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Volumn 50, Issue 12, 2009, Pages 2340-2357

Thematic review series: Bile acids. Bile acid transporters

Author keywords

Bile acids; Cholestasis; Cholesterol; Enterohepatic circulation; Nuclear receptors

Indexed keywords

BILE ACID TRANSPORTER; CARRIER PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN NTCP; PROTEIN OST ALPHA; PROTEIN OST BETA; RETINOID X RECEPTOR ALPHA; SODIUM ION; TAUROCHOLIC ACID; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; BILE ACID;

EID: 70849133150     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R900012-JLR200     Document Type: Review
Times cited : (565)

References (267)
  • 1
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann, A. F., and L. R. Hagey. 2008. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell. Mol. Life Sci. 65: 2461-2483.
    • (2008) Cell. Mol. Life Sci , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 2
    • 34548572892 scopus 로고    scopus 로고
    • Bile acid transporters: Structure, function, regulation and pathophysiological implications
    • Alrefai, W. A., and R. K. Gill. 2007. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm. Res. 24: 1803-1823.
    • (2007) Pharm. Res , vol.24 , pp. 1803-1823
    • Alrefai, W.A.1    Gill, R.K.2
  • 3
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner, M., and J. L. Boyer. 2003. Bile salt transporters: molecular characterization, function, and regulation. Physiol. Rev. 83: 633-671.
    • (2003) Physiol. Rev , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 4
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang, J. Y. 2009. Bile acids: regulation of synthesis. J Lipid Res. 50: 1955-1966
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 7
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre, P., B. Cariou, F. Lien, F. Kuipers, and B. Staels. 2009. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89: 147-191.
    • (2009) Physiol. Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 8
    • 33947134611 scopus 로고    scopus 로고
    • Bile formation and the enterohepatic circulation
    • L. R. Johnson, editor. Elsevier Academic Press, Amsterdam. Chapter 56
    • Dawson, P. A. Shneider. B. L., Hofmann A.F. 2006. Bile formation and the enterohepatic circulation. In Physiology of the Gastrointestinal Tract. L. R. Johnson, editor. Elsevier Academic Press, Amsterdam. Chapter 56: 1437-1462.
    • (2006) Physiology of the Gastrointestinal Tract , pp. 1437-1462
    • Dawson, P.A.1    Shneider, B.L.2    Hofmann, A.F.3
  • 9
    • 0014289540 scopus 로고
    • Mechanisms for the intestinal absorption of bile acids
    • Dietschy, J. M. 1968. Mechanisms for the intestinal absorption of bile acids. J. Lipid Res. 9: 297-309.
    • (1968) J. Lipid Res , vol.9 , pp. 297-309
    • Dietschy, J.M.1
  • 10
    • 0016254128 scopus 로고
    • Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum
    • Krag, E., and S. F. Phillips. 1974. Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum. J. Clin. Invest. 53: 1686-1694.
    • (1974) J. Clin. Invest , vol.53 , pp. 1686-1694
    • Krag, E.1    Phillips, S.F.2
  • 11
    • 0015351260 scopus 로고
    • Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat
    • Schiff, E. R., N. C. Small, and J. M. Dietschy. 1972. Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat. J. Clin. Invest. 51: 1351-1362.
    • (1972) J. Clin. Invest , vol.51 , pp. 1351-1362
    • Schiff, E.R.1    Small, N.C.2    Dietschy, J.M.3
  • 12
    • 0035204295 scopus 로고    scopus 로고
    • Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: Application to rodents and humans
    • Hulzebos, C. V., L. Renfurm, R. H. Bandsma, H. J. Verkade, T. Boer, R. Boverhof, H. Tanaka, I. Mierau, P. J. Sauer, F. Kuipers, et al. 2001. Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: application to rodents and humans. J. Lipid Res. 42: 1923-1929.
    • (2001) J. Lipid Res , vol.42 , pp. 1923-1929
    • Hulzebos, C.V.1    Renfurm, L.2    Bandsma, R.H.3    Verkade, H.J.4    Boer, T.5    Boverhof, R.6    Tanaka, H.7    Mierau, I.8    Sauer, P.J.9    Kuipers, F.10
  • 13
    • 0020679384 scopus 로고
    • Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man
    • Hofmann, A. F., G. Molino, M. Milanese, and G. Belforte. 1983. Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man. J. Clin. Invest. 71: 1003-1022.
    • (1983) J. Clin. Invest , vol.71 , pp. 1003-1022
    • Hofmann, A.F.1    Molino, G.2    Milanese, M.3    Belforte, G.4
  • 14
    • 0027501003 scopus 로고
    • Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
    • Dietschy, J. M., S. D. Turley, and D. K. Spady. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34: 1637-1659.
    • (1993) J. Lipid Res , vol.34 , pp. 1637-1659
    • Dietschy, J.M.1    Turley, S.D.2    Spady, D.K.3
  • 15
    • 0037040184 scopus 로고    scopus 로고
    • Control of cholesterol turnover in the mouse
    • Dietschy, J. M., and S. D. Turley. 2002. Control of cholesterol turnover in the mouse. J. Biol. Chem. 277: 3801-3804.
    • (2002) J. Biol. Chem , vol.277 , pp. 3801-3804
    • Dietschy, J.M.1    Turley, S.D.2
  • 16
    • 0025766414 scopus 로고
    • Biological and medical aspects of active ileal transport of bile acids
    • Hofmann, A. F., C. D. Schteingart, and J. Lillienau. 1991. Biological and medical aspects of active ileal transport of bile acids. Ann. Med. 23: 169-175.
    • (1991) Ann. Med , vol.23 , pp. 169-175
    • Hofmann, A.F.1    Schteingart, C.D.2    Lillienau, J.3
  • 17
    • 0346100571 scopus 로고    scopus 로고
    • Enterohepatic bile salt transporters in normal physiology and liver disease
    • Kullak-Ublick, G. A., B. Stieger, and P. J. Meier. 2004. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 126: 322-342.
    • (2004) Gastroenterology , vol.126 , pp. 322-342
    • Kullak-Ublick, G.A.1    Stieger, B.2    Meier, P.J.3
  • 18
    • 0028153313 scopus 로고
    • Free concentrations of intracellular fl uorescent anions determined by cytoplasmic dialysis of isolated hepatocytes
    • Weinman, S. A., and L. M. Maglova. 1994. Free concentrations of intracellular fl uorescent anions determined by cytoplasmic dialysis of isolated hepatocytes. Am. J. Physiol. 267: G922-G931.
    • (1994) Am. J. Physiol , vol.267
    • Weinman, S.A.1    Maglova, L.M.2
  • 19
    • 0027405329 scopus 로고
    • Hepatic taurocholate uptake is electrogenic and infl uenced by transmembrane potential difference
    • Lidofsky, S. D., J. G. Fitz, R. A. Weisiger, and B. F. Scharschmidt. 1993. Hepatic taurocholate uptake is electrogenic and infl uenced by transmembrane potential difference. Am. J. Physiol. 264: G478-G485.
    • (1993) Am. J. Physiol , vol.264
    • Lidofsky, S.D.1    Fitz, J.G.2    Weisiger, R.A.3    Scharschmidt, B.F.4
  • 20
    • 0017092068 scopus 로고
    • Uptake of bile acids by perfused rat liver
    • Reichen, J., and G. Paumgartner. 1976. Uptake of bile acids by perfused rat liver. Am. J. Physiol. 231: 734-742.
    • (1976) Am. J. Physiol , vol.231 , pp. 734-742
    • Reichen, J.1    Paumgartner, G.2
  • 22
    • 0032422456 scopus 로고    scopus 로고
    • Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes
    • Kouzuki, H., H. Suzuki, K. Ito, R. Ohashi, and Y. Sugiyama. 1998. Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J. Pharmacol. Exp. Ther. 286: 1043-1050.
    • (1998) J. Pharmacol. Exp. Ther , vol.286 , pp. 1043-1050
    • Kouzuki, H.1    Suzuki, H.2    Ito, K.3    Ohashi, R.4    Sugiyama, Y.5
  • 23
    • 0026529394 scopus 로고
    • ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles
    • Stieger, B., B. O'Neill, and P. J. Meier. 1992. ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles. Biochem. J. 284: 67-74.
    • (1992) Biochem. J , vol.284 , pp. 67-74
    • Stieger, B.1    O'Neill, B.2    Meier, P.J.3
  • 25
    • 0035831094 scopus 로고    scopus 로고
    • Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
    • Akita, H., H. Suzuki, K. Ito, S. Kinoshita, N. Sato, H. Takikawa, and Y. Sugiyama. 2001. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta. 1511: 7-16.
    • (2001) Biochim. Biophys. Acta , vol.1511 , pp. 7-16
    • Akita, H.1    Suzuki, H.2    Ito, K.3    Kinoshita, S.4    Sato, N.5    Takikawa, H.6    Sugiyama, Y.7
  • 26
    • 33846706434 scopus 로고    scopus 로고
    • The apical conjugate efflux pump ABCC2 (MRP2)
    • Nies, A. T., and D. Keppler. 2007. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch. 453: 643-659.
    • (2007) Pflugers Arch , vol.453 , pp. 643-659
    • Nies, A.T.1    Keppler, D.2
  • 27
    • 24944483081 scopus 로고    scopus 로고
    • Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice
    • Lam, P., R. Wang, and V. Ling. 2005. Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry. 44: 12598-12605.
    • (2005) Biochemistry , vol.44 , pp. 12598-12605
    • Lam, P.1    Wang, R.2    Ling, V.3
  • 28
    • 33745774784 scopus 로고    scopus 로고
    • Role of nuclear receptors in the adaptive response to bile acids and cholestasis: Pathogenetic and therapeutic considerations
    • Zollner, G., H. U. Marschall, M. Wagner, and M. Trauner. 2006. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol. Pharm. 3: 231-251.
    • (2006) Mol. Pharm , vol.3 , pp. 231-251
    • Zollner, G.1    Marschall, H.U.2    Wagner, M.3    Trauner, M.4
  • 29
    • 0035080391 scopus 로고    scopus 로고
    • Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
    • Soroka, C. J., J. M. Lee, F. Azzaroli, and J. L. Boyer. 2001. Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology. 33: 783-791.
    • (2001) Hepatology , vol.33 , pp. 783-791
    • Soroka, C.J.1    Lee, J.M.2    Azzaroli, F.3    Boyer, J.L.4
  • 30
    • 0034723163 scopus 로고    scopus 로고
    • ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)
    • Hirohashi, T., H. Suzuki, H. Takikawa, and Y. Sugiyama. 2000. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J. Biol. Chem. 275: 2905-2910.
    • (2000) J. Biol. Chem , vol.275 , pp. 2905-2910
    • Hirohashi, T.1    Suzuki, H.2    Takikawa, H.3    Sugiyama, Y.4
  • 31
    • 2542440464 scopus 로고    scopus 로고
    • Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
    • Assem, M., E. G. Schuetz, M. Leggas, D. Sun, K. Yasuda, G. Reid, N. Zelcer, M. Adachi, S. Strom, R. M. Evans, et al. 2004. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J. Biol. Chem. 279: 22250-22257.
    • (2004) J. Biol. Chem , vol.279 , pp. 22250-22257
    • Assem, M.1    Schuetz, E.G.2    Leggas, M.3    Sun, D.4    Yasuda, K.5    Reid, G.6    Zelcer, N.7    Adachi, M.8    Strom, S.9    Evans, R.M.10
  • 32
    • 65449177586 scopus 로고    scopus 로고
    • High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    • Schaap, F. G., N. A. van der Gaag, D. J. Gouma, and P. L. Jansen. 2009. High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology. 49: 1228-1235.
    • (2009) Hepatology , vol.49 , pp. 1228-1235
    • Schaap, F.G.1    van der Gaag, N.A.2    Gouma, D.J.3    Jansen, P.L.4
  • 34
    • 0042766881 scopus 로고    scopus 로고
    • Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
    • Rius, M., A. T. Nies, J. Hummel-Eisenbeiss, G. Jedlitschky, and D. Keppler. 2003. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 38: 374-384.
    • (2003) Hepatology , vol.38 , pp. 374-384
    • Rius, M.1    Nies, A.T.2    Hummel-Eisenbeiss, J.3    Jedlitschky, G.4    Keppler, D.5
  • 37
    • 0034802573 scopus 로고    scopus 로고
    • Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver
    • Akita, H., H. Suzuki, and Y. Sugiyama. 2001. Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver. Pharm. Res. 18: 1119-1125.
    • (2001) Pharm. Res , vol.18 , pp. 1119-1125
    • Akita, H.1    Suzuki, H.2    Sugiyama, Y.3
  • 38
    • 15444373825 scopus 로고    scopus 로고
    • Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis
    • Trauner, M., M. Wagner, P. Fickert, and G. Zollner. 2005. Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J. Clin. Gastroenterol. 39: S111-S124.
    • (2005) J. Clin. Gastroenterol , vol.39
    • Trauner, M.1    Wagner, M.2    Fickert, P.3    Zollner, G.4
  • 39
    • 34547870567 scopus 로고    scopus 로고
    • Expression of bile acid synthesis and detoxifi cation enzymes and the alternative bile acid effl ux pump MRP4 in patients with primary biliary cirrhosis
    • Zollner, G., M. Wagner, P. Fickert, D. Silbert, J. Gumhold, K. Zatloukal, H. Denk, and M. Trauner. 2007. Expression of bile acid synthesis and detoxifi cation enzymes and the alternative bile acid effl ux pump MRP4 in patients with primary biliary cirrhosis. Liver Int. 27: 920-929.
    • (2007) Liver Int , vol.27 , pp. 920-929
    • Zollner, G.1    Wagner, M.2    Fickert, P.3    Silbert, D.4    Gumhold, J.5    Zatloukal, K.6    Denk, H.7    Trauner, M.8
  • 40
    • 34249747403 scopus 로고    scopus 로고
    • Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis
    • Teng, S., and M. Piquette-Miller. 2007. Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. Br. J. Pharmacol. 151: 367-376.
    • (2007) Br. J. Pharmacol , vol.151 , pp. 367-376
    • Teng, S.1    Piquette-Miller, M.2
  • 41
    • 23344432870 scopus 로고    scopus 로고
    • Nuclear receptor ligands: Rational and effective therapy for chronic cholestatic liver disease?
    • Boyer, J. L. 2005. Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease? Gastroenterology. 129: 735-740.
    • (2005) Gastroenterology , vol.129 , pp. 735-740
    • Boyer, J.L.1
  • 43
    • 1242317691 scopus 로고    scopus 로고
    • The sodium bile salt cotransport family SLC10
    • Hagenbuch, B., and P. Dawson. 2004. The sodium bile salt cotransport family SLC10. Pflugers Arch. 447: 566-570.
    • (2004) Pflugers Arch , vol.447 , pp. 566-570
    • Hagenbuch, B.1    Dawson, P.2
  • 44
    • 33645119837 scopus 로고    scopus 로고
    • The solute carrier family SLC10: More than a family of bile acid transporters regarding function and phylogenetic relationships
    • Geyer, J., T. Wilke, and E. Petzinger. 2006. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch. Pharmacol. 372: 413-431.
    • (2006) Naunyn Schmiedebergs Arch. Pharmacol , vol.372 , pp. 413-431
    • Geyer, J.1    Wilke, T.2    Petzinger, E.3
  • 45
    • 34547096264 scopus 로고    scopus 로고
    • Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria
    • Godoy, J. R., C. Fernandes, B. Doring, K. Beuerlein, E. Petzinger, and J. Geyer. 2007. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Eur. J. Cell Biol. 86: 445-460.
    • (2007) Eur. J. Cell Biol , vol.86 , pp. 445-460
    • Godoy, J.R.1    Fernandes, C.2    Doring, B.3    Beuerlein, K.4    Petzinger, E.5    Geyer, J.6
  • 46
    • 0029893370 scopus 로고    scopus 로고
    • Sinusoidal (basolateral) bile salt uptake systems of hepatocytes
    • Hagenbuch, B., and P. J. Meier. 1996. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin. Liver Dis. 16: 129-136.
    • (1996) Semin. Liver Dis , vol.16 , pp. 129-136
    • Hagenbuch, B.1    Meier, P.J.2
  • 47
    • 0031392308 scopus 로고    scopus 로고
    • Electrogenicity of Na(+)-coupled bile acid transporters
    • Weinman, S. A. 1997. Electrogenicity of Na(+)-coupled bile acid transporters. Yale J. Biol. Med. 70: 331-340.
    • (1997) Yale J. Biol. Med , vol.70 , pp. 331-340
    • Weinman, S.A.1
  • 49
    • 0028231206 scopus 로고
    • Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter
    • Hagenbuch, B., and P. J. Meier. 1994. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J. Clin. Invest. 93: 1326-1331.
    • (1994) J. Clin. Invest , vol.93 , pp. 1326-1331
    • Hagenbuch, B.1    Meier, P.J.2
  • 51
    • 0032822957 scopus 로고    scopus 로고
    • Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters
    • Kramer, W., S. Stengelin, K. H. Baringhaus, A. Enhsen, H. Heuer, W. Becker, D. Corsiero, F. Girbig, R. Noll, and C. Weyland. 1999. Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters. J. Lipid Res. 40: 1604-1617.
    • (1999) J. Lipid Res , vol.40 , pp. 1604-1617
    • Kramer, W.1    Stengelin, S.2    Baringhaus, K.H.3    Enhsen, A.4    Heuer, H.5    Becker, W.6    Corsiero, D.7    Girbig, F.8    Noll, R.9    Weyland, C.10
  • 52
    • 0030000768 scopus 로고    scopus 로고
    • Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts
    • Platte, H. D., W. Honscha, K. Schuh, and E. Petzinger. 1996. Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts. Eur. J. Cell Biol. 70: 54-60.
    • (1996) Eur. J. Cell Biol , vol.70 , pp. 54-60
    • Platte, H.D.1    Honscha, W.2    Schuh, K.3    Petzinger, E.4
  • 53
    • 10844270655 scopus 로고    scopus 로고
    • Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump
    • Mita, S., H. Suzuki, H. Akita, B. Stieger, P. J. Meier, A. F. Hofmann, and Y. Sugiyama. 2005. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G159-G167.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol , vol.288
    • Mita, S.1    Suzuki, H.2    Akita, H.3    Stieger, B.4    Meier, P.J.5    Hofmann, A.F.6    Sugiyama, Y.7
  • 54
    • 33644980997 scopus 로고    scopus 로고
    • Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep
    • Mita, S., H. Suzuki, H. Akita, H. Hayashi, R. Onuki, A. F. Hofmann, and Y. Sugiyama. 2006. Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G550-G556.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol , vol.290
    • Mita, S.1    Suzuki, H.2    Akita, H.3    Hayashi, H.4    Onuki, R.5    Hofmann, A.F.6    Sugiyama, Y.7
  • 55
  • 56
    • 0036238779 scopus 로고    scopus 로고
    • Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2
    • Meng, L. J., P. Wang, A. W. Wolkoff, R. B. Kim, R. G. Tirona, A. F. Hofmann, and K. S. Pang. 2002. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology. 35: 1031-1040.
    • (2002) Hepatology , vol.35 , pp. 1031-1040
    • Meng, L.J.1    Wang, P.2    Wolkoff, A.W.3    Kim, R.B.4    Tirona, R.G.5    Hofmann, A.F.6    Pang, K.S.7
  • 57
    • 0030725999 scopus 로고    scopus 로고
    • Substrate specifi city of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    • Meier, P. J., U. Eckhardt, A. Schroeder, B. Hagenbuch, and B. Stieger. 1997. Substrate specifi city of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 26: 1667-1677.
    • (1997) Hepatology , vol.26 , pp. 1667-1677
    • Meier, P.J.1    Eckhardt, U.2    Schroeder, A.3    Hagenbuch, B.4    Stieger, B.5
  • 58
    • 0032732615 scopus 로고    scopus 로고
    • Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity
    • Kim, R. B., B. Leake, M. Cvetkovic, M. M. Roden, J. Nadeau, A. Walubo, and G. R. Wilkinson. 1999. Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J. Pharmacol. Exp. Ther. 291: 1204-1209.
    • (1999) J. Pharmacol. Exp. Ther , vol.291 , pp. 1204-1209
    • Kim, R.B.1    Leake, B.2    Cvetkovic, M.3    Roden, M.M.4    Nadeau, J.5    Walubo, A.6    Wilkinson, G.R.7
  • 59
    • 33747838057 scopus 로고    scopus 로고
    • Inhibition of bile acid transport across Na+/ taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs
    • Mita, S., H. Suzuki, H. Akita, H. Hayashi, R. Onuki, A. F. Hofmann, and Y. Sugiyama. 2006. Inhibition of bile acid transport across Na+/ taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. Drug Metab. Dispos. 34: 1575-1581.
    • (2006) Drug Metab. Dispos , vol.34 , pp. 1575-1581
    • Mita, S.1    Suzuki, H.2    Akita, H.3    Hayashi, H.4    Onuki, R.5    Hofmann, A.F.6    Sugiyama, Y.7
  • 60
    • 34248562942 scopus 로고    scopus 로고
    • Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: A mechanism for species differences in hepatotoxicity
    • Leslie, E. M., P. B. Watkins, R. B. Kim, and K. L. Brouwer. 2007. Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. J. Pharmacol. Exp. Ther. 321: 1170-1178.
    • (2007) J. Pharmacol. Exp. Ther , vol.321 , pp. 1170-1178
    • Leslie, E.M.1    Watkins, P.B.2    Kim, R.B.3    Brouwer, K.L.4
  • 62
    • 0029822980 scopus 로고    scopus 로고
    • Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes
    • Hagenbuch, B., B. F. Scharschmidt, and P. J. Meier. 1996. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem. J. 316: 901-904.
    • (1996) Biochem. J , vol.316 , pp. 901-904
    • Hagenbuch, B.1    Scharschmidt, B.F.2    Meier, P.J.3
  • 63
    • 0027410816 scopus 로고
    • Na(+)- dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase
    • Von Dippe, P., M. Amoui, C. Alves, and D. Levy. 1993. Na(+)- dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase. Am. J. Physiol. 264: G528-G534.
    • (1993) Am. J. Physiol , vol.264
    • Von Dippe, P.1    Amoui, M.2    Alves, C.3    Levy, D.4
  • 64
    • 1342304081 scopus 로고    scopus 로고
    • Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition
    • Ho, R. H., B. F. Leake, R. L. Roberts, W. Lee, and R. B. Kim. 2004. Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J. Biol. Chem. 279: 7213-7222.
    • (2004) J. Biol. Chem , vol.279 , pp. 7213-7222
    • Ho, R.H.1    Leake, B.F.2    Roberts, R.L.3    Lee, W.4    Kim, R.B.5
  • 67
    • 33847011377 scopus 로고    scopus 로고
    • Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    • Geier, A., M. Wagner, C. G. Dietrich, and M. Trauner. 2007. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim. Biophys. Acta. 1773: 283-308.
    • (2007) Biochim. Biophys. Acta , vol.1773 , pp. 283-308
    • Geier, A.1    Wagner, M.2    Dietrich, C.G.3    Trauner, M.4
  • 68
    • 1542724881 scopus 로고    scopus 로고
    • Cellular regulation of hepatic bile acid transport in health and cholestasis
    • Anwer, M. S. 2004. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology. 39: 581-590.
    • (2004) Hepatology , vol.39 , pp. 581-590
    • Anwer, M.S.1
  • 69
    • 15844426563 scopus 로고    scopus 로고
    • Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter
    • Karpen, S. J., A. Q. Sun, B. Kudish, B. Hagenbuch, P. J. Meier, M. Ananthanarayanan, and F. J. Suchy. 1996. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J. Biol. Chem. 271: 15211-15221.
    • (1996) J. Biol. Chem , vol.271 , pp. 15211-15221
    • Karpen, S.J.1    Sun, A.Q.2    Kudish, B.3    Hagenbuch, B.4    Meier, P.J.5    Ananthanarayanan, M.6    Suchy, F.J.7
  • 72
    • 0037371120 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 alpha: A key mediator of the effect of bile acids on gene expression
    • Jung, D., and G. A. Kullak-Ublick. 2003. Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. Hepatology. 37: 622-631.
    • (2003) Hepatology , vol.37 , pp. 622-631
    • Jung, D.1    Kullak-Ublick, G.A.2
  • 74
    • 0033776792 scopus 로고    scopus 로고
    • Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes infl uence expression of genes involved in bile acid and glucose homeostasis
    • Rausa, F. M., Y. Tan, H. Zhou, K. W. Yoo, D. B. Stolz, S. C. Watkins, R. R. Franks, T. G. Unterman, and R. H. Costa. 2000. Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes infl uence expression of genes involved in bile acid and glucose homeostasis. Mol. Cell. Biol. 20: 8264-8282.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 8264-8282
    • Rausa, F.M.1    Tan, Y.2    Zhou, H.3    Yoo, K.W.4    Stolz, D.B.5    Watkins, S.C.6    Franks, R.R.7    Unterman, T.G.8    Costa, R.H.9
  • 76
    • 29444434655 scopus 로고    scopus 로고
    • The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism
    • Eloranta, J. J., D. Jung, and G. A. Kullak-Ublick. 2006. The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol. Endocrinol. 20: 65-79.
    • (2006) Mol. Endocrinol , vol.20 , pp. 65-79
    • Eloranta, J.J.1    Jung, D.2    Kullak-Ublick, G.A.3
  • 77
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez. 2001. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21: 1393-1403.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 80
    • 0242582371 scopus 로고    scopus 로고
    • Resistance of SHP-null mice to bile acid-induced liver damage
    • Wang, L., Y. Han, C. S. Kim, Y. K. Lee, and D. D. Moore. 2003. Resistance of SHP-null mice to bile acid-induced liver damage. J. Biol. Chem. 278: 44475-44481.
    • (2003) J. Biol. Chem , vol.278 , pp. 44475-44481
    • Wang, L.1    Han, Y.2    Kim, C.S.3    Lee, Y.K.4    Moore, D.D.5
  • 81
    • 49149090637 scopus 로고    scopus 로고
    • Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    • Bochkis, I. M., N. E. Rubins, P. White, E. E. Furth, J. R. Friedman, and K. H. Kaestner. 2008. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat. Med. 14: 828-836.
    • (2008) Nat. Med , vol.14 , pp. 828-836
    • Bochkis, I.M.1    Rubins, N.E.2    White, P.3    Furth, E.E.4    Friedman, J.R.5    Kaestner, K.H.6
  • 82
    • 0035844156 scopus 로고    scopus 로고
    • Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway
    • Gupta, S., R. T. Stravitz, P. Dent, and P. B. Hylemon. 2001. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J. Biol. Chem. 276: 15816-15822.
    • (2001) J. Biol. Chem , vol.276 , pp. 15816-15822
    • Gupta, S.1    Stravitz, R.T.2    Dent, P.3    Hylemon, P.B.4
  • 83
    • 0037200089 scopus 로고    scopus 로고
    • Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent
    • Li, D., T. L. Zimmerman, S. Thevananther, H. Y. Lee, J. M. Kurie, and S. J. Karpen. 2002. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J. Biol. Chem. 277: 31416-31422.
    • (2002) J. Biol. Chem , vol.277 , pp. 31416-31422
    • Li, D.1    Zimmerman, T.L.2    Thevananther, S.3    Lee, H.Y.4    Kurie, J.M.5    Karpen, S.J.6
  • 84
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • Green, R. M., D. Beier, and J. L. Gollan. 1996. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology. 111: 193-198.
    • (1996) Gastroenterology , vol.111 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 86
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
    • Trauner, M., M. Arrese, H. Lee, J. L. Boyer, and S. J. Karpen. 1998. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. 101: 2092-2100.
    • (1998) J. Clin. Invest , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 87
    • 61449142646 scopus 로고    scopus 로고
    • Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6
    • Vee, M. L., V. Lecureur, B. Stieger, and O. Fardel. 2009. Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab. Dispos. 37: 685-693.
    • (2009) Drug Metab. Dispos , vol.37 , pp. 685-693
    • Vee, M.L.1    Lecureur, V.2    Stieger, B.3    Fardel, O.4
  • 89
    • 33847350212 scopus 로고    scopus 로고
    • Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1-beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis
    • Lickteig, A. J., A. L. Slitt, M. C. Arkan, M. Karin, and N. J. Cherrington. 2007. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1-beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab. Dispos. 35: 402-409.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 402-409
    • Lickteig, A.J.1    Slitt, A.L.2    Arkan, M.C.3    Karin, M.4    Cherrington, N.J.5
  • 92
    • 0033986961 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: Two mechanisms for repression
    • Lee, Y. K., H. Dell, D. H. Dowhan, M. Hadzopoulou-Cladaras, and D. D. Moore. 2000. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol. Cell. Biol. 20: 187-195.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 187-195
    • Lee, Y.K.1    Dell, H.2    Dowhan, D.H.3    Hadzopoulou-Cladaras, M.4    Moore, D.D.5
  • 93
    • 33744957050 scopus 로고    scopus 로고
    • Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: Roles for JNK and SER260
    • Zimmerman, T. L., S. Thevananther, R. Ghose, A. R. Burns, and S. J. Karpen. 2006. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J. Biol. Chem. 281: 15434-15440.
    • (2006) J. Biol. Chem , vol.281 , pp. 15434-15440
    • Zimmerman, T.L.1    Thevananther, S.2    Ghose, R.3    Burns, A.R.4    Karpen, S.J.5
  • 94
    • 18144387309 scopus 로고    scopus 로고
    • Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation
    • Ghose, R., T. L. Zimmerman, S. Thevananther, and S. J. Karpen. 2004. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: a novel mechanism for reduced hepatic gene expression in inflammation. Nucl. Recept. 2: 4.
    • (2004) Nucl. Recept , vol.2 , pp. 4
    • Ghose, R.1    Zimmerman, T.L.2    Thevananther, S.3    Karpen, S.J.4
  • 96
    • 0034768779 scopus 로고    scopus 로고
    • Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver
    • Wang, B., S. R. Cai, C. Gao, F. M. Sladek, and K. P. Ponder. 2001. Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver. Hepatology. 34: 979-989.
    • (2001) Hepatology , vol.34 , pp. 979-989
    • Wang, B.1    Cai, S.R.2    Gao, C.3    Sladek, F.M.4    Ponder, K.P.5
  • 97
    • 0030848766 scopus 로고    scopus 로고
    • Modulation of hepatic gene expression by hepatocyte nuclear factor 1
    • Ktistaki, E., and I. Talianidis. 1997. Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science. 277: 109-112.
    • (1997) Science , vol.277 , pp. 109-112
    • Ktistaki, E.1    Talianidis, I.2
  • 100
    • 84920357266 scopus 로고    scopus 로고
    • Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver
    • Gerloff, T., A. Geier, B. Stieger, B. Hagenbuch, P. J. Meier, S. Matern, and C. Gartung. 1999. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. Gastroenterology. 117: 1408-1415.
    • (1999) Gastroenterology , vol.117 , pp. 1408-1415
    • Gerloff, T.1    Geier, A.2    Stieger, B.3    Hagenbuch, B.4    Meier, P.J.5    Matern, S.6    Gartung, C.7
  • 102
    • 0030994363 scopus 로고    scopus 로고
    • Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5
    • Ganguly, T. C., M. L. O'Brien, S. J. Karpen, J. F. Hyde, F. J. Suchy, and M. Vore. 1997. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J. Clin. Invest. 99: 2906-2914.
    • (1997) J. Clin. Invest , vol.99 , pp. 2906-2914
    • Ganguly, T.C.1    O'Brien, M.L.2    Karpen, S.J.3    Hyde, J.F.4    Suchy, F.J.5    Vore, M.6
  • 103
    • 0034807523 scopus 로고    scopus 로고
    • PRL, placental lactogen, and GH induce NA(+)/ taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells
    • Cao, J., P. M. Gowri, T. C. Ganguly, M. Wood, J. F. Hyde, F. Talamantes, and M. Vore. 2001. PRL, placental lactogen, and GH induce NA(+)/ taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells. Endocrinology. 142: 4212-4222.
    • (2001) Endocrinology , vol.142 , pp. 4212-4222
    • Cao, J.1    Gowri, P.M.2    Ganguly, T.C.3    Wood, M.4    Hyde, J.F.5    Talamantes, F.6    Vore, M.7
  • 106
    • 0027295492 scopus 로고
    • Role of intracellular calcium and protein kinases in the activation of hepatic Na+/ taurocholate cotransport by cyclic AMP
    • Grune, S., L. R. Engelking, and M. S. Anwer. 1993. Role of intracellular calcium and protein kinases in the activation of hepatic Na+/ taurocholate cotransport by cyclic AMP. J. Biol. Chem. 268: 17734-17741.
    • (1993) J. Biol. Chem , vol.268 , pp. 17734-17741
    • Grune, S.1    Engelking, L.R.2    Anwer, M.S.3
  • 107
    • 0032491597 scopus 로고    scopus 로고
    • Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/ taurocholate cotransport
    • Mukhopadhyay, S., C. R. Webster, and M. S. Anwer. 1998. Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/ taurocholate cotransport. J. Biol. Chem. 273: 30039-30045.
    • (1998) J. Biol. Chem , vol.273 , pp. 30039-30045
    • Mukhopadhyay, S.1    Webster, C.R.2    Anwer, M.S.3
  • 108
    • 0031738338 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
    • Mukhopadhyay, S., M. Ananthanarayanan, B. Stieger, P. J. Meier, F. J. Suchy, and M. S. Anwer. 1998. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology. 28: 1629-1636.
    • (1998) Hepatology , vol.28 , pp. 1629-1636
    • Mukhopadhyay, S.1    Ananthanarayanan, M.2    Stieger, B.3    Meier, P.J.4    Suchy, F.J.5    Anwer, M.S.6
  • 112
    • 0037047389 scopus 로고    scopus 로고
    • Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation
    • Webster, C. R., U. Srinivasulu, M. Ananthanarayanan, F. J. Suchy, and M. S. Anwer. 2002. Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. J. Biol. Chem. 277: 28578-28583.
    • (2002) J. Biol. Chem , vol.277 , pp. 28578-28583
    • Webster, C.R.1    Srinivasulu, U.2    Ananthanarayanan, M.3    Suchy, F.J.4    Anwer, M.S.5
  • 113
    • 2442681520 scopus 로고    scopus 로고
    • Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes
    • McConkey, M., H. Gillin, C. R. Webster, and M. S. Anwer. 2004. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J. Biol. Chem. 279: 20882-20888.
    • (2004) J. Biol. Chem , vol.279 , pp. 20882-20888
    • McConkey, M.1    Gillin, H.2    Webster, C.R.3    Anwer, M.S.4
  • 114
    • 33745757459 scopus 로고    scopus 로고
    • PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter
    • Sarkar, S., E. Bananis, S. Nath, M. S. Anwer, A. W. Wolkoff, and J. W. Murray. 2006. PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic. 7: 1078-1091.
    • (2006) Traffic , vol.7 , pp. 1078-1091
    • Sarkar, S.1    Bananis, E.2    Nath, S.3    Anwer, M.S.4    Wolkoff, A.W.5    Murray, J.W.6
  • 115
    • 42249111198 scopus 로고    scopus 로고
    • Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes
    • Schonhoff, C. M., H. Gillin, C. R. Webster, and M. S. Anwer. 2008. Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology. 47: 1309-1316.
    • (2008) Hepatology , vol.47 , pp. 1309-1316
    • Schonhoff, C.M.1    Gillin, H.2    Webster, C.R.3    Anwer, M.S.4
  • 116
    • 0036828271 scopus 로고    scopus 로고
    • Functional expression of the canalicular bile salt export pump of human liver
    • Noe, J., B. Stieger, and P. J. Meier. 2002. Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology. 123: 1659-1666.
    • (2002) Gastroenterology , vol.123 , pp. 1659-1666
    • Noe, J.1    Stieger, B.2    Meier, P.J.3
  • 117
    • 0036829089 scopus 로고    scopus 로고
    • The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors
    • Byrne, J. A., S. S. Strautnieks, G. Mieli-Vergani, C. F. Higgins, K. J. Linton, and R. J. Thompson. 2002. The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 123: 1649-1658.
    • (2002) Gastroenterology , vol.123 , pp. 1649-1658
    • Byrne, J.A.1    Strautnieks, S.S.2    Mieli-Vergani, G.3    Higgins, C.F.4    Linton, K.J.5    Thompson, R.J.6
  • 118
    • 0037313267 scopus 로고    scopus 로고
    • Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2
    • Tomer, G., M. Ananthanarayanan, A. Weymann, N. Balasubramanian, and F. J. Suchy. 2003. Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2. Pediatr. Res. 53: 288-294.
    • (2003) Pediatr. Res , vol.53 , pp. 288-294
    • Tomer, G.1    Ananthanarayanan, M.2    Weymann, A.3    Balasubramanian, N.4    Suchy, F.J.5
  • 119
    • 4444266366 scopus 로고    scopus 로고
    • Differential expression of bile salt and organic anion transporters in developing rat liver
    • Gao, B., M. V. St Pierre, B. Stieger, and P. J. Meier. 2004. Differential expression of bile salt and organic anion transporters in developing rat liver. J. Hepatol. 41: 201-208.
    • (2004) J. Hepatol , vol.41 , pp. 201-208
    • Gao, B.1    St Pierre, M.V.2    Stieger, B.3    Meier, P.J.4
  • 122
    • 31044446504 scopus 로고    scopus 로고
    • Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: A comparison of human BSEP with rat Bsep
    • Hayashi, H., T. Takada, H. Suzuki, R. Onuki, A. F. Hofmann, and Y. Sugiyama. 2005. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim. Biophys. Acta. 1738: 54-62.
    • (2005) Biochim. Biophys. Acta , vol.1738 , pp. 54-62
    • Hayashi, H.1    Takada, T.2    Suzuki, H.3    Onuki, R.4    Hofmann, A.F.5    Sugiyama, Y.6
  • 123
    • 22944458539 scopus 로고    scopus 로고
    • Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
    • Hirano, M., K. Maeda, H. Hayashi, H. Kusuhara, and Y. Sugiyama. 2005. Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J. Pharmacol. Exp. Ther. 314: 876-882.
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , pp. 876-882
    • Hirano, M.1    Maeda, K.2    Hayashi, H.3    Kusuhara, H.4    Sugiyama, Y.5
  • 124
    • 85009593103 scopus 로고    scopus 로고
    • Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans
    • Horikawa, M., Y. Kato, C. A. Tyson, and Y. Sugiyama. 2003. Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab. Pharmacokinet. 18: 16-22.
    • (2003) Drug Metab. Pharmacokinet , vol.18 , pp. 16-22
    • Horikawa, M.1    Kato, Y.2    Tyson, C.A.3    Sugiyama, Y.4
  • 127
    • 61949292897 scopus 로고    scopus 로고
    • Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing
    • Byrne, J. A., S. S. Strautnieks, G. Ihrke, F. Pagani, A. S. Knisely, K. J. Linton, G. Mieli-Vergani, and R. J. Thompson. 2009. Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing. Hepatology. 49: 553-567.
    • (2009) Hepatology , vol.49 , pp. 553-567
    • Byrne, J.A.1    Strautnieks, S.S.2    Ihrke, G.3    Pagani, F.4    Knisely, A.S.5    Linton, K.J.6    Mieli-Vergani, G.7    Thompson, R.J.8
  • 128
    • 33750610841 scopus 로고    scopus 로고
    • Hepatobiliary transporters and drug-induced cholestasis
    • Pauli-Magnus, C., and P. J. Meier. 2006. Hepatobiliary transporters and drug-induced cholestasis. Hepatology. 44: 778-787.
    • (2006) Hepatology , vol.44 , pp. 778-787
    • Pauli-Magnus, C.1    Meier, P.J.2
  • 133
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan, M., N. Balasubramanian, M. Makishima, D. J. Mangelsdorf, and F. J. Suchy. 2001. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J. Biol. Chem. 276: 28857-28865.
    • (2001) J. Biol. Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 134
    • 0036186337 scopus 로고    scopus 로고
    • Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
    • Plass, J. R., O. Mol, J. Heegsma, M. Geuken, K. N. Faber, P. L. Jansen, and M. Muller. 2002. Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology. 35: 589-596.
    • (2002) Hepatology , vol.35 , pp. 589-596
    • Plass, J.R.1    Mol, O.2    Heegsma, J.3    Geuken, M.4    Faber, K.N.5    Jansen, P.L.6    Muller, M.7
  • 135
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal, C. J., M. Tohkin, M. Miyata, J. M. Ward, G. Lambert, and F. J. Gonzalez. 2000. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 102: 731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 136
    • 12444301770 scopus 로고    scopus 로고
    • Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
    • Zollner, G., P. Fickert, A. Fuchsbichler, D. Silbert, M. Wagner, S. Arbeiter, F. J. Gonzalez, H. U. Marschall, K. Zatloukal, H. Denk, et al. 2003. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J. Hepatol. 39: 480-488.
    • (2003) J. Hepatol , vol.39 , pp. 480-488
    • Zollner, G.1    Fickert, P.2    Fuchsbichler, A.3    Silbert, D.4    Wagner, M.5    Arbeiter, S.6    Gonzalez, F.J.7    Marschall, H.U.8    Zatloukal, K.9    Denk, H.10
  • 138
    • 1542275425 scopus 로고    scopus 로고
    • The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion
    • Lew, J. L., A. Zhao, J. Yu, L. Huang, N. De Pedro, F. Pelaez, S. D. Wright, and J. Cui. 2004. The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J. Biol. Chem. 279: 8856-8861.
    • (2004) J. Biol. Chem , vol.279 , pp. 8856-8861
    • Lew, J.L.1    Zhao, A.2    Yu, J.3    Huang, L.4    De Pedro, N.5    Pelaez, F.6    Wright, S.D.7    Cui, J.8
  • 139
    • 0037199946 scopus 로고    scopus 로고
    • Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity
    • Yu, J., J. L. Lo, L. Huang, A. Zhao, E. Metzger, A. Adams, P. T. Meinke, S. D. Wright, and J. Cui. 2002. Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J. Biol. Chem. 277: 31441-31447.
    • (2002) J. Biol. Chem , vol.277 , pp. 31441-31447
    • Yu, J.1    Lo, J.L.2    Huang, L.3    Zhao, A.4    Metzger, E.5    Adams, A.6    Meinke, P.T.7    Wright, S.D.8    Cui, J.9
  • 140
    • 7544221726 scopus 로고    scopus 로고
    • Detoxification of lithocholic acid, a toxic bile acid: Relevance to drug hepatotoxicity
    • Hofmann, A. F. 2004. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab. Rev. 36: 703-722.
    • (2004) Drug Metab. Rev , vol.36 , pp. 703-722
    • Hofmann, A.F.1
  • 141
    • 11144227974 scopus 로고    scopus 로고
    • Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1
    • Ananthanarayanan, M., S. Li, N. Balasubramaniyan, F. J. Suchy, and M. J. Walsh. 2004. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J. Biol. Chem. 279: 54348-54357.
    • (2004) J. Biol. Chem , vol.279 , pp. 54348-54357
    • Ananthanarayanan, M.1    Li, S.2    Balasubramaniyan, N.3    Suchy, F.J.4    Walsh, M.J.5
  • 142
    • 23044444663 scopus 로고    scopus 로고
    • The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes
    • Rizzo, G., B. Renga, E. Antonelli, D. Passeri, R. Pellicciari, and S. Fiorucci. 2005. The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol. Pharmacol. 68: 551-558.
    • (2005) Mol. Pharmacol , vol.68 , pp. 551-558
    • Rizzo, G.1    Renga, B.2    Antonelli, E.3    Passeri, D.4    Pellicciari, R.5    Fiorucci, S.6
  • 143
    • 0038701656 scopus 로고    scopus 로고
    • Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding
    • Kassam, A., B. Miao, P. R. Young, and R. Mukherjee. 2003. Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. J. Biol. Chem. 278: 10028-10032.
    • (2003) J. Biol. Chem , vol.278 , pp. 10028-10032
    • Kassam, A.1    Miao, B.2    Young, P.R.3    Mukherjee, R.4
  • 145
    • 33644859036 scopus 로고    scopus 로고
    • Hepatocanalicular transport defects: Pathophysiologic mechanisms of rare diseases
    • Oude Elferink, R. P., C. C. Paulusma, and A. K. Groen. 2006. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology. 130: 908-925.
    • (2006) Gastroenterology , vol.130 , pp. 908-925
    • Oude Elferink, R.P.1    Paulusma, C.C.2    Groen, A.K.3
  • 146
    • 65649087129 scopus 로고    scopus 로고
    • Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content
    • Paulusma, C. C., D. R. de Waart, C. Kunne, K. S. Mok, and R. P. Elferink. 2009. Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J. Biol. Chem. 284: 9947-9954.
    • (2009) J. Biol. Chem , vol.284 , pp. 9947-9954
    • Paulusma, C.C.1    de Waart, D.R.2    Kunne, C.3    Mok, K.S.4    Elferink, R.P.5
  • 147
    • 67649279563 scopus 로고    scopus 로고
    • P4 ATPases-lipid flippases and their role in disease
    • Folmer, D. E., R. P. Elferink, and C. C. Paulusma. 2009. P4 ATPases-lipid flippases and their role in disease. Biochim Biophys Acta. 1791: 628-635.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 628-635
    • Folmer, D.E.1    Elferink, R.P.2    Paulusma, C.C.3
  • 148
    • 60449097716 scopus 로고    scopus 로고
    • ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained
    • Cai, S. Y., S. Gautam, T. Nguyen, C. J. Soroka, C. Rahner, and J. L. Boyer. 2009. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 136: 1060-1069.
    • (2009) Gastroenterology , vol.136 , pp. 1060-1069
    • Cai, S.Y.1    Gautam, S.2    Nguyen, T.3    Soroka, C.J.4    Rahner, C.5    Boyer, J.L.6
  • 149
    • 0035021435 scopus 로고    scopus 로고
    • Intestinal bile acid transport: Biology, physiology, and pathophysiology
    • Shneider, B. L. 2001. Intestinal bile acid transport: biology, physiology, and pathophysiology. J. Pediatr. Gastroenterol. Nutr. 32: 407-417.
    • (2001) J. Pediatr. Gastroenterol. Nutr , vol.32 , pp. 407-417
    • Shneider, B.L.1
  • 150
    • 14844291348 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
    • Dawson, P. A., M. Hubbert, J. Haywood, A. L. Craddock, N. Zerangue, W. V. Christian, and N. Ballatori. 2005. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J. Biol. Chem. 280: 6960-6968.
    • (2005) J. Biol. Chem , vol.280 , pp. 6960-6968
    • Dawson, P.A.1    Hubbert, M.2    Haywood, J.3    Craddock, A.L.4    Zerangue, N.5    Christian, W.V.6    Ballatori, N.7
  • 151
    • 30844460667 scopus 로고    scopus 로고
    • OSTalpha-OSTbeta: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • Ballatori, N., W. V. Christian, J. Y. Lee, P. A. Dawson, C. J. Soroka, J. L. Boyer, M. S. Madejczyk, and N. Li. 2005. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 42: 1270-1279.
    • (2005) Hepatology , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3    Dawson, P.A.4    Soroka, C.J.5    Boyer, J.L.6    Madejczyk, M.S.7    Li, N.8
  • 152
    • 0015338557 scopus 로고
    • Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride
    • Hofmann, A. F., and J. R. Poley. 1972. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology. 62: 918-934.
    • (1972) Gastroenterology , vol.62 , pp. 918-934
    • Hofmann, A.F.1    Poley, J.R.2
  • 155
    • 0030020934 scopus 로고    scopus 로고
    • Intestinal absorption of bile acids in the rabbit: Different transport rates in jejunum and ileum
    • Aldini, R., M. Montagnani, A. Roda, S. Hrelia, P. L. Biagi, and E. Roda. 1996. Intestinal absorption of bile acids in the rabbit: different transport rates in jejunum and ileum. Gastroenterology. 110: 459-468.
    • (1996) Gastroenterology , vol.110 , pp. 459-468
    • Aldini, R.1    Montagnani, M.2    Roda, A.3    Hrelia, S.4    Biagi, P.L.5    Roda, E.6
  • 156
    • 3242699674 scopus 로고    scopus 로고
    • Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats
    • Gui, X., and R. E. Carraway. 2004. Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G408-G416.
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol , vol.287
    • Gui, X.1    Carraway, R.E.2
  • 157
    • 0141818009 scopus 로고    scopus 로고
    • Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice
    • Dawson, P. A., J. Haywood, A. L. Craddock, M. Wilson, M. Tietjen, K. Kluckman, N. Maeda, and J. S. Parks. 2003. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J. Biol. Chem. 278: 33920-33927.
    • (2003) J. Biol. Chem , vol.278 , pp. 33920-33927
    • Dawson, P.A.1    Haywood, J.2    Craddock, A.L.3    Wilson, M.4    Tietjen, M.5    Kluckman, K.6    Maeda, N.7    Parks, J.S.8
  • 158
    • 0020613211 scopus 로고
    • Determination of acid surface pH in vivo in rat proximal jejunum
    • Lucas, M. 1983. Determination of acid surface pH in vivo in rat proximal jejunum. Gut. 24: 734-739.
    • (1983) Gut , vol.24 , pp. 734-739
    • Lucas, M.1
  • 159
    • 0027250469 scopus 로고
    • Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis
    • Kramer, W., F. Girbig, U. Gutjahr, S. Kowalewski, K. Jouvenal, G. Muller, D. Tripier, and G. Wess. 1993. Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis. J. Biol. Chem. 268: 18035-18046.
    • (1993) J. Biol. Chem , vol.268 , pp. 18035-18046
    • Kramer, W.1    Girbig, F.2    Gutjahr, U.3    Kowalewski, S.4    Jouvenal, K.5    Muller, G.6    Tripier, D.7    Wess, G.8
  • 160
    • 0030273188 scopus 로고    scopus 로고
    • Relationship between structure and intestinal absorption of bile acids with a steroid or side-chain modification
    • Aldini, R., A. Roda, M. Montagnani, C. Cerre, R. Pellicciari, and E. Roda. 1996. Relationship between structure and intestinal absorption of bile acids with a steroid or side-chain modification. Steroids. 61: 590-597.
    • (1996) Steroids , vol.61 , pp. 590-597
    • Aldini, R.1    Roda, A.2    Montagnani, M.3    Cerre, C.4    Pellicciari, R.5    Roda, E.6
  • 161
    • 0029920858 scopus 로고    scopus 로고
    • Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig
    • Amelsberg, A., C. D. Schteingart, H. T. Ton-Nu, and A. F. Hofmann. 1996. Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig. Gastroenterology. 110: 1098-1106.
    • (1996) Gastroenterology , vol.110 , pp. 1098-1106
    • Amelsberg, A.1    Schteingart, C.D.2    Ton-Nu, H.T.3    Hofmann, A.F.4
  • 162
    • 0032925208 scopus 로고    scopus 로고
    • Evidence for an anion exchange mechanism for uptake of conjugated bile acid from the rat jejunum
    • Amelsberg, A., C. Jochims, C. P. Richter, R. Nitsche, and U. R. Folsch. 1999. Evidence for an anion exchange mechanism for uptake of conjugated bile acid from the rat jejunum. Am. J. Physiol. 276: G737-G742.
    • (1999) Am. J. Physiol , vol.276
    • Amelsberg, A.1    Jochims, C.2    Richter, C.P.3    Nitsche, R.4    Folsch, U.R.5
  • 164
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch, B., and P. J. Meier. 2004. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 447: 653-665.
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 166
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • Dresser, G. K., D. G. Bailey, B. F. Leake, U. I. Schwarz, P. A. Dawson, D. J. Freeman, and R. B. Kim. 2002. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin. Pharmacol. Ther. 71: 11-20.
    • (2002) Clin. Pharmacol. Ther , vol.71 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3    Schwarz, U.I.4    Dawson, P.A.5    Freeman, D.J.6    Kim, R.B.7
  • 167
    • 33847235324 scopus 로고    scopus 로고
    • Identification of influx transporter for the quinolone antibacterial agent levofloxacin
    • Maeda, T., K. Takahashi, N. Ohtsu, T. Oguma, T. Ohnishi, R. Atsumi, and I. Tamai. 2007. Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol. Pharm. 4: 85-94.
    • (2007) Mol. Pharm , vol.4 , pp. 85-94
    • Maeda, T.1    Takahashi, K.2    Ohtsu, N.3    Oguma, T.4    Ohnishi, T.5    Atsumi, R.6    Tamai, I.7
  • 169
    • 0030944084 scopus 로고    scopus 로고
    • Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
    • Oelkers, P., L. C. Kirby, J. E. Heubi, and P. A. Dawson. 1997. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J. Clin. Invest. 99: 1880-1887.
    • (1997) J. Clin. Invest , vol.99 , pp. 1880-1887
    • Oelkers, P.1    Kirby, L.C.2    Heubi, J.E.3    Dawson, P.A.4
  • 170
    • 51149089559 scopus 로고    scopus 로고
    • Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    • Ballatori, N., F. Fang, W. V. Christian, N. Li, and C. L. Hammond. 2008. Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G179-G186.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol , vol.295
    • Ballatori, N.1    Fang, F.2    Christian, W.V.3    Li, N.4    Hammond, C.L.5
  • 171
    • 41649089141 scopus 로고    scopus 로고
    • The organic solute transporter alphabeta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis
    • Rao, A., J. Haywood, A. L. Craddock, M. G. Belinsky, G. D. Kruh, and P. A. Dawson. 2008. The organic solute transporter alphabeta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc. Natl. Acad. Sci. USA. 105: 3891-3896.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3891-3896
    • Rao, A.1    Haywood, J.2    Craddock, A.L.3    Belinsky, M.G.4    Kruh, G.D.5    Dawson, P.A.6
  • 173
    • 0032567523 scopus 로고    scopus 로고
    • Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic
    • Weinman, S. A., M. W. Carruth, and P. A. Dawson. 1998. Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J. Biol. Chem. 273: 34691-34695.
    • (1998) J. Biol. Chem , vol.273 , pp. 34691-34695
    • Weinman, S.A.1    Carruth, M.W.2    Dawson, P.A.3
  • 174
    • 0028800562 scopus 로고
    • Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter
    • Shneider, B. L., P. A. Dawson, D. M. Christie, W. Hardikar, M. H. Wong, and F. J. Suchy. 1995. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J. Clin. Invest. 95: 745-754.
    • (1995) J. Clin. Invest , vol.95 , pp. 745-754
    • Shneider, B.L.1    Dawson, P.A.2    Christie, D.M.3    Hardikar, W.4    Wong, M.H.5    Suchy, F.J.6
  • 175
    • 0028039878 scopus 로고
    • Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
    • Wong, M. H., P. Oelkers, A. L. Craddock, and P. A. Dawson. 1994. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J. Biol. Chem. 269: 1340-1347.
    • (1994) J. Biol. Chem , vol.269 , pp. 1340-1347
    • Wong, M.H.1    Oelkers, P.2    Craddock, A.L.3    Dawson, P.A.4
  • 176
    • 0029792840 scopus 로고    scopus 로고
    • Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum
    • Christie, D. M., P. A. Dawson, S. Thevananther, and B. L. Shneider. 1996. Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum. Am. J. Physiol. 271: G377-G385.
    • (1996) Am. J. Physiol , vol.271
    • Christie, D.M.1    Dawson, P.A.2    Thevananther, S.3    Shneider, B.L.4
  • 178
    • 0031467883 scopus 로고    scopus 로고
    • Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
    • Lazaridis, K., L. Pham, P. Tietz, R. Marinelli, P. deGroen, S. Levine, P. Dawson, and N. LaRusso. 1997. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J. Clin. Invest. 100: 2714-2721.
    • (1997) J. Clin. Invest , vol.100 , pp. 2714-2721
    • Lazaridis, K.1    Pham, L.2    Tietz, P.3    Marinelli, R.4    deGroen, P.5    Levine, S.6    Dawson, P.7    LaRusso, N.8
  • 180
    • 0024239734 scopus 로고
    • Active absorption of vitamin B12 and conjugated bile salts by guinea pig ileum occurs in villous and not crypt cells
    • Kapadia, C. R., and L. K. Essandoh. 1988. Active absorption of vitamin B12 and conjugated bile salts by guinea pig ileum occurs in villous and not crypt cells. Dig. Dis. Sci. 33: 1377-1382.
    • (1988) Dig. Dis. Sci , vol.33 , pp. 1377-1382
    • Kapadia, C.R.1    Essandoh, L.K.2
  • 181
    • 0032961354 scopus 로고    scopus 로고
    • Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter
    • Saeki, T., K. Matoba, H. Furukawa, K. Kirifuji, R. Kanamoto, and K. Iwami. 1999. Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter. J. Biochem. 125: 846-851.
    • (1999) J. Biochem , vol.125 , pp. 846-851
    • Saeki, T.1    Matoba, K.2    Furukawa, H.3    Kirifuji, K.4    Kanamoto, R.5    Iwami, K.6
  • 182
    • 0036742375 scopus 로고    scopus 로고
    • Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice
    • Hakansson, P., I. Andersson, S. Nystrom, L. Lofgren, L. F. Amrot, and H. Li. 2002. Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice. Scand. J. Gastroenterol. 37: 1089-1096.
    • (2002) Scand. J. Gastroenterol , vol.37 , pp. 1089-1096
    • Hakansson, P.1    Andersson, I.2    Nystrom, S.3    Lofgren, L.4    Amrot, L.F.5    Li, H.6
  • 183
    • 0034062956 scopus 로고    scopus 로고
    • Distribution of bile acid absorption and bile acid transporter gene message in the hamster ileum
    • Stelzner, M., V. Hoagland, and S. Somasundaram. 2000. Distribution of bile acid absorption and bile acid transporter gene message in the hamster ileum. Pflugers Arch. 440: 157-162.
    • (2000) Pflugers Arch , vol.440 , pp. 157-162
    • Stelzner, M.1    Hoagland, V.2    Somasundaram, S.3
  • 184
    • 0010552586 scopus 로고    scopus 로고
    • Distribution of bile acid transport capacities in the human ileum (abstract)
    • Stelzner, M., S. Somasundaram, and D. Kearney. 2000. Distribution of bile acid transport capacities in the human ileum (abstract). Gastroenterology. 118: A77.
    • (2000) Gastroenterology , vol.118
    • Stelzner, M.1    Somasundaram, S.2    Kearney, D.3
  • 188
    • 85047685788 scopus 로고    scopus 로고
    • Analysis of the effect of intestinal resection on rat ileal bile acid transporter expression and on bile acid and cholesterol homeostasis
    • Al-Ansari, N., G. Xu, K. Kollman-Bauerly, C. Coppola, S. Shefer, P. Ujhazy, D. Ortiz, L. Ma, S. Yang, R. Tsai, et al. 2002. Analysis of the effect of intestinal resection on rat ileal bile acid transporter expression and on bile acid and cholesterol homeostasis. Pediatr. Res. 52: 286-291.
    • (2002) Pediatr. Res , vol.52 , pp. 286-291
    • Al-Ansari, N.1    Xu, G.2    Kollman-Bauerly, K.3    Coppola, C.4    Shefer, S.5    Ujhazy, P.6    Ortiz, D.7    Ma, L.8    Yang, S.9    Tsai, R.10
  • 189
    • 0029862132 scopus 로고    scopus 로고
    • Ileal transposition into the upper jejunum affects lipid and bile salt absorption in rats
    • Tsuchiya, T., T. J. Kalogeris, and P. Tso. 1996. Ileal transposition into the upper jejunum affects lipid and bile salt absorption in rats. Am. J. Physiol. 271: G681-G691.
    • (1996) Am. J. Physiol , vol.271
    • Tsuchiya, T.1    Kalogeris, T.J.2    Tso, P.3
  • 190
    • 0034878273 scopus 로고    scopus 로고
    • Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption
    • Montagnani, M., M. W. Love, P. Rossel, P. A. Dawson, and P. Qvist. 2001. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand. J. Gastroenterol. 36: 1077-1080.
    • (2001) Scand. J. Gastroenterol , vol.36 , pp. 1077-1080
    • Montagnani, M.1    Love, M.W.2    Rossel, P.3    Dawson, P.A.4    Qvist, P.5
  • 191
    • 67349228148 scopus 로고    scopus 로고
    • Renner, O., S. Harsch, E. Schaeffeler, M. Schwab, D. M. Klass, W. Kratzer, and E. F. Stange. 2009. Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identifi ed variants linked to reduced expression. Hum. Genet. 125: 381-391.
    • Renner, O., S. Harsch, E. Schaeffeler, M. Schwab, D. M. Klass, W. Kratzer, and E. F. Stange. 2009. Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identifi ed variants linked to reduced expression. Hum. Genet. 125: 381-391.
  • 193
    • 0033797032 scopus 로고    scopus 로고
    • Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia
    • Duane, W. C., L. A. Hartich, A. E. Bartman, and S. B. Ho. 2000. Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia. J. Lipid Res. 41: 1384-1389.
    • (2000) J. Lipid Res , vol.41 , pp. 1384-1389
    • Duane, W.C.1    Hartich, L.A.2    Bartman, A.E.3    Ho, S.B.4
  • 194
    • 0023233054 scopus 로고
    • Studies of the prevalence and signifi cance of radiolabeled bile acid malabsorption in a group of patients with idiopathic chronic diarrhea
    • Schiller, L. R., R. B. Hogan, S. G. Morawski, C. A. Santa Ana, M. J. Bern, R. P. Norgaard, G. W. Bo-Linn, and J. S. Fordtran. 1987. Studies of the prevalence and signifi cance of radiolabeled bile acid malabsorption in a group of patients with idiopathic chronic diarrhea. Gastroenterology. 92: 151-160.
    • (1987) Gastroenterology , vol.92 , pp. 151-160
    • Schiller, L.R.1    Hogan, R.B.2    Morawski, S.G.3    Santa Ana, C.A.4    Bern, M.J.5    Norgaard, R.P.6    Bo-Linn, G.W.7    Fordtran, J.S.8
  • 195
    • 0014254324 scopus 로고
    • Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea
    • Meihoff, W. E., and F. Kern, Jr. 1968. Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea. J. Clin. Invest. 47: 261-267.
    • (1968) J. Clin. Invest , vol.47 , pp. 261-267
    • Meihoff, W.E.1    Kern Jr., F.2
  • 196
    • 0042834374 scopus 로고    scopus 로고
    • Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life
    • Vitek, L., and M. C. Carey. 2003. Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life. Eur. J. Clin. Invest. 33: 799-810.
    • (2003) Eur. J. Clin. Invest , vol.33 , pp. 799-810
    • Vitek, L.1    Carey, M.C.2
  • 197
    • 52849088394 scopus 로고    scopus 로고
    • Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation
    • Holzer, A., S. Harsch, O. Renner, A. Strohmeyer, S. Schimmel, J. Wehkamp, P. Fritz, and E. F. Stange. 2008. Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion. 78: 52-59.
    • (2008) Digestion , vol.78 , pp. 52-59
    • Holzer, A.1    Harsch, S.2    Renner, O.3    Strohmeyer, A.4    Schimmel, S.5    Wehkamp, J.6    Fritz, P.7    Stange, E.F.8
  • 198
    • 0027977042 scopus 로고
    • Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT
    • Nyhlin, H., M. Merrick, and M. Eastwood. 1994. Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT. Gut. 35: 90-93.
    • (1994) Gut , vol.35 , pp. 90-93
    • Nyhlin, H.1    Merrick, M.2    Eastwood, M.3
  • 199
    • 0017081286 scopus 로고
    • Regional ileitis (Crohn's disease): I. Kinetics of bile acid absorption in the perfused ileum
    • Krag, B., and B. Krag. 1976. Regional ileitis (Crohn's disease): I. Kinetics of bile acid absorption in the perfused ileum. Scand. J. Gastroenterol. 11: 481-486.
    • (1976) Scand. J. Gastroenterol , vol.11 , pp. 481-486
    • Krag, B.1    Krag, B.2
  • 201
    • 0022462290 scopus 로고
    • Bile acid metabolism in patients with Crohn's disease in terminal ileum
    • Tougaard, L., B. Giese, B. Pedersen, and V. Binder. 1986. Bile acid metabolism in patients with Crohn's disease in terminal ileum. Scand. J. Gastroenterol. 21: 627-633.
    • (1986) Scand. J. Gastroenterol , vol.21 , pp. 627-633
    • Tougaard, L.1    Giese, B.2    Pedersen, B.3    Binder, V.4
  • 203
    • 67650480494 scopus 로고    scopus 로고
    • Camilleri, M., A. Nadeau, W. J. Tremaine, J. Lamsam, D. Burton, S. Odunsi, S. Sweetser, and R. Singh. 2009. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil. 21: 734-e43.
    • Camilleri, M., A. Nadeau, W. J. Tremaine, J. Lamsam, D. Burton, S. Odunsi, S. Sweetser, and R. Singh. 2009. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil. 21: 734-e43.
  • 204
    • 0027977645 scopus 로고
    • Downregulation of taurocholate transport by ileal BBM and liver BLM in biliary-diverted rats
    • Higgins, J. V., J. M. Paul, R. Dumaswala, and J. E. Heubi. 1994. Downregulation of taurocholate transport by ileal BBM and liver BLM in biliary-diverted rats. Am. J. Physiol. 267: G501-G507.
    • (1994) Am. J. Physiol , vol.267
    • Higgins, J.V.1    Paul, J.M.2    Dumaswala, R.3    Heubi, J.E.4
  • 206
    • 0030781406 scopus 로고    scopus 로고
    • Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid
    • Stravitz, R. T., A. J. Sanyal, W. M. Pandak, Z. R. Vlahcevic, J. W. Beets, and P. A. Dawson. 1997. Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid. Gastroenterology. 113: 1599-1608.
    • (1997) Gastroenterology , vol.113 , pp. 1599-1608
    • Stravitz, R.T.1    Sanyal, A.J.2    Pandak, W.M.3    Vlahcevic, Z.R.4    Beets, J.W.5    Dawson, P.A.6
  • 207
    • 0031682708 scopus 로고    scopus 로고
    • Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter
    • Arrese, M., M. Trauner, R. J. Sacchiero, M. W. Crossman, and B. L. Shneider. 1998. Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology. 28: 1081-1087.
    • (1998) Hepatology , vol.28 , pp. 1081-1087
    • Arrese, M.1    Trauner, M.2    Sacchiero, R.J.3    Crossman, M.W.4    Shneider, B.L.5
  • 208
    • 36749080990 scopus 로고    scopus 로고
    • Effects of bile acids on expression of the human apical sodium dependent bile acid transporter gene
    • Duane, W. C., W. Xiong, and J. Wolvers. 2007. Effects of bile acids on expression of the human apical sodium dependent bile acid transporter gene. Biochim. Biophys. Acta. 1771: 1380-1388.
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 1380-1388
    • Duane, W.C.1    Xiong, W.2    Wolvers, J.3
  • 209
    • 85046518258 scopus 로고    scopus 로고
    • Regulation of ileal bile acid transport: Desirability of measuring transport function as well as transporter activity
    • Hofmann, A. F. 1999. Regulation of ileal bile acid transport: desirability of measuring transport function as well as transporter activity. Hepatology. 29: 1335-1337.
    • (1999) Hepatology , vol.29 , pp. 1335-1337
    • Hofmann, A.F.1
  • 210
    • 0037827787 scopus 로고    scopus 로고
    • Liver receptor homologue-1 mediates species- and cell linespecific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    • Chen, F., L. Ma, P. A. Dawson, C. J. Sinal, E. Sehayek, F. J. Gonzalez, J. Breslow, M. Ananthanarayanan, and B. L. Shneider. 2003. Liver receptor homologue-1 mediates species- and cell linespecific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J. Biol. Chem. 278: 19909-19916.
    • (2003) J. Biol. Chem , vol.278 , pp. 19909-19916
    • Chen, F.1    Ma, L.2    Dawson, P.A.3    Sinal, C.J.4    Sehayek, E.5    Gonzalez, F.J.6    Breslow, J.7    Ananthanarayanan, M.8    Shneider, B.L.9
  • 212
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    • Kok, T., C. V. Hulzebos, H. Wolters, R. Havinga, L. B. Agellon, F. Stellaard, B. Shan, M. Schwarz, and F. Kuipers. 2003. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J. Biol. Chem. 278: 41930-41937.
    • (2003) J. Biol. Chem , vol.278 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3    Havinga, R.4    Agellon, L.B.5    Stellaard, F.6    Shan, B.7    Schwarz, M.8    Kuipers, F.9
  • 214
    • 3042828426 scopus 로고    scopus 로고
    • Bile acid-induced negative feedback regulation of the human ileal bile acid transporter
    • Neimark, E., F. Chen, X. Li, and B. L. Shneider. 2004. Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. Hepatology. 40: 149-156.
    • (2004) Hepatology , vol.40 , pp. 149-156
    • Neimark, E.1    Chen, F.2    Li, X.3    Shneider, B.L.4
  • 215
    • 0042508785 scopus 로고    scopus 로고
    • Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration
    • Lanzini, A., M. G. De Tavonatti, B. Panarotto, S. Scalia, A. Mora, F. Benini, O. Baisini, and F. Lanzarotto. 2003. Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. Gut. 52: 1371-1375.
    • (2003) Gut , vol.52 , pp. 1371-1375
    • Lanzini, A.1    De Tavonatti, M.G.2    Panarotto, B.3    Scalia, S.4    Mora, A.5    Benini, F.6    Baisini, O.7    Lanzarotto, F.8
  • 216
    • 33244460809 scopus 로고    scopus 로고
    • Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis
    • Hruz, P., C. Zimmermann, H. Gutmann, L. Degen, U. Beuers, L. Terracciano, J. Drewe, and C. Beglinger. 2006. Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. Gut. 55: 395-402.
    • (2006) Gut , vol.55 , pp. 395-402
    • Hruz, P.1    Zimmermann, C.2    Gutmann, H.3    Degen, L.4    Beuers, U.5    Terracciano, L.6    Drewe, J.7    Beglinger, C.8
  • 217
    • 57349124804 scopus 로고    scopus 로고
    • Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
    • Sinha, J., F. Chen, T. Miloh, R. C. Burns, Z. Yu, and B. L. Shneider. 2008. Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G996-G1003.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol , vol.295
    • Sinha, J.1    Chen, F.2    Miloh, T.3    Burns, R.C.4    Yu, Z.5    Shneider, B.L.6
  • 218
    • 65249104853 scopus 로고    scopus 로고
    • Bile acid signaling pathways increase stability of small heterodimer partner (SHP) by inhibiting ubiquitin-proteasomal degradation
    • Miao, J., Z. Xiao, D. Kanamaluru, G. Min, P. M. Yau, T. D. Veenstra, E. Ellis, S. Strom, K. Suino-Powell, H. E. Xu, et al. 2009. Bile acid signaling pathways increase stability of small heterodimer partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev. 23: 986-996.
    • (2009) Genes Dev , vol.23 , pp. 986-996
    • Miao, J.1    Xiao, Z.2    Kanamaluru, D.3    Min, G.4    Yau, P.M.5    Veenstra, T.D.6    Ellis, E.7    Strom, S.8    Suino-Powell, K.9    Xu, H.E.10
  • 220
    • 33747798368 scopus 로고    scopus 로고
    • Cholesterol dependent down-regulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: Molecular mechanism and physiological consequences
    • Thomas, C., J. F. Landrier, D. Gaillard, J. Grober, M. C. Monnot, A. Athias, and P. Besnard. 2006. Cholesterol dependent down-regulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences. Gut. 55: 1321-1331.
    • (2006) Gut , vol.55 , pp. 1321-1331
    • Thomas, C.1    Landrier, J.F.2    Gaillard, D.3    Grober, J.4    Monnot, M.C.5    Athias, A.6    Besnard, P.7
  • 221
    • 59649099592 scopus 로고    scopus 로고
    • Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption
    • Miyata, M., Y. Matsuda, M. Nomoto, Y. Takamatsu, N. Sato, M. Hamatsu, P. A. Dawson, F. J. Gonzalez, and Y. Yamazoe. 2009. Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. Drug Metab. Dispos. 37: 338-344.
    • (2009) Drug Metab. Dispos , vol.37 , pp. 338-344
    • Miyata, M.1    Matsuda, Y.2    Nomoto, M.3    Takamatsu, Y.4    Sato, N.5    Hamatsu, M.6    Dawson, P.A.7    Gonzalez, F.J.8    Yamazoe, Y.9
  • 222
    • 0034894970 scopus 로고    scopus 로고
    • Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption
    • Stelzner, M., S. Somasundaram, and T. Khakberdiev. 2001. Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption. J. Surg. Res. 99: 359-364.
    • (2001) J. Surg. Res , vol.99 , pp. 359-364
    • Stelzner, M.1    Somasundaram, S.2    Khakberdiev, T.3
  • 223
    • 0346607187 scopus 로고    scopus 로고
    • Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
    • Jung, D., A. C. Fantin, U. Scheurer, M. Fried, and G. A. Kullak-Ublick. 2004. Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut. 53: 78-84.
    • (2004) Gut , vol.53 , pp. 78-84
    • Jung, D.1    Fantin, A.C.2    Scheurer, U.3    Fried, M.4    Kullak-Ublick, G.A.5
  • 224
    • 0035914393 scopus 로고    scopus 로고
    • The role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporter
    • Chen, F., L. Ma, N. Al-Ansari, and B. Shneider. 2001. The role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporter. J. Biol. Chem. 276: 38703-38714.
    • (2001) J. Biol. Chem , vol.276 , pp. 38703-38714
    • Chen, F.1    Ma, L.2    Al-Ansari, N.3    Shneider, B.4
  • 225
    • 0036892294 scopus 로고    scopus 로고
    • Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
    • Chen, F., L. Ma, R. B. Sartor, F. Li, H. Xiong, A. Q. Sun, and B. Shneider. 2002. Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology. 123: 2005-2016.
    • (2002) Gastroenterology , vol.123 , pp. 2005-2016
    • Chen, F.1    Ma, L.2    Sartor, R.B.3    Li, F.4    Xiong, H.5    Sun, A.Q.6    Shneider, B.7
  • 226
    • 0030767968 scopus 로고    scopus 로고
    • Glucorticoids up-regulate taurocholate transport by the ileal brush border membrane
    • Nowicki, M., B. Shneider, J. Paul, and J. Heubi. 1997. Glucorticoids up-regulate taurocholate transport by the ileal brush border membrane. Am. J. Physiol. 273: G197-G203.
    • (1997) Am. J. Physiol , vol.273
    • Nowicki, M.1    Shneider, B.2    Paul, J.3    Heubi, J.4
  • 227
    • 0346461667 scopus 로고    scopus 로고
    • Do steroids ameliorate bile acid malabsorption in Crohn's disease?
    • Kwon, R. S., and M. C. Carey. 2004. Do steroids ameliorate bile acid malabsorption in Crohn's disease? Gut. 53: 10-11.
    • (2004) Gut , vol.53 , pp. 10-11
    • Kwon, R.S.1    Carey, M.C.2
  • 228
    • 0037163053 scopus 로고    scopus 로고
    • Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha
    • Jung, D., M. Fried, and G. A. Kullak-Ublick. 2002. Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 277: 30559-30566.
    • (2002) J. Biol. Chem , vol.277 , pp. 30559-30566
    • Jung, D.1    Fried, M.2    Kullak-Ublick, G.A.3
  • 229
    • 33745122240 scopus 로고    scopus 로고
    • Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor
    • Chen, X., F. Chen, S. Liu, H. Glaeser, P. A. Dawson, A. F. Hofmann, R. B. Kim, B. L. Shneider, and K. S. Pang. 2006. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Mol. Pharmacol. 69: 1913-1923.
    • (2006) Mol. Pharmacol , vol.69 , pp. 1913-1923
    • Chen, X.1    Chen, F.2    Liu, S.3    Glaeser, H.4    Dawson, P.A.5    Hofmann, A.F.6    Kim, R.B.7    Shneider, B.L.8    Pang, K.S.9
  • 231
    • 7244253050 scopus 로고    scopus 로고
    • Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes
    • Xia, X., M. Roundtree, A. Merikhi, X. Lu, S. Shentu, and G. Lesage. 2004. Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes. J. Biol. Chem. 279: 44931-44937.
    • (2004) J. Biol. Chem , vol.279 , pp. 44931-44937
    • Xia, X.1    Roundtree, M.2    Merikhi, A.3    Lu, X.4    Shentu, S.5    Lesage, G.6
  • 232
    • 0022483282 scopus 로고
    • Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system
    • Weinberg, S. L., G. Burckhardt, and F. A. Wilson. 1986. Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system. J. Clin. Invest. 78: 44-50.
    • (1986) J. Clin. Invest , vol.78 , pp. 44-50
    • Weinberg, S.L.1    Burckhardt, G.2    Wilson, F.A.3
  • 233
    • 0024120055 scopus 로고
    • Identification and comparison of bile acid-binding polypeptides in ileal basolateral membrane
    • Lin, M. C., S. L. Weinberg, W. Kramer, G. Burckhardt, and F. A. Wilson. 1988. Identification and comparison of bile acid-binding polypeptides in ileal basolateral membrane. J. Membr. Biol. 106: 1-11.
    • (1988) J. Membr. Biol , vol.106 , pp. 1-11
    • Lin, M.C.1    Weinberg, S.L.2    Kramer, W.3    Burckhardt, G.4    Wilson, F.A.5
  • 234
    • 0034718614 scopus 로고    scopus 로고
    • Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties
    • Lazaridis, K. N., P. Tietz, T. Wu, S. Kip, P. A. Dawson, and N. F. LaRusso. 2000. Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. Proc. Natl. Acad. Sci. USA. 97: 11092-11097.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11092-11097
    • Lazaridis, K.N.1    Tietz, P.2    Wu, T.3    Kip, S.4    Dawson, P.A.5    LaRusso, N.F.6
  • 235
    • 0345724724 scopus 로고    scopus 로고
    • The MRP family of drug effl ux pumps
    • Kruh, G. D., and M. G. Belinsky. 2003. The MRP family of drug effl ux pumps. Oncogene. 22: 7537-7552.
    • (2003) Oncogene , vol.22 , pp. 7537-7552
    • Kruh, G.D.1    Belinsky, M.G.2
  • 238
    • 0035979303 scopus 로고    scopus 로고
    • Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate
    • Wang, W., D. J. Seward, L. Li, J. L. Boyer, and N. Ballatori. 2001. Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proc. Natl. Acad. Sci. USA. 98: 9431-9436.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9431-9436
    • Wang, W.1    Seward, D.J.2    Li, L.3    Boyer, J.L.4    Ballatori, N.5
  • 239
    • 0041344702 scopus 로고    scopus 로고
    • Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta
    • Seward, D. J., A. S. Koh, J. L. Boyer, and N. Ballatori. 2003. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J. Biol. Chem. 278: 27473-27482.
    • (2003) J. Biol. Chem , vol.278 , pp. 27473-27482
    • Seward, D.J.1    Koh, A.S.2    Boyer, J.L.3    Ballatori, N.4
  • 241
    • 35748954385 scopus 로고    scopus 로고
    • Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter
    • Li, N., Z. Cui, F. Fang, J. Y. Lee, and N. Ballatori. 2007. Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem. J. 407: 363-372.
    • (2007) Biochem. J , vol.407 , pp. 363-372
    • Li, N.1    Cui, Z.2    Fang, F.3    Lee, J.Y.4    Ballatori, N.5
  • 242
  • 244
    • 42449087199 scopus 로고    scopus 로고
    • Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool
    • Davis, R. A., and A. D. Attie. 2008. Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool. Proc. Natl. Acad. Sci. USA. 105: 4965-4966.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4965-4966
    • Davis, R.A.1    Attie, A.D.2
  • 245
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • Kim, I., S. H. Ahn, T. Inagaki, M. Choi, S. Ito, G. L. Guo, S. A. Kliewer, and F. J. Gonzalez. 2007. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J. Lipid Res. 48: 2664-2672.
    • (2007) J. Lipid Res , vol.48 , pp. 2664-2672
    • Kim, I.1    Ahn, S.H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6    Kliewer, S.A.7    Gonzalez, F.J.8
  • 246
    • 38049103287 scopus 로고    scopus 로고
    • Resolving the mechanism of bile acid negative-feedback regulation, a Journal of Lipid Research tradition
    • Davis, R. A. 2008. Resolving the mechanism of bile acid negative-feedback regulation, a Journal of Lipid Research tradition. J. Lipid Res. 49: 2-3.
    • (2008) J. Lipid Res , vol.49 , pp. 2-3
    • Davis, R.A.1
  • 248
    • 0036692428 scopus 로고    scopus 로고
    • Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94
    • Root, C., C. D. Smith, S. S. Sundseth, H. M. Pink, J. G. Wilson, and M. C. Lewis. 2002. Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94. J. Lipid Res. 43: 1320-1330.
    • (2002) J. Lipid Res , vol.43 , pp. 1320-1330
    • Root, C.1    Smith, C.D.2    Sundseth, S.S.3    Pink, H.M.4    Wilson, J.G.5    Lewis, M.C.6
  • 250
    • 53149086301 scopus 로고    scopus 로고
    • Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease
    • Renner, O., S. Harsch, A. Strohmeyer, S. Schimmel, and E. F. Stange. 2008. Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. J. Lipid Res. 49: 2045-2054.
    • (2008) J. Lipid Res , vol.49 , pp. 2045-2054
    • Renner, O.1    Harsch, S.2    Strohmeyer, A.3    Schimmel, S.4    Stange, E.F.5
  • 251
    • 30844445030 scopus 로고    scopus 로고
    • FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine
    • Lee, H., Y. Zhang, F. Y. Lee, S. F. Nelson, F. J. Gonzalez, and P. A. Edwards. 2006. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J. Lipid Res. 47: 201-214.
    • (2006) J. Lipid Res , vol.47 , pp. 201-214
    • Lee, H.1    Zhang, Y.2    Lee, F.Y.3    Nelson, S.F.4    Gonzalez, F.J.5    Edwards, P.A.6
  • 253
    • 33846049564 scopus 로고    scopus 로고
    • LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR
    • Okuwaki, M., T. Takada, Y. Iwayanagi, S. Koh, Y. Kariya, H. Fujii, and H. Suzuki. 2007. LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR. Pharm. Res. 24: 390-398.
    • (2007) Pharm. Res , vol.24 , pp. 390-398
    • Okuwaki, M.1    Takada, T.2    Iwayanagi, Y.3    Koh, S.4    Kariya, Y.5    Fujii, H.6    Suzuki, H.7
  • 254
    • 0015978687 scopus 로고
    • Bile salt sulphates in cholestasis
    • Stiehl, A. 1974. Bile salt sulphates in cholestasis. Eur. J. Clin. Invest. 4: 59-63.
    • (1974) Eur. J. Clin. Invest , vol.4 , pp. 59-63
    • Stiehl, A.1
  • 255
    • 0016480048 scopus 로고
    • Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver
    • Stiehl, A., D. L. Earnest, and W. H. Admirant. 1975. Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver. Gastroenterology. 68: 534-544.
    • (1975) Gastroenterology , vol.68 , pp. 534-544
    • Stiehl, A.1    Earnest, D.L.2    Admirant, W.H.3
  • 256
    • 0019519798 scopus 로고
    • Altered bile acid metabolism in primary biliary cirrhosis
    • Raedsch, R., B. H. Lauterburg, and A. F. Hofmann. 1981. Altered bile acid metabolism in primary biliary cirrhosis. Dig. Dis. Sci. 26: 394-401.
    • (1981) Dig. Dis. Sci , vol.26 , pp. 394-401
    • Raedsch, R.1    Lauterburg, B.H.2    Hofmann, A.F.3
  • 257
    • 0346020356 scopus 로고
    • Bile acid content of human serum. I. Serum bile acids in patients with hepatic disease
    • Rudman, D., and F. E. Kendall. 1957. Bile acid content of human serum. I. Serum bile acids in patients with hepatic disease. J. Clin. Invest. 36: 530-537.
    • (1957) J. Clin. Invest , vol.36 , pp. 530-537
    • Rudman, D.1    Kendall, F.E.2
  • 258
    • 0019425060 scopus 로고
    • Sodium-coupled taurocholate transport in the proximal convolution of the rat kidney in vivo and in vitro
    • Wilson, F. A., G. Burckhardt, H. Murer, G. Rumrich, and K. J. Ullrich. 1981. Sodium-coupled taurocholate transport in the proximal convolution of the rat kidney in vivo and in vitro. J. Clin. Invest. 67: 1141-1150.
    • (1981) J. Clin. Invest , vol.67 , pp. 1141-1150
    • Wilson, F.A.1    Burckhardt, G.2    Murer, H.3    Rumrich, G.4    Ullrich, K.J.5
  • 259
    • 0010670423 scopus 로고
    • Renal excretion of bile acids: Taurocholic, glycocholic, and colic acids
    • Weiner, I. M., J. E. Glasser, and L. Lack. 1964. Renal excretion of bile acids: taurocholic, glycocholic, and colic acids. Am. J. Physiol. 207: 964-970.
    • (1964) Am. J. Physiol , vol.207 , pp. 964-970
    • Weiner, I.M.1    Glasser, J.E.2    Lack, L.3
  • 261
    • 0031842184 scopus 로고    scopus 로고
    • Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits
    • Higaki, J., S. Hara, N. Takasu, K. Tonda, K. Miyata, T. Shike, K. Nagata, and T. Mizui. 1998. Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler. Thromb. Vasc. Biol. 18: 1304-1311.
    • (1998) Arterioscler. Thromb. Vasc. Biol , vol.18 , pp. 1304-1311
    • Higaki, J.1    Hara, S.2    Takasu, N.3    Tonda, K.4    Miyata, K.5    Shike, T.6    Nagata, K.7    Mizui, T.8
  • 263
    • 0017580907 scopus 로고
    • Evidence for renal control of urinary excretion of bile acids and bile acid sulphates in the cholestatic syndrome
    • Summerfield, J. A., J. Cullen, S. Barnes, and B. H. Billing. 1977. Evidence for renal control of urinary excretion of bile acids and bile acid sulphates in the cholestatic syndrome. Clin. Sci. Mol. Med. 52: 51-65.
    • (1977) Clin. Sci. Mol. Med , vol.52 , pp. 51-65
    • Summerfield, J.A.1    Cullen, J.2    Barnes, S.3    Billing, B.H.4
  • 264
    • 0019859425 scopus 로고
    • Urinary excretion of bile acids in cholestasis: Evidence for renal tubular secretion in man
    • Corbett, C. L., T. C. Bartholomew, B. H. Billing, and J. A. Summerfield. 1981. Urinary excretion of bile acids in cholestasis: evidence for renal tubular secretion in man. Clin. Sci. (Lond.). 61: 773-780.
    • (1981) Clin. Sci. (Lond.) , vol.61 , pp. 773-780
    • Corbett, C.L.1    Bartholomew, T.C.2    Billing, B.H.3    Summerfield, J.A.4
  • 265
    • 36248935603 scopus 로고    scopus 로고
    • The use of high performance thin-layer chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage
    • Morgan, W. A., T. Nk, and Y. Ding. 2008. The use of high performance thin-layer chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage. J. Pharmacol. Toxicol. Methods. 57: 70-73.
    • (2008) J. Pharmacol. Toxicol. Methods , vol.57 , pp. 70-73
    • Morgan, W.A.1    Nk, T.2    Ding, Y.3
  • 266
    • 62149137376 scopus 로고    scopus 로고
    • Analysis of DNA methylation and histone modification profiles of liver-specific transporters
    • Imai, S., R. Kikuchi, H. Kusuhara, S. Yagi, K. Shiota, and Y. Sugiyama. 2009. Analysis of DNA methylation and histone modification profiles of liver-specific transporters. Mol. Pharmacol. 75: 568-576.
    • (2009) Mol. Pharmacol , vol.75 , pp. 568-576
    • Imai, S.1    Kikuchi, R.2    Kusuhara, H.3    Yagi, S.4    Shiota, K.5    Sugiyama, Y.6


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