-
1
-
-
0024464260
-
Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trial
-
Leuschner, U., Fischer, H., Kurtz, W., Guldutuna, S., Hubner, K., Hellstern, A., Gatzen, M. and Leuschner, M. (1989) Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trial. Gastroenterology 97, 1268-1274
-
(1989)
Gastroenterology
, vol.97
, pp. 1268-1274
-
-
Leuschner, U.1
Fischer, H.2
Kurtz, W.3
Guldutuna, S.4
Hubner, K.5
Hellstern, A.6
Gatzen, M.7
Leuschner, M.8
-
2
-
-
0021178162
-
Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties: studies on isolated hepatocytes and lipid membrane vesicles
-
Scholmerich, J., Becher, M. S., Schmidt, K., Schubert, R., Kremer, B., Feldhaus, S. and Gerok, W. (1984) Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties: studies on isolated hepatocytes and lipid membrane vesicles. Hepatology 4, 661-666
-
(1984)
Hepatology
, vol.4
, pp. 661-666
-
-
Scholmerich, J.1
Becher, M.S.2
Schmidt, K.3
Schubert, R.4
Kremer, B.5
Feldhaus, S.6
Gerok, W.7
-
3
-
-
65649124573
-
Bile-acid-induced cell injury and protection
-
Perez, M. J. and Briz, O. (2009) Bile-acid-induced cell injury and protection. World J. Gastroenterol. 15, 1677-1689
-
(2009)
World J. Gastroenterol.
, vol.15
, pp. 1677-1689
-
-
Perez, M.J.1
Briz, O.2
-
4
-
-
0027998655
-
Pharmacology of ursodeoxycholic acid, an enterohepatic drug
-
Hofmann, A. F. (1994) Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand. J. Gastroenterol. Suppl. 204, 1-15
-
(1994)
Scand. J. Gastroenterol. Suppl.
, vol.204
, pp. 1-15
-
-
Hofmann, A.F.1
-
5
-
-
0027406096
-
Serum bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid therapy
-
Poupon, R. E., Chretien, Y., Poupon, R. and Paumgartner, G. (1993) Serum bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid therapy. Hepatology 17, 599-604
-
(1993)
Hepatology
, vol.17
, pp. 599-604
-
-
Poupon, R.E.1
Chretien, Y.2
Poupon, R.3
Paumgartner, G.4
-
6
-
-
0026596936
-
Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease
-
Beuers, U., Spengler, U., Zwiebel, F. M., Pauletzki, J., Fischer, S. and Paumgartner, G. (1992) Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease. Hepatology 15, 603-608
-
(1992)
Hepatology
, vol.15
, pp. 603-608
-
-
Beuers, U.1
Spengler, U.2
Zwiebel, F.M.3
Pauletzki, J.4
Fischer, S.5
Paumgartner, G.6
-
7
-
-
0027280229
-
Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis
-
Rudolph, G., Endele, R., Senn, M. and Stiehl, A. (1993) Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis. Hepatology 17, 1028-1032
-
(1993)
Hepatology
, vol.17
, pp. 1028-1032
-
-
Rudolph, G.1
Endele, R.2
Senn, M.3
Stiehl, A.4
-
8
-
-
77954231348
-
Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: relation to disease progression
-
Sinakos, E., Marschall, H. U., Kowdley, K. V., Befeler, A., Keach, J. and Lindor, K. (2010) Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: relation to disease progression. Hepatology 52, 197-203
-
(2010)
Hepatology
, vol.52
, pp. 197-203
-
-
Sinakos, E.1
Marschall, H.U.2
Kowdley, K.V.3
Befeler, A.4
Keach, J.5
Lindor, K.6
-
9
-
-
0027297995
-
Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis
-
Mazzella, G., Parini, P., Bazzoli, F., Villanova, N., Festi, D., Aldini, R., Roda, A., Cipolla, A., Polimeni, C., Tonelli, D. and Roda, E. (1993) Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis. Dig. Dis. Sci. 38, 896-902
-
(1993)
Dig. Dis. Sci.
, vol.38
, pp. 896-902
-
-
Mazzella, G.1
Parini, P.2
Bazzoli, F.3
Villanova, N.4
Festi, D.5
Aldini, R.6
Roda, A.7
Cipolla, A.8
Polimeni, C.9
Tonelli, D.10
Roda, E.11
-
10
-
-
0344133016
-
Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid
-
Brites, D. (2002) Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid. Ann. Hepatol. 1, 20-28
-
(2002)
Ann. Hepatol.
, vol.1
, pp. 20-28
-
-
Brites, D.1
-
11
-
-
77949272728
-
Longitudinal profiles of 15 serum bile acids in patients with intrahepatic cholestasis of pregnancy
-
Tribe, R. M., Dann, A. T., Kenyon, A. P., Seed, P., Shennan, A. H. and Mallet, A. (2010) Longitudinal profiles of 15 serum bile acids in patients with intrahepatic cholestasis of pregnancy. Am. J. Gastroenterol. 105, 585-595
-
(2010)
Am. J. Gastroenterol.
, vol.105
, pp. 585-595
-
-
Tribe, R.M.1
Dann, A.T.2
Kenyon, A.P.3
Seed, P.4
Shennan, A.H.5
Mallet, A.6
-
12
-
-
33144465413
-
Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice
-
Fickert, P., Fuchsbichler, A., Marschall, H. U., Wagner, M., Zollner, G., Krause, R., Zatloukal, K., Jaeschke, H., Denk, H. and Trauner, M. (2006) Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am. J. Pathol. 168, 410-422
-
(2006)
Am. J. Pathol.
, vol.168
, pp. 410-422
-
-
Fickert, P.1
Fuchsbichler, A.2
Marschall, H.U.3
Wagner, M.4
Zollner, G.5
Krause, R.6
Zatloukal, K.7
Jaeschke, H.8
Denk, H.9
Trauner, M.10
-
13
-
-
70349263453
-
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
-
Lindor, K. D., Kowdley, K. V., Luketic, V. A., Harrison, M. E., McCashland, T., Befeler, A. S., Harnois, D., Jorgensen, R., Petz, J., Keach, J. et al. (2009) High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 50, 808-814
-
(2009)
Hepatology
, vol.50
, pp. 808-814
-
-
Lindor, K.D.1
Kowdley, K.V.2
Luketic, V.A.3
Harrison, M.E.4
McCashland, T.5
Befeler, A.S.6
Harnois, D.7
Jorgensen, R.8
Petz, J.9
Keach, J.10
-
14
-
-
0034945397
-
Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'
-
Lazaridis, K. N., Gores, G. J. and Lindor, K. D. (2001) Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J. Hepatol. 35, 134-146
-
(2001)
J. Hepatol.
, vol.35
, pp. 134-146
-
-
Lazaridis, K.N.1
Gores, G.J.2
Lindor, K.D.3
-
15
-
-
0031024075
-
Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
-
Setchell, K. D., Rodrigues, C. M., Clerici, C., Solinas, A., Morelli, A., Gartung, C. and Boyer, J. (1997) Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 112, 226-235
-
(1997)
Gastroenterology
, vol.112
, pp. 226-235
-
-
Setchell, K.D.1
Rodrigues, C.M.2
Clerici, C.3
Solinas, A.4
Morelli, A.5
Gartung, C.6
Boyer, J.7
-
16
-
-
75349107079
-
Liver disease associated with canalicular transport defects: current and future therapies
-
Stapelbroek, J. M., van Erpecum, K. J., Klomp, L. W. and Houwen, R. H. (2010) Liver disease associated with canalicular transport defects: current and future therapies. J. Hepatol. 52, 258-271
-
(2010)
J. Hepatol.
, vol.52
, pp. 258-271
-
-
Stapelbroek, J.M.1
van Erpecum, K.J.2
Klomp, L.W.3
Houwen, R.H.4
-
17
-
-
0030606673
-
Hepatic levels of bile acids in end-stage chronic cholestatic liver disease
-
Fischer, S., Beuers, U., Spengler, U., Zwiebel, F. M. and Koebe, H. G. (1996) Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. Clin. Chim. Acta 251, 173-186
-
(1996)
Clin. Chim. Acta
, vol.251
, pp. 173-186
-
-
Fischer, S.1
Beuers, U.2
Spengler, U.3
Zwiebel, F.M.4
Koebe, H.G.5
-
18
-
-
0033470181
-
Bile acids: the good, the bad, and the ugly
-
Hofmann, A. F. (1999) Bile acids: the good, the bad, and the ugly. News Physiol. Sci. 14, 24-29
-
(1999)
News Physiol. Sci.
, vol.14
, pp. 24-29
-
-
Hofmann, A.F.1
-
19
-
-
0031911131
-
Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes
-
Benz, C., Angermuller, S., Tox, U., Kloters-Plachky, P., Riedel, H. D., Sauer, P., Stremmel,W. and Stiehl, A. (1998) Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. J. Hepatol. 28, 99-106
-
(1998)
J. Hepatol.
, vol.28
, pp. 99-106
-
-
Benz, C.1
Angermuller, S.2
Tox, U.3
Kloters-Plachky, P.4
Riedel, H.D.5
Sauer, P.6
Stremmel, W.7
Stiehl, A.8
-
20
-
-
1842479900
-
What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis
-
Maher, J. J. (2004) What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis. Hepatology 39, 1141-1143
-
(2004)
Hepatology
, vol.39
, pp. 1141-1143
-
-
Maher, J.J.1
-
22
-
-
0036204957
-
Ursodeoxy-cholic acid cytoprotection: dancing with death receptors and survival pathways
-
Guicciardi, M. E. and Gores, G. J. (2002) Ursodeoxy-cholic acid cytoprotection: dancing with death receptors and survival pathways. Hepatology 35, 971-973
-
(2002)
Hepatology
, vol.35
, pp. 971-973
-
-
Guicciardi, M.E.1
Gores, G.J.2
-
23
-
-
2442662132
-
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
-
Schoemaker, M. H., Conde de la, R. L., Buist-Homan, M., Vrenken, T. E., Havinga, R., Poelstra, K., Haisma, H. J., Jansen, P. L. and Moshage, H. (2004) Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 39, 1563-1573
-
(2004)
Hepatology
, vol.39
, pp. 1563-1573
-
-
Schoemaker, M.H.1
Conde de la, R.L.2
Buist-Homan, M.3
Vrenken, T.E.4
Havinga, R.5
Poelstra, K.6
Haisma, H.J.7
Jansen, P.L.8
Moshage, H.9
-
24
-
-
2442644019
-
Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis
-
Rolo, A. P., Palmeira, C. M., Holy, J. M. and Wallace, K. B. (2004) Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. Toxicol. Sci. 79, 196-204
-
(2004)
Toxicol. Sci.
, vol.79
, pp. 196-204
-
-
Rolo, A.P.1
Palmeira, C.M.2
Holy, J.M.3
Wallace, K.B.4
-
25
-
-
0034102505
-
Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes
-
Benz, C., Angermuller, S., Otto, G., Sauer, P., Stremmel, W. and Stiehl, A. (2000) Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur. J. Clin. Invest. 30, 203-209
-
(2000)
Eur. J. Clin. Invest.
, vol.30
, pp. 203-209
-
-
Benz, C.1
Angermuller, S.2
Otto, G.3
Sauer, P.4
Stremmel, W.5
Stiehl, A.6
-
26
-
-
0035990970
-
An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis
-
Neuman, M. G., Cameron, R. G., Haber, J. A., Katz, G. G. and Blendis, L. M. (2002) An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis. Liver 22, 235-244
-
(2002)
Liver
, vol.22
, pp. 235-244
-
-
Neuman, M.G.1
Cameron, R.G.2
Haber, J.A.3
Katz, G.G.4
Blendis, L.M.5
-
27
-
-
0031005366
-
Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
-
Koga, H., Sakisaka, S., Ohishi, M., Sata, M. and Tanikawa, K. (1997) Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 25, 1077-1084
-
(1997)
Hepatology
, vol.25
, pp. 1077-1084
-
-
Koga, H.1
Sakisaka, S.2
Ohishi, M.3
Sata, M.4
Tanikawa, K.5
-
28
-
-
77956627699
-
Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
-
Lleo, A., Bowlus, C. L., Yang, G. X., Invernizzi, P., Podda, M., Van de Water, J., Ansari, A. A., Coppel, R. L., Worman, H. J., Gores, G. J. and Gershwin, M. E. (2010) Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 52, 987-998
-
(2010)
Hepatology
, vol.52
, pp. 987-998
-
-
Lleo, A.1
Bowlus, C.L.2
Yang, G.X.3
Invernizzi, P.4
Podda, M.5
Van de Water, J.6
Ansari, A.A.7
Coppel, R.L.8
Worman, H.J.9
Gores, G.J.10
Gershwin, M.E.11
-
29
-
-
0035069055
-
Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids
-
Sokol, R. J., Straka, M. S., Dahl, R., Devereaux, M. W., Yerushalmi, B., Gumpricht, E., Elkins, N. and Everson, G. (2001) Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids. Pediatr. Res. 49, 519-531
-
(2001)
Pediatr. Res.
, vol.49
, pp. 519-531
-
-
Sokol, R.J.1
Straka, M.S.2
Dahl, R.3
Devereaux, M.W.4
Yerushalmi, B.5
Gumpricht, E.6
Elkins, N.7
Everson, G.8
-
30
-
-
0035129976
-
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition
-
Yerushalmi, B., Dahl, R., Devereaux, M. W., Gumpricht, E. and Sokol, R. J. (2001) Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 33, 616-626
-
(2001)
Hepatology
, vol.33
, pp. 616-626
-
-
Yerushalmi, B.1
Dahl, R.2
Devereaux, M.W.3
Gumpricht, E.4
Sokol, R.J.5
-
31
-
-
0034899577
-
Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria
-
Rolo, A. P., Oliveira, P. J., Moreno, A. J. and Palmeira, C. M. (2001) Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria. Biosci. Rep. 21, 73-80
-
(2001)
Biosci. Rep.
, vol.21
, pp. 73-80
-
-
Rolo, A.P.1
Oliveira, P.J.2
Moreno, A.J.3
Palmeira, C.M.4
-
32
-
-
23244439961
-
Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids
-
Sokol, R. J., Dahl, R., Devereaux, M. W., Yerushalmi, B., Kobak, G. E. and Gumpricht, E. (2005) Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. J. Pediatr. Gastroenterol. Nutr. 41, 235-243
-
(2005)
J. Pediatr. Gastroenterol. Nutr.
, vol.41
, pp. 235-243
-
-
Sokol, R.J.1
Dahl, R.2
Devereaux, M.W.3
Yerushalmi, B.4
Kobak, G.E.5
Gumpricht, E.6
-
33
-
-
0028091169
-
Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria
-
Krahenbuhl, S., Talos, C., Fischer, S. and Reichen, J. (1994) Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria. Hepatology 19, 471-479
-
(1994)
Hepatology
, vol.19
, pp. 471-479
-
-
Krahenbuhl, S.1
Talos, C.2
Fischer, S.3
Reichen, J.4
-
34
-
-
0027227827
-
Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes Role of ATP depletion and cytosolic free calcium
-
Spivey, J. R., Bronk, S. F. and Gores, G. J. (1993) Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J. Clin. Invest. 92, 17-24
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 17-24
-
-
Spivey, J.R.1
Bronk, S.F.2
Gores, G.J.3
-
35
-
-
28844489800
-
Bile salt-induced apoptosis involves NADPH oxidase isoform activation
-
Reinehr, R., Becker, S., Keitel, V., Eberle, A., Grether-Beck, S. and Haussinger, D. (2005) Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 129, 2009-2031
-
(2005)
Gastroenterology
, vol.129
, pp. 2009-2031
-
-
Reinehr, R.1
Becker, S.2
Keitel, V.3
Eberle, A.4
Grether-Beck, S.5
Haussinger, D.6
-
36
-
-
0028816461
-
Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection
-
Botla, R., Spivey, J. R., Aguilar,H., Bronk, S. F. and Gores, G. J. (1995) Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J. Pharmacol. Exp. Ther. 272, 930-938
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.272
, pp. 930-938
-
-
Botla, R.1
Spivey, J.R.2
Aguilar, H.3
Bronk, S.F.4
Gores, G.J.5
-
37
-
-
0031950282
-
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
-
Rodrigues, C. M., Fan, G.,Wong, P. Y., Kren, B. T. and Steer, C. J. (1998) Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol. Med. 4, 165-178
-
(1998)
Mol. Med.
, vol.4
, pp. 165-178
-
-
Rodrigues, C.M.1
Fan, G.2
Wong, P.Y.3
Kren, B.T.4
Steer, C.J.5
-
38
-
-
0036890346
-
Antioxidant properties of ursodeoxycholic acid
-
Lapenna, D., Ciofani, G., Festi, D., Neri, M., Pierdomenico, S. D., Giamberardino, M. A. and Cuccurullo, F. (2002) Antioxidant properties of ursodeoxycholic acid. Biochem. Pharmacol. 64, 1661-1667
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1661-1667
-
-
Lapenna, D.1
Ciofani, G.2
Festi, D.3
Neri, M.4
Pierdomenico, S.D.5
Giamberardino, M.A.6
Cuccurullo, F.7
-
39
-
-
57349108021
-
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
-
Okada, K., Shoda, J., Taguchi, K., Maher, J. M., Ishizaki, K., Inoue, Y., Ohtsuki, M., Goto, N., Takeda, K., Utsunomiya, H. et al. (2008) Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G735-G747
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.295
-
-
Okada, K.1
Shoda, J.2
Taguchi, K.3
Maher, J.M.4
Ishizaki, K.5
Inoue, Y.6
Ohtsuki, M.7
Goto, N.8
Takeda, K.9
Utsunomiya, H.10
-
40
-
-
77954101086
-
Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
-
Kawata, K., Kobayashi, Y., Souda, K., Kawamura, K., Sumiyoshi, S., Takahashi, Y., Noritake, H., Watanabe, S., Suehiro, T. and Nakamura, H. (2010) Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. Antioxid. Redox. Signaling 13, 259-268
-
(2010)
Antioxid. Redox. Signaling
, vol.13
, pp. 259-268
-
-
Kawata, K.1
Kobayashi, Y.2
Souda, K.3
Kawamura, K.4
Sumiyoshi, S.5
Takahashi, Y.6
Noritake, H.7
Watanabe, S.8
Suehiro, T.9
Nakamura, H.10
-
41
-
-
0033600824
-
Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants
-
Mitsuyoshi, H., Nakashima, T., Sumida, Y., Yoh, T., Nakajima, Y., Ishikawa, H., Inaba, K., Sakamoto, Y., Okanoue, T. and Kashima, K. (1999) Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem. Biophys. Res. Commun. 263, 537-542
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 537-542
-
-
Mitsuyoshi, H.1
Nakashima, T.2
Sumida, Y.3
Yoh, T.4
Nakajima, Y.5
Ishikawa, H.6
Inaba, K.7
Sakamoto, Y.8
Okanoue, T.9
Kashima, K.10
-
42
-
-
12144286014
-
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
-
Serviddio, G., Pereda, J., Pallardo, F. V., Carretero, J., Borras, C., Cutrin, J., Vendemiale, G., Poli, G., Vina, J. and Sastre, J. (2004) Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 39, 711-720
-
(2004)
Hepatology
, vol.39
, pp. 711-720
-
-
Serviddio, G.1
Pereda, J.2
Pallardo, F.V.3
Carretero, J.4
Borras, C.5
Cutrin, J.6
Vendemiale, G.7
Poli, G.8
Vina, J.9
Sastre, J.10
-
43
-
-
0036129525
-
Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate
-
Bernstein, C., Payne, C. M., Bernstein, H. and Garewal, H. (2002) Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate. Pharmacology 65, 2-9
-
(2002)
Pharmacology
, vol.65
, pp. 2-9
-
-
Bernstein, C.1
Payne, C.M.2
Bernstein, H.3
Garewal, H.4
-
44
-
-
59749083235
-
Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells
-
Arisawa, S., Ishida, K., Kameyama, N., Ueyama, J., Hattori, A., Tatsumi, Y., Hayashi, H., Yano, M., Hayashi, K., Katano, Y. et al. (2009) Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem. Pharmacol. 77, 858-866
-
(2009)
Biochem. Pharmacol.
, vol.77
, pp. 858-866
-
-
Arisawa, S.1
Ishida, K.2
Kameyama, N.3
Ueyama, J.4
Hattori, A.5
Tatsumi, Y.6
Hayashi, H.7
Yano, M.8
Hayashi, K.9
Katano, Y.10
-
45
-
-
0036775488
-
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
-
Lemasters, J. J., Qian, T., He, L., Kim, J. S., Elmore, S. P., Cascio, W. E. and Brenner, D. A. (2002) Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid. Redox. Signaling 4, 769-781
-
(2002)
Antioxid. Redox. Signaling
, vol.4
, pp. 769-781
-
-
Lemasters, J.J.1
Qian, T.2
He, L.3
Kim, J.S.4
Elmore, S.P.5
Cascio, W.E.6
Brenner, D.A.7
-
46
-
-
0032846812
-
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
-
Rodrigues, C. M., Ma, X., Linehan-Stieers, C., Fan, G., Kren, B. T. and Steer, C. J. (1999) Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation. Cell Death. Differ. 6, 842-854
-
(1999)
Cell Death. Differ.
, vol.6
, pp. 842-854
-
-
Rodrigues, C.M.1
Ma, X.2
Linehan-Stieers, C.3
Fan, G.4
Kren, B.T.5
Steer, C.J.6
-
47
-
-
64849113485
-
Control of mitochondrial apoptosis by the Bcl-2 family
-
Brunelle, J. K. and Letai, A. (2009) Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci. 122, 437-441
-
(2009)
J. Cell Sci.
, vol.122
, pp. 437-441
-
-
Brunelle, J.K.1
Letai, A.2
-
48
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian, E. and Karin, M. (2002) AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4, E131-E136
-
(2002)
Nat. Cell Biol.
, vol.4
-
-
Shaulian, E.1
Karin, M.2
-
49
-
-
30144436018
-
The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis
-
Bernt, C., Vennegeerts, T., Beuers, U. and Rust, C. (2006) The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. Biochem. Biophys. Res. Commun. 340, 800-806
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.340
, pp. 800-806
-
-
Bernt, C.1
Vennegeerts, T.2
Beuers, U.3
Rust, C.4
-
50
-
-
38049021096
-
Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
-
Pusl, T., Vennegeerts, T.,Wimmer, R., Denk, G. U., Beuers, U. and Rust, C. (2008) Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. Biochem. Biophys. Res. Commun. 367, 208-212
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.367
, pp. 208-212
-
-
Pusl, T.1
Vennegeerts, T.2
Wimmer, R.3
Denk, G.U.4
Beuers, U.5
Rust, C.6
-
51
-
-
0036211298
-
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
-
Qiao, L., Yacoub, A., Studer, E., Gupta, S., Pei, X. Y., Grant, S., Hylemon, P. B. and Dent, P. (2002) Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35, 779-789
-
(2002)
Hepatology
, vol.35
, pp. 779-789
-
-
Qiao, L.1
Yacoub, A.2
Studer, E.3
Gupta, S.4
Pei, X.Y.5
Grant, S.6
Hylemon, P.B.7
Dent, P.8
-
52
-
-
34247181117
-
Game and players: mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid
-
Sola, S., Aranha, M. M., Steer, C. J. and Rodrigues, C. M. (2007) Game and players: mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid. Curr. Issues Mol. Biol. 9, 123-138
-
(2007)
Curr. Issues Mol. Biol.
, vol.9
, pp. 123-138
-
-
Sola, S.1
Aranha, M.M.2
Steer, C.J.3
Rodrigues, C.M.4
-
53
-
-
34547921190
-
Tauroursodeoxycholic acid inhibits apoptosis induced by Z α-1 antitrypsin via inhibition of Bad
-
Miller, S. D., Greene, C. M., McLean, C., Lawless, M.W., Taggart, C. C., O'Neill, S. J. and McElvaney, N. G. (2007) Tauroursodeoxycholic acid inhibits apoptosis induced by Z α-1 antitrypsin via inhibition of Bad. Hepatology 46, 496-503
-
(2007)
Hepatology
, vol.46
, pp. 496-503
-
-
Miller, S.D.1
Greene, C.M.2
McLean, C.3
Lawless, M.W.4
Taggart, C.C.5
O'Neill, S.J.6
McElvaney, N.G.7
-
54
-
-
36348941176
-
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis
-
Amaral, J. D., Castro, R. E., Sola, S., Steer, C. J. and Rodrigues, C. M. (2007) p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. J. Biol. Chem. 282, 34250-34259
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34250-34259
-
-
Amaral, J.D.1
Castro, R.E.2
Sola, S.3
Steer, C.J.4
Rodrigues, C.M.5
-
55
-
-
77957258575
-
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53
-
Amaral, J. D., Castro, R. E., Sola, S., Steer, C. J. and Rodrigues, C. M. (2010) Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53. Biochem. Biophys. Res. Commun. 400, 649-654
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.400
, pp. 649-654
-
-
Amaral, J.D.1
Castro, R.E.2
Sola, S.3
Steer, C.J.4
Rodrigues, C.M.5
-
56
-
-
34248168218
-
Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines
-
Liu, H., Qin, C. Y., Han, G. Q., Xu, H.W., Meng, M. and Yang, Z. (2007) Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines. World J. Gastroenterol. 13, 1652-1658
-
(2007)
World J. Gastroenterol.
, vol.13
, pp. 1652-1658
-
-
Liu, H.1
Qin, C.Y.2
Han, G.Q.3
Xu, H.W.4
Meng, M.5
Yang, Z.6
-
57
-
-
12844288888
-
Ursodiol use is possibly associated with lower incidence of hepatocellular carcinoma in hepatitis C virus-associated liver cirrhosis
-
Tarao, K., Fujiyama, S., Ohkawa, S., Miyakawa, K., Tamai, S., Hirokawa, S., Masaki, T. and Tanaka, K. (2005) Ursodiol use is possibly associated with lower incidence of hepatocellular carcinoma in hepatitis C virus-associated liver cirrhosis. Cancer Epidemiol. Biomarkers Prev. 14, 164-169
-
(2005)
Cancer Epidemiol. Biomarkers Prev.
, vol.14
, pp. 164-169
-
-
Tarao, K.1
Fujiyama, S.2
Ohkawa, S.3
Miyakawa, K.4
Tamai, S.5
Hirokawa, S.6
Masaki, T.7
Tanaka, K.8
-
58
-
-
25644448987
-
The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
-
Utanohara, S., Tsuji, M., Momma, S., Morio, Y. and Oguchi, K. (2005) The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. Toxicology 214, 77-86
-
(2005)
Toxicology
, vol.214
, pp. 77-86
-
-
Utanohara, S.1
Tsuji, M.2
Momma, S.3
Morio, Y.4
Oguchi, K.5
-
60
-
-
0030003493
-
Bile acid conjugation in early stage cholestatic liver disease before and during treatment with ursodeoxycholic acid
-
Fracchia, M., Setchell, K. D., Crosignani, A., Podda, M., O'Connell, N., Ferraris, R., Hofmann, A. F. and Galatola, G. (1996) Bile acid conjugation in early stage cholestatic liver disease before and during treatment with ursodeoxycholic acid. Clin. Chim. Acta 248, 175-185
-
(1996)
Clin. Chim. Acta
, vol.248
, pp. 175-185
-
-
Fracchia, M.1
Setchell, K.D.2
Crosignani, A.3
Podda, M.4
O'Connell, N.5
Ferraris, R.6
Hofmann, A.F.7
Galatola, G.8
-
61
-
-
0026479097
-
Effect of S-adenosyl-l-methionine administration on plasma levels of sulphur-containing amino acids in patients with liver cirrhosis
-
Marchesini, G., Bugianesi, E., Bianchi, G., Fabbri, A., Marchi, E., Zoli, M. and Pisi, E. (1992) Effect of S-adenosyl-l-methionine administration on plasma levels of sulphur-containing amino acids in patients with liver cirrhosis. Clin. Nutr. 11, 303-308
-
(1992)
Clin. Nutr.
, vol.11
, pp. 303-308
-
-
Marchesini, G.1
Bugianesi, E.2
Bianchi, G.3
Fabbri, A.4
Marchi, E.5
Zoli, M.6
Pisi, E.7
-
62
-
-
0021178014
-
Plasma cysteine, cystine, and glutathione in cirrhosis
-
Chawla, R. K., Lewis, F. W., Kutner, M. H., Bate, D. M., Roy, R. G. and Rudman, D. (1984) Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterology 87, 770-776
-
(1984)
Gastroenterology
, vol.87
, pp. 770-776
-
-
Chawla, R.K.1
Lewis, F.W.2
Kutner, M.H.3
Bate, D.M.4
Roy, R.G.5
Rudman, D.6
-
63
-
-
0017336689
-
Bile salts secretion in cirrhosis
-
Correia, J. P., Areias, E., Meneses, L. and Tiago, E. (1977) Bile salts secretion in cirrhosis. Acta Hepatogastroenterol. 24, 15-19
-
(1977)
Acta Hepatogastroenterol
, vol.24
, pp. 15-19
-
-
Correia, J.P.1
Areias, E.2
Meneses, L.3
Tiago, E.4
-
64
-
-
77958100236
-
A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis
-
Adams, L. A., Angulo, P., Petz, J., Keach, J. and Lindor, K. D. (2010) A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis. Hepatol. Int. 4, 628-633
-
(2010)
Hepatol. Int.
, vol.4
, pp. 628-633
-
-
Adams, L.A.1
Angulo, P.2
Petz, J.3
Keach, J.4
Lindor, K.D.5
-
65
-
-
77955699301
-
High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
-
Leuschner, U. F., Lindenthal, B., Herrmann, G., Arnold, J. C., Rossle, M., Cordes, H. J., Zeuzem, S., Hein, J. and Berg, T. (2010) High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology 52, 472-479
-
(2010)
Hepatology
, vol.52
, pp. 472-479
-
-
Leuschner, U.F.1
Lindenthal, B.2
Herrmann, G.3
Arnold, J.C.4
Rossle, M.5
Cordes, H.J.6
Zeuzem, S.7
Hein, J.8
Berg, T.9
-
66
-
-
0035990949
-
Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
-
Tinmouth, J., Lee, M., Wanless, I. R., Tsui, F. W., Inman, R. and Heathcote, E. J. (2002) Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. Liver 22, 228-234
-
(2002)
Liver
, vol.22
, pp. 228-234
-
-
Tinmouth, J.1
Lee, M.2
Wanless, I.R.3
Tsui, F.W.4
Inman, R.5
Heathcote, E.J.6
-
67
-
-
70349972775
-
Apoptosis and cytokines in non-alcoholic steatohepatitis
-
Syn, W. K., Choi, S. S. and Diehl, A. M. (2009) Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin. Liver Dis. 13, 565-580
-
(2009)
Clin. Liver Dis.
, vol.13
, pp. 565-580
-
-
Syn, W.K.1
Choi, S.S.2
Diehl, A.M.3
-
68
-
-
0033936183
-
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
-
Sodeman, T., Bronk, S. F., Roberts, P. J., Miyoshi, H. and Gores, G. J. (2000) Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am. J. Physiol. Gastrointest. Liver Physiol 278, G992-G999
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.278
-
-
Sodeman, T.1
Bronk, S.F.2
Roberts, P.J.3
Miyoshi, H.4
Gores, G.J.5
-
69
-
-
0035914341
-
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
-
Higuchi, H., Bronk, S. F., Takikawa, Y., Werneburg, N., Takimoto, R., El-Deiry, W. and Gores, G. J. (2001) The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J. Biol. Chem. 276, 38610-38618
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38610-38618
-
-
Higuchi, H.1
Bronk, S.F.2
Takikawa, Y.3
Werneburg, N.4
Takimoto, R.5
El-Deiry, W.6
Gores, G.J.7
-
70
-
-
0037178881
-
Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
-
Li, S., Zhao, Y., He, X., Kim, T. H., Kuharsky, D. K., Rabinowich, H., Chen, J., Du, C. and Yin, X. M. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277, 26912-26920
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26912-26920
-
-
Li, S.1
Zhao, Y.2
He, X.3
Kim, T.H.4
Kuharsky, D.K.5
Rabinowich, H.6
Chen, J.7
Du, C.8
Yin, X.M.9
-
71
-
-
0036291806
-
Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes
-
Azzaroli, F., Mehal, W., Soroka, C. J., Wang, L., Lee, J., Crispe, N. and Boyer, J. L. (2002) Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology 36, 49-54
-
(2002)
Hepatology
, vol.36
, pp. 49-54
-
-
Azzaroli, F.1
Mehal, W.2
Soroka, C.J.3
Wang, L.4
Lee, J.5
Crispe, N.6
Boyer, J.L.7
-
72
-
-
79952708723
-
Endoplasmic reticulum stress in liver disease
-
Malhi, H. and Kaufman, R. J. (2011) Endoplasmic reticulum stress in liver disease. J. Hepatol. 54, 795-809
-
(2011)
J. Hepatol.
, vol.54
, pp. 795-809
-
-
Malhi, H.1
Kaufman, R.J.2
-
73
-
-
33846168143
-
Endoplasmic reticulum stress and apoptosis
-
Faitova, J., Krekac, D., Hrstka, R. and Vojtesek, B. (2006) Endoplasmic reticulum stress and apoptosis. Cell. Mol. Biol. Lett. 11, 488-505
-
(2006)
Cell. Mol. Biol. Lett.
, vol.11
, pp. 488-505
-
-
Faitova, J.1
Krekac, D.2
Hrstka, R.3
Vojtesek, B.4
-
74
-
-
1842832932
-
Caspase-12: an overview
-
Lamkanfi, M., Kalai, M. and Vandenabeele, P. (2004) Caspase-12: an overview. Cell Death. Differ. 11, 365-368
-
(2004)
Cell Death. Differ.
, vol.11
, pp. 365-368
-
-
Lamkanfi, M.1
Kalai, M.2
Vandenabeele, P.3
-
75
-
-
33747871436
-
Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
-
Tsuchiya, S., Tsuji, M., Morio, Y. and Oguchi, K. (2006) Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. Toxicol. Lett. 166, 140-149
-
(2006)
Toxicol. Lett.
, vol.166
, pp. 140-149
-
-
Tsuchiya, S.1
Tsuji, M.2
Morio, Y.3
Oguchi, K.4
-
76
-
-
0036725164
-
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
-
Xie, Q., Khaoustov, V. I., Chung, C. C., Sohn, J., Krishnan, B., Lewis, D. E. and Yoffe, B. (2002) Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 36, 592-601
-
(2002)
Hepatology
, vol.36
, pp. 592-601
-
-
Xie, Q.1
Khaoustov, V.I.2
Chung, C.C.3
Sohn, J.4
Krishnan, B.5
Lewis, D.E.6
Yoffe, B.7
-
77
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan, U., Yilmaz, E., Ozcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Gorgun, C. Z. and Hotamisligil, G. S. (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
78
-
-
70350043699
-
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis
-
Balmer, M. L., Siegrist, K., Zimmermann, A. and Dufour, J. F. (2009) Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int. 29, 1184-1188
-
(2009)
Liver Int
, vol.29
, pp. 1184-1188
-
-
Balmer, M.L.1
Siegrist, K.2
Zimmermann, A.3
Dufour, J.F.4
-
79
-
-
14744304730
-
Modulation of apoptosis as a target for liver disease
-
Eichhorst, S. T. (2005) Modulation of apoptosis as a target for liver disease. Expert Opin. Ther. Targets 9, 83-99
-
(2005)
Expert Opin. Ther. Targets
, vol.9
, pp. 83-99
-
-
Eichhorst, S.T.1
-
80
-
-
44949195877
-
Bile acids for viral hepatitis
-
doi: 101002/14651858. CD003181.pub2
-
Chen, W., Liu, J. and Gluud, C. (2007) Bile acids for viral hepatitis. Cochrane Database Syst. Rev. 2007, CD003181, doi: 10.1002/14651858.CD003181.pub2
-
(2007)
Cochrane Database Syst. Rev.
, vol.2007
-
-
Chen, W.1
Liu, J.2
Gluud, C.3
-
81
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
-
Malhotra, J. D. and Kaufman, R. J. (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox. Signaling 9, 2277-2293
-
(2007)
Antioxid.Redox. Signaling
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
82
-
-
70349768065
-
Endoplasmic reticulum stress and the unfolded protein response
-
Kapoor, A. and Sanyal, A. J. (2009) Endoplasmic reticulum stress and the unfolded protein response. Clin. Liver Dis. 13, 581-590
-
(2009)
Clin. Liver Dis.
, vol.13
, pp. 581-590
-
-
Kapoor, A.1
Sanyal, A.J.2
-
83
-
-
1542314311
-
The protective effect of ursodeoxycholic acid in alloxan-induced diabetes
-
Lukivskaya, O., Lis, R., Egorov, A., Naruta, E., Tauschel, H. D. and Buko, V. U. (2004) The protective effect of ursodeoxycholic acid in alloxan-induced diabetes. Cell. Biochem. Funct. 22, 97-103
-
(2004)
Cell. Biochem. Funct.
, vol.22
, pp. 97-103
-
-
Lukivskaya, O.1
Lis, R.2
Egorov, A.3
Naruta, E.4
Tauschel, H.D.5
Buko, V.U.6
-
84
-
-
39149099114
-
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease
-
Ramalho, R. M., Viana, R. J., Low, W. C., Steer, C. J. and Rodrigues, C. M. (2008) Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease. Trends Mol. Med. 14, 54-62
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 54-62
-
-
Ramalho, R.M.1
Viana, R.J.2
Low, W.C.3
Steer, C.J.4
Rodrigues, C.M.5
-
85
-
-
0035998716
-
Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease
-
Duan, W. M., Rodrigues, C. M., Zhao, L. R., Steer, C. J. and Low, W. C. (2002) Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. Cell Transplant. 11, 195-205
-
(2002)
Cell Transplant
, vol.11
, pp. 195-205
-
-
Duan, W.M.1
Rodrigues, C.M.2
Zhao, L.R.3
Steer, C.J.4
Low, W.C.5
-
86
-
-
0036677435
-
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
-
Keene, C. D., Rodrigues, C. M., Eich, T., Chhabra, M. S., Steer, C. J. and Low, W. C. (2002) Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc. Natl. Acad. Sci. U.S.A. 99, 10671-10676
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 10671-10676
-
-
Keene, C.D.1
Rodrigues, C.M.2
Eich, T.3
Chhabra, M.S.4
Steer, C.J.5
Low, W.C.6
-
87
-
-
0032525819
-
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
-
Rodrigues, C. M., Fan, G., Ma, X., Kren, B. T. and Steer, C. J. (1998) A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J. Clin. Invest. 101, 2790-2799
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2790-2799
-
-
Rodrigues, C.M.1
Fan, G.2
Ma, X.3
Kren, B.T.4
Steer, C.J.5
-
88
-
-
0034761961
-
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione
-
Colell, A., Coll, O., Garcia-Ruiz, C., Paris, R., Tiribelli, C., Kaplowitz, N. and Fernandez-Checa, J. C. (2001) Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology 34, 964-971
-
(2001)
Hepatology
, vol.34
, pp. 964-971
-
-
Colell, A.1
Coll, O.2
Garcia-Ruiz, C.3
Paris, R.4
Tiribelli, C.5
Kaplowitz, N.6
Fernandez-Checa, J.C.7
-
89
-
-
66549101781
-
Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers
-
Kremer, A. E., Rust, C., Eichhorn, P., Beuers, U. and Holdenrieder, S. (2009) Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers. Expert Rev. Mol. Diagn. 9, 139-156
-
(2009)
Expert Rev. Mol. Diagn.
, vol.9
, pp. 139-156
-
-
Kremer, A.E.1
Rust, C.2
Eichhorn, P.3
Beuers, U.4
Holdenrieder, S.5
-
90
-
-
0030663215
-
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis
-
Harada, K., Ozaki, S., Gershwin, M. E. and Nakanuma, Y. (1997) Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis. Hepatology 26, 1399-1405
-
(1997)
Hepatology
, vol.26
, pp. 1399-1405
-
-
Harada, K.1
Ozaki, S.2
Gershwin, M.E.3
Nakanuma, Y.4
-
91
-
-
78049486376
-
Pathogenesis of cholestatic liver disease and therapeutic approaches
-
Hirschfield, G. M., Heathcote, E. J. and Gershwin, M. E. (2010) Pathogenesis of cholestatic liver disease and therapeutic approaches. Gastroenterology 139, 1481-1496
-
(2010)
Gastroenterology
, vol.139
, pp. 1481-1496
-
-
Hirschfield, G.M.1
Heathcote, E.J.2
Gershwin, M.E.3
-
92
-
-
25844516609
-
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-β1-induced apoptosis in rat hepatocytes
-
Sola, S., Amaral, J. D., Castro, R. E., Ramalho, R. M., Borralho, P. M., Kren, B. T., Tanaka, H., Steer, C. J. and Rodrigues, C. M. (2005) Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-β1-induced apoptosis in rat hepatocytes. Hepatology 42, 925-934
-
(2005)
Hepatology
, vol.42
, pp. 925-934
-
-
Sola, S.1
Amaral, J.D.2
Castro, R.E.3
Ramalho, R.M.4
Borralho, P.M.5
Kren, B.T.6
Tanaka, H.7
Steer, C.J.8
Rodrigues, C.M.9
-
93
-
-
0035861563
-
Functional modulation of the glucocorticoid receptor and suppression of NF-κB-dependent transcription by ursodeoxycholic acid
-
Miura, T., Ouchida, R., Yoshikawa, N., Okamoto, K., Makino, Y., Nakamura, T., Morimoto, C., Makino, I. and Tanaka, H. (2001) Functional modulation of the glucocorticoid receptor and suppression of NF-κB-dependent transcription by ursodeoxycholic acid. J. Biol. Chem. 276, 47371-47378
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47371-47378
-
-
Miura, T.1
Ouchida, R.2
Yoshikawa, N.3
Okamoto, K.4
Makino, Y.5
Nakamura, T.6
Morimoto, C.7
Makino, I.8
Tanaka, H.9
-
94
-
-
10744225137
-
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-κ B activation
-
Schoemaker, M. H., Gommans, W. M., Conde de la Rosa, L., Homan, M., Klok, P., Trautwein, C., van Goor, H., Poelstra, K., Haisma, H. J., Jansen, P. L. and Moshage, H. (2003) Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-κ B activation. J. Hepatol. 39, 153-161
-
(2003)
J. Hepatol.
, vol.39
, pp. 153-161
-
-
Schoemaker, M.H.1
Gommans, W.M.2
Conde de la Rosa, L.3
Homan, M.4
Klok, P.5
Trautwein, C.6
van Goor, H.7
Poelstra, K.8
Haisma, H.J.9
Jansen, P.L.10
Moshage, H.11
-
95
-
-
49449097533
-
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
-
Takeda, K., Kojima, Y., Ikejima, K., Harada, K., Yamashina, S., Okumura, K., Aoyama, T., Frese, S., Ikeda, H., Haynes, N. M. et al. (2008) Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. Proc. Natl. Acad. Sci. U.S.A. 105, 10895-10900
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 10895-10900
-
-
Takeda, K.1
Kojima, Y.2
Ikejima, K.3
Harada, K.4
Yamashina, S.5
Okumura, K.6
Aoyama, T.7
Frese, S.8
Ikeda, H.9
Haynes, N.M.10
-
96
-
-
34347375167
-
Antioxidant mechanism of hepatoprotection by ursodeoxycholic acid in experimental alcoholic steatohepatitis
-
Lukivskaya, O., Zavodnik, L., Knas, M. and Buko, V. (2006) Antioxidant mechanism of hepatoprotection by ursodeoxycholic acid in experimental alcoholic steatohepatitis. Adv. Med. Sci. 51, 54-59
-
(2006)
Adv. Med. Sci.
, vol.51
, pp. 54-59
-
-
Lukivskaya, O.1
Zavodnik, L.2
Knas, M.3
Buko, V.4
-
97
-
-
40749133389
-
Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity
-
Uraz, S., Tahan, V., Aygun, C., Eren, F., Unluguzel, G., Yuksel, M., Senturk, O., Avsar, E., Haklar, G., Celikel, C., Hulagu, S. and Tozun, N. (2008) Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig. Dis. Sci. 53, 1071-1077
-
(2008)
Dig. Dis. Sci.
, vol.53
, pp. 1071-1077
-
-
Uraz, S.1
Tahan, V.2
Aygun, C.3
Eren, F.4
Unluguzel, G.5
Yuksel, M.6
Senturk, O.7
Avsar, E.8
Haklar, G.9
Celikel, C.10
Hulagu, S.11
Tozun, N.12
-
98
-
-
0033292009
-
Hepatotoxicity by amoxicillin/clavulanic acid: case report
-
Soza, A., Riquelme, F., Alvarez, M., Duarte, I., Glasinovic, J. C. and Arrese, M. (1999) Hepatotoxicity by amoxicillin/clavulanic acid: case report. Rev. Med. Chil. 127, 1487-1491
-
(1999)
Rev. Med. Chil.
, vol.127
, pp. 1487-1491
-
-
Soza, A.1
Riquelme, F.2
Alvarez, M.3
Duarte, I.4
Glasinovic, J.C.5
Arrese, M.6
-
99
-
-
36749071397
-
Ursodeoxycholic acid in chronic hepatitis C
-
Poupon, R. and Serfaty, L. (2007) Ursodeoxycholic acid in chronic hepatitis C. Gut 56, 1652-1653
-
(2007)
Gut
, vol.56
, pp. 1652-1653
-
-
Poupon, R.1
Serfaty, L.2
-
100
-
-
0030028668
-
Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum γ-glutamyltranspeptidase levels
-
Kiso, S., Kawata, S., Imai, Y., Tamura, S., Inui, Y., Ito, N. and Matsuzawa, Y. (1996) Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum γ-glutamyltranspeptidase levels. J. Gastroenterol. 31, 75-80
-
(1996)
J. Gastroenterol.
, vol.31
, pp. 75-80
-
-
Kiso, S.1
Kawata, S.2
Imai, Y.3
Tamura, S.4
Inui, Y.5
Ito, N.6
Matsuzawa, Y.7
-
101
-
-
0038623782
-
Taurourso-deoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats
-
Rodrigues, C. M., Sola, S., Nan, Z., Castro, R. E., Ribeiro, P. S., Low, W. C. and Steer, C. J. (2003) Taurourso-deoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc. Natl. Acad. Sci. U.S.A. 100, 6087-6092
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 6087-6092
-
-
Rodrigues, C.M.1
Sola, S.2
Nan, Z.3
Castro, R.E.4
Ribeiro, P.S.5
Low, W.C.6
Steer, C.J.7
-
102
-
-
3042698849
-
Tauroursodeoxycholic acid prevents amyloid-β peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway
-
Sola, S., Castro, R. E., Laires, P. A., Steer, C. J. and Rodrigues, C. M. (2003) Tauroursodeoxycholic acid prevents amyloid-β peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. Mol. Med. 9, 226-234
-
(2003)
Mol. Med.
, vol.9
, pp. 226-234
-
-
Sola, S.1
Castro, R.E.2
Laires, P.A.3
Steer, C.J.4
Rodrigues, C.M.5
-
103
-
-
0033769186
-
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition
-
Rodrigues, C. M., Stieers, C. L., Keene, C. D., Ma, X., Kren, B. T., Low, W. C. and Steer, C. J. (2000) Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. J. Neurochem. 75, 2368-2379
-
(2000)
J. Neurochem.
, vol.75
, pp. 2368-2379
-
-
Rodrigues, C.M.1
Stieers, C.L.2
Keene, C.D.3
Ma, X.4
Kren, B.T.5
Low, W.C.6
Steer, C.J.7
-
104
-
-
13844292752
-
Oncosis represents the main type of cell death in mouse models of cholestasis
-
Fickert, P., Trauner, M., Fuchsbichler, A., Zollner, G., Wagner, M., Marschall, H. U., Zatloukal, K. and Denk, H. (2005) Oncosis represents the main type of cell death in mouse models of cholestasis. J. Hepatol. 42, 378-385
-
(2005)
J. Hepatol.
, vol.42
, pp. 378-385
-
-
Fickert, P.1
Trauner, M.2
Fuchsbichler, A.3
Zollner, G.4
Wagner, M.5
Marschall, H.U.6
Zatloukal, K.7
Denk, H.8
-
105
-
-
0344586817
-
Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein
-
Wang, R., Lam, P., Liu, L., Forrest, D., Yousef, I. M., Mignault, D., Phillips, M. J. and Ling, V. (2003) Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein. Hepatology 38, 1489-1499
-
(2003)
Hepatology
, vol.38
, pp. 1489-1499
-
-
Wang, R.1
Lam, P.2
Liu, L.3
Forrest, D.4
Yousef, I.M.5
Mignault, D.6
Phillips, M.J.7
Ling, V.8
-
106
-
-
0027363563
-
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
-
Smit, J. J., Schinkel, A. H., Oude Elferink, R. P., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A., Ottenhoff, R., van der Lugt, N. M., van Roon, M. A. et al. (1993) Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75, 451-462
-
(1993)
Cell
, vol.75
, pp. 451-462
-
-
Smit, J.J.1
Schinkel, A.H.2
Oude Elferink, R.P.3
Groen, A.K.4
Wagenaar, E.5
van Deemter, L.6
Mol, C.A.7
Ottenhoff, R.8
van der Lugt, N.M.9
van Roon, M.A.10
-
107
-
-
0027190653
-
Necroinflammatory changes in hepatic lobules in primary biliary cirrhosis with less well-defined cholestatic changes
-
Nakanuma, Y. (1993) Necroinflammatory changes in hepatic lobules in primary biliary cirrhosis with less well-defined cholestatic changes. Hum. Pathol. 24, 378-383
-
(1993)
Hum. Pathol.
, vol.24
, pp. 378-383
-
-
Nakanuma, Y.1
-
108
-
-
0032898075
-
Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression
-
Degott, C., Zafrani, E. S., Callard, P., Balkau, B., Poupon, R. E. and Poupon, R. (1999) Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression. Hepatology 29, 1007-1012
-
(1999)
Hepatology
, vol.29
, pp. 1007-1012
-
-
Degott, C.1
Zafrani, E.S.2
Callard, P.3
Balkau, B.4
Poupon, R.E.5
Poupon, R.6
-
109
-
-
0023279107
-
Primary sclerosing cholangitis: a long-term follow-up study
-
Aadland, E., Schrumpf, E., Fausa, O., Elgjo, K., Heilo, A., Aakhus, T. and Gjone, E. (1987) Primary sclerosing cholangitis: a long-term follow-up study. Scand. J. Gastroenterol. 22, 655-664
-
(1987)
Scand. J. Gastroenterol.
, vol.22
, pp. 655-664
-
-
Aadland, E.1
Schrumpf, E.2
Fausa, O.3
Elgjo, K.4
Heilo, A.5
Aakhus, T.6
Gjone, E.7
-
110
-
-
79954623913
-
Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies
-
Evason, K., Bove, K. E., Finegold, M. J., Knisely, A. S., Rhee, S., Rosenthal, P., Miethke, A. G., Karpen, S. J., Ferrell, L. D. and Kim, G. E. (2011) Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies. Am. J. Surg. Pathol. 35, 687-696
-
(2011)
Am. J. Surg. Pathol.
, vol.35
, pp. 687-696
-
-
Evason, K.1
Bove, K.E.2
Finegold, M.J.3
Knisely, A.S.4
Rhee, S.5
Rosenthal, P.6
Miethke, A.G.7
Karpen, S.J.8
Ferrell, L.D.9
Kim, G.E.10
-
111
-
-
0025790578
-
Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes
-
Heuman, D. M., Pandak, W. M., Hylemon, P. B. and Vlahcevic, Z. R. (1991) Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14, 920-926
-
(1991)
Hepatology
, vol.14
, pp. 920-926
-
-
Heuman, D.M.1
Pandak, W.M.2
Hylemon, P.B.3
Vlahcevic, Z.R.4
-
112
-
-
0027467410
-
Tauroursodeoxycholate and tauro-β-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content
-
Ohiwa, T., Katagiri, K., Hoshino, M., Hayakawa, T. and Nakai, T. (1993) Tauroursodeoxycholate and tauro-β-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. Hepatology 17, 470-476
-
(1993)
Hepatology
, vol.17
, pp. 470-476
-
-
Ohiwa, T.1
Katagiri, K.2
Hoshino, M.3
Hayakawa, T.4
Nakai, T.5
-
113
-
-
78149468784
-
Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition
-
Basiglio, C. L., Mottino, A. D. and Roma, M. G. (2010) Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition. Chem.-Biol. Interact. 188, 386-392
-
(2010)
Chem.-Biol. Interact.
, vol.188
, pp. 386-392
-
-
Basiglio, C.L.1
Mottino, A.D.2
Roma, M.G.3
-
114
-
-
0026086134
-
Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts
-
Heuman, D. M., Mills, A. S., McCall, J., Hylemon, P. B., Pandak, W. M. and Vlahcevic, Z. R. (1991) Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology 100, 203-211
-
(1991)
In vivo studies in the rat. Gastroenterology
, vol.100
, pp. 203-211
-
-
Heuman, D.M.1
Mills, A.S.2
McCall, J.3
Hylemon, P.B.4
Pandak, W.M.5
Vlahcevic, Z.R.6
-
115
-
-
0027207769
-
Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
-
Sokol, R. J., Devereaux, M., Khandwala, R. and O'Brien, K. (1993) Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Hepatology 17, 869-881
-
(1993)
Hepatology
, vol.17
, pp. 869-881
-
-
Sokol, R.J.1
Devereaux, M.2
Khandwala, R.3
O'Brien, K.4
-
116
-
-
0029123537
-
Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids
-
Sokol, R. J., Winklhofer-Roob, B. M., Devereaux, M. W. and McKim, Jr, J. M. (1995) Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology 109, 1249-1256
-
(1995)
Gastroenterology
, vol.109
, pp. 1249-1256
-
-
Sokol, R.J.1
Winklhofer-Roob, B.M.2
Devereaux, M.W.3
McKim Jr., J.M.4
-
117
-
-
0031983188
-
Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat
-
Sokol, R. J., McKim, Jr, J. M., Goff, M. C., Ruyle, S. Z., Devereaux, M. W., Han, D., Packer, L. and Everson, G. (1998) Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology 114, 164-174
-
(1998)
Gastroenterology
, vol.114
, pp. 164-174
-
-
Sokol, R.J.1
McKim Jr., J.M.2
Goff, M.C.3
Ruyle, S.Z.4
Devereaux, M.W.5
Han, D.6
Packer, L.7
Everson, G.8
-
118
-
-
12344332518
-
Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes
-
Borgognone, M., Perez, L. M., Basiglio, C. L., Ochoa, J. E. and Roma, M. G. (2005) Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes. Toxicol. Sci. 83, 114-125
-
(2005)
Toxicol. Sci.
, vol.83
, pp. 114-125
-
-
Borgognone, M.1
Perez, L.M.2
Basiglio, C.L.3
Ochoa, J.E.4
Roma, M.G.5
-
119
-
-
0018868656
-
Effects of bile salts on the plasma membranes of isolated rat hepatocytes
-
Billington, D., Evans, C. E., Godfrey, P. P. and Coleman, R. (1980) Effects of bile salts on the plasma membranes of isolated rat hepatocytes. Biochem. J. 188, 321-327
-
(1980)
Biochem. J.
, vol.188
, pp. 321-327
-
-
Billington, D.1
Evans, C.E.2
Godfrey, P.P.3
Coleman, R.4
-
120
-
-
78650779111
-
Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes
-
Woudenberg-Vrenken, T. E., Buist-Homan, M., Conde de la, R. L., Faber, K. N. and Moshage, H. (2010) Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes. Liver Int. 30, 1511-1521
-
(2010)
Liver Int
, vol.30
, pp. 1511-1521
-
-
Woudenberg-Vrenken, T.E.1
Buist-Homan, M.2
Conde de la, R.L.3
Faber, K.N.4
Moshage, H.5
-
121
-
-
0028351832
-
Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts
-
Heuman, D. M. and Bajaj, R. (1994) Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology 106, 1333-1341
-
(1994)
Gastroenterology
, vol.106
, pp. 1333-1341
-
-
Heuman, D.M.1
Bajaj, R.2
-
122
-
-
0343488500
-
Ursodeoxycholate stabilizes phospholipid-rich membranes and mimics the effect of cholesterol: investigations on large unilamellar vesicles
-
Guldutuna, S., Deisinger, B., Weiss, A., Freisleben, H. J., Zimmer, G., Sipos, P. and Leuschner, U. (1997) Ursodeoxycholate stabilizes phospholipid-rich membranes and mimics the effect of cholesterol: investigations on large unilamellar vesicles. Biochim. Biophys. Acta 1326, 265-274
-
(1997)
Biochim. Biophys. Acta
, vol.1326
, pp. 265-274
-
-
Guldutuna, S.1
Deisinger, B.2
Weiss, A.3
Freisleben, H.J.4
Zimmer, G.5
Sipos, P.6
Leuschner, U.7
-
123
-
-
59249108194
-
The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
-
Zhou, Y., Doyen, R. and Lichtenberger, L. M. (2009) The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid. Biochim. Biophys. Acta 1788, 507-513
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 507-513
-
-
Zhou, Y.1
Doyen, R.2
Lichtenberger, L.M.3
-
124
-
-
0029863204
-
Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection
-
Heuman, D. M., Bajaj, R. S. and Lin, Q. (1996) Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. J. Lipid Res. 37, 562-573
-
(1996)
J. Lipid Res.
, vol.37
, pp. 562-573
-
-
Heuman, D.M.1
Bajaj, R.S.2
Lin, Q.3
-
125
-
-
62549116131
-
Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis
-
Basiglio, C. L., Sanchez Pozzi, E. J., Mottino, A. D. and Roma, M. G. (2009) Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chem.-Biol. Interact. 179, 297-303
-
(2009)
Chem.-Biol. Interact.
, vol.179
, pp. 297-303
-
-
Basiglio, C.L.1
Sanchez Pozzi, E.J.2
Mottino, A.D.3
Roma, M.G.4
-
126
-
-
34547382615
-
Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene
-
Rosmorduc, O. and Poupon, R. (2007) Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene. Orphanet J. Rare Dis. 2, 29
-
(2007)
Orphanet J. Rare Dis.
, vol.2
, pp. 29
-
-
Rosmorduc, O.1
Poupon, R.2
-
127
-
-
0030926120
-
Cytotoxicity of bile salts against biliary epithelium: a study in isolated bile ductule fragments and isolated perfused rat liver
-
Benedetti, A., Alvaro, D., Bassotti, C., Gigliozzi, A., Ferretti, G., La Rosa, T., Di Sario, A., Baiocchi, L. and Jezequel, A. M. (1997) Cytotoxicity of bile salts against biliary epithelium: a study in isolated bile ductule fragments and isolated perfused rat liver. Hepatology 26, 9-21
-
(1997)
Hepatology
, vol.26
, pp. 9-21
-
-
Benedetti, A.1
Alvaro, D.2
Bassotti, C.3
Gigliozzi, A.4
Ferretti, G.5
La Rosa, T.6
Di Sario, A.7
Baiocchi, L.8
Jezequel, A.M.9
-
128
-
-
0035230550
-
Pathology and pathogenesis of intrahepatic bile duct loss
-
Nakanuma, Y., Tsuneyama, K. and Harada, K. (2001) Pathology and pathogenesis of intrahepatic bile duct loss. J. Hepatobiliary Pancreat. Surg. 8, 303-315
-
(2001)
J. Hepatobiliary Pancreat. Surg.
, vol.8
, pp. 303-315
-
-
Nakanuma, Y.1
Tsuneyama, K.2
Harada, K.3
-
129
-
-
0033562147
-
GUDC inhibits cytochrome c release from human cholangiocyte mitochondria
-
Que, F. G., Phan, V. A., Phan, V. H., LaRusso, N. F. and Gores, G. J. (1999) GUDC inhibits cytochrome c release from human cholangiocyte mitochondria. J. Surg. Res. 83, 100-105
-
(1999)
J. Surg. Res.
, vol.83
, pp. 100-105
-
-
Que, F.G.1
Phan, V.A.2
Phan, V.H.3
LaRusso, N.F.4
Gores, G.J.5
-
130
-
-
77955666599
-
Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat
-
Rodriguez-Ortigosa, C. M., Banales, J. M., Olivas, I., Uriarte, I., Marin, J. J., Corrales, F. J., Medina, J. F. and Prieto, J. (2010) Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat. Hepatology 52, 667-677
-
(2010)
Hepatology
, vol.52
, pp. 667-677
-
-
Rodriguez-Ortigosa, C.M.1
Banales, J.M.2
Olivas, I.3
Uriarte, I.4
Marin, J.J.5
Corrales, F.J.6
Medina, J.F.7
Prieto, J.8
-
131
-
-
0034949811
-
Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver
-
Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Pojer, C., Zenz, R., Lammert, F., Stieger, B., Meier, P. J., Zatloukal, K. et al. (2001) Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 121, 170-183
-
(2001)
Gastroenterology
, vol.121
, pp. 170-183
-
-
Fickert, P.1
Zollner, G.2
Fuchsbichler, A.3
Stumptner, C.4
Pojer, C.5
Zenz, R.6
Lammert, F.7
Stieger, B.8
Meier, P.J.9
Zatloukal, K.10
-
132
-
-
12444301770
-
Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
-
Zollner, G., Fickert, P., Fuchsbichler, A., Silbert, D., Wagner, M., Arbeiter, S., Gonzalez, F. J., Marschall, H. U., Zatloukal, K., Denk, H. and Trauner, M. (2003) Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J. Hepatol. 39, 480-488
-
(2003)
J. Hepatol.
, vol.39
, pp. 480-488
-
-
Zollner, G.1
Fickert, P.2
Fuchsbichler, A.3
Silbert, D.4
Wagner, M.5
Arbeiter, S.6
Gonzalez, F.J.7
Marschall, H.U.8
Zatloukal, K.9
Denk, H.10
Trauner, M.11
-
133
-
-
33645839049
-
Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids
-
Zollner, G., Wagner, M., Moustafa, T., Fickert, P., Silbert, D., Gumhold, J., Fuchsbichler, A., Halilbasic, E., Denk, H., Marschall, H. U. and Trauner, M. (2006) Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G923-G932
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
-
-
Zollner, G.1
Wagner, M.2
Moustafa, T.3
Fickert, P.4
Silbert, D.5
Gumhold, J.6
Fuchsbichler, A.7
Halilbasic, E.8
Denk, H.9
Marschall, H.U.10
Trauner, M.11
-
134
-
-
0023938705
-
Urinary excretion of bile acids during acute administration in man
-
Salvioli, G., Lugli, R., Pradelli, J. M., Frignani, A. and Boccalletti, V. (1988) Urinary excretion of bile acids during acute administration in man. Eur. J. Clin. Invest. 18, 22-28
-
(1988)
Eur. J. Clin. Invest.
, vol.18
, pp. 22-28
-
-
Salvioli, G.1
Lugli, R.2
Pradelli, J.M.3
Frignani, A.4
Boccalletti, V.5
-
135
-
-
0021136349
-
Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases
-
Takikawa, H., Beppu, T. and Seyama, Y. (1984) Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases. Gastroenterol. Jpn 19, 104-109
-
(1984)
Gastroenterol. Jpn
, vol.19
, pp. 104-109
-
-
Takikawa, H.1
Beppu, T.2
Seyama, Y.3
-
136
-
-
0021134465
-
Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5′-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes
-
Matern, S., Matern, H., Farthmann, E. H. and Gerok, W. (1984) Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5′-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes. J. Clin. Invest. 74, 402-410
-
(1984)
J. Clin. Invest.
, vol.74
, pp. 402-410
-
-
Matern, S.1
Matern, H.2
Farthmann, E.H.3
Gerok, W.4
-
137
-
-
77149132772
-
Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)
-
Huang, J., Bathena, S. P., Tong, J., Roth, M., Hagenbuch, B. and Alnouti, Y. (2010) Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica 40, 184-194
-
(2010)
Xenobiotica
, vol.40
, pp. 184-194
-
-
Huang, J.1
Bathena, S.P.2
Tong, J.3
Roth, M.4
Hagenbuch, B.5
Alnouti, Y.6
-
138
-
-
0035914467
-
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
-
Schuetz, E. G., Strom, S., Yasuda, K., Lecureur, V., Assem, M., Brimer, C., Lamba, J., Kim, R. B., Ramachandran, V., Komoroski, B. J. et al. (2001) Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J. Biol. Chem. 276, 39411-39418
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39411-39418
-
-
Schuetz, E.G.1
Strom, S.2
Yasuda, K.3
Lecureur, V.4
Assem, M.5
Brimer, C.6
Lamba, J.7
Kim, R.B.8
Ramachandran, V.9
Komoroski, B.J.10
-
139
-
-
77951561501
-
Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis
-
Wagner, M., Zollner, G. and Trauner, M. (2010) Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis. Semin. Liver Dis. 30, 160-177
-
(2010)
Semin. Liver Dis.
, vol.30
, pp. 160-177
-
-
Wagner, M.1
Zollner, G.2
Trauner, M.3
-
140
-
-
48749087793
-
Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis
-
Stahl, S., Davies, M. R., Cook, D. I. and Graham, M. J. (2008) Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis. Xenobiotica 38, 725-777
-
(2008)
Xenobiotica
, vol.38
, pp. 725-777
-
-
Stahl, S.1
Davies, M.R.2
Cook, D.I.3
Graham, M.J.4
-
141
-
-
0042825756
-
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
-
Wagner, M., Fickert, P., Zollner, G., Fuchsbichler, A., Silbert, D., Tsybrovskyy, O., Zatloukal, K., Guo, G. L., Schuetz, J. D., Gonzalez, F. J. et al. (2003) Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 125, 825-838
-
(2003)
Gastroenterology
, vol.125
, pp. 825-838
-
-
Wagner, M.1
Fickert, P.2
Zollner, G.3
Fuchsbichler, A.4
Silbert, D.5
Tsybrovskyy, O.6
Zatloukal, K.7
Guo, G.L.8
Schuetz, J.D.9
Gonzalez, F.J.10
-
142
-
-
33847011377
-
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
-
Geier, A., Wagner, M., Dietrich, C. G. and Trauner, M. (2007) Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim. Biophys. Acta 1773, 283-308
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 283-308
-
-
Geier, A.1
Wagner, M.2
Dietrich, C.G.3
Trauner, M.4
-
143
-
-
0036788262
-
Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
-
Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Weiglein, A. H., Lammert, F., Marschall, H. U., Tsybrovskyy, O., Zatloukal, K., Denk, H. and Trauner, M. (2002) Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 123, 1238-1251
-
(2002)
Gastroenterology
, vol.123
, pp. 1238-1251
-
-
Fickert, P.1
Zollner, G.2
Fuchsbichler, A.3
Stumptner, C.4
Weiglein, A.H.5
Lammert, F.6
Marschall, H.U.7
Tsybrovskyy, O.8
Zatloukal, K.9
Denk, H.10
Trauner, M.11
-
144
-
-
23244465392
-
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
-
Marschall, H. U., Wagner, M., Zollner, G., Fickert, P., Diczfalusy, U., Gumhold, J., Silbert, D., Fuchsbichler, A., Benthin, L., Grundstrom, R. et al. (2005) Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 129, 476-485
-
(2005)
Gastroenterology
, vol.129
, pp. 476-485
-
-
Marschall, H.U.1
Wagner, M.2
Zollner, G.3
Fickert, P.4
Diczfalusy, U.5
Gumhold, J.6
Silbert, D.7
Fuchsbichler, A.8
Benthin, L.9
Grundstrom, R.10
-
145
-
-
14244269427
-
No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis
-
Dilger, K., Denk, A., Heeg, M. H. and Beuers, U. (2005) No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis. Hepatology 41, 595-602
-
(2005)
Hepatology
, vol.41
, pp. 595-602
-
-
Dilger, K.1
Denk, A.2
Heeg, M.H.3
Beuers, U.4
-
146
-
-
0013138711
-
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
-
Zollner, G., Fickert, P., Silbert, D., Fuchsbichler, A., Marschall, H. U., Zatloukal, K., Denk, H. and Trauner, M. (2003) Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J. Hepatol. 38, 717-727
-
(2003)
J. Hepatol.
, vol.38
, pp. 717-727
-
-
Zollner, G.1
Fickert, P.2
Silbert, D.3
Fuchsbichler, A.4
Marschall, H.U.5
Zatloukal, K.6
Denk, H.7
Trauner, M.8
-
147
-
-
0030977867
-
Cytokines in primary biliary cirrhosis
-
Berg, P. A., Klein, R. and Rocken, M. (1997) Cytokines in primary biliary cirrhosis. Semin. Liver Dis. 17, 115-123
-
(1997)
Semin. Liver Dis.
, vol.17
, pp. 115-123
-
-
Berg, P.A.1
Klein, R.2
Rocken, M.3
-
148
-
-
31944435265
-
Ursodeoxycholic acid therapy for intractable total parenteral nutrition-associated cholestasis in surgical very low birth weight infants
-
Al-Hathlol, K., Al-Madani, A., Al-Saif, S., Abulaimoun, B., Al-Tawil, K. and El-Demerdash, A. (2006) Ursodeoxycholic acid therapy for intractable total parenteral nutrition-associated cholestasis in surgical very low birth weight infants. Singapore Med. J. 47, 147-151
-
(2006)
Singapore Med. J.
, vol.47
, pp. 147-151
-
-
Al-Hathlol, K.1
Al-Madani, A.2
Al-Saif, S.3
Abulaimoun, B.4
Al-Tawil, K.5
El-Demerdash, A.6
-
149
-
-
4444256601
-
Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis
-
Chen, C. Y., Tsao, P. N., Chen, H. L., Chou, H. C., Hsieh, W. S. and Chang, M. H. (2004) Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis. J. Pediatr. 145, 317-321
-
(2004)
J. Pediatr.
, vol.145
, pp. 317-321
-
-
Chen, C.Y.1
Tsao, P.N.2
Chen, H.L.3
Chou, H.C.4
Hsieh, W.S.5
Chang, M.H.6
-
150
-
-
0030944967
-
Ursodeoxycholic acid in the management of prolonged cholestasis of acute hepatitis B
-
Kadayifci, A., Savas, M. C., Arslan, S. and Gullu, I. H. (1997) Ursodeoxycholic acid in the management of prolonged cholestasis of acute hepatitis B. J. Clin. Gastroenterol. 24, 125-126
-
(1997)
J. Clin. Gastroenterol.
, vol.24
, pp. 125-126
-
-
Kadayifci, A.1
Savas, M.C.2
Arslan, S.3
Gullu, I.H.4
-
151
-
-
26044465791
-
Vanishing bile duct syndrome: amoxicillin-clavulanic acid associated intra-hepatic cholestasis responsive to ursodeoxycholic acid
-
Smith, L. A., Ignacio, J. R., Winesett, M. P., Kaiser, G. C., Lacson, A. G., Gilbert-Barness, E., Gonzalez-Peralta, R. P. and Wilsey, Jr, M. J. (2005) Vanishing bile duct syndrome: amoxicillin-clavulanic acid associated intra-hepatic cholestasis responsive to ursodeoxycholic acid. J. Pediatr. Gastroenterol. Nutr. 41, 469-473
-
(2005)
J. Pediatr. Gastroenterol. Nutr.
, vol.41
, pp. 469-473
-
-
Smith, L.A.1
Ignacio, J.R.2
Winesett, M.P.3
Kaiser, G.C.4
Lacson, A.G.5
Gilbert-Barness, E.6
Gonzalez-Peralta, R.P.7
Wilsey Jr., M.J.8
-
152
-
-
2442680778
-
Ursodeoxycholic acid for terbinafine-induced toxic hepatitis
-
Agca, E., Akcay, A. and Simsek, H. (2004) Ursodeoxycholic acid for terbinafine-induced toxic hepatitis. Ann. Pharmacother. 38, 1088-1089
-
(2004)
Ann. Pharmacother.
, vol.38
, pp. 1088-1089
-
-
Agca, E.1
Akcay, A.2
Simsek, H.3
-
153
-
-
0031049399
-
Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis
-
Jacquemin, E., Hermans, D., Myara, A., Habes, D., Debray, D., Hadchouel, M., Sokal, E. M. and Bernard, O. (1997) Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis. Hepatology 25, 519-523
-
(1997)
Hepatology
, vol.25
, pp. 519-523
-
-
Jacquemin, E.1
Hermans, D.2
Myara, A.3
Habes, D.4
Debray, D.5
Hadchouel, M.6
Sokal, E.M.7
Bernard, O.8
-
155
-
-
0030730043
-
Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo
-
Palma, J., Reyes, H., Ribalta, J., Hernandez, I., Sandoval, L., Almuna, R., Liepins, J., Lira, F., Sedano, M., Silva, O. et al. (1997) Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J. Hepatol. 27, 1022-1028
-
(1997)
J. Hepatol.
, vol.27
, pp. 1022-1028
-
-
Palma, J.1
Reyes, H.2
Ribalta, J.3
Hernandez, I.4
Sandoval, L.5
Almuna, R.6
Liepins, J.7
Lira, F.8
Sedano, M.9
Silva, O.10
-
156
-
-
0030963906
-
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
-
Trauner, M., Arrese, M., Soroka, C. J., Ananthanarayanan, M., Koeppel, T. A., Schlosser, S. F., Suchy, F. J., Keppler, D. and Boyer, J. L. (1997) The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113, 255-264
-
(1997)
Gastroenterology
, vol.113
, pp. 255-264
-
-
Trauner, M.1
Arrese, M.2
Soroka, C.J.3
Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
-
157
-
-
0036667784
-
Effect of ursodeoxycholic acid on the expression of the hepatocellular bile acid transporters (Ntcp and bsep) in rats with estrogen-induced cholestasis
-
Micheline, D., Emmanuel, J. and Serge, E. (2002) Effect of ursodeoxycholic acid on the expression of the hepatocellular bile acid transporters (Ntcp and bsep) in rats with estrogen-induced cholestasis. J. Pediatr. Gastroenterol. Nutr. 35, 185-191
-
(2002)
J. Pediatr. Gastroenterol. Nutr.
, vol.35
, pp. 185-191
-
-
Micheline, D.1
Emmanuel, J.2
Serge, E.3
-
158
-
-
0033980287
-
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
-
Lee, J. M., Trauner, M., Soroka, C. J., Stieger, B., Meier, P. J. and Boyer, J. L. (2000) Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 118, 163-172
-
(2000)
Gastroenterology
, vol.118
, pp. 163-172
-
-
Lee, J.M.1
Trauner, M.2
Soroka, C.J.3
Stieger, B.4
Meier, P.J.5
Boyer, J.L.6
-
159
-
-
22344435453
-
Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat
-
Crocenzi, F. A., D'Andrea, V., Catania, V. A., Luquita, M. G., Pellegrino, J. M., Ochoa, J. E., Mottino, A. D. and Sanchez Pozzi, E. J. (2005) Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. Drug Metab. Dispos. 33, 888-891
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 888-891
-
-
Crocenzi, F.A.1
D'Andrea, V.2
Catania, V.A.3
Luquita, M.G.4
Pellegrino, J.M.5
Ochoa, J.E.6
Mottino, A.D.7
Sanchez Pozzi, E.J.8
-
160
-
-
33646785035
-
Galactosamine prevents ethinylestracliolinduced cholestasis
-
Crocenzi, F. A., Pellegrino, J. M., Catania, V. A., Luquita, M. G., Roma, M. G., Mottino, A. D. and Sãnchez Pozzi, E. J. (2006) Galactosamine prevents ethinylestracliolinduced cholestasis. Drug Metab. Dispos. 34, 993-997
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 993-997
-
-
Crocenzi, F.A.1
Pellegrino, J.M.2
Catania, V.A.3
Luquita, M.G.4
Roma, M.G.5
Mottino, A.D.6
Sãnchez Pozzi, E.J.7
-
161
-
-
14944361288
-
The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
-
Corpechot, C., Carrat, F., Bahr, A., Chretien, Y., Poupon, R. E. and Poupon, R. (2005) The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 128, 297-303
-
(2005)
Gastroenterology
, vol.128
, pp. 297-303
-
-
Corpechot, C.1
Carrat, F.2
Bahr, A.3
Chretien, Y.4
Poupon, R.E.5
Poupon, R.6
-
162
-
-
79959773908
-
Surgical outcome in relation to duct size at the porta hepatis and the use of cholagogues in patients with biliary atresia
-
Mohanty, M. K., Gupta, S. D. and Bhatnagar, V. (2010) Surgical outcome in relation to duct size at the porta hepatis and the use of cholagogues in patients with biliary atresia. Trop. Gastroenterol. 31, 184-189
-
(2010)
Trop. Gastroenterol.
, vol.31
, pp. 184-189
-
-
Mohanty, M.K.1
Gupta, S.D.2
Bhatnagar, V.3
-
163
-
-
68949136756
-
Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis
-
Glaser, S. S. and Alpini, G. (2009) Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis. Hepatology 49, 1795-1797
-
(2009)
Hepatology
, vol.49
, pp. 1795-1797
-
-
Glaser, S.S.1
Alpini, G.2
-
164
-
-
0023873690
-
Ursodeoxycholic acid choleresis: relationship to biliary HCO-3 and effects of Na+ -H+ exchange inhibitors
-
Renner, E. L., Lake, J. R., Cragoe, Jr, E. J., Van Dyke, R. W. and Scharschmidt, B. F. (1988) Ursodeoxycholic acid choleresis: relationship to biliary HCO-3 and effects of Na+ -H+ exchange inhibitors. Am. J. Physiol. 254, G232-G241
-
(1988)
Am. J. Physiol.
, vol.254
-
-
Renner, E.L.1
Lake, J.R.2
Cragoe Jr., E.J.3
Van Dyke, R.W.4
Scharschmidt, B.F.5
-
165
-
-
0024309202
-
The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man
-
Knyrim, K., Vakil, N., Pfab, R. and Classen, M. (1989) The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man. Hepatology 10, 134-142
-
(1989)
Hepatology
, vol.10
, pp. 134-142
-
-
Knyrim, K.1
Vakil, N.2
Pfab, R.3
Classen, M.4
-
166
-
-
0030012966
-
Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene
-
Van Nieuwkerk, C. M., Elferink, R. P., Groen, A. K., Ottenhoff, R., Tytgat, G. N., Dingemans, K. P., Van Den BerghWeerman, M. A. and Offerhaus, G. J. (1996) Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 111, 165-171
-
(1996)
Gastroenterology
, vol.111
, pp. 165-171
-
-
Van Nieuwkerk, C.M.1
Elferink, R.P.2
Groen, A.K.3
Ottenhoff, R.4
Tytgat, G.N.5
Dingemans, K.P.6
Van Den BerghWeerman, M.A.7
Offerhaus, G.J.8
-
167
-
-
32044467118
-
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
-
Fickert, P., Wagner, M., Marschall, H. U., Fuchsbichler, A., Zollner, G., Tsybrovskyy, O., Zatloukal, K., Liu, J., Waalkes, M. P., Cover, C. et al. (2006) 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 130, 465-481
-
(2006)
Gastroenterology
, vol.130
, pp. 465-481
-
-
Fickert, P.1
Wagner, M.2
Marschall, H.U.3
Fuchsbichler, A.4
Zollner, G.5
Tsybrovskyy, O.6
Zatloukal, K.7
Liu, J.8
Waalkes, M.P.9
Cover, C.10
-
168
-
-
32044462778
-
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans
-
Hofmann, A. F., Zakko, S. F., Lira, M., Clerici, C., Hagey, L. R., Lambert, K. K., Steinbach, J. H., Schteingart, C. D., Olinga, P. and Groothuis, G. M. (2005) Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology 42, 1391-1398
-
(2005)
Hepatology
, vol.42
, pp. 1391-1398
-
-
Hofmann, A.F.1
Zakko, S.F.2
Lira, M.3
Clerici, C.4
Hagey, L.R.5
Lambert, K.K.6
Steinbach, J.H.7
Schteingart, C.D.8
Olinga, P.9
Groothuis, G.M.10
-
169
-
-
77951571805
-
The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects
-
vit-Spraul, A., Gonzales, E., Baussan, C. and Jacquemin, E. (2010) The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. Semin. Liver Dis. 30, 134-146
-
(2010)
Semin. Liver Dis.
, vol.30
, pp. 134-146
-
-
vit-Spraul, A.1
Gonzales, E.2
Baussan, C.3
Jacquemin, E.4
-
170
-
-
0028362860
-
Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage
-
Puglielli, L., Amigo, L., Arrese, M., Nunez, L., Rigotti, A., Garrido, J., Gonzalez, S., Mingrone, G., Greco, A. V., Accatino, L. et al. (1994) Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage. Gastroenterology 107, 244-254
-
(1994)
Gastroenterology
, vol.107
, pp. 244-254
-
-
Puglielli, L.1
Amigo, L.2
Arrese, M.3
Nunez, L.4
Rigotti, A.5
Garrido, J.6
Gonzalez, S.7
Mingrone, G.8
Greco, A.V.9
Accatino, L.10
-
171
-
-
0033033458
-
Assessment of biliary bicarbonate secretion in humans by positron emission tomography
-
Prieto, J., Garcia, N., Marti-Climent, J. M., Penuelas, I., Richter, J. A. and Medina, J. F. (1999) Assessment of biliary bicarbonate secretion in humans by positron emission tomography. Gastroenterology 117, 167-172
-
(1999)
Gastroenterology
, vol.117
, pp. 167-172
-
-
Prieto, J.1
Garcia, N.2
Marti-Climent, J.M.3
Penuelas, I.4
Richter, J.A.5
Medina, J.F.6
-
172
-
-
77958092715
-
Cystic fibrosis-associated liver disease
-
Herrmann, U., Dockter, G. and Lammert, F. (2010) Cystic fibrosis-associated liver disease. Best Pract. Res. Clin. Gastroenterol. 24, 585-592
-
(2010)
Best Pract. Res. Clin. Gastroenterol.
, vol.24
, pp. 585-592
-
-
Herrmann, U.1
Dockter, G.2
Lammert, F.3
-
173
-
-
0027325467
-
Abnormal expression of anion exchanger genes in primary biliary cirrhosis
-
Prieto, J., Qian, C., Garcia, N., Diez, J. and Medina, J. F. (1993) Abnormal expression of anion exchanger genes in primary biliary cirrhosis. Gastroenterology 105, 572-578
-
(1993)
Gastroenterology
, vol.105
, pp. 572-578
-
-
Prieto, J.1
Qian, C.2
Garcia, N.3
Diez, J.4
Medina, J.F.5
-
174
-
-
38849104576
-
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
-
Arenas, F., Hervias, I., Uriz, M., Joplin, R., Prieto, J. and Medina, J. F. (2008) Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J. Clin. Invest. 118, 695-709
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 695-709
-
-
Arenas, F.1
Hervias, I.2
Uriz, M.3
Joplin, R.4
Prieto, J.5
Medina, J.F.6
-
175
-
-
0035881821
-
Stimulation of ATP secretion in the liver by therapeutic bile acids
-
Nathanson, M. H., Burgstahler, A. D., Masyuk, A. and LaRusso, N. F. (2001) Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochem. J. 358, 1-5
-
(2001)
Biochem. J.
, vol.358
, pp. 1-5
-
-
Nathanson, M.H.1
Burgstahler, A.D.2
Masyuk, A.3
LaRusso, N.F.4
-
176
-
-
35648934624
-
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion
-
Fiorotto, R., Spirli, C., Fabris, L., Cadamuro, M., Okolicsanyi, L. and Strazzabosco, M. (2007) Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion. Gastroenterology 133, 1603-1613
-
(2007)
Gastroenterology
, vol.133
, pp. 1603-1613
-
-
Fiorotto, R.1
Spirli, C.2
Fabris, L.3
Cadamuro, M.4
Okolicsanyi, L.5
Strazzabosco, M.6
-
177
-
-
0036238347
-
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKCα
-
Alpini, G., Baiocchi, L., Glaser, S., Ueno, Y., Marzioni, M., Francis, H., Phinizy, J. L., Angelico, M. and Lesage, G. (2002) Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKCα. Hepatology 35, 1041-1052
-
(2002)
Hepatology
, vol.35
, pp. 1041-1052
-
-
Alpini, G.1
Baiocchi, L.2
Glaser, S.3
Ueno, Y.4
Marzioni, M.5
Francis, H.6
Phinizy, J.L.7
Angelico, M.8
Lesage, G.9
-
178
-
-
0036614376
-
Altered localization and activity of canalicular Mrp2 in estradiol-17β-d-glucuronide-induced cholestasis
-
Mottino, A. D., Cao, J., Veggi, L. M., Crocenzi, F. A., Roma, M. G. and Vore, M. (2002) Altered localization and activity of canalicular Mrp2 in estradiol-17β-d-glucuronide-induced cholestasis. Hepatology 35, 1409-1419
-
(2002)
Hepatology
, vol.35
, pp. 1409-1419
-
-
Mottino, A.D.1
Cao, J.2
Veggi, L.M.3
Crocenzi, F.A.4
Roma, M.G.5
Vore, M.6
-
179
-
-
0141630543
-
Biliary secretion of glutathione in estradiol 17β-d-glucuronide-induced cholestasis
-
Mottino, A. D., Veggi, L. M., Wood, M., Roman, J. M. and Vore, M. (2003) Biliary secretion of glutathione in estradiol 17β-d-glucuronide-induced cholestasis. J. Pharmacol. Exp. Ther. 307, 306-313
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.307
, pp. 306-313
-
-
Mottino, A.D.1
Veggi, L.M.2
Wood, M.3
Roman, J.M.4
Vore, M.5
-
180
-
-
0037483657
-
Impaired localisation and transport function of canalicular Bsep in taurolithocholate-induced cholestasis in the rat
-
Crocenzi, F. A., Mottino, A. D., Sanchez Pozzi, E. J., Pellegrino, J. M., Rodríguez Garay, E. A., Milkiewicz, P., Vore, M., Coleman, R. and Roma, M. G. (2003) Impaired localisation and transport function of canalicular Bsep in taurolithocholate-induced cholestasis in the rat. Gut 52, 1170-1177
-
(2003)
Gut
, vol.52
, pp. 1170-1177
-
-
Crocenzi, F.A.1
Mottino, A.D.2
Sanchez Pozzi, E.J.3
Pellegrino, J.M.4
Rodríguez Garay, E.A.5
Milkiewicz, P.6
Vore, M.7
Coleman, R.8
Roma, M.G.9
-
181
-
-
17544372167
-
Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
-
Paulusma, C. C., Kothe, M. J., Bakker, C. T., Bosma, P. J., van, B., I, van Marle, J., Bolder, U., Tytgat, G. N. and Oude Elferink, R. P. (2000) Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. Hepatology 31, 684-693
-
(2000)
Hepatology
, vol.31
, pp. 684-693
-
-
Paulusma, C.C.1
Kothe, M.J.2
Bakker, C.T.3
Bosma, P.J.4
van, B.I.5
van Marle, J.6
Bolder, U.7
Tytgat, G.N.8
Oude Elferink, R.P.9
-
182
-
-
0035668415
-
The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function
-
Shoda, J., Kano, M., Oda, K., Kamiya, J., Nimura, Y., Suzuki, H., Sugiyama, Y., Miyazaki, H., Todoroki, T., Stengelin, S. et al. (2001) The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. Am. J. Gastroenterol. 96, 3368-3378
-
(2001)
Am. J. Gastroenterol.
, vol.96
, pp. 3368-3378
-
-
Shoda, J.1
Kano, M.2
Oda, K.3
Kamiya, J.4
Nimura, Y.5
Suzuki, H.6
Sugiyama, Y.7
Miyazaki, H.8
Todoroki, T.9
Stengelin, S.10
-
183
-
-
38549116688
-
Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases
-
Kojima, H., Sakurai, S., Uemura, M., Kitamura, K., Kanno, H., Nakai, Y. and Fukui, H. (2008) Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. J. Gastroenterol. Hepatol. 23, e120-e128
-
(2008)
J. Gastroenterol. Hepatol.
, vol.23
-
-
Kojima, H.1
Sakurai, S.2
Uemura, M.3
Kitamura, K.4
Kanno, H.5
Nakai, Y.6
Fukui, H.7
-
184
-
-
33746537974
-
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy
-
Keitel, V., Vogt, C., Haussinger, D. and Kubitz, R. (2006) Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology 131, 624-629
-
(2006)
Gastroenterology
, vol.131
, pp. 624-629
-
-
Keitel, V.1
Vogt, C.2
Haussinger, D.3
Kubitz, R.4
-
185
-
-
0242690430
-
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
-
Kojima, H., Nies, A. T., Konig, J., Hagmann, W., Spring, H., Uemura, M., Fukui, H. and Keppler, D. (2003) Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J. Hepatol. 39, 693-702
-
(2003)
J. Hepatol.
, vol.39
, pp. 693-702
-
-
Kojima, H.1
Nies, A.T.2
Konig, J.3
Hagmann, W.4
Spring, H.5
Uemura, M.6
Fukui, H.7
Keppler, D.8
-
186
-
-
34347349034
-
Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis
-
Watanabe, N., Takashimizu, S., Kojima, S., Kagawa, T., Nishizaki, Y., Mine, T. and Matsuzaki, S. (2007) Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis. Hepatol. Res. 37, 598-607
-
(2007)
Hepatol. Res.
, vol.37
, pp. 598-607
-
-
Watanabe, N.1
Takashimizu, S.2
Kojima, S.3
Kagawa, T.4
Nishizaki, Y.5
Mine, T.6
Matsuzaki, S.7
-
188
-
-
0030829597
-
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
-
Schliess, F., Kurz, A. K., vom, D. S. and Haussinger, D. (1997) Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 113, 1306-1314
-
(1997)
Gastroenterology
, vol.113
, pp. 1306-1314
-
-
Schliess, F.1
Kurz, A.K.2
vom, D.S.3
Haussinger, D.4
-
189
-
-
3042594002
-
Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
-
Haussinger, D., Kurz, A. K., Wettstein, M., Graf, D., vom, D. S. and Schliess, F. (2003) Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. Gastroenterology 124, 1476-1487
-
(2003)
Gastroenterology
, vol.124
, pp. 1476-1487
-
-
Haussinger, D.1
Kurz, A.K.2
Wettstein, M.3
Graf, D.4
vom, D.S.5
Schliess, F.6
-
190
-
-
0034663645
-
Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver
-
Kurz, A. K., Block, C., Graf, D., Dahl, S. V., Schliess, F. and Haussinger, D. (2000) Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. Biochem. J. 350, 207-213
-
(2000)
Biochem. J.
, vol.350
, pp. 207-213
-
-
Kurz, A.K.1
Block, C.2
Graf, D.3
Dahl, S.V.4
Schliess, F.5
Haussinger, D.6
-
191
-
-
0842299393
-
Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase
-
Kubitz, R., Sutfels, G., Kuhlkamp, T., Kolling, R. and Haussinger, D. (2004) Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 126, 541-553
-
(2004)
Gastroenterology
, vol.126
, pp. 541-553
-
-
Kubitz, R.1
Sutfels, G.2
Kuhlkamp, T.3
Kolling, R.4
Haussinger, D.5
-
192
-
-
30944462200
-
Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
-
Dombrowski, F., Stieger, B. and Beuers, U. (2006) Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab. Invest. 86, 166-174
-
(2006)
Lab. Invest.
, vol.86
, pp. 166-174
-
-
Dombrowski, F.1
Stieger, B.2
Beuers, U.3
-
193
-
-
0035038177
-
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
-
Beuers, U., Bilzer, M., Chittattu, A., Kullak-Ublick, G. A., Keppler, D., Paumgartner, G. and Dombrowski, F. (2001) Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33, 1206-1216
-
(2001)
Hepatology
, vol.33
, pp. 1206-1216
-
-
Beuers, U.1
Bilzer, M.2
Chittattu, A.3
Kullak-Ublick, G.A.4
Keppler, D.5
Paumgartner, G.6
Dombrowski, F.7
-
194
-
-
44649169780
-
Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver
-
Denk, G. U., Hohenester, S., Wimmer, R., Bohland, C., Rust, C. and Beuers, U. (2008) Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver. Hepatol. Res. 38, 717-726
-
(2008)
Hepatol. Res.
, vol.38
, pp. 717-726
-
-
Denk, G.U.1
Hohenester, S.2
Wimmer, R.3
Bohland, C.4
Rust, C.5
Beuers, U.6
-
195
-
-
52649131370
-
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKCα-/PKA-dependent mechanism in rat liver
-
Wimmer, R., Hohenester, S., Pusl, T., Denk, G. U., Rust, C. and Beuers, U. (2008) Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKCα-/PKA-dependent mechanism in rat liver. Gut 57, 1448-1454
-
(2008)
Gut
, vol.57
, pp. 1448-1454
-
-
Wimmer, R.1
Hohenester, S.2
Pusl, T.3
Denk, G.U.4
Rust, C.5
Beuers, U.6
-
196
-
-
0023896588
-
Increased expression of major histocompatibility antigens in the liver as a result of cholestasis
-
Innes, G. K., Nagafuchi, Y., Fuller, B. J. and Hobbs, K. E. (1988) Increased expression of major histocompatibility antigens in the liver as a result of cholestasis. Transplantation 45, 749-752
-
(1988)
Transplantation
, vol.45
, pp. 749-752
-
-
Innes, G.K.1
Nagafuchi, Y.2
Fuller, B.J.3
Hobbs, K.E.4
-
197
-
-
0021219387
-
Aberrant expression of HLA-DR antigens on bile duct epithelium in primary biliary cirrhosis: relevance to pathogenesis
-
Ballardini, G., Mirakian, R., Bianchi, F. B., Pisi, E., Doniach, D. and Bottazzo, G. F. (1984) Aberrant expression of HLA-DR antigens on bile duct epithelium in primary biliary cirrhosis: relevance to pathogenesis. Lancet ii, 1009-1013
-
(1984)
Lancet ii
, pp. 1009-1013
-
-
Ballardini, G.1
Mirakian, R.2
Bianchi, F.B.3
Pisi, E.4
Doniach, D.5
Bottazzo, G.F.6
-
198
-
-
0027932658
-
Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
-
Hillaire, S., Boucher, E., Calmus, Y., Gane, P., Ballet, F., Franco, D., Moukthar, M. and Poupon, R. (1994) Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 107, 781-788
-
(1994)
Gastroenterology
, vol.107
, pp. 781-788
-
-
Hillaire, S.1
Boucher, E.2
Calmus, Y.3
Gane, P.4
Ballet, F.5
Franco, D.6
Moukthar, M.7
Poupon, R.8
-
199
-
-
0033658752
-
The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis
-
Corpechot, C., Carrat, F., Bonnand, A. M., Poupon, R. E. and Poupon, R. (2000) The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 32, 1196-1199
-
(2000)
Hepatology
, vol.32
, pp. 1196-1199
-
-
Corpechot, C.1
Carrat, F.2
Bonnand, A.M.3
Poupon, R.E.4
Poupon, R.5
-
200
-
-
33846272384
-
Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation
-
Tay, J., Tinmouth, A., Fergusson, D., Huebsch, L. and Allan, D. S. (2007) Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 13, 206-217
-
(2007)
Biol. Blood Marrow Transplant.
, vol.13
, pp. 206-217
-
-
Tay, J.1
Tinmouth, A.2
Fergusson, D.3
Huebsch, L.4
Allan, D.S.5
-
201
-
-
12644250099
-
A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection
-
Barnes, D., Talenti, D., Cammell, G., Goormastic, M., Farquhar, L., Henderson, M., Vogt, D., Mayes, J., Westveer, M. K. and Carey, W. (1997) A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection. Hepatology 26, 853-857
-
(1997)
Hepatology
, vol.26
, pp. 853-857
-
-
Barnes, D.1
Talenti, D.2
Cammell, G.3
Goormastic, M.4
Farquhar, L.5
Henderson, M.6
Vogt, D.7
Mayes, J.8
Westveer, M.K.9
Carey, W.10
-
202
-
-
0028815893
-
Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis
-
Martinez, O. M., Villanueva, J. C., Gershwin, M. E. and Krams, S. M. (1995) Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 21, 113-119
-
(1995)
Hepatology
, vol.21
, pp. 113-119
-
-
Martinez, O.M.1
Villanueva, J.C.2
Gershwin, M.E.3
Krams, S.M.4
-
203
-
-
0026657890
-
Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-α production by monocytes
-
Calmus, Y., Guechot, J., Podevin, P., Bonnefis, M. T., Giboudeau, J. and Poupon, R. (1992) Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-α production by monocytes. Hepatology 16, 719-723
-
(1992)
Hepatology
, vol.16
, pp. 719-723
-
-
Calmus, Y.1
Guechot, J.2
Podevin, P.3
Bonnefis, M.T.4
Giboudeau, J.5
Poupon, R.6
-
204
-
-
0026642157
-
Immunomodulatory effects of ursodeoxycholic acid on immune responses
-
Yoshikawa, M., Tsujii, T., Matsumura, K., Yamao, J., Matsumura, Y., Kubo, R., Fukui, H. and Ishizaka, S. (1992) Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 16, 358-364
-
(1992)
Hepatology
, vol.16
, pp. 358-364
-
-
Yoshikawa, M.1
Tsujii, T.2
Matsumura, K.3
Yamao, J.4
Matsumura, Y.5
Kubo, R.6
Fukui, H.7
Ishizaka, S.8
-
205
-
-
0027221534
-
The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells
-
Lacaille, F. and Paradis, K. (1993) The immunos-uppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 18, 165-172
-
(1993)
Hepatology
, vol.18
, pp. 165-172
-
-
Lacaille, F.1
Paradis, K.2
-
206
-
-
0037532351
-
Tumor necrosis factor-α and interferon-γ directly impair epithelial barrier function in cultured mouse cholangiocytes
-
Hanada, S., Harada, M., Koga, H., Kawaguchi, T., Taniguchi, E., Kumashiro, R., Ueno, T., Ueno, Y., Ishii, M., Sakisaka, S. and Sata, M. (2003) Tumor necrosis factor-α and interferon-γ directly impair epithelial barrier function in cultured mouse cholangiocytes. Liver Int. 23, 3-11
-
(2003)
Liver Int
, vol.23
, pp. 3-11
-
-
Hanada, S.1
Harada, M.2
Koga, H.3
Kawaguchi, T.4
Taniguchi, E.5
Kumashiro, R.6
Ueno, T.7
Ueno, Y.8
Ishii, M.9
Sakisaka, S.10
Sata, M.11
-
207
-
-
0021277952
-
Impairment of human lymphocyte function by bile salts
-
Keane, R. M., Gadacz, T. R., Munster, A. M., Birmingham, W. and Winchurch, R. A. (1984) Impairment of human lymphocyte function by bile salts. Surgery 95, 439-443
-
(1984)
Surgery
, vol.95
, pp. 439-443
-
-
Keane, R.M.1
Gadacz, T.R.2
Munster, A.M.3
Birmingham, W.4
Winchurch, R.A.5
-
208
-
-
0030947259
-
Bile acids with differing hydrophilic-hydrophobic properties do not influence cytokine production by human monocytes and murine Kupffer cells
-
Bergamini, A., Dini, L., Baiocchi, L., Cappannoli, L., Falasca, L., Bolacchi, F., Capozzi, M., Faggioli, E., Nistri, A., Salanitro, A. et al. (1997) Bile acids with differing hydrophilic-hydrophobic properties do not influence cytokine production by human monocytes and murine Kupffer cells. Hepatology 25, 927-933
-
(1997)
Hepatology
, vol.25
, pp. 927-933
-
-
Bergamini, A.1
Dini, L.2
Baiocchi, L.3
Cappannoli, L.4
Falasca, L.5
Bolacchi, F.6
Capozzi, M.7
Faggioli, E.8
Nistri, A.9
Salanitro, A.10
-
209
-
-
0036226760
-
Tumor necrosis factor-α and transforming growth factor-β reflect severity of liver damage in primary biliary cirrhosis
-
Neuman, M., Angulo, P., Malkiewicz, I., Jorgensen, R., Shear, N., Dickson, E. R., Haber, J., Katz, G. and Lindor, K. (2002) Tumor necrosis factor-α and transforming growth factor-β reflect severity of liver damage in primary biliary cirrhosis. J. Gastroenterol. Hepatol. 17, 196-202
-
(2002)
J. Gastroenterol. Hepatol.
, vol.17
, pp. 196-202
-
-
Neuman, M.1
Angulo, P.2
Malkiewicz, I.3
Jorgensen, R.4
Shear, N.5
Dickson, E.R.6
Haber, J.7
Katz, G.8
Lindor, K.9
-
210
-
-
36549034307
-
Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production
-
Ishizaki, K., Iwaki, T., Kinoshita, S., Koyama, M., Fukunari, A., Tanaka, H., Tsurufuji, M., Sakata, K., Maeda, Y., Imada, T. and Chiba, K. (2008) Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production. Eur. J. Pharmacol. 578, 57-64
-
(2008)
Eur. J. Pharmacol.
, vol.578
, pp. 57-64
-
-
Ishizaki, K.1
Iwaki, T.2
Kinoshita, S.3
Koyama, M.4
Fukunari, A.5
Tanaka, H.6
Tsurufuji, M.7
Sakata, K.8
Maeda, Y.9
Imada, T.10
Chiba, K.11
-
211
-
-
34548454884
-
Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin
-
Fernandes, A., Vaz, A. R., Falcao, A. S., Silva, R. F., Brito, M. A. and Brites, D. (2007) Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin. J. Neuropathol. Exp. Neurol. 66, 789-798
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 789-798
-
-
Fernandes, A.1
Vaz, A.R.2
Falcao, A.S.3
Silva, R.F.4
Brito, M.A.5
Brites, D.6
-
212
-
-
0032908642
-
Does ursodeoxycholic acid mediate immunomodulatory and anti-inflammatory effects in patients with primary sclerosing cholangitis? Eur
-
van Milligen de Wit, A. W., Kuiper, H., Camoglio, L., van Bracht, J., Jones, E. A., Tytgat, G. N. and van Deventer, S. J. (1999) Does ursodeoxycholic acid mediate immunomodulatory and anti-inflammatory effects in patients with primary sclerosing cholangitis? Eur. J. Gastroenterol. Hepatol. 11, 129-136
-
(1999)
J. Gastroenterol. Hepatol.
, vol.11
, pp. 129-136
-
-
van Milligen de Wit, A.W.1
Kuiper, H.2
Camoglio, L.3
van Bracht, J.4
Jones, E.A.5
Tytgat, G.N.6
van Deventer, S.J.7
-
213
-
-
79958847483
-
NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells
-
Crescenzi, E., Pacifico, F., Lavorgna, A., De Palma, R., D'Aiuto, E., Palumbo, G., Formisano, S. and Leonardi, A. (2011) NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells. Oncogene 30, 2707-2717
-
(2011)
Oncogene
, vol.30
, pp. 2707-2717
-
-
Crescenzi, E.1
Pacifico, F.2
Lavorgna, A.3
De Palma, R.4
D'Aiuto, E.5
Palumbo, G.6
Formisano, S.7
Leonardi, A.8
-
214
-
-
30444446498
-
Ursodeoxycholic acid inhibits interleukin 1 β and deoxycholic acid-induced activation of NF-κB and AP-1 in human colon cancer cells
-
Shah, S. A., Volkov, Y., Arfin, Q., bdel-Latif, M. M. and Kelleher, D. (2006) Ursodeoxycholic acid inhibits interleukin 1 β and deoxycholic acid-induced activation of NF-κB and AP-1 in human colon cancer cells. Int. J. Cancer 118, 532-539
-
(2006)
Int. J. Cancer
, vol.118
, pp. 532-539
-
-
Shah, S.A.1
Volkov, Y.2
Arfin, Q.3
bdel-Latif, M.M.4
Kelleher, D.5
-
215
-
-
16644371986
-
Potential role of ursodeoxycholic acid in suppression of nuclear factor κB in microglial cell line (BV-2)
-
Joo, S. S., Won, T. J. and Lee, D. I. (2004) Potential role of ursodeoxycholic acid in suppression of nuclear factor κB in microglial cell line (BV-2). Arch. Pharm. Res. 27, 954-960
-
(2004)
Arch. Pharm. Res.
, vol.27
, pp. 954-960
-
-
Joo, S.S.1
Won, T.J.2
Lee, D.I.3
-
216
-
-
77958458317
-
Ursodeoxycholic acid and chemoprevention of colorectal cancer
-
Serfaty, L., Bissonnette, M. and Poupon, R. (2010) Ursodeoxycholic acid and chemoprevention of colorectal cancer. Gastroenterol. Clin. Biol. 34, 516-522
-
(2010)
Gastroenterol. Clin. Biol.
, vol.34
, pp. 516-522
-
-
Serfaty, L.1
Bissonnette, M.2
Poupon, R.3
-
217
-
-
0026503561
-
Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat
-
Poo, J. L., Feldmann, G., Erlinger, S., Braillon, A., Gaudin, C., Dumont, M. and Lebrec, D. (1992) Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology 102, 1752-1759
-
(1992)
Gastroenterology
, vol.102
, pp. 1752-1759
-
-
Poo, J.L.1
Feldmann, G.2
Erlinger, S.3
Braillon, A.4
Gaudin, C.5
Dumont, M.6
Lebrec, D.7
-
218
-
-
0025098908
-
Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid
-
Calmus, Y., Gane, P., Rouger, P. and Poupon, R. (1990) Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 11, 12-15
-
(1990)
Hepatology
, vol.11
, pp. 12-15
-
-
Calmus, Y.1
Gane, P.2
Rouger, P.3
Poupon, R.4
-
219
-
-
0026054966
-
Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy
-
Terasaki, S., Nakanuma, Y., Ogino, H., Unoura, M. and Kobayashi, K. (1991) Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy. Am. J. Gastroenterol. 86, 1194-1199
-
(1991)
Am. J. Gastroenterol.
, vol.86
, pp. 1194-1199
-
-
Terasaki, S.1
Nakanuma, Y.2
Ogino, H.3
Unoura, M.4
Kobayashi, K.5
-
220
-
-
0026485634
-
Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor
-
Tanaka, H. and Makino, I. (1992) Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 188, 942-948
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.188
, pp. 942-948
-
-
Tanaka, H.1
Makino, I.2
-
221
-
-
0027509817
-
Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein
-
Celada, A., McKercher, S. and Maki, R. A. (1993) Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein. J. Exp. Med. 177, 691-698
-
(1993)
J. Exp. Med.
, vol.177
, pp. 691-698
-
-
Celada, A.1
McKercher, S.2
Maki, R.A.3
-
222
-
-
0030043423
-
Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid Repression of IFN-γ -induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway
-
Tanaka, H., Makino, Y., Miura, T., Hirano, F., Okamoto, K., Komura, K., Sato, Y. and Makino, I. (1996) Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-γ -induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway. J. Immunol. 156, 1601-1608
-
(1996)
J. Immunol.
, vol.156
, pp. 1601-1608
-
-
Tanaka, H.1
Makino, Y.2
Miura, T.3
Hirano, F.4
Okamoto, K.5
Komura, K.6
Sato, Y.7
Makino, I.8
-
223
-
-
0029558670
-
Effects of chenodeoxycholic and ursodeoxycholic acids on interferon-γ production by peripheral blood mononuclear cells from patients with primary biliary cirrhosis
-
Saeki, R., Ogino, H., Kaneko, S., Unoura, M. and Kobayashi, K. (1995) Effects of chenodeoxycholic and ursodeoxycholic acids on interferon-γ production by peripheral blood mononuclear cells from patients with primary biliary cirrhosis. J. Gastroenterol. 30, 739-744
-
(1995)
J. Gastroenterol.
, vol.30
, pp. 739-744
-
-
Saeki, R.1
Ogino, H.2
Kaneko, S.3
Unoura, M.4
Kobayashi, K.5
-
224
-
-
1642504302
-
Ursodeoxycholic acid therapy attenuated expression of adhesion molecule in primary biliary cirrhosis
-
Yokomori, H., Oda, M., Wakabayashi, G., Kitajima, M. and Ishii, H. (2003) Ursodeoxycholic acid therapy attenuated expression of adhesion molecule in primary biliary cirrhosis. Intern. Med. 42, 1259-1261
-
(2003)
Intern. Med.
, vol.42
, pp. 1259-1261
-
-
Yokomori, H.1
Oda, M.2
Wakabayashi, G.3
Kitajima, M.4
Ishii, H.5
-
225
-
-
0005593109
-
Soluble intercellular adhesion molecule-1 in primary biliary cirrhosis: effect of ursodeoxycholic acid and immunosuppressive therapy
-
Lim, A. G., Wolfhagen, F. H., Verma, A., van Buuren, H. R., Jazrawi, R. P., Levy, J. H., Northfield, T. C. and Schalm, S.W. (1997) Soluble intercellular adhesion molecule-1 in primary biliary cirrhosis: effect of ursodeoxycholic acid and immunosuppressive therapy. Eur. J. Gastroenterol. Hepatol. 9, 155-161
-
(1997)
Eur. J. Gastroenterol. Hepatol.
, vol.9
, pp. 155-161
-
-
Lim, A.G.1
Wolfhagen, F.H.2
Verma, A.3
van Buuren, H.R.4
Jazrawi, R.P.5
Levy, J.H.6
Northfield, T.C.7
Schalm, S.W.8
|