Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

Journal of Hepatology

Volumn 62, Issue 6, 2015, Pages 1398-1404

  Mueller, Michaela ^a,b   Thorell, Anders ^c,d   Claudel, Thierry ^a   Jha, Pooja ^a,b   Koefeler, Harald ^b   Lackner, Carolin ^b   Hoesel, Bastian ^a   Fauler, Guenter ^b   Stojakovic, Tatjana ^b   Einarsson, Curt ^e   Marschall, Hanns Ulrich ^f   Trauner, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c DANDERYD HOSPITAL   (Sweden)

^d ERSTA HOSPITAL   (Sweden)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

3 hydroxy 3 methylglutaryl CoA reductase; FGF19; Lipogenesis; Non alcoholic fatty liver disease; Stearoyl CoA desaturase

Indexed keywords

7 ALPHA HYDROXY 4 CHOLESTEN 3 ONE; 7ALPHA HYDROXYCHOLESTEROL; ACYL COENZYME A DESATURASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL DERIVATIVE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; OLEIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; BILE ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; SCD1 PROTEIN, HUMAN;

ARTICLE; BILE ACID SYNTHESIS; BLOOD SAMPLING; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; LAPAROSCOPIC SURGERY; LIPID HOMEOSTASIS; LIVER; MALE; MEDICATION COMPLIANCE; MORBID OBESITY; NONALCOHOLIC FATTY LIVER; OPEN STUDY; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; ROUX Y ANASTOMOSIS; SHORT COURSE THERAPY; STOMACH BYPASS; VISCERA; WHITE ADIPOSE TISSUE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; INTRAABDOMINAL FAT; LIPID METABOLISM; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID;

BILE ACIDS AND SALTS; HUMANS; INTRA-ABDOMINAL FAT; LIPID METABOLISM; LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; OLEIC ACID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEAROYL-COA DESATURASE; URSODEOXYCHOLIC ACID;

EID: 84929607710     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.12.034     Document Type: Article

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