Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 1, 2005, Pages 359-365

  Korner, Judith ^a   Bessler, Marc ^a   Cirilo, L J ^a   Conwell, Irene M ^a   Daud, Amna ^a   Restuccia, Nancy L ^a   Wardlaw, Sharon L ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LEPTIN; PEPTIDE YY;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; ROUX Y ANASTOMOSIS; STOMACH BYPASS; TEST MEAL; WEIGHT REDUCTION;

ADULT; ANASTOMOSIS, ROUX-EN-Y; APPETITE; BLOOD GLUCOSE; FASTING; FEMALE; GASTRIC BYPASS; HUMANS; INSULIN; LEPTIN; PAIN MEASUREMENT; PEPTIDE HORMONES; PEPTIDE YY; WEIGHT LOSS;

EID: 12244288887     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1076     Document Type: Article

References (48)

1. Brolin RE 2002 Bariatric surgery and long-term control of morbid obesity. JAMA 288:2793-2796
2. Steinbrook R 2004 Surgery for severe obesity. N Engl J Med 350:1075-1079
3. Näslund I 1987 Gastric bypass versus gastroplasty. A prospective study of differences in two surgical procedures for morbid obesity. Acta Chir Scand Suppl 536:1-60
4. MacLean LD, Rhode BM, Nohr CW 2001 Long- or short-limb gastric bypass? J Gastrointest Surg 5:525-530
5. Faraj M, Jones P, Sniderman AD, Cianflone K 2001 Enhanced dietary fat clearance in postobese women. J Lipid Res 42:571-580
6. Halmi KA, Mason E, Falk JR, Stunkard A 1981 Appetitive behavior after gastric bypass for obesity. Int J Obes 5:457-464
7. Rand CS, Macgregor AM, Hankins GC 1987 Eating behavior after gastric bypass surgery for obesity. South Med J 80:961-964
8. Cummings DE, Shannon MH 2003 Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss? J Clin Endocrinol Metab 88:2999-3002
9. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
10. Banks WA, Tschöp M, Robinson SM, Heiman ML 2002 Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822-827
11. Tschöp M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
12. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198
13. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992-5995
14. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
15. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
16. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S-I, Hosoda H, Kangawa K, Matsukura S 2002 Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87:240-244
17. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
18. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP 2002 Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 87:2984-2987
19. Leonetti F, Silecchia G, Iacobellis G, Ribaudo MC, Zappaterreno A, Tiberri C, Iannucci CV, Perrotta N, Bacci V, Basso MS, Basso N, Di Mario U 2003 Different plasma ghrelin levels after laparoscopic gastric bypass and adjustable gastric banding in morbid obese subjects. J Clin Endocrinol Metab 88:4227-4231
20. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster, KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS 2002 Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 8:643-644
21. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR 2002 Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654
22. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR 2003 Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349:941-948
23. Chen CH, Rogers RC 1997 Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus. Am J Physiol 273:R213-R218
24. Korner J, Leibel RL 2003 To eat or not to eat-how the gut talks to the brain. N Engl J Med 349:926-928
25. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL 1996 Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424-3427
26. Pöykkö SM, Kellokoski E, Hörkkö S, Kauma H, Kesäniemi YA, Ukkola O 2003 Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52:2546-2553
27. Flint A, Raben A, Blundell JE, Astrup A 2000 Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24:38-48
28. Freda PU, Reyes CM, Conwell IM, Sundeen RE, Wardlaw SL 2003 Serum ghrelin levels in acromegaly: effects of surgical and long-acting octreotide therapy. J Clin Endocrinol Metab 88:2037-2044
29. Haffner SM, Miettinen H, Stern MP 1997 The homeostasis model in the San Antonio Heart Study. Diabetes Care 20:1087-1092
30. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
31. Geloneze B, Tambascia MA, Pilla VF, Geloneze SR, Repetto EM, Pareja JC 2003 Ghrelin: a gut-brain hormone: effect of gastric bypass surgery. Obes Surg 13:17-22
32. Tritos NA, Mun E, Bertkau A, Grayson R, Maratos-Flier E, Goldfine A 2003 Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery. Obes Res 11:919-924
33. Faraj M, Havel PJ, Phelis S, Blank D, Sniderman AD, Cianflone K 2003 Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 88:1594-1602
34. Stoeckli R, Chanda R, Langer I, Keller U 2004 Changes of body weight and plasma ghrelin levels after gastric banding and gastric bypass. Obes Res 12:346-350
35. Holdstock C, Engstrom BE, Ohrvall M, Lind L, Sundbom M, Karlsson FA 2003 Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab 88:3177-3183
36. Williams DL, Grill HJ, Cummings DE, Kaplan JM 2003 Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144:5184-5187
37. Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC, Wells T 2004 Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145:234-242
38. Alvarez Bartolomé M, Borque M, Martinez-Sarmiento J, Aparicio E, Hernández C, Cabrerizo L, Fernández-Represa JA 2002 Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty. Obes Surg 12:324-327
39. Näslund E, Grybäck P, Hellstrom PM, Jacobsson H, Hoist JJ, Theodorsson E, Backman L 1997 Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity. Int J Obes Relat Metab Disord 21:387-392
40. Hagan MM 2002 Peptide YY: a key mediator of orexigenic behavior. Peptides 23:377-382
41. Harding RK, McDonald TJ 1989 Identification and characterization of the emetic effects of peptide YY. Peptides 10:21-24
42. Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-Sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Withcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML 2004 Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature 430:1 p following 165; discussion 2 p following 165
43. Flier JS 2004 Obesity wars: molecular progress confronts an expanding epidemic. Cell 116:337-350
44. Hickey MS, Pories WJ, MacDonald Jr KG, Cory KA, Dohm GL, Swanson MS, Israel RG, Barakat HA, Considine RV, Caro JF, Houmard JA 1998 A new paradigm for type 2 diabetes mellitus: could it be a disease of the foregut? Ann Surg 227:637-643
45. Kellum JM, Kuemmerle JF, O'Dorisio TM, Rayford P, Martin D, Engle K, Wolf L, Sugerman HJ 1990 Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 211:763-770
46. Rosenbaum M, Nicolson M, Hirsch J, Murphy E, Chu F, Leibel RL 1997 Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab 82:3647-3654
47. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M 1999 Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282:1568-1575
48. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL 2002 Low dose leptin administration reverses effects of sustained weight reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87:2391-2394