Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation

Annals of Surgery

Volumn 252, Issue 1, 2010, Pages 50-56

  Le Roux, Carel W ^a   Borg, Cynthia ^b   Wallis, Katharina ^a   Vincent, Royce P ^a   Bueter, Marco ^c   Goodlad, Robert ^a   Ghatei, Mohammed A ^a   Patel, Ameet ^b   Bloom, Stephen R ^a   Aylwin, Simon J B ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; KI 67 ANTIGEN; PEPTIDE YY; PEPTIDE YY [3-36];

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CRYPT CELL; FEMALE; HUMAN; HYPERTROPHY; ILEUM; INTESTINE ADAPTATION; INTESTINE CELL; INTESTINE CRYPT; INTESTINE HYPERTROPHY; INTESTINE INJURY; MALABSORPTION; MALE; MITOSIS RATE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; ROUX Y ANASTOMOSIS; STOMACH BYPASS; WEIGHT REDUCTION; WISTAR RAT;

ADULT; ANIMALS; FEMALE; GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; HUMANS; ILEUM; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MITOSIS; RATS; RATS, WISTAR;

EID: 77954083189     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3181d3d21f     Document Type: Article

References (41)

1. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002;418:650-654.
2. Feltrin KL, Patterson M, Ghatei MA, et al. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides. 2006;27:1638-1643.
3. Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987;2:1300-1304.
4. Pilkington TR, Gazet JC, Ang L, et al. Explanations for weight loss after ileojejunal bypass in gross obesity. Br Med J. 1976;1:1504-1505.
5. Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004; 351:2683-2693.
6. Ugleholdt R, Zhu X, Deacon CF, et al. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology. 2004; 145:1349-1355.
7. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724-1737.
8. Skroubis G, Anesidis S, Kehagias I, et al. Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies. Obes Surg. 2006;16:488-495.
9. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab. 2004;89:2608-2615.
10. Stock-Damge C, Aprahamian M, Raul F, et al. Small-intestinal and colonic changes after biliopancreatic bypass for morbid obesity. Scand J Gastroen-terol. 1986;21:1115-1123.
11. Adrian TE, Savage AP, Bacarese-Hamilton AJ, et al. Peptide YY abnormalities in gastrointestinal diseases. Gastroenterology. 1986;90:379-384.
12. Besterman HS, Adrian TE, Mallinson CN, et al. Gut hormone release after intestinal resection. Gut. 1982;23:854-861.
13. Drucker DJ. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol. 2003;17:161-171.
14. Estall JL, Drucker DJ. Dual regulation of cell proliferation and survival via activation of glucagon-like peptide-2 receptor signaling. J Nutr. 2003;133: 3708-3711.
15. Jeppesen PB. Clinical significance of GLP-2 in short-bowel syndrome. J Nutr. 2003;133:3721-3724.
16. Martin GR, Wallace LE, Hartmann B, et al. Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2005;288:G431-G438.
17. Batterham RL, Heffron H, Kapoor S, et al. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 2006;4: 223-233.
18. le Roux CW, Batterham RL, Aylwin SJ, et al. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology. 2006; 147:3-8.
19. Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93:210-215.
20. Ogden J, Clementi C, Aylwin S, et al. Exploring the impact of obesity surgery on patients' health status: a quantitative and qualitative study. Obes Surg. 2005;15:266-272.
21. Korner J, Bessler M, Cirilo LJ, et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab. 2005;90:359-365.
22. le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243:108-114.
23. Morinigo R, Moize V, Musri M, et al. Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab. 2006;91:1735-1740.
24. Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg. 2004;240:236-242.
25. Polyzogopoulou EV, Kalfarentzos F, Vagenakis AG, et al. Restoration of eug-lycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes. 2003;52:1098-1103.
26. Jackson RJ, Davis WB, Macdonald I. The energy values of carbohydrates: should bomb calorimeter data be modified? Proc Nutr Soc. 1977;36:90A.
27. Lonroth H, Dalenback J, Haglind E, et al. Laparoscopic gastric bypass: another option in bariatric surgery. Surg Endosc. 1996;10:636-638.
28. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med. 2003;349:941-948.
29. Savage AP, Adrian TE, Carolan G, et al. Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers. Gut. 1987;28:166-170.
30. Vage V, Solhaug JH, Berstad A, et al. Jejunoileal bypass in the treatment of morbid obesity: a 25-year follow-up study of 36 patients. Obes Surg. 2002; 12:312-318.
31. Murray ME, Franks G, Gazet J, et al. Radiologic Demonstration of small bowel adaptation following modified scopinaro procedure for morbid obesity. Obes Surg. 1993;3:165-168.
32. Nadreau E, Baraboi ED, Samson P, et al. Effects of the biliopancreatic diversion on energy balance in the rat. Int J Obes (Lond). 2006;30:419-429.
33. Evrard S, Aprahamian M, Hoeltzel A, et al. Trophic and enzymatic adaptation of the intestine to biliopancreatic bypass in the rat. Int J Obes Relat Metab Disord. 1993;17:541-547.
34. Greenway SE, Greenway FL III, Klein S. Effects of obesity surgery on non-insulin-dependent diabetes mellitus. Arch Surg. 2002;137:1109-1117.
35. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab. 2004;287:E199-E206.
36. Korner J, Inabnet W, Conwell IM, et al. Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels. Obesity (Silver Spring). 2006;14:1553-1561.
37. Foster-Schubert KE, Cummings DE. Emerging therapeutic strategies for obesity. Endocr Rev. 2006;27:779-793.
38. Alvarez BM, Borque M, Martinez-Sarmiento J, et al. Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty. Obes Surg. 2002;12:324-327.
39. le Roux CW, Welbourn R, Werling M, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg. 2007; 246:780-785.
40. Lakhani SV, Shah HN, Alexander K, et al. Small intestinal bacterial overgrowth and thiamine deficiency after Roux-en-Y gastric bypass surgery in obese patients. Nutr Res. 2008;28:293-298.
41. Sundbom M, Elphick DA, Mahida YR, et al. Alteration in human defensin-5 expression following gastric bypass surgery. J Clin Pathol. 2007;60:1029-1034.