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Volumn 273, Issue 3, 2013, Pages 680-690

Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice

Author keywords

12 hydroxylated BAs; BA profiling; Bile acids; Calorie restriction; Enterohepatic circulation; UPLC MS MS

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; CHOLESTEROL 7ALPHA MONOOXYGENASE; DEHYDROCHOLIC ACID; FIBROBLAST GROWTH FACTOR RECEPTOR 4; HYODEOXYCHOLIC ACID; LITHOCHOLIC ACID; MESSENGER RNA; OMEGA MURICHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84888857095     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.10.020     Document Type: Article
Times cited : (48)

References (60)
  • 1
    • 20444411508 scopus 로고    scopus 로고
    • Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice
    • Amador-Noguez D., Zimmerman J., Venable S., Darlington G. Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem. Biophys. Res. Commun. 2005, 332:1086-1100.
    • (2005) Biochem. Biophys. Res. Commun. , vol.332 , pp. 1086-1100
    • Amador-Noguez, D.1    Zimmerman, J.2    Venable, S.3    Darlington, G.4
  • 2
    • 1542724881 scopus 로고    scopus 로고
    • Cellular regulation of hepatic bile acid transport in health and cholestasis
    • Anwer M.S. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology 2004, 39:581-590.
    • (2004) Hepatology , vol.39 , pp. 581-590
    • Anwer, M.S.1
  • 6
    • 0035845492 scopus 로고    scopus 로고
    • Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice
    • Cao S.X., Dhahbi J.M., Mote P.L., Spindler S.R. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:10630-10635.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10630-10635
    • Cao, S.X.1    Dhahbi, J.M.2    Mote, P.L.3    Spindler, S.R.4
  • 7
    • 78649752866 scopus 로고    scopus 로고
    • Commonly adopted caloric restriction protocols often involve malnutrition
    • Cerqueira F.M., Kowaltowski A.J. Commonly adopted caloric restriction protocols often involve malnutrition. Ageing Res. Rev. 2010, 9:424-430.
    • (2010) Ageing Res. Rev. , vol.9 , pp. 424-430
    • Cerqueira, F.M.1    Kowaltowski, A.J.2
  • 8
    • 80052720863 scopus 로고    scopus 로고
    • TGR5: a novel target for weight maintenance and glucose metabolism
    • Chen X., Lou G., Meng Z., Huang W. TGR5: a novel target for weight maintenance and glucose metabolism. Exp. Diabetes Res. 2011, 2011:853501.
    • (2011) Exp. Diabetes Res. , vol.2011 , pp. 853501
    • Chen, X.1    Lou, G.2    Meng, Z.3    Huang, W.4
  • 9
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • Chiang J.Y. Regulation of bile acid synthesis. Front. Biosci. 1998, 3:d176-d193.
    • (1998) Front. Biosci. , vol.3
    • Chiang, J.Y.1
  • 10
    • 0037369402 scopus 로고    scopus 로고
    • Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors
    • Chiang J.Y. Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 284:G349-G356.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.284
    • Chiang, J.Y.1
  • 11
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism
    • Claudel T., Staels B., Kuipers F. The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2020-2030.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 12
    • 78751502413 scopus 로고    scopus 로고
    • Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice
    • Csanaky I.L., Lu H., Zhang Y., Ogura K., Choudhuri S., Klaassen C.D. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology 2011, 53:272-281.
    • (2011) Hepatology , vol.53 , pp. 272-281
    • Csanaky, I.L.1    Lu, H.2    Zhang, Y.3    Ogura, K.4    Choudhuri, S.5    Klaassen, C.D.6
  • 14
    • 0141866661 scopus 로고    scopus 로고
    • Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    • De Fabiani E., Mitro N., Gilardi F., Caruso D., Galli G., Crestani M. Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J. Biol. Chem. 2003, 278:39124-39132.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39124-39132
    • De Fabiani, E.1    Mitro, N.2    Gilardi, F.3    Caruso, D.4    Galli, G.5    Crestani, M.6
  • 15
    • 65349191234 scopus 로고    scopus 로고
    • Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways
    • Estep P.W., Warner J.B., Bulyk M.L. Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways. PLoS One 2009, 4:e5242.
    • (2009) PLoS One , vol.4
    • Estep, P.W.1    Warner, J.B.2    Bulyk, M.L.3
  • 16
    • 33747472602 scopus 로고    scopus 로고
    • Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition
    • Faulks S.C., Turner N., Else P.L., Hulbert A.J. Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition. J. Gerontol. A Biol. Sci. Med. Sci. 2006, 61:781-794.
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci. , vol.61 , pp. 781-794
    • Faulks, S.C.1    Turner, N.2    Else, P.L.3    Hulbert, A.J.4
  • 18
    • 84857750771 scopus 로고    scopus 로고
    • Gender-divergent profile of bile acid homeostasis during aging of mice
    • Fu Z.D., Csanaky I.L., Klaassen C.D. Gender-divergent profile of bile acid homeostasis during aging of mice. PLoS One 2012, 7:e32551.
    • (2012) PLoS One , vol.7
    • Fu, Z.D.1    Csanaky, I.L.2    Klaassen, C.D.3
  • 20
    • 0033570028 scopus 로고    scopus 로고
    • Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer
    • Grober J., Zaghini I., Fujii H., Jones S.A., Kliewer S.A., Willson T.M., Ono T., Besnard P. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J. Biol. Chem. 1999, 274:29749-29754.
    • (1999) J. Biol. Chem. , vol.274 , pp. 29749-29754
    • Grober, J.1    Zaghini, I.2    Fujii, H.3    Jones, S.A.4    Kliewer, S.A.5    Willson, T.M.6    Ono, T.7    Besnard, P.8
  • 21
    • 84855427221 scopus 로고    scopus 로고
    • Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia
    • Haeusler R.A., Pratt-Hyatt M., Welch C.L., Klaassen C.D., Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab. 2012, 15:65-74.
    • (2012) Cell Metab. , vol.15 , pp. 65-74
    • Haeusler, R.A.1    Pratt-Hyatt, M.2    Welch, C.L.3    Klaassen, C.D.4    Accili, D.5
  • 23
    • 0033470181 scopus 로고    scopus 로고
    • Bile acids: the good, the bad, and the ugly
    • Hofmann A.F. Bile acids: the good, the bad, and the ugly. News Physiol. Sci. 1999, 14:24-29.
    • (1999) News Physiol. Sci. , vol.14 , pp. 24-29
    • Hofmann, A.F.1
  • 24
    • 63849295015 scopus 로고    scopus 로고
    • The enterohepatic circulation of bile acids in mammals: form and functions
    • Hofmann A.F. The enterohepatic circulation of bile acids in mammals: form and functions. Front. Biosci. 2009, 14:2584-2598.
    • (2009) Front. Biosci. , vol.14 , pp. 2584-2598
    • Hofmann, A.F.1
  • 27
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • Kim I., Ahn S.H., Inagaki T., Choi M., Ito S., Guo G.L., Kliewer S.A., Gonzalez F.J. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J. Lipid Res. 2007, 48:2664-2672.
    • (2007) J. Lipid Res. , vol.48 , pp. 2664-2672
    • Kim, I.1    Ahn, S.H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6    Kliewer, S.A.7    Gonzalez, F.J.8
  • 28
    • 40849139052 scopus 로고    scopus 로고
    • Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat
    • Kim J.H., Kwak H.B., Leeuwenburgh C., Lawler J.M. Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Exp. Gerontol. 2008, 43:317-329.
    • (2008) Exp. Gerontol. , vol.43 , pp. 317-329
    • Kim, J.H.1    Kwak, H.B.2    Leeuwenburgh, C.3    Lawler, J.M.4
  • 29
    • 84865540426 scopus 로고    scopus 로고
    • Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
    • Kong B., Wang L., Chiang J.Y., Zhang Y., Klaassen C.D., Guo G.L. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012, 56:1034-1043.
    • (2012) Hepatology , vol.56 , pp. 1034-1043
    • Kong, B.1    Wang, L.2    Chiang, J.Y.3    Zhang, Y.4    Klaassen, C.D.5    Guo, G.L.6
  • 30
    • 0037069375 scopus 로고    scopus 로고
    • Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
    • Lee C.K., Allison D.B., Brand J., Weindruch R., Prolla T.A. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:14988-14993.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 14988-14993
    • Lee, C.K.1    Allison, D.B.2    Brand, J.3    Weindruch, R.4    Prolla, T.A.5
  • 31
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P., Cariou B., Lien F., Kuipers F., Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 2009, 89:147-191.
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 32
    • 79952218554 scopus 로고    scopus 로고
    • Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis
    • Li T., Matozel M., Boehme S., Kong B., Nilsson L.M., Guo G., Ellis E., Chiang J.Y. Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 2011, 53:996-1006.
    • (2011) Hepatology , vol.53 , pp. 996-1006
    • Li, T.1    Matozel, M.2    Boehme, S.3    Kong, B.4    Nilsson, L.M.5    Guo, G.6    Ellis, E.7    Chiang, J.Y.8
  • 34
    • 0034595650 scopus 로고    scopus 로고
    • Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
    • Li-Hawkins J., Lund E.G., Bronson A.D., Russell D.W. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J. Biol. Chem. 2000, 275:16543-16549.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16543-16549
    • Li-Hawkins, J.1    Lund, E.G.2    Bronson, A.D.3    Russell, D.W.4
  • 37
    • 0025368250 scopus 로고
    • Lipid analysis and fatty acid profiles of individual arterial atherosclerotic plaques
    • McGrath L.T., Elliott R.J. Lipid analysis and fatty acid profiles of individual arterial atherosclerotic plaques. Anal. Biochem. 1990, 187:273-276.
    • (1990) Anal. Biochem. , vol.187 , pp. 273-276
    • McGrath, L.T.1    Elliott, R.J.2
  • 38
    • 46749147548 scopus 로고    scopus 로고
    • Age-specific effects of short- and long-term caloric restriction on the expression of adiponectin and adiponectin receptors: influence of intensity of food restriction
    • Niemann B., Silber R.E., Rohrbach S. Age-specific effects of short- and long-term caloric restriction on the expression of adiponectin and adiponectin receptors: influence of intensity of food restriction. Exp. Gerontol. 2008, 43:706-713.
    • (2008) Exp. Gerontol. , vol.43 , pp. 706-713
    • Niemann, B.1    Silber, R.E.2    Rohrbach, S.3
  • 39
    • 84883386133 scopus 로고    scopus 로고
    • Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1
    • Nogueira L.M., Lavigne J.A., Chandramouli G.V., Lui H., Barrett J.C., Hursting S.D. Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1. Cancer Med. 2012, 1:275-288.
    • (2012) Cancer Med. , vol.1 , pp. 275-288
    • Nogueira, L.M.1    Lavigne, J.A.2    Chandramouli, G.V.3    Lui, H.4    Barrett, J.C.5    Hursting, S.D.6
  • 40
    • 80055082476 scopus 로고    scopus 로고
    • Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms
    • Park W.H., Pak Y.K. Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms. Exp. Mol. Med. 2011, 43:571-579.
    • (2011) Exp. Mol. Med. , vol.43 , pp. 571-579
    • Park, W.H.1    Pak, Y.K.2
  • 42
    • 79957460967 scopus 로고    scopus 로고
    • Appetite and endocrine regulators of energy balance after 2days of energy restriction: insulin, leptin, ghrelin, and DHEA-S
    • Pasiakos S.M., Caruso C.M., Kellogg M.D., Kramer F.M., Lieberman H.R. Appetite and endocrine regulators of energy balance after 2days of energy restriction: insulin, leptin, ghrelin, and DHEA-S. Obesity 2011, 19:1124-1130.
    • (2011) Obesity , vol.19 , pp. 1124-1130
    • Pasiakos, S.M.1    Caruso, C.M.2    Kellogg, M.D.3    Kramer, F.M.4    Lieberman, H.R.5
  • 43
    • 35649000891 scopus 로고    scopus 로고
    • Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c
    • Ponugoti B., Fang S., Kemper J.K. Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol. Endocrinol. 2007, 21:2698-2712.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 2698-2712
    • Ponugoti, B.1    Fang, S.2    Kemper, J.K.3
  • 45
    • 41649089141 scopus 로고    scopus 로고
    • The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis
    • Rao A., Haywood J., Craddock A.L., Belinsky M.G., Kruh G.D., Dawson P.A. The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:3891-3896.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 3891-3896
    • Rao, A.1    Haywood, J.2    Craddock, A.L.3    Belinsky, M.G.4    Kruh, G.D.5    Dawson, P.A.6
  • 46
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon J.M., Kang D.J., Hylemon P.B. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 2006, 47:241-259.
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 47
    • 34247100654 scopus 로고    scopus 로고
    • Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis
    • Rocha J.S., Bonkowski M.S., de Franca L.R., Bartke A. Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis. Mech. Ageing Dev. 2007, 128:317-331.
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 317-331
    • Rocha, J.S.1    Bonkowski, M.S.2    de Franca, L.R.3    Bartke, A.4
  • 48
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 2003, 72:137-174.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 49
    • 0346118926 scopus 로고    scopus 로고
    • PGC-1alpha activates CYP7A1 and bile acid biosynthesis
    • Shin D.J., Campos J.A., Gil G., Osborne T.F. PGC-1alpha activates CYP7A1 and bile acid biosynthesis. J. Biol. Chem. 2003, 278:50047-50052.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50047-50052
    • Shin, D.J.1    Campos, J.A.2    Gil, G.3    Osborne, T.F.4
  • 50
    • 0023526078 scopus 로고
    • Dietary restriction influences bile formation in aging rats
    • Tuchweber B., Perea A., Ferland G., Yousef I.M. Dietary restriction influences bile formation in aging rats. Life Sci. 1987, 41:2091-2099.
    • (1987) Life Sci. , vol.41 , pp. 2091-2099
    • Tuchweber, B.1    Perea, A.2    Ferland, G.3    Yousef, I.M.4
  • 51
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 1999, 3:543-553.
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 55
    • 33644901529 scopus 로고    scopus 로고
    • Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death: implications in changes in number of hemopoietic progenitor cells
    • Yoshida K., Hirabayashi Y., Watanabe F., Sado T., Inoue T. Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death: implications in changes in number of hemopoietic progenitor cells. Exp. Hematol. 2006, 34:274-283.
    • (2006) Exp. Hematol. , vol.34 , pp. 274-283
    • Yoshida, K.1    Hirabayashi, Y.2    Watanabe, F.3    Sado, T.4    Inoue, T.5
  • 56
    • 78149295983 scopus 로고    scopus 로고
    • Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice
    • Zhang Y., Klaassen C.D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 2010, 51:3230-3242.
    • (2010) J. Lipid Res. , vol.51 , pp. 3230-3242
    • Zhang, Y.1    Klaassen, C.D.2
  • 57
    • 81855211098 scopus 로고    scopus 로고
    • Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability
    • Zhang Y., Csanaky I.L., Lehman-McKeeman L.D., Klaassen C.D. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicol. Sci. 2011, 124:251-260.
    • (2011) Toxicol. Sci. , vol.124 , pp. 251-260
    • Zhang, Y.1    Csanaky, I.L.2    Lehman-McKeeman, L.D.3    Klaassen, C.D.4
  • 58
    • 79951571030 scopus 로고    scopus 로고
    • Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters
    • Zhang Y.K., Guo G.L., Klaassen C.D. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One 2011, 6:e16683.
    • (2011) PLoS One , vol.6
    • Zhang, Y.K.1    Guo, G.L.2    Klaassen, C.D.3
  • 60
    • 84859294062 scopus 로고    scopus 로고
    • Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice
    • Zhang Y., Limaye P.B., Lehman-McKeeman L.D., Klaassen C.D. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One 2012, 7:e34522.
    • (2012) PLoS One , vol.7
    • Zhang, Y.1    Limaye, P.B.2    Lehman-McKeeman, L.D.3    Klaassen, C.D.4


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