Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia

Gut

Volumn 63, Issue 8, 2014, Pages 1238-1246

  Habegger, Kirk M ^a   Al Massadi, Omar ^a   Heppner, Kristy M ^a   Myronovych, Andriy ^b   Holland, Jenna ^a   Berger, Jose ^a   Yi, Chun Xia ^c   Gao, Yuanging ^a   Lehti, Maarit ^a   Ottaway, Nickki ^a   Amburgy, Sarah ^a   Raver, Christine ^a   Müller, Timo D ^c   Pfluger, Paul T ^c   Kohli, Rohit ^b   Perez Tilve, Diego ^a   Seeley, Randy J ^a   Tschöp, Matthias H ^c  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; FAT; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLYCEROL; LIPID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DUODENAL ENDOLUMINAL SLEEVE; DUODENUM; ENERGY BALANCE; FAT MASS; FOOD INTAKE; GASTRIC SLEEVE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HISTOLOGY; HYPERPLASIA; INTESTINE VILLUS; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; NONHUMAN; NUTRIENT LIMITATION; OBESITY; ORGAN GROWTH; PRIORITY JOURNAL; RAT;

BASIC SCIENCES; ENDOCRINE HORMONES; GASTROINTESTINAL ENDOCRINOLOGY; OBESITY; OBESITY SURGERY;

ANIMALS; BILE ACIDS AND SALTS; BLOOD GLUCOSE; BODY COMPOSITION; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DUODENUM; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; GLYCEROL; HOMEOSTASIS; ILEUM; INTESTINAL ABSORPTION; JEJUNUM; MALE; METABOLIC SYNDROME X; OBESITY; PROSTHESES AND IMPLANTS; RANDOM ALLOCATION; RATS; RATS, ZUCKER; TRIGLYCERIDES;

EID: 84904044265     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-304583     Document Type: Article

References (28)

1. Piya MK, Tahrani AA, Barnett AH. Emerging treatment options for type 2 diabetes. Br J Clin Pharmacol 2010.
2. Steinbrook R. Surgery for severe obesity. N Engl J Med 2004;350:1075-9. (Pubitemid 38298986)
3. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta- Analysis. Am J Med 2009;122:248-56.
4. Wickremesekera K, Miller G, Naotunne TD, et al. Loss of insulin resistance after Roux-en-Y gastric bypass surgery: A time course study. Obes Surg 2005;15:474-81. (Pubitemid 40605068)
5. Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 2004;240:236-42. (Pubitemid 38963013)
6. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004;89:2608-15. (Pubitemid 38766339)
7. Jacobsen SH, Olesen SC, Dirksen C, et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes Surg 2012;22:1084-96.
8. Korner J, Bessler M, Cirilo LJ, et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 2005;90:359-65. (Pubitemid 40116682)
9. Laferrere B, Teixeira J, McGinty J, et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 2008;93:2479-85. (Pubitemid 352008510)
10. Patti ME, Houten SM, Bianco AC, et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) 2009;17:1671-7.
11. Nakatani H, Kasama K, Oshiro T, et al. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism 2009;58:1400-7.
12. Li JV, Ashrafian H, Bueter M, et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross- Talk. Gut 2011;60:1214-23.
13. Cohen RV, Schiavon CA, Pinheiro JS, et al. Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22-34 kg/m2: A report of 2 cases. Surg Obes Relat Dis 2007;3:195-7. (Pubitemid 46444706)
14. Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg 2006;244:741-9. (Pubitemid 44629948)
15. Speck M, Cho YM, Asadi A, et al. Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab 2011;300: 923-32.
16. Aguirre V, Stylopoulos N, Grinbaum R, et al. An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity. Obesity (Silver Spring) 2008;16:2585-92.
17. Rodriguez-Grunert L, Galvao Neto MP, Alamo M, et al. First human experience with endoscopically delivered and retrieved duodenal-jejunal bypass sleeve. Surg Obes Relat Dis 2008;4:55-9.
18. Tarnoff M, Shikora S, Lembo A, et al. Chronic in-vivo experience with an endoscopically delivered and retrieved duodenal-jejunal bypass sleeve in a porcine model. Surg Endosc 2008;22:1023-8.
19. Lam TK. Neuronal regulation of homeostasis by nutrient sensing. Nat Med 2010;16:392-5.
20. Breen DM, Rasmussen BA, Kokorovic A, et al. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med 2012;18:950-5.
21. Reidelberger RD, Kalogeris TJ, Leung PM, et al. Postgastric satiety in the sham-feeding rat. Am J Physiol 1983;244:872-81.
22. Kohli R, Kirby M, Setchell KD, et al. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol 2010;299:652-60.
23. Saeidi N, Meoli L, Nestoridi E, et al. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science 2013;341:406-10.
24. Dixon JB, le Roux CW, Rubino F, et al. Bariatric surgery for type 2 diabetes. Lancet 2012;379:2300-11.
25. Chambers AP, Jessen L, Ryan KK, et al. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology 2011;141:950-8.
26. Barretti DL, Magalhaes FdeC, Fernandes T, et al. Effects of aerobic exercise training on cardiac renin- Angiotensin system in an obese Zucker rat strain. PLoS One 2012;7:46114.
27. Simonen M, Dali-Youcef N, Kaminska D, et al. Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass. Obes Surg 2012;22:1473-80.
28. Stearns AT, Balakrishnan A, Tavakkolizadeh A. Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport. Am J Physiol Gastrointest Liver Physiol 2009;297:950-7.