N.N., Breitman, I., Wattacheril, J., Hubbard, W.J., Chaudry, I.H., Metabolic and inflammatory responses to trauma and infection. Fischers Mastery of Surgery, 2012, Lippincott Williams & Wilkins, 1–49.
2. Adams, T.D., Hunt, S.C., Cancer and obesity: effect of bariatric surgery. World J. Surg. 33 (2009), 2028–2033, 10.1007/s00268-009-0169-1.
3. Ahmad, N.N., Pfalzer, A., Kaplan, L.M., Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int. J. Obes. (Lond) 37 (2013), 1553–1559, 10.1038/ijo.2013.38.
4. Ajouz, H., Mukherji, D., Shamseddine, A., Secondary bile acids: an underrecognized cause of colon cancer. World J. Surg. Oncol., 12, 2014, 164, 10.1186/1477-7819-12-164.
5. Albaugh, V.L., Flynn, C.R., Cai, S., Xiao, Y., Tamboli, R.A., Abumrad, N.N., early increases in bile acids post Roux-en-Y gastric bypass are driven by insulin-sensitizing, secondary bile acids. J. Clin. Endocrinol. Metab. 100 (2015), E1225–E1233, 10.1210/jc.2015-2467.
6. Amaral, J.D., Viana, R.J.S., Ramalho, R.M., Steer, C.J., Rodrigues, C.M.P., Bile acids: regulation of apoptosis by ursodeoxycholic acid. J. Lipid Res. 50 (2009), 1721–1734, 10.1194/jlr.R900011-JLR200.
7. Andersén, E., Hellström, K., Influence of fat-rich versus carbohydrate-rich diets on bile acid kinetics, biliary lipids, and net steroid balance in hyperlipidemic subjects. Metabolism 29 (1980), 400–409, 10.1016/0026-0495(80)90163-8.
8. Andersén, E., Karlaganis, G., Sjövall, J., Altered bile acid profiles in duodenal bile and urine in diabetic subjects. Eur. J. Clin. Invest. 18 (1988), 166–172, 10.1111/j.1365-2362.1988.tb02408.x.
9. Arterburn, D.E., Bogart, A., Sherwood, N.E., Sidney, S., Coleman, K.J., Haneuse, S., O'Connor, P.J., Theis, M.K., Campos, G.M., McCulloch, D., Selby, J., A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass. Obes. Surg. 23 (2012), 93–102, 10.1007/s11695-012-0802-1.
10. Ashrafian, H., Ahmed, K., Rowland, S.P., Patel, V.M., Gooderham, N.J., Holmes, E., Darzi, A., Athanasiou, T., Metabolic surgery and cancer. Cancer 117 (2011), 1788–1799, 10.1002/cncr.25738.
11. Ballatori, N., Christian, W.V., Lee, J.Y., Dawson, P.A., Soroka, C.J., Boyer, J.L., Madejczyk, M.S., Li, N., OSTα-OSTβ: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology 42 (2005), 1270–1279, 10.1002/hep.20961.
12. Barrasa, J.I., Olmo, N., Lizarbe, M.A., Turnay, J., Bile acids in the colon, from healthy to cytotoxic molecules. Toxicol In Vitro 27 (2013), 964–977, 10.1016/j.tiv.2012.12.020.
13. Baud, G., Daoudi, M., Hubert, T., Raverdy, V., Pigeyre, M., Hervieux, E., Devienne, M., Ghunaim, M., Bonner, C., Quenon, A., Pigny, P., Klein, A., Kerr-Conte, J., Gmyr, V., Caiazzo, R., Pattou, F., bile diversion in Roux-en-Y gastric bypass modulates sodium-dependent glucose intestinal uptake. Cell Metab., 2016, 1–14, 10.1016/j.cmet.2016.01.018.
14. Belgaumkar, A.P., Vincent, R.P., Carswell, K.A., Hughes, R.D., Alaghband-Zadeh, J., Mitry, R.R., le Roux, C.W., Patel, A.G., Changes in bile acid profile after laparoscopic sleeve gastrectomy are associated with improvements in metabolic profile and fatty liver disease. Obes. Surg. 26 (2016), 1195–1202, 10.1007/s11695-015-1878-1.
15. Berr, F., Stellaard, F., Pratschke, E., Paumgartner, G., Effects of cholecystectomy on the kinetics of primary and secondary bile acids. J. Clin. Invest. 83 (1989), 1541–1550, 10.1172/JCI114050.
16. Beysen, C., Murphy, E.J., Deines, K., Chan, M., Tsang, E., Glass, A., Turner, S.M., Protasio, J., Riiff, T., Hellerstein, M.K., Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. Diabetologia 55 (2011), 432–442, 10.1007/s00125-011-2382-3.
17. Bhutta, H.Y., Rajpal, N., White, W., Freudenberg, J.M., Liu, Y., Way, J., Rajpal, D., Cooper, D.C., Young, A., Tavakkoli, A., Chen, L., Effect of Roux-en-Y gastric bypass surgery on bile acid metabolism in normal and obese diabetic rats. PLoS One, 10, 2015, e0122273, 10.1371/journal.pone.0122273.
18. Bisschop, P.H., Bandsma, R., Stellaard, F., Harmsel ter, A., Meijer, A.J., Sauerwein, H.P., Kuipers, F., Romijn, J.A., Low-fat, high-carbohydrate and high-fat, low-carbohydrate diets decrease primary bile acid synthesis in humans. Am. J. Clin. Nutr. 79 (2004), 570–576.
19. Blackburn, G., Effect of degree of weight loss on health benefits. Obes. Res. 3:Suppl. 2 (1995), 211s–216s.
20. Bose, M., Teixeira, J., Olivan, B., Bawa, B., Arias, S., Machineni, S., Pi Sunyer, F.X., Scherer, P.E., Laferrère, B., Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery. J. Diabetes 2 (2010), 47–55, 10.1111/j.1753-0407.2009.00064.x.
21. Bradley, D., Conte, C., Mittendorfer, B., Eagon, J.C., Varela, J.E., Fabbrini, E., Gastaldelli, A., Chambers, K.T., Su, X., Okunade, A., Patterson, B.W., Klein, S., Gastric bypass and banding equally improve insulin sensitivity and β cell function. J. Clin. Invest. 122 (2012), 4667–4674, 10.1172/JCI64895.
22. Breen, D.M., Rasmussen, B.A., Kokorovic, A., Wang, R., Cheung, G.W.C., Lam, T.K.T., Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat. Med. 18 (2012), 950–955, 10.1038/nm.2745.
23. Brighton, C.A., Rievaj, J., Kuhre, R.E., Glass, L.L., Schoonjans, K., Holst, J.J., Gribble, F.M., Reimann, F., Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G protein–coupled bile acid receptors. Endocrinology 156 (2015), 3961–3970, 10.1210/en.2015-1321.
24. Broeders, E.P.M., Nascimento, E.B.M., Havekes, B., Brans, B., Roumans, K.H.M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B., Bouvy, N.D., Mottaghy, F., Staels, B., van Marken Lichtenbelt, W.D., Schrauwen, P., The bile acid chenodeoxycholic acid increases human brown adipose tissue activity. Cell Metab. 22:3 (2015), 418–426.
25. Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M.D., Pories, W.J., Fahrbach, K., Schoelles, K., Bariatric surgery: a systematic review and meta-analysis. JAMA 292 (2004), 1724–1737, 10.1001/jama.292.14.1724.
26. Buchwald, H., Estok, R., Fahrbach, K., Banel, D., Jensen, M.D., Pories, W.J., Bantle, J.P., Sledge, I., Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am. J. Med., 122, 2009, 10.1016/j.amjmed.2008.09.041 248–256.e5.
27. Bueter, M., Löwenstein, C., Olbers, T., Wang, M., Cluny, N.L., Bloom, S.R., Sharkey, K.A., Lutz, T.A., le Roux, C.W., Gastric bypass increases energy expenditure in rats. Gastroenterology 138 (2010), 1845–1853.e1, 10.1053/j.gastro.2009.11.012.
28. Carey, D.G., Pliego, G.J., Raymond, R.L., Body composition and metabolic changes following bariatric surgery: effects on fat mass, lean mass and basal metabolic rate: six months to one-year follow-up. Obes. Surg. 16 (2006), 1602–1608, 10.1381/096089206779319347.
29. Cariou, B., Staels, B., FXR: a promising target for the metabolic syndrome?. Trends Pharmacol. Sci. 28 (2007), 236–243.
30. Cariou, B., Chetiveaux, M., Zaïr, Y., Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutrition, 2011, 10.1186/s12986-015-0029-y.
31. Carswell, K.A., Vincent, R.P., Belgaumkar, A.P., Sherwood, R.A., Amiel, S.A., Patel, A.G., le Roux, C.W., The effect of bariatric surgery on intestinal absorption and transit time. Obes. Surg. 24 (2014), 796–805, 10.1007/s11695-013-1166-x.
32. Cefalu, W.T., Rubino, F., Cummings, D.E., Metabolic surgery for type 2 diabetes: changing the landscape of diabetes care. Diabetes Care 39 (2016), 857–860, 10.2337/dc16-0686.
33. Chiang, J.Y.L., Bile acids: regulation of synthesis. J. Lipid Res. 50 (2009), 1955–1966, 10.1194/jlr.R900010-JLR200.
34. Chiang, J.Y.L., Bile acid metabolism and signaling. Compr. Physiol. 3 (2013), 1191–1212, 10.1002/cphy.c120023.
35. Christiansen, M.P., Linfoot, P.A., Neese, R.A., Hellerstein, M.K., Effect of dietary energy restriction on glucose production and substrate utilization in type 2 diabetes. Diabetes 49 (2000), 1691–1699, 10.2337/diabetes.49.10.1691.
36. Cipriani, S., Mencarelli, A., Palladino, G., Fiorucci, S., FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J. Lipid Res. 51 (2010), 771–784, 10.1194/jlr.M001602.
37. Coupaye, M., Rivière, P., Breuil, M.C., Castel, B., Bogard, C., Dupré, T., Flamant, M., Msika, S., Ledoux, S., comparison of nutritional status during the first year after sleeve gastrectomy and Roux-en-Y gastric bypass. Obes. Surg. 24 (2013), 276–283, 10.1007/s11695-013-1089-6.
38. Culnan, D.M., Albaugh, V.L., Sun, M., Lynch, C.J., Lang, C.H., Cooney, R.N., Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (2010), G751–G760, 10.1152/ajpgi.00525.2009.
39. Cummings, D.E., Weigle, D.S., Frayo, R.S., Breen, P.A., Ma, M.K., Dellinger, E.P., Purnell, J.Q., Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346 (2002), 1623–1630, 10.1056/NEJMoa012908.
40. Cummings, B.P., Strader, A.D., Stanhope, K.L., Graham, J.L., Lee, J., Raybould, H.E., Baskin, D.G., Havel, P.J., Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology, 138, 2010, 10.1053/j.gastro.2010.03.005 2437–2446– 2446.e1.
41. Cummings, B.P., Bettaieb, A., Graham, J.L., Stanhope, K.L., Kowala, M., Haj, F.G., Chouinard, M.L., Havel, P.J., Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology 153 (2012), 3620–3632, 10.1210/en.2012-1131.
42. Dawson, P.A., Haywood, J., Craddock, A.L., Wilson, M., Tietjen, M., Kluckman, K., Maeda, N., Parks, J.S., Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J. Biol. Chem. 278 (2003), 33920–33927, 10.1074/jbc.M306370200.
43. Dawson, P.A., Hubbert, M., Haywood, J., Craddock, A.L., Zerangue, N., Christian, W.V., Ballatori, N., The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J. Biol. Chem. 280 (2005), 6960–6968, 10.1074/jbc.M412752200.
44. Dawson, P.A., Lan, T., Rao, A., Bile acid transporters. J. Lipid Res. 50 (2009), 2340–2357, 10.1194/jlr.R900012-JLR200.
45. de Aguiar Vallim, T.Q., Tarling, E.J., Edwards, P.A., Pleiotropic roles of bile acids in metabolism. Cell Metab. 17 (2013), 657–669, 10.1016/j.cmet.2013.03.013.
46. de Almeida, S.R., Rocha, P.R.S., Sanches, M.D., Leite, V.H.R., da Silva, R.A.P., Diniz, M.T.C., de Fátima Haueisen Sander Diniz, M., Rocha, A.L.S., Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity. Obes. Surg. 16 (2006), 270–278, 10.1381/096089206776116462.
47. De Giorgi, S., Campos, V., Egli, L., Toepel, U., Carrel, G., Cariou, B., Rainteau, D., Schneiter, P., Tappy, L., Giusti, V., Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: a cross-sectional pilot study. Clin. Nutr. 34 (2015), 911–917, 10.1016/j.clnu.2014.09.018.
48. Ding, L., Sousa, K.M., Jin, L., Dong, B., Kim, B.W., Ramirez, R., Xiao, Z., Gu, Y., Yang, Q., Wang, J., Yu, D., Pigazzi, A., Schones, D., Yang, L., Moore, D., Wang, Z., Huang, W., Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice. Hepatology 64 (2016), 760–773, 10.1002/hep.28689.
49. Dirksen, C., Jørgensen, N.B., Bojsen-Møller, K.N., Kielgast, U., Jacobsen, S.H., Clausen, T.R., Worm, D., Hartmann, B., Rehfeld, J.F., Damgaard, M., Madsen, J.L., Madsbad, S., Holst, J.J., Hansen, D.L., Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int. J. Obes. (Lond) 37 (2013), 1452–1459, 10.1038/ijo.2013.15.
50. Dixon, J.B., O'Brien, P.E., Playfair, J., Chapman, L., Schachter, L.M., Skinner, S., Proietto, J., Bailey, M., Anderson, M., Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299 (2008), 316–323, 10.1001/jama.299.3.316.
51. Duane, W.C., Simulation of the defect of bile acid metabolism associated with cholesterol cholelithiasis by sorbitol ingestion in man. J. Lab. Clin. Med. 91 (1978), 969–978.
52. Duane, W.C., Hanson, K.C., Role of gallbladder emptying and small bowel transit in regulation of bile-acid pool size in man. J. Lab. Clin. Med. 92 (1978), 858–872.
53. Duane, W.C., Ginsberg, R.L., Bennion, L.J., Effects of fasting on bile acid metabolism and biliary lipid composition in man. J. Lipid Res. 17 (1976), 211–219.
54. Dudrick, S.J., Daly, J.M., Castro, G., Akhtar, M., Gastrointestinal adaptation following small bowel bypass for obesity. Ann. Surg. 185 (1977), 642–648.
55. Düfer, M., Hörth, K., Wagner, R., Schittenhelm, B., Prowald, S., Wagner, T.F.J., Oberwinkler, J., Lukowski, R., Gonzalez, F.J., Krippeit-Drews, P., Drews, G., Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes 61 (2012), 1479–1489, 10.2337/db11-0815.
56. Dunn, J.P., Abumrad, N.N., Breitman, I., Marks-Shulman, P.A., Flynn, C.R., Jabbour, K., Feurer, I.D., Tamboli, R.A., Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy. Diabetes Care 35 (2012), 137–142, 10.2337/dc11-1383.
57. Einar Krag, S.F.P., Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum. J. Clin. Investigation 53 (1974), 1686–1694, 10.1172/JCI107720.
58. Engelstoft, M.S., Egerod, K.L., Holst, B., Schwartz, T.W., A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab. 8 (2008), 447–449, 10.1016/j.cmet.2008.11.004.
59. Ermini, M., Iaconis, E., Mori, A., The effects of bilio-jejunal diversion on streptozotocin diabetes in the rat. Acta Diabetol. Lat. 28 (1991), 79–89.
60. Escalona, A., Muñoz, R., Irribarra, V., Solari, S., Allende, F., Francisco Miquel, J., Bile acids synthesis decreases after laparoscopic sleeve gastrectomy. Surg. Obes. Relat. Dis. 12 (2016), 763–769, 10.1016/j.soard.2015.11.015.
61. Everson, G.T., Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry. J. Lipid Res. 28 (1987), 238–252.
62. Fabbrini, E., Tamboli, R.A., Magkos, F., Marks-Shulman, P.A., Eckhauser, A.W., Richards, W.O., Klein, S., Abumrad, N.N., Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Gastroenterology 139 (2010), 448–455, 10.1053/j.gastro.2010.04.056.
63. Ferland, G., Tuchweber, B., Perea, A., Yousef, I.M., Effect of aging and dietary restriction on bile acid metabolism in rats. Lipids 24 (1989), 842–848, 10.1007/BF02535757.
64. Ferrannini, E., Camastra, S., Astiarraga, B., Nannipieri, M., Castro-Perez, J., Xie, D., Wang, L., Chakravarthy, M., Haeusler, R.A., Increased bile acid synthesis and deconjugation after biliopancreatic diversion. Diabetes 64 (2015), 3377–3385, 10.2337/db15-0214.
65. Finkelstein, E.A., Trogdon, J.G., Cohen, J.W., Dietz, W., Annual medical spending attributable to obesity: payer-and service-specific estimates. Health Aff. (Millwood), 28, 2009, 10.1377/hlthaff.28.5.w822 w822–31.
66. Fiorucci, S., Distrutti, E., Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends Mol. Med. 21 (2015), 702–714.
67. Flegal, K.M., Kit, B.K., Orpana, H., Graubard, B.I., Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 309 (2013), 71–82, 10.1001/jama.2012.113905.
68. Flynn, C.R., Albaugh, V.L., Cai, S., Cheung-Flynn, J., Williams, P.E., Brucker, R.M., Bordenstein, S.R., Guo, Y., Wasserman, D.H., Abumrad, N.N., Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat. Commun., 6, 2015, 7715, 10.1038/ncomms8715.
69. Frikke Schmidt, H., O'Rourke, R.W., Lumeng, C.N., Sandoval, D.A., Seeley, R.J., Does bariatric surgery improve adipose tissue function?. Obes. Rev. 17 (2016), 795–809, 10.1111/obr.12429.
70. Frikke-Schmidt, H., Seeley, R.J., Defending a new hypothesis of how bariatric surgery works. Obesity, 2016, 10.1002/oby.21444 (Silver Spring) n/a–n/a.
71. Frommherz, L., Bub, A., Hummel, E., Rist, M.J., Roth, A., Watzl, B., Kulling, S.E., Age-related changes of plasma bile acid concentrations in healthy adults—results from the cross-sectional KarMeN study. PLoS One, 11, 2016, e0153959, 10.1371/journal.pone.0153959.
72. Fu, Z.D., Klaassen, C.D., Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicol. Appl. Pharmacol. 273 (2013), 680–690, 10.1016/j.taap.2013.10.020.
73. Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., Rizkalla, S., Clement, K., Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 59 (2010), 3049–3057, 10.2337/db10-0253.
74. Garg, S.K., Ritchie, P.J., Moser, E.G., Snell Bergeon, J.K., Freson, B.J., Hazenfield, R.M., Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized double-blind trial. Diabetes Obes. Metab. 13 (2011), 137–143, 10.1111/j.1463-1326.2010.01320.x.
75. Gerhard, G.S., Styer, A.M., Wood, G.C., Roesch, S.L., Petrick, A.T., Gabrielsen, J., Strodel, W.E., Still, C.D., Argyropoulos, G., A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass. Diabetes Care 36 (2013), 1859–1864, 10.2337/dc12-2255.
76. Goncalves, D., Barataud, A., De Vadder, F., Vinera, J., Zitoun, C., Duchampt, A., Mithieux, G., Bile routing modification reproduces key features of gastric bypass in rat. Ann. Surgery 262 (2015), 1006–1015, 10.1097/SLA.0000000000001121.
77. Gumbs, A.A., Modlin, I.M., Ballantyne, G.H., Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes. Surg. 15 (2005), 462–473, 10.1381/0960892053723367.
78. Habegger, K.M., Al-Massadi, O., Heppner, K.M., Myronovych, A., Holland, J., Berger, J., Yi, C.-X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Müller, T.D., Pfluger, P.T., Kohli, R., Perez-Tilve, D., Seeley, R.J., Tschöp, M.H., Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut 63 (2014), 1238–1246, 10.1136/gutjnl-2013-304583.
79. Habib, A.M., Richards, P., Rogers, G.J., Reimann, F., Gribble, F.M., Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia 56 (2013), 1413–1416, 10.1007/s00125-013-2887-z.
80. Haeusler, R.A., Pratt-Hyatt, M., Welch, C.L., Klaassen, C.D., Accili, D., Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab. 15 (2012), 65–74, 10.1016/j.cmet.2011.11.010.
81. Haeusler, R.A., Astiarraga, B., Camastra, S., Accili, D., Ferrannini, E., Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids. Diabetes 62 (2013), 4184–4191, 10.2337/db13-0639.
82. Haeusler, R.A., Camastra, S., Nannipieri, M., Astiarraga, B., Castro-Perez, J., Xie, D., Wang, L., Chakravarthy, M., Ferrannini, E., Increased bile acid synthesis and impaired bile acid transport in human obesity. J. Clin. Endocrinol. Metab. jc, 2015, 10.1210/jc.2015-2583 2015–2583.
83. Hansen, E.N., Tamboli, R.A., Isbell, J.M., Saliba, J., Dunn, J.P., Marks-Shulman, P.A., Abumrad, N.N., Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am. J. Physiol. Gastrointest. Liver Physiol. 300 (2011), G795–G802, 10.1152/ajpgi.00019.2011.
84. Hansen, C.F., Vassiliadis, E., Vrang, N., Sangild, P.T., Cummings, B.P., Havel, P., Jelsing, J., The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat. Regul. Pept. 189 (2014), 31–39.
85. Hao, Z., Zhao, Z., Berthoud, H.-R., Ye, J., Development and verification of a mouse model for Roux-en-Y gastric bypass surgery with a small gastric pouch. PLoS One, 8, 2013, e52922, 10.1371/journal.pone.0052922.
86. Harris, R.B., Role of set-point theory in regulation of body weight. FASEB J. 4 (1990), 3310–3318.
87. Henry, R.R., Schaeffer, L., Olefsky, J.M., Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 61 (1985), 917–925, 10.1210/jcem-61-5-917.
88. Hulzebos, C.V., Renfurm, L., Bandsma, R.H., Verkade, H.J., Boer, T., Boverhof, R., Tanaka, H., Mierau, I., Sauer, P.J., Kuipers, F., Stellaard, F., Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: application to rodents and humans. J. Lipid Res. 42 (2001), 1923–1929.
89. Ikezawa, F., Shibata, C., Kikuchi, D., Imoto, H., Miura, K., Naitoh, T., Ogawa, H., Sasaki, I., Tsuchiya, T., Effects of ileal interposition on glucose metabolism in obese rats with diabetes. Surgery 151 (2012), 822–830, 10.1016/j.surg.2011.12.026.
90. Ikramuddin, S., Livingston, E.H., New insights on bariatric surgery outcomes. JAMA 310 (2013), 2401–2402, 10.1001/jama.2013.280927.
91. Isbell, J.M., Tamboli, R.A., Hansen, E.N., Saliba, J., Dunn, J.P., Phillips, S.E., Marks-Shulman, P.A., Abumrad, N.N., The importance of caloric restriction in the early improvements in insulin sensitivity after Roux-en-Y gastric bypass surgery. Diabetes Care 33 (2010), 1438–1442, 10.2337/dc09-2107.
92. Jahansouz, C., Xu, H., Hertzel, A.V., Serrot, F.J., Kvalheim, N., Cole, A., Abraham, A., Luthra, G., Ewing, K., Leslie, D.B., Bernlohr, D.A., Ikramuddin, S., Bile acids increase independently from hypocaloric restriction after bariatric surgery. Ann. Surg. 264 (2016), 1022–1028, 10.1097/SLA.0000000000001552.
93. Jansen, P.L.M., van Werven, J., Aarts, E., Berends, F., Janssen, I., Stoker, J., Schaap, F.G., Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery. Dig. Dis. 29 (2011), 48–51, 10.1159/000324128.
94. Jazet, I.M., Pijl, H., Frölich, M., Romijn, J.A., Meinders, A.E., Two days of a very low calorie diet reduces endogenous glucose production in obese type 2 diabetic patients despite the withdrawal of blood glucose–lowering therapies including insulin. Metabolism 54 (2005), 705–712, 10.1016/j.metabol.2004.12.015.
95. Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K.W., Shi, J., Brocker, C.N., Desai, D., Amin, S.G., Bisson, W.H., Liu, Y., Gavrilova, O., Patterson, A.D., Gonzalez, F.J., Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat. Commun., 6, 2015, 10166, 10.1038/ncomms10166.
96. Jiao, Y., Lu, Y., Li, X.-Y., Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis. Acta Pharmacol. Sin. 36 (2015), 44–50, 10.1038/aps.2014.116.
97. Jørgensen, N.B., Jacobsen, S.H., Dirksen, C., Bojsen-Møller, K.N., Naver, L., Hvolris, L., Clausen, T.R., Wulff, B.S., Worm, D., Lindqvist Hansen, D., Madsbad, S., Holst, J.J., Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance. Am. J. Physiol. Endocrinol. Metab. 303 (2012), E122–E131, 10.1152/ajpendo.00073.2012.
98. Jørgensen, N.B., Dirksen, C., Bojsen-Møller, K.N., Kristiansen, V.B., Wulff, B.S., Rainteau, D., Humbert, L., Rehfeld, J.F., Holst, J.J., Madsbad, S., Clausen, T.R., Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations. J. Clin. Endocrinol. Metab. 100 (2015), E396–E406, 10.1210/jc.2014-1658.
99. Kars, M., Yang, L., Gregor, M.F., Mohammed, B.S., Pietka, T.A., Finck, B.N., Patterson, B.W., Horton, J.D., Mittendorfer, B., Hotamisligil, G.S., Klein, S., Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 59 (2010), 1899–1905, 10.2337/db10-0308.
100. Kashyap, S.R., Daud, S., Kelly, K.R., Gastaldelli, A., Win, H., Brethauer, S., Kirwan, J.P., Schauer, P.R., Acute effects of gastric bypass versus gastric restrictive surgery on |[beta]|-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes. Int. J. Obes. Relat. Metab. Disord. 34 (2010), 462–471, 10.1038/ijo.2009.254.
101. Kaska, L., Sledzinski, T., Chomiczewska, A., Dettlaff-Pokora, A., Swierczynski, J., Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome. WJG 22 (2016), 8698–8719, 10.3748/wjg.v22.i39.8698.
102. Katsuma, S., Hirasawa, A., Tsujimoto, G., Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem. Biophysical Res. Commun. 329 (2005), 386–390, 10.1016/j.bbrc.2005.01.139.
103. Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., Hinuma, S., Fujisawa, Y., Fujino, M., A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278 (2003), 9435–9440, 10.1074/jbc.M209706200.
104. Keitel, V., Donner, M., Winandy, S., Kubitz, R., Häussinger, D., Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem. Biophysical Res. Commun. 372 (2008), 78–84, 10.1016/j.bbrc.2008.04.171.
105. Kelley, D.E., Wing, R., Buonocore, C., Sturis, J., Polonsky, K., Fitzsimmons, M., Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 77 (1993), 1287–1293, 10.1210/jcem.77.5.8077323.
106. Khan, F.H., Shaw, L., Zhang, W., Salazar-Gonzalez, R.-M., Mowery, S., Oehrle, M., Zhao, X., Jenkins, T., Setchell, K.D.R., Inge, T.H., Kohli, R., Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents. Obes. (Silver Spring) 24 (2016), 2377–2383, 10.1002/oby.21658.
107. Kindel, T.L., Yoder, S.M., Seeley, R.J., D'Alessio, D.A., Tso, P., Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J. Gastrointest. Surg. 13 (2009), 1762–1772, 10.1007/s11605-009-0912-9.
108. Kindel, T.L., Martins, P.J.F., Yoder, S.M., Jandacek, R.J., Seeley, R.J., D'Alessio, D.A., Obici, S., Tso, P., Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. Obes. (Silver Spring) 19 (2011), 380–387, 10.1038/oby.2010.263.
109. Knop, F.K., Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?. Am. J. Physiol. Endocrinol. Metab. 299 (2010), E10–E13, 10.1152/ajpendo.00137.2010.
110. Knop, F.K., Taylor, R., Mechanism of metabolic advantages after bariatric surgery: it“s all gastrointestinal factors versus it”s all food restriction. Diabetes Care 36:Suppl. 2 (2013), S287–S291, 10.2337/dcS13-2032.
111. Knuth, N.D., Johannsen, D.L., Tamboli, R.A., Marks-Shulman, P.A., Huizenga, R., Chen, K.Y., Abumrad, N.N., Ravussin, E., Hall, K.D., Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obes. (Silver Spring) 22 (2014), 2563–2569, 10.1002/oby.20900.
112. Kohli, R., Kirby, M., Setchell, K.D.R., Jha, P., Klustaitis, K., Woollett, L.A., Pfluger, P.T., Balistreri, W.F., Tso, P., Jandacek, R.J., Woods, S.C., Heubi, J.E., Tschoep, M.H., D'Alessio, D.A., Shroyer, N.F., Seeley, R.J., Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (2010), G652–G660, 10.1152/ajpgi.00221.2010.
113. Kohli, R., Bradley, D., Setchell, K.D., Eagon, J.C., Abumrad, N.A., Klein, S., weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J. Clin. Endocrinol. Metabolism 98 (2013), E708–E712, 10.1210/jc.2012-3736.
114. Kohli, R., Setchell, K.D., Kirby, M., Myronovych, A., Ryan, K.K., Ibrahim, S.H., Berger, J., Smith, K., Toure, M., Woods, S.C., Seeley, R.J., A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology 154 (2013), 2341–2351, 10.1210/en.2012-2069.
115. Korner, J., Bessler, M., Cirilo, L.J., Conwell, I.M., Daud, A., Restuccia, N.L., Wardlaw, S.L., Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J. Clin. Endocrinol. Metab. 90 (2005), 359–365, 10.1210/jc.2004-1076.
116. Kosters, A., Dawson, P.A., The Na+-taurocholate cotransporting polypeptide knockout mouse: a new tool for study of bile acids and hepatitis B virus biology. Hepatology 62 (2015), 19–21, 10.1002/hep.27780.
117. Kremen, A.J., Linner, J.H., Nelson, C.H., An experimental evaluation of the nutritional importance of proximal and distal small intestine. Ann. Surg. 140 (1954), 439–448.
118. Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V.M., Schüppel, V.L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., Schmitt-Kopplin, P., Haller, D., Clavel, T., Klingenspor, M., Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol. Metab. 5 (2016), 1162–1174, 10.1016/j.molmet.2016.10.001.
119. Kumar, D.P., Rajagopal, S., Mahavadi, S., Mirshahi, F., Grider, J.R., Murthy, K.S., Sanyal, A.J., Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic beta cells. Biochem. Biophysical Res. Commun. 427 (2012), 600–605, 10.1016/j.bbrc.2012.09.104.
120. Kumar, D.P., Asgharpour, A., Mirshahi, F., Park, S.H., Liu, S., Imai, Y., Nadler, J.L., Grider, J.R., Murthy, K.S., Sanyal, A.J., Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis. J. Biol. Chem. 291 (2016), 6626–6640, 10.1074/jbc.M115.699504.
121. Laferrère, B., Heshka, S., Wang, K., Khan, Y., McGinty, J., Teixeira, J., Hart, A.B., Olivan, B., Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 30 (2007), 1709–1716, 10.2337/dc06-1549.
122. Lam, C.K.L., Chari, M., Rutter, G.A., Lam, T.K.T., Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo. Diabetes 60 (2010), 107–113, 10.2337/db10-0994.
123. Lassailly, G., Caiazzo, R., Pattou, F., Mathurin, P., Bariatric surgery for curing NASH in the morbidly obese?. J. Hepatology 58 (2013), 1249–1251, 10.1016/j.jhep.2012.12.026.
124. Lavie, C.J., Milani, R.V., Ventura, H.O., Obesity and cardiovascular disease. J. Am. Coll. Cardiol. 53 (2009), 1925–1932.
125. le Roux, C.W., Welbourn, R., Werling, M., Osborne, A., Kokkinos, A., Laurenius, A., Lönroth, H., Fändriks, L., Ghatei, M.A., Bloom, S.R., Olbers, T., Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann. Surg. 246 (2007), 780–785, 10.1097/SLA.0b013e3180caa3e3.
126. le Roux, C.W., Borg, C., Wallis, K., Vincent, R.P., Bueter, M., Goodlad, R., Ghatei, M.A., Patel, A., Bloom, S.R., Aylwin, S.J.B., Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation. Ann. Surg. 252 (2010), 50–56, 10.1097/SLA.0b013e3181d3d21f.
127. Leriche, R., Joung, A., Essai sur le traitement chirurgical du diabete par la derivation biliaire: documents experimentaux et cliniques. Ann. dEndocrinologie 1 (1939), 3–10.
128. Li, T., Owsley, E., Matozel, M., Hsu, P., Novak, C.M., Chiang, J.Y.L., Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet–induced obesity and insulin resistance in mice. Hepatology 52 (2010), 678–690, 10.1002/hep.23721.
129. Li, J.V., Ashrafian, H., Bueter, M., Kinross, J., Sands, C., le Roux, C.W., Bloom, S.R., Darzi, A., Athanasiou, T., Marchesi, J.R., Nicholson, J.K., Holmes, E., Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 60 (2011), 1214–1223, 10.1136/gut.2010.234708.
130. Li, T., Holmstrom, S.R., Kir, S., Umetani, M., Schmidt, D.R., Kliewer, S.A., Mangelsdorf, D.J., The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol. Endocrinol. 25 (2011), 1066–1071, 10.1210/me.2010-0460.
131. Li, T., Francl, J.M., Boehme, S., Ochoa, A., Zhang, Y., Klaassen, C.D., Erickson, S.K., Chiang, J.Y.L., Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J. Biol. Chem. 287 (2012), 1861–1873, 10.1074/jbc.M111.305789.
132. Li, B., Lu, Y., Srikant, C.B., Gao, Z.-H., Liu, J.-L., Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats. Am. J. Physiol. Gastrointest. Liver Physiol. 304 (2013), G635–G645, 10.1152/ajpgi.00275.2012.
133. Li, F., Jiang, C., Krausz, K.W., Li, Y., Albert, I., Hao, H., Fabre, K.M., Mitchell, J.B., Patterson, A.D., Gonzalez, F.J., Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat. Commun., 4, 2013, 2384, 10.1038/ncomms3384.
134. Li, S., Hsu, D.D.F., Li, B., Luo, X., Alderson, N., Qiao, L., Ma, L., Zhu, H.H., He, Z., Suino-Powell, K., Ji, K., Li, J., Shao, J., Xu, H.E., Li, T., Feng, G.-S., Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 20 (2014), 320–332, 10.1016/j.cmet.2014.05.020.
135. Lindstedt, S., Avigan, J., Goodman, D.S., Sjövall, J., Steinberg, D., The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man. J. Clin. Investigation 44 (1965), 1754–1765, 10.1172/JCI105283.
136. Lou, G., Ma, X., Fu, X., Meng, Z., Zhang, W., Wang, Y.-D., Van Ness, C., Yu, D., Xu, R., Huang, W., GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine kupffer cells. PLoS One, 9, 2014, e93567, 10.1371/journal.pone.0093567.
137. Ma, K., Saha, P.K., Chan, L., Moore, D.D., Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116 (2006), 1102–1109, 10.1172/JCI25604.
138. Ma, K., Saha, P.K., Chan, L., Moore, D.D., Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116 (2006), 1102–1109, 10.1172/JCI25604.
139. Mahawar, K.K., Gastric bypass is not a “restrictive and malabsorptive” procedure. Obes. Surg., 2016, 1–2, 10.1007/s11695-016-2270-5.
140. Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., Shan, B., Identification of a nuclear receptor for bile acids. Science 284 (1999), 1362–1365, 10.1126/science.284.5418.1362.
141. Manfredini, G., Ermini, M., Scopsi, L., Bonaguidi, F., Ferrannini, E., Internal biliary diversion improves glucose tolerance in the rat. AJP Gastrointest. Liver Physiology 249 (1985), G519–G527.
142. Marina, A.L., Utzschneider, K.M., Wright, L.A., Montgomery, B.K., Marcovina, S.M., Kahn, S.E., Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function. Diabetes Care 35 (2012), 1119–1125, 10.2337/dc11-2050.
143. Markovic, T.P., Jenkins, A.B., Campbell, L.V., Furler, S.M., Kraegen, E.W., Chisholm, D.J., The determinants of glycemic responses to diet restriction and weight loss in obesity and NIDDM. Diabetes Care 21 (1998), 687–694, 10.2337/diacare.21.5.687.
144. Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., Tanaka, K., Identification of membrane-type receptor for bile acids (M-BAR). Biochem. Biophysical Res. Commun. 298 (2002), 714–719, 10.1016/S0006-291X(02)02550-0.
145. Maruyama, T., Tanaka, K., Suzuki, J., Miyoshi, H., Harada, N., Nakamura, T., Miyamoto, Y., Kanatani, A., Tamai, Y., Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J. Endocrinol. 191 (2006), 197–205, 10.1677/joe.1.06546.
146. Mathier, M.A., Zhang, J., Ramanathan, R.C., Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. Chest 133 (2008), 789–792, 10.1378/chest.07-0815.
147. McGavigan, A.K., Garibay, D., Henseler, Z.M., Chen, J., Bettaieb, A., Haj, F.G., Ley, R.E., Chouinard, M.L., Cummings, B.P., TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 66 (2017), 226–234, 10.1136/gutjnl-2015-309871.
148. Melissas, J., Koukouraki, S., Askoxylakis, J., Stathaki, M., Daskalakis, M., Perisinakis, K., Karkavitsas, N., Sleeve gastrectomy — a restrictive procedure?. Obes. Surg. 17 (2007), 57–62, 10.1007/s11695-007-9006-5.
149. Mencarelli, A., Renga, B., D'Amore, C., Santorelli, C., Graziosi, L., Bruno, A., Monti, M.C., Distrutti, E., Cipriani, S., Donini, A., Fiorucci, S., Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents. Diabetes 62 (2013), 3384–3393, 10.2337/db13-0299.
150. Midtvedt, T., Microbial bile acid transformation. Am. J. Clin. Nutr. 27 (1974), 1341–1347.
151. Mingrone, G., Panunzi, S., De Gaetano, A., Guidone, C., Iaconelli, A., Leccesi, L., Nanni, G., Pomp, A., Castagneto, M., Ghirlanda, G., Rubino, F., Bariatric surgery versus conventional medical therapy for type 2 diabetes. N. Engl. J. Med. 366 (2012), 1577–1585, 10.1056/NEJMoa1200111.
152. Morínigo, R., Lacy, A.M., Casamitjana, R., Delgado, S., Gomis, R., Vidal, J., GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects. Obes. Surg. 16 (2006), 1594–1601, 10.1381/096089206779319338.
153. Morínigo, R., Moizé, V., Musri, M., Lacy, A.M., Navarro, S., Marín, J.L., Delgado, S., Casamitjana, R., Vidal, J., Glucagon-like Peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J. Clin. Endocrinol. Metab. 91 (2006), 1735–1740, 10.1210/jc.2005-0904.
154. Mueller, M., Thorell, A., Claudel, T., Jha, P., Koefeler, H., Lackner, C., Hoesel, B., Fauler, G., Stojakovic, T., Einarsson, C., Marschall, H.-U., Trauner, M., Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. J. Hepatology 62 (2015), 1398–1404, 10.1016/j.jhep.2014.12.034.
155. Murakami, M., Une, N., Nishizawa, M., Suzuki, S., Ito, H., Horiuchi, T., Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects. Springerplus, 2, 2013, 20, 10.1186/2193-1801-2-20.
156. Myronovych, A., Kirby, M., Ryan, K.K., Zhang, W., Jha, P., Setchell, K.D., Dexheimer, P.J., Aronow, B., Seeley, R.J., Kohli, R., Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obes. (Silver Spring) 22 (2014), 390–400, 10.1002/oby.20548.
157. Nakatani, H., Kasama, K., Oshiro, T., Watanabe, M., Hirose, H., Itoh, H., Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery. Metabolism 58 (2009), 1400–1407, 10.1016/j.metabol.2009.05.006.
158. Nestoridi, E., Kvas, S., Kucharczyk, J., Stylopoulos, N., Resting energy expenditure and energetic cost of feeding are augmented after Roux-en-Y gastric bypass in obese mice. Endocrinology 153 (2012), 2234–2244, 10.1210/en.2011-2041.
159. Nguyen, N.T., Blackstone, R.P., Morton, J.M., Ponce, J., Rosenthal, R.J., The ASMBS Textbook of Bariatric Surgery. 2014, Springer, New York, NY, 10.1007/978-1-4939-1206-3.
160. Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R.O., Görgün, C.Z., Hotamisligil, G.S., Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313 (2006), 1137–1140, 10.1126/science.1128294.
161. O'Brien, P.E., McPhail, T., Chaston, T.B., Dixon, J.B., Systematic review of medium-term weight loss after bariatric operations. Obes. Surg. 16 (2006), 1032–1040, 10.1381/096089206778026316.
162. Pal, A., Rhoads, D.B., Tavakkoli, A., Foregut exclusion disrupts intestinal glucose sensing and alters portal nutrient and hormonal milieu. Diabetes 64 (2015), 1941–1950, 10.2337/db14-1578.
163. Patti, M.E., Houten, S.M., Bianco, A.C., Bernier, R., Larsen, P.R., Holst, J.J., Badman, M.K., Maratos-Flier, E., Mun, E.C., Pihlajamäki, J., Auwerx, J., Goldfine, A.B., Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity 17 (2009), 1671–1677, 10.1038/oby.2009.102.
164. Payne, J.H., DeWind, L.T., Commons, R.R., Metabolic observations in patients with jejunocolic shunts. Am. J. Surg. 106 (1963), 273–289, 10.1016/0002-9610(63)90017-5.
165. Péan, N., Doignon, I., Garcin, I., Besnard, A., Julien, B., Liu, B., Branchereau, S., Spraul, A., Guettier, C., Humbert, L., Schoonjans, K., Rainteau, D., Tordjmann, T., The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology 58 (2013), 1451–1460, 10.1002/hep.26463.
166. Pierre, J.F., Martinez, K.B., Ye, H., Nadimpalli, A., Morton, T.C., Yang, J., Wang, Q., Patno, N., Chang, E.B., Yin, D.P., Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice. AJP Gastrointest. Liver Physiology 311 (2016), G286–G304, 10.1152/ajpgi.00202.2016.
167. Poole, D.P., Godfrey, C., Cattaruzza, F., Cottrell, G.S., Kirkland, J.G., Pelayo, J.C., Bunnett, N.W., Corvera, C.U., Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. - PubMed - NCBI. Neurogastroenterol. Motil., 22, 2010 814–e228.
168. Pories, W.J., Swanson, M.S., MacDonald, K.G., Long, S.B., Morris, P.G., Brown, B.M., Barakat, H.A., deRamon, R.A., Israel, G., Dolezal, J.M., Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg. 222 (1995), 339–350 discussion 350–2.
169. Potthoff, M.J., Potts, A., He, T., Duarte, J.A., Taussig, R., Mangelsdorf, D.J., Kliewer, S.A., Burgess, S.C., Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am. J. Physiol. Gastrointest. Liver Physiol. 304 (2013), G371–G380, 10.1152/ajpgi.00400.2012.
170. Pournaras, D.J., Glicksman, C., Vincent, R.P., Kuganolipava, S., Alaghband-Zadeh, J., Mahon, D., Bekker, J.H.R., Ghatei, M.A., Bloom, S.R., Walters, J.R.F., Welbourn, R., le Roux, C.W., The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology 153 (2012), 3613–3619, 10.1210/en.2011-2145.
171. Prinz, P., Hofmann, T., Ahnis, A., Elbelt, U., Goebel-Stengel, M., Klapp, B.F., Rose, M., Stengel, A., Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients. Front. Neurosci., 9(S498), 2015, 10.3389/fnins.2015.00199.
172. Pugh, M.E., Newman, J.H., Williams, D.B., Brittain, E., Robbins, I.M., Hemnes, A.R., Hemodynamic improvement of pulmonary arterial hypertension after bariatric surgery: potential role for metabolic regulation. Diabetes Care 36 (2013), e32–e33, 10.2337/dc12-1650.
173. Qi, Y., Jiang, C., Cheng, J., Krausz, K.W., Li, T., Ferrell, J.M., Gonzalez, F.J., Chiang, J.Y.L., Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim. Biophys. Acta 1851 (2014), 19–29, 10.1016/j.bbalip.2014.04.008.
174. Rafferty, E.P., Wylie, A.R., Hand, K.H., Elliott, C.E., Grieve, D.J., Green, B.D., Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R(-/-) mice. Biol. Chem. 392 (2011), 539–546, 10.1515/BC.2011.050.
175. Rajagopal, S., Kumar, D.P., Mahavadi, S., Bhattacharya, S., Zhou, R., Corvera, C.U., Bunnett, N.W., Grider, J.R., Murthy, K.S., Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 304 (2013), G527–G535, 10.1152/ajpgi.00388.2012.
176. Reimann, F., Tolhurst, G., Gribble, F.M., G-protein-coupled receptors in intestinal chemosensation. Cell Metab. 15 (2012), 421–431, 10.1016/j.cmet.2011.12.019.
177. Ridlon, J.M., Kang, D.-J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47 (2006), 241–259, 10.1194/jlr.R500013-JLR200.
178. Risstad, H., Søvik, T.T., Engström, M., Aasheim, E.T., Fagerland, M.W., Olsén, M.F., Kristinsson, J.A., le Roux, C.W., Bøhmer, T., Birkeland, K.I., Mala, T., Olbers, T., Five-year outcomes after laparoscopic gastric bypass and lapar oscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 150 (2015), 352–361, 10.1001/jamasurg.2014.3579.
179. Robins, S.J., Brunengraber, H., Origin of biliary cholesterol and lecithin in the rat: contribution of new synthesis and preformed hepatic stores. J. Lipid Res. 23 (1982), 604–608.
180. Roma, M.G., Toledo, F.D., Boaglio, A.C., Basiglio, C.L., Crocenzi, F.A., Sánchez Pozzi, E.J., Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. Clin. Sci. 121 (2011), 523–544, 10.1042/CS20110184.
181. Roux, C.W.L., Aylwin, S.J.B., Batterham, R.L., Borg, C.M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M.A., Patel, A.G., Bloom, S.R., Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss. Improve Metabolic Param. Ann. Surg 243 (2006), 108–114, 10.1097/01.sla.0000183349.16877.84.
182. Rubino, F., Marescaux, J., Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann. Surg. 239 (2004), 1–11, 10.1097/01.sla.0000102989.54824.fc.
183. Rubino, F., Nathan, D.M., Eckel, R.H., Schauer, P.R., Alberti, K.G.M.M., Zimmet, P.Z., Del Prato, S., Ji, L., Sadikot, S.M., Herman, W.H., Amiel, S.A., Kaplan, L.M., Taroncher-Oldenburg, G., Cummings, D.E., Albache, N., Batterham, R.L., Bhatt, D.L., Boza, C., Cefalu, W.T., Cohen, R.V., Courcoulas, A.P., Dinneen, S.F., Dixon, J.B., Ferrannini, E., Fioretto, P., Frühbeck, G., Gagner, M., Grant, R.W., Ikramuddin, S., Johnston, D.G., Kashyap, S.R., Kelly, T., Klupa, T., Korner, J., Laferrère, B., Lebovitz, H.E., Lee, W.-J., le Roux, C.W., Mechanick, J.I., Mingrone, G., Morton, J.M., Pories, W.J., Ratner, R.E., Rayman, G., Sugerman, H.J., Van Gaal, L., Vidal, J., Weng, J., Wolfe, B.M., Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care 39 (2016), 861–877, 10.2337/dc16-0236.
184. Russell, D.W., The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72 (2003), 137–174, 10.1146/annurev.biochem.72.121801.161712.
185. Ryan, K.K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Perez, H.E., Sandoval, D.A., Kohli, R., Bäckhed, F., Seeley, R.J., FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509 (2014), 183–188, 10.1038/nature13135.
186. Saeidi, N., Meoli, L., Nestoridi, E., Gupta, N.K., Kvas, S., Kucharczyk, J., Bonab, A.A., Fischman, A.J., Yarmush, M.L., Stylopoulos, N., Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science 341 (2013), 406–410, 10.1126/science.1235103.
187. Sayin, S.I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., Bäckhed, F., Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17 (2013), 225–235, 10.1016/j.cmet.2013.01.003.
188. Schauer, P.R., Kashyap, S.R., Wolski, K., Brethauer, S.A., Kirwan, J.P., Pothier, C.E., Thomas, S., Abood, B., Nissen, S.E., Bhatt, D.L., Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N. Engl. J. Med. 366 (2012), 1567–1576, 10.1056/NEJMoa1200225.
189. Schauer, P.R., Bhatt, D.L., Kirwan, J.P., Wolski, K., Brethauer, S.A., Navaneethan, S.D., Aminian, A., Pothier, C.E., Kim, E.S.H., Nissen, S.E., Kashyap, S.R., STAMPEDE Investigators. Bariatric surgery versus intensive medical therapy for diabetes–3-year outcomes. N. Engl. J. Med. 370 (2014), 2002–2013, 10.1056/NEJMoa1401329.
190. Schiff, E.R., Small, N.C., Dietschy, J.M., Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat. J. Clin. Investigation 51 (1972), 1351–1362, 10.1172/JCI106931.
191. Schmidt, J.B., Pedersen, S.D., Gregersen, N.T., Vestergaard, L., Nielsen, M.S., Ritz, C., Madsbad, S., Worm, D., Hansen, D.L., Clausen, T.R., Rehfeld, J.F., Astrup, A., Holst, J.J., Sjödin, A., Effects of RYGB on energy expenditure, appetite and glycemic control: a randomized controlled clinical trial. Int. J. Obes. (Lond), 2015, 10.1038/ijo.2015.162.
192. Schwarz, M., Russell, D.W., Dietschy, J.M., Turley, S.D., Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. J. Lipid Res. 42 (2001), 1594–1603, 10.1146/annurev.cellbio.16.1.459.
193. Seeley, R.J., Chambers, A.P., Sandoval, D.A., The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 21 (2015), 369–378, 10.1016/j.cmet.2015.01.001.
194. Shang, Q., Saumoy, M., Holst, J.J., Salen, G., Xu, G., Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. AJP Gastrointest. Liver Physiology 298 (2010), G419–G424, 10.1152/ajpgi.00362.2009.
195. Sheu, E.G., Channick, R., Gee, D.W., Improvement in severe pulmonary hypertension in obese patients after laparoscopic gastric bypass or sleeve gastrectomy. Surg. Endosc. 30 (2015), 633–637, 10.1007/s00464-015-4251-5.
196. Shin, A.C., Zheng, H., Townsend, R.L., Patterson, L.M., Holmes, G.M., Berthoud, H.-R., Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat-fed obese rats. Obes. Surg. 23 (2013), 531–540, 10.1007/s11695-012-0846-2.
197. Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., Laakso, M., Gylling, H., Patti, M.E., Auwerx, J., Pihlajamäki, J., Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass. Obes. Surg. 22 (2012), 1473–1480, 10.1007/s11695-012-0673-5.
198. Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., Gonzalez, F.J., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102 (2000), 731–744.
199. Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C.D., Sullivan, M., Wedel, H., Lifestyle, diabetes, and cardiovascular risk factors 10 Years after bariatric surgery. N. Engl. J. Med. 351 (2004), 2683–2693, 10.1056/NEJMoa035622.
200. Sjöström, L., Narbro, K., Sjöström, C.D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., Bengtsson, C., Dahlgren, S., Gummesson, A., Jacobson, P., Karlsson, J., Lindroos, A.-K., Lönroth, H., Näslund, I., Olbers, T., Stenlöf, K., Torgerson, J., Ågren, G., Carlsson, L.M.S., Effects of bariatric surgery on mortality in Swedish obese subjects. N. Engl. J. Med. 357 (2007), 741–752, 10.1056/NEJMoa066254.
201. Sjöström, L., Gummesson, A., Sjöström, C.D., Narbro, K., Peltonen, M., Wedel, H., Bengtsson, C., Bouchard, C., Carlsson, B., Dahlgren, S., Jacobson, P., Karason, K., Karlsson, J., Larsson, B., Lindroos, A.-K., Lönroth, H., Näslund, I., Olbers, T., Stenlöf, K., Torgerson, J., Carlsson, L.M., Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 10 (2009), 653–662, 10.1016/S1470-2045(09)70159-7.
202. Sjöström, L., Peltonen, M., Jacobson, P., Sjöström, C.D., Karason, K., Wedel, H., Ahlin, S., Anveden, Å., Bengtsson, C., Bergmark, G., Bouchard, C., Carlsson, B., Dahlgren, S., Karlsson, J., Lindroos, A.-K., Lönroth, H., Narbro, K., Näslund, I., Olbers, T., Svensson, P.-A., Carlsson, L.M.S., Bariatric surgery and long-term cardiovascular events. JAMA 307 (2012), 56–65, 10.1001/jama.2011.1914.
203. Smushkin, G., Sathananthan, M., Piccinini, F., Man, C.D., Law, J.H., Cobelli, C., Zinsmeister, A.R., Rizza, R.A., Vella, A., The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes. Diabetes 62 (2013), 1094–1101, 10.2337/db12-0923.
204. Spak, E., Björklund, P., Helander, H.F., Vieth, M., Olbers, T., Casselbrant, A., Lönroth, H., Fändriks, L., Changes in the mucosa of the Roux-limb after gastric bypass surgery. Histopathology 57 (2010), 680–688, 10.1111/j.1365-2559.2010.03677.x.
205. Spinelli, V., Lalloyer, F., Baud, G., Osto, E., Kouach, M., Daoudi, M., Vallez, E., Raverdy, V., Goossens, J.-F., Descat, A., Doytcheva, P., Hubert, T., Lutz, T.A., Lestavel, S., Staels, B., Pattou, F., Tailleux, A., Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans. Int. J. Obes. (Lond) 40 (2016), 1260–1267, 10.1038/ijo.2016.46.
206. Staels, B., Fonseca, V.A., Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care 32:Suppl. 2 (2009), S237–S245, 10.2337/dc09-S355.
207. Stefater, M.A., Wilson-Pérez, H.E., Chambers, A.P., All bariatric surgeries are not created equal: insights from mechanistic comparisons. Endocrine 33 (2012), 595–622, 10.1210/er.2011-1044.
208. Steinert, R.E., Peterli, R., Keller, S., Meyer-Gerspach, A.C., Drewe, J., Peters, T., Beglinger, C., Bile acids and gut peptide secretion after bariatric surgery: a 1-year prospective randomized pilot trial. Obes. (Silver Spring) 21 (2013), E660–E668, 10.1002/oby.20522.
209. Stellaard, F., Sackmann, M., Sauerbruch, T., Paumgartner, G., Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates in human serum using 13C-labeled bile acids. J. Lipid Res. 25 (1984), 1313–1319.
210. Stenman, L.K., Holma, R., Eggert, A., Korpela, R., A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids. AJP: Gastrointest. Liver Physiology 304 (2013), G227–G234, 10.1152/ajpgi.00267.2012.
211. Strader, A.D., Clausen, T.R., Goodin, S.Z., Wendt, D., Ileal interposition improves glucose tolerance in low dose streptozotocin-treated diabetic and euglycemic rats. Obes. Surg. 19 (2009), 96–104, 10.1007/s11695-008-9754-x.
212. Stylopoulos, N., Hoppin, A.G., Kaplan, L.M., Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats. Obesity 17 (2009), 1839–1847, 10.1038/oby.2009.207.
213. Sun, W., Zhang, D., Wang, Z., Sun, J., Xu, B., Chen, Y., Ding, L., Huang, X., Lv, X., Lu, J., Bi, Y., Xu, Q., Insulin resistance is associated with total bile acid level in type 2 diabetic and nondiabetic population. Med. Baltim., 95, 2016, e2778, 10.1097/MD.0000000000002778.
214. Svensson, P.A., Olsson, M., Andersson-Assarsson, J.C., Taube, M., Pereira, M.J., Froguel, P., Jacobson, P., The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate. Biochem. Biophysical Res. Commun. 433 (2013), 563–566, 10.1016/j.bbrc.2013.03.031.
215. Swann, J.R., Want, E.J., Geier, F.M., Spagou, K., Wilson, I.D., Sidaway, J.E., Nicholson, J.K., Holmes, E., Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. U.S.A. 108:Suppl. 1 (2011), 4523–4530, 10.1073/pnas.1006734107.
216. Swinburn, B.A., Sacks, G., Hall, K.D., McPherson, K., Finegood, D.T., Moodie, M.L., Gortmaker, S.L., The global obesity pandemic: shaped by global drivers and local environments. Lancet 378 (2011), 804–814, 10.1016/S0140-6736(11)60813-1.
217. Takahashi, M., Sasaki, I., Naito, H., Funayama, Y., Chronic bile diversion to the urinary bladder enhances cholecystokinin release and suppresses gastric inhibitory polypeptide release in dogs. Tohoku J. Exp Med. 178:2 (1996), 151–162.
218. Tamboli, R.A., Hossain, H.A., Marks, P.A., Eckhauser, A.W., Rathmacher, J.A., Phillips, S.E., Buchowski, M.S., Chen, K.Y., Abumrad, N.N., Body composition and energy metabolism following Roux-en-Y gastric bypass surgery. Obes. (Silver Spring) 18 (2010), 1718–1724, 10.1038/oby.2010.89.
219. Tamboli, R.A., Hajri, T., Jiang, A., Marks-Shulman, P.A., Williams, D.B., Clements, R.H., Melvin, W., Bowen, B.P., Shyr, Y., Abumrad, N.N., Flynn, C.R., Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy. PLoS One, 6, 2011, e28577, 10.1371/journal.pone.0028577.
220. Tamboli, R.A., Breitman, I., Marks-Shulman, P.A., Jabbour, K., Melvin, W., Williams, B., Clements, R.H., Feurer, I.D., Abumrad, N.N., Early weight regain after gastric bypass does not affect insulin sensitivity but is associated with elevated ghrelin. Obes. (Silver Spring) 22 (2014), 1617–1622, 10.1002/oby.20776.
221. Taylor, D.R., Alaghband-Zadeh, J., Cross, G.F., Omar, S., le Roux, C.W., Vincent, R.P., Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m 2. PLoS One, 9, 2014, e93540, 10.1371/journal.pone.0093540.
222. The Look AHEAD Research Group, Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obes. (Silver Spring) 22 (2014), 5–13, 10.1002/oby.20662.
223. Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., Schoonjans, K., Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 7 (2008), 678–693, 10.1038/nrd2619.
224. Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., Pellicciari, R., Auwerx, J., Schoonjans, K., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10 (2009), 167–177, 10.1016/j.cmet.2009.08.001.
225. Trogdon, J.G., Finkelstein, E.A., Hylands, T., Dellea, P.S., Kamal Bahl, S.J., Indirect costs of obesity: a review of the current literature. Obes. Rev. 9 (2008), 489–500, 10.1111/j.1467-789X.2008.00472.x.
226. Tsuchiya, T., Kalogeris, T.J., Tso, P., Ileal transposition into the upper jejunum affects lipid and bile salt absorption in rats. Am. J. Physiol 271 (1996), G681–G691.
227. Kullak Ublick, G.A., Paumgartner, G., Berr, F., Long-term effects of cholecystectomy on bile acid metabolism. Hepatology 21 (1995), 41–45, 10.1002/hep.1840210109.
228. van Nierop, F.S., Kulik, W., Endert, E., Schaap, F.G., Olde Damink, S.W., Romijn, J.A., Soeters, M.R., Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects. Clin. Nutr., 2016, 10.1016/j.clnu.2016.10.006.
229. Vassileva, G., Golovko, A., Markowitz, L., Abbondanzo, S.J., Zeng, M., Yang, S., Hoos, L., Tetzloff, G., Levitan, D., Murgolo, N.J., Keane, K., Davis, H.R., Hedrick, J., Gustafson, E.L., Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem. J. 398 (2006), 423–430, 10.1042/BJ20060537.
230. Vernon, G., Baranova, A., Younossi, Z.M., Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 34 (2011), 274–285, 10.1111/j.1365-2036.2011.04724.x.
231. Vettorazzi, J.F., Ribeiro, R.A., Borck, P.C., Branco, R.C.S., Soriano, S., Merino, B., Boschero, A.C., Nadal, A., Quesada, I., Carneiro, E.M., The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells. Metabolism 65 (2016), 54–63, 10.1016/j.metabol.2015.10.021.
232. Vidal, J., Nicolau, J., Romero, F., Casamitjana, R., Momblan, D., Conget, I., Morínigo, R., Lacy, A.M., Long-Term Effects of Roux-en-Y Gastric Bypass Surgery on Plasma Glucagon-Like Peptide-1 and Islet Function in Morbidly Obese Subjects. J. Clin. Endocrinol. Metab. 94 (2009), 884–891, 10.1210/jc.2008-1620.
233. Wang, H., Chen, J., Hollister, K., Sowers, L.C., Forman, B.M., Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 3 (1999), 543–553, 10.1016/S1097-2765(00)80348-2.
234. Wang, Y.D., Chen, W.D., Wang, M., Yu, D., Forman, B.M., Huang, W., Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48 (2008), 1632–1643, 10.1002/hep.22519.
235. Wang, G., Agenor, K., Pizot, J., Kotler, D.P., Harel, Y., Van Der Schueren, B.J., Quercia, I., McGinty, J., Laferrère, B., Accelerated gastric emptying but No carbohydrate malabsorption 1 Year after gastric bypass surgery (GBP). Obes. Surg. 22 (2012), 1263–1267, 10.1007/s11695-012-0656-6.
236. Watanabe, M., Houten, S.M., Mataki, C., Christoffolete, M.A., Kim, B.W., Sato, H., Messaddeq, N., Harney, J.W., Ezaki, O., Kodama, T., Schoonjans, K., Bianco, A.C., Auwerx, J., Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439 (2006), 484–489, 10.1038/nature04330.
237. Watanabe, M., Horai, Y., Houten, S.M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., Itoh, H., Auwerx, J., Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J. Biol. Chem. 286 (2011), 26913–26920, 10.1074/jbc.M111.248203.
238. Weckesser, E.C., Chinn, A.B., Scott, M.W. Jr., Price, J.W., Extensive resection of the small intestine. Am. J. Surg. 78 (1949), 706–714, 10.1016/0002-9610(49)90312-8.
239. Werling, M., Olbers, T., Fändriks, L., Bueter, M., Lönroth, H., Stenlöf, K., le Roux, C.W., Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-y gastric bypass compared to vertical banded gastroplasty. PLoS One, 8, 2013, e60280, 10.1371/journal.pone.0060280.
240. Werling, M., Vincent, R.P., Cross, G.F., Marschall, H.-U., Fändriks, L., Lönroth, H., Taylor, D.R., Alaghband-Zadeh, J., Olbers, T., le Roux, C.W., Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery. Scand. J. Gastroenterol. 48 (2013), 1257–1264, 10.3109/00365521.2013.833647.
241. Wewalka, M., Patti, M.E., Barbato, C., Houten, S.M., Goldfine, A.B., Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. J. Clin. Endocrinol. Metab. 99 (2014), 1442–1451, 10.1210/jc.2013-3367.
242. Williams, K.V., Mullen, M.L., Kelley, D.E., Wing, R.R., The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care 21 (1998), 2–8.
243. Wing, R.R., Lang, W., Wadden, T.A., Safford, M., Knowler, W.C., Bertoni, A.G., Hill, J.O., Brancati, F.L., Peters, A., Wagenknecht, L., Look AHEAD Research Group. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 34 (2011), 1481–1486, 10.2337/dc10-2415.
244. Wu, Q., Zhang, X., Zhong, M., Han, H., Liu, S., Liu, T., Wei, M., Guo, W., Xie, H., Hu, S., Zhang, G., Effects of bariatric surgery on serum bile acid composition and conjugation in a diabetic rat model. Obes. Surg. 26 (2016), 2384–2392, 10.1007/s11695-016-2087-2.
245. Xie, G., Wang, Y., Wang, X., Zhao, A., Chen, T., Ni, Y., Wong, L., Zhang, H., Zhang, J., Liu, C., Liu, P., Jia, W., Profiling of serum bile acids in a healthy Chinese population using UPLC–MS/MS. J. Proteome Res. 14 (2015), 850–859, 10.1021/pr500920q.
246. Zadeh-Tahmasebi, M., Duca, F.A., Rasmussen, B.A., Bauer, P.V., Côté, C.D., Filippi, B.M., Lam, T.K.T., Activation of short and long chain fatty acid sensing machinery in the ileum lowers glucose production in vivo. J. Biol. Chem. 291 (2016), 8816–8824, 10.1074/jbc.M116.718460.
247. Zhang, M., Yang, X.-J., Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases. WJG, 22, 2016, 8905, 10.3748/wjg.v22.i40.8905.
248. Zhang, Y., Lee, F.Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F.J., Willson, T.M., Edwards, P.A., Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc. Natl. Acad. Sci. 103 (2006), 1006–1011, 10.1073/pnas.0506982103.
249. Zhang, X., Liu, T., Wang, Y., Zhong, M., Zhang, G., Liu, S., Wu, T., Rayner, C.K., Hu, S., Comparative effects of bile diversion and duodenal-jejunal bypass on glucose and lipid metabolism in male diabetic rats. Obes. Surg., 2015, 1–11, 10.1007/s11695-015-1925-y.