The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 563-566

  Svensson, Per Arne ^a   Olsson, Maja ^a   Andersson Assarsson, Johanna C ^a   Taube, Magdalena ^a   Pereira, Maria J ^a,b   Froguel, Philippe ^c,d   Jacobson, Peter ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d CNRS   (France)

Author keywords

Gene expression; Human adipose tissue; Obesity; Resting metabolic rate; TGR5

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METABOLISM; OBESITY; PRIORITY JOURNAL; RESTING METABOLIC RATE; SUBCUTANEOUS FAT; WEIGHT REDUCTION;

ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ADULT; BASAL METABOLISM; BIOPSY, NEEDLE; BODY MASS INDEX; CALORIC RESTRICTION; CASE-CONTROL STUDIES; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ION CHANNELS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; OBESITY; RECEPTORS, G-PROTEIN-COUPLED; SUBCUTANEOUS FAT; THYROID GLAND; WEIGHT LOSS;

MUS;

EID: 84876486261     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.031     Document Type: Article

References (20)

1. Claudel T., Staels B., Kuipers F. The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2020-2030.
2. Maruyama T., Miyamoto Y., Nakamura T., Tamai Y., Okada H., Sugiyama E., Itadani H., Tanaka K. Identification of membrane-type receptor for bile acids (M-BAR). Biochem. Biophys. Res. Commun. 2002, 298:714-719.
3. Watanabe M., Houten S.M., Mataki C., Christoffolete M.A., Kim B.W., Sato H., Messaddeq N., Harney J.W., Ezaki O., Kodama T., Schoonjans K., Bianco A.C., Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006, 439:484-489.
4. Thomas C., Gioiello A., Noriega L., Strehle A., Oury J., Rizzo G., Macchiarulo A., Yamamoto H., Mataki C., Pruzanski M., Pellicciari R., Auwerx J., Schoonjans K. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009, 10:167-177.
5. Carlsson L.M., Jacobson P., Walley A., Froguel P., Sjöström L., Svensson P.A., Sjöholm K. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem. Biophys. Res. Commun. 2009, 382:309-314.
6. Nookaew I., Svensson P.A., Jacobson P., Jernås M., Taube M., Larsson I., Andersson-Assarsson J.C., Sjöström L., Froguel P., Walley A., Nielsen J., Carlsson L.M. Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men. J. Clin. Endocrinol. Metab. 2012, 98:E370-E378.
7. Saiki A., Olsson M., Jernås M., Gummesson A., McTernan P.G., Andersson J., Jacobson P., Sjöholm K., Olsson B., Yamamura S., Walley A., Froguel P., Carlsson B., Sjöström L., Svensson P.A., Carlsson L.M. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. J. Clin. Endocrinol. Metab. 2009, 94:3987-3994.
8. Magnusson B., Gummesson A., Glad C.A., Goedecke J.H., Jernås M., Lystig T.C., Carlsson B., Fagerberg B., Carlsson L.M., Svensson P.A. Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism. Metabolism 2008, 57:1307-1313.
9. Svensson P.A., Jernås M., Sjöholm K., Hoffmann J.M., Nilsson B.E., Hansson M., Carlsson L.M. Gene expression in human brown adipose tissue. Int. J. Mol. Med. 2011, 27:227-232.
10. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162:156-159.
11. Gabrielsson B.G., Olofsson L.E., Sjogren A., Jernås M., Elander A., Lönn M., Rudemo M., Carlsson L.M. Evaluation of reference genes for studies of gene expression in human adipose tissue. Obes. Res. 2005, 13:649-652.
12. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., Lempicki R.A. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 2003, 4:P3.
13. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4:44-57.
14. Zingaretti M.C., Crosta F., Vitali A., Guerrieri M., Frontini A., Cannon B., Nedergaard J., Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 2009, 23:3113-3120.
15. Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., Taittonen M., Laine J., Savisto N.J., Enerback S., Nuutila P. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 2009, 360:1518-1525.
16. Wu J., Bostrom P., Sparks L.M., Ye L., Choi J.H., Giang A.H., Khandekar M., Virtanen K.A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W.D., Hoeks J., Enerback S., Schrauwen P., Spiegelman B.M. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
17. Van Gaal L.F., Vansant G.A., De Leeuw I.H. Factors determining energy expenditure during very-low-calorie diets. Am. J. Clin. Nutr. 1992, 56:224S-229S.
18. Brufau G., Bahr M.J., Staels B., Claudel T., Ockenga J., Boker K.H., Murphy E.J., Prado K., Stellaard F., Manns M.P., Kuipers F., Tietge U.J. Plasma bile acids are not associated with energy metabolism in humans. Nutr. Metab. (Lond.) 2010, 7:73.
19. Hubert H.B., Feinleib M., McNamara P.M., Castelli W.P. Obesity as an independent risk factor for cardiovascular disease: a 26year follow-up of participants in the Framingham heart study. Circulation 1983, 67:968-977.
20. Pols T.W., Nomura M., Harach T., Lo Sasso G., Oosterveer M.H., Thomas C., Rizzo G., Gioiello A., Adorini L., Pellicciari R., Auwerx J., Schoonjans K. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab. 2011, 14:747-757.