Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Nature Medicine

Volumn 18, Issue 6, 2012, Pages 950-955

  Breen, Danna M ^a,b   Rasmussen, Brittany A ^a,b   Kokorovic, Andrea ^a,b   Wang, Rennian ^c   Cheung, Grace W C ^a,b   Lam, Tony K T ^a,b,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; GLUCOSE; INSULIN; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BYPASS SURGERY; CONTROLLED STUDY; DIABETES MELLITUS; DUODENAL JEJUNAL BYPASS SURGERY; DUODENUM; FEEDING; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; NUTRIENT UPTAKE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SURGICAL TECHNIQUE;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DUODENUM; GASTRIC BYPASS; JEJUNUM; MALE; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

RATTUS;

EID: 84862017831     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2745     Document Type: Article

References (33)

1. Rubino, F., Schauer, P.R., Kaplan, L.M. & Cummings, D.E. Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu. Rev. Med. 61, 393-411 (2010).
2. Rubino, F. & Marescaux, J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann. Surg. 239, 1-11 (2004). (Pubitemid 38176365)
3. Wang, T.T. et al. Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann. Surg. 247, 968-975 (2008). (Pubitemid 351770417)
4. Pacheco, D. et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am. J. Surg. 194, 221-224 (2007). (Pubitemid 47008973)
5. Kindel, T.L., Yoder, S.M., Seeley, R.J., D'Alessio, D.A. & Tso, P. Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J. Gastrointest. Surg. 13, 1762-1772 (2009).
6. Drewe, J., Gadient, A., Rovati, L.C. & Beglinger, C. Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans. Gastroenterology 102, 1654-1659 (1992).
7. Ogawa, N. et al. The vagal afferent pathway does not play a major role in the induction of satiety by intestinal fatty acid in rats. Neurosci. Lett. 433, 38-42 (2008).
8. Cohen, R.V. et al. Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22-34 kg/m2: a report of 2 cases. Surg. Obes. Relat. Dis. 3, 195-197 (2007). (Pubitemid 46444706)
9. Cohen, R.V. et al. Glycemic control after stomach-sparing duodenal-jejunal bypass surgery in diabetic patients with low body mass index. Surg. Obes. Relat. Dis. published online, doi:10.1016/j.soard.2012.01.017 (2 February 2012).
10. Badman, M.K. & Flier, J.S. The gut and energy balance: visceral allies in the obesity wars. Science 307, 1909-1914 (2005). (Pubitemid 40404693)
11. Cummings, D.E. & Overduin, J. Gastrointestinal regulation of food intake. J. Clin. Invest. 117, 13-23 (2007). (Pubitemid 46048445)
12. Murphy, K.G. & Bloom, S.R. Gut hormones and the regulation of energy homeostasis. Nature 444, 854-859 (2006). (Pubitemid 46024992)
13. Coll, A.P., Farooqi, I.S. & O'Rahilly, S. The hormonal control of food intake. Cell 129, 251-262 (2007). (Pubitemid 46574977)
14. Lam, T.K. Neuronal regulation of homeostasis by nutrient sensing. Nat. Med. 16, 392-395 (2010).
15. Greenberg, D., Smith, G.P. & Gibbs, J. Intraduodenal infusions of fats elicit satiety in sham-feeding rats. Am. J. Physiol. 259, R110-R118 (1990). (Pubitemid 20246449)
16. Matzinger, D. et al. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 46, 688-693 (2000). (Pubitemid 30305787)
17. Wang, P.Y. et al. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 452, 1012-1016 (2008). (Pubitemid 351589616)
18. Cheung, G.W., Kokorovic, A., Lam, C.K., Chari, M. & Lam, T.K. Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab. 10, 99-109 (2009).
19. Lal, S., Kirkup, A.J., Brunsden, A.M., Thompson, D.G. & Grundy, D. Vagal afferent responses to fatty acids of different chain length in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G907-G915 (2001).
20. Randich, A. et al. Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R166-R173 (2004). (Pubitemid 38055906)
21. Ehrenkranz, J.R., Lewis, N.G., Kahn, C.R. & Roth, J. Phlorizin: a review. Diabetes Metab. Res. Rev. 21, 31-38 (2005).
22. Mordes, J.P., Bortell, R., Blankenhorn, E.P., Rossini, A.A. & Greiner, D.L. Rat models of type 1 diabetes: genetics, environment and autoimmunity. ILAR J. 45, 278-291 (2004).
23. Cohen, R., Pinheiro, J.S., Correa, J.L. & Schiavon, C.A. Laparoscopic Roux-en-Y gastric bypass for BMI (Pubitemid 43812096)
24. Kim, Z. & Hur, K.Y. Laparoscopic mini-gastric bypass for type 2 diabetes: the preliminary report. World J. Surg. 35, 631-636 (2011).
25. Thaler, J.P. & Cummings, D.E. Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology 150, 2518-2525 (2009).
26. Rubino, F. Is type 2 diabetes an operable intestinal disease? A provocative yet reasonable hypothesis. Diabetes Care 31 (suppl. 2), S290-S296 (2008).
27. Cox, J.E., Kelm, G.R., Meller, S.T., Spraggins, D.S. & Randich, A. Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions. Physiol. Behav. 81, 29-36 (2004). (Pubitemid 38430039)
28. Troy, S. et al. Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. Cell Metab. 8, 201-211 (2008).
29. Chambers, A.P. et al. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology 141, 950-958 (2011).
30. Patti, M.E. et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) 17, 1671-1677 (2009).
31. Watkins, J.B. III & Dykstra, T.P. Alterations in biliary excretory function by streptozotocin-induced diabetes. Drug Metab. Dispos. 15, 177-183 (1987). (Pubitemid 17056759)
32. Breen, D.M. et al. Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production. Diabetes 60, 3148-3153 (2011).
33. Kokorovic, A. et al. Duodenal mucosal protein kinase C-δ regulates glucose production in rats. Gastroenterology 141, 1720-1727 (2011).