Activation of transmembrane bile acid receptor tgr5 modulates pancreatic islet - Cells to promote glucose homeostasis

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 6626-6640

  Kumar, Divya P ^a   Asgharpour, Amon ^b   Mirshahi, Faridoddin ^b   Park, So Hyun ^c   Liu, Sichen ^c   Imai, Yumi ^c   Nadler, Jerry L ^c   Grider, John R ^a   Murthy, Karnam S ^a   Sanyal, Arun J ^b  

^a Internal Medicine   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BODY FLUIDS; CELL PROLIFERATION; CHEMICAL ACTIVATION; CROSSTALK; CYTOLOGY; GLUCOSE; INSULIN; MAMMALS; MEDICAL PROBLEMS; PHYSIOLOGY;

ELEMENT-BINDING PROTEINS; GLUCOSE HOMEOSTASIS; INSULIN SENSITIVITY; PANCREATIC BETA CELLS; PANCREATIC ISLET CELLS; PHYSIOLOGICAL ROLES; RECEPTOR ANTAGONISTS; TYPE 2 DIABETES MELLITUS;

CELLS;

ANTIDIABETIC AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; INT 777; MEMBRANE RECEPTOR; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROTEIN TGR5; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; 4,4,',4'',4'''-(CARBONYLBIS(IMINO-5,1,3-BENZENETRIYLBIS(CARBONYLIMINO)))TETRAKIS(BENZENE-1,3-DISULFONATE); 6ALPHA-ETHYL-23(S)-METHYLCHOLIC ACID; BENZENE DERIVATIVE; BENZENESULFONIC ACID DERIVATIVE; CHOLIC ACID DERIVATIVE; ESI-05; ESTRANE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, MOUSE; SULFONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; GLUCAGON RELEASE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WEIGHT GAIN; AGONISTS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; BENZENE DERIVATIVES; BENZENESULFONATES; CELL LINE; CHOLIC ACIDS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ESTRENES; GENE EXPRESSION REGULATION; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-SECRETING CELLS; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PARACRINE COMMUNICATION; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PYRROLIDINONES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SULFONES;

EID: 84964896040     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.699504     Document Type: Article

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