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Volumn 12, Issue 1, 2014, Pages

Secondary bile acids: An underrecognized cause of colon cancer

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; DEOXYCHOLIC ACID; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K RAS PROTEIN; LITHOCHOLIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PREGNANE X RECEPTOR; PROTEIN BCL XL; PROTEIN KINASE C; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; SECONDARY BILE ACID; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

EID: 84901846653     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-12-164     Document Type: Review
Times cited : (301)

References (57)
  • 2
    • 7544221726 scopus 로고    scopus 로고
    • Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity
    • 10.1081/DMR-200033475, 15554243
    • Hofmann AF. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev 2004, 36:703-722. 10.1081/DMR-200033475, 15554243.
    • (2004) Drug Metab Rev , vol.36 , pp. 703-722
    • Hofmann, A.F.1
  • 3
    • 0000535267 scopus 로고
    • Production of tumors in mice by deoxycholic acid
    • Cook JW, Kennaway EL, Kennaway NM. Production of tumors in mice by deoxycholic acid. Nature 1940, 145:627.
    • (1940) Nature , vol.145 , pp. 627
    • Cook, J.W.1    Kennaway, E.L.2    Kennaway, N.M.3
  • 4
    • 70349570937 scopus 로고    scopus 로고
    • Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis
    • 3108627, 21677822
    • Payne CM, Bernstein C, Dvorak K, Bernstein H. Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis. Clin Exp Gastroenterol 2008, 1:19-47. 3108627, 21677822.
    • (2008) Clin Exp Gastroenterol , vol.1 , pp. 19-47
    • Payne, C.M.1    Bernstein, C.2    Dvorak, K.3    Bernstein, H.4
  • 6
    • 0036718353 scopus 로고    scopus 로고
    • Bile reflux gastritis and intestinal metaplasia at the cardia
    • 10.1136/gut.51.3.351, 1773352, 12171955
    • Dixon MFMN, Neville PM, Moayyedi P, Axon AT. Bile reflux gastritis and intestinal metaplasia at the cardia. Gut 2002, 51:351-355. 10.1136/gut.51.3.351, 1773352, 12171955.
    • (2002) Gut , vol.51 , pp. 351-355
    • Dixon, M.F.M.N.1    Neville, P.M.2    Moayyedi, P.3    Axon, A.T.4
  • 7
    • 0026021722 scopus 로고
    • Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen?
    • 10.1038/bjc.1991.29, 1971637, 1989654
    • Ross RK, Hartnett NM, Bernstein L, Henderson BE. Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen?. Br J Cancer 1991, 63:143-145. 10.1038/bjc.1991.29, 1971637, 1989654.
    • (1991) Br J Cancer , vol.63 , pp. 143-145
    • Ross, R.K.1    Hartnett, N.M.2    Bernstein, L.3    Henderson, B.E.4
  • 8
    • 0029939634 scopus 로고    scopus 로고
    • Deoxycholic acid as an endogenous risk factor for hepatocarcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits
    • Ohtaki YHT, Hiramatsu K, Kanitani M, Ohshima T, Nomura M, Wakita H, Aburada M, Miyamoto KI. Deoxycholic acid as an endogenous risk factor for hepatocarcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits. Anticancer Res 1996, 16:751-755.
    • (1996) Anticancer Res , vol.16 , pp. 751-755
    • Ohtaki, Y.H.T.1    Hiramatsu, K.2    Kanitani, M.3    Ohshima, T.4    Nomura, M.5    Wakita, H.6    Aburada, M.7    Miyamoto, K.I.8
  • 9
    • 33748875447 scopus 로고    scopus 로고
    • Bile-reflux into the pancreatic ducts is associated with the development of intraductal papillary carcinoma in hamsters
    • 10.1016/j.jss.2006.04.025, 16863651
    • Adachi TTY, Kuroki T, Mishima T, Kitasato A, Fukuda K, Tsutsumi R, Kanematsu T. Bile-reflux into the pancreatic ducts is associated with the development of intraductal papillary carcinoma in hamsters. J Surg Res 2006, 136:106-111. 10.1016/j.jss.2006.04.025, 16863651.
    • (2006) J Surg Res , vol.136 , pp. 106-111
    • Adachi, T.T.Y.1    Kuroki, T.2    Mishima, T.3    Kitasato, A.4    Fukuda, K.5    Tsutsumi, R.6    Kanematsu, T.7
  • 10
    • 27544447260 scopus 로고    scopus 로고
    • Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage
    • 10.1016/j.freeradbiomed.2005.07.005, 16274877
    • Komichi D, Tazuma S, Nishioka T, Hyogo H, Chayama K. Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage. Free Radic Biol Med 2005, 39:1418-1427. 10.1016/j.freeradbiomed.2005.07.005, 16274877.
    • (2005) Free Radic Biol Med , vol.39 , pp. 1418-1427
    • Komichi, D.1    Tazuma, S.2    Nishioka, T.3    Hyogo, H.4    Chayama, K.5
  • 11
    • 0035076216 scopus 로고    scopus 로고
    • Genes involved in initial steps of bile acid synthesis
    • 10.1097/00041433-200104000-00002, 11264980
    • Björkhem I, Eggertsen G. Genes involved in initial steps of bile acid synthesis. Curr Opin Lipidol 2001, 12:97-103. 10.1097/00041433-200104000-00002, 11264980.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 97-103
    • Björkhem, I.1    Eggertsen, G.2
  • 13
    • 0023280880 scopus 로고
    • Simulation of the metabolism and enterohepatic circulation of endogenous deoxycholic acid in humans using a physiologic pharmacokinetic model for bile acid metabolism
    • Hofmann AF, Cravetto C, Molino G, Belforte G, Bona B. Simulation of the metabolism and enterohepatic circulation of endogenous deoxycholic acid in humans using a physiologic pharmacokinetic model for bile acid metabolism. Gastroenterology 1987, 93:693-709.
    • (1987) Gastroenterology , vol.93 , pp. 693-709
    • Hofmann, A.F.1    Cravetto, C.2    Molino, G.3    Belforte, G.4    Bona, B.5
  • 14
    • 0033611305 scopus 로고    scopus 로고
    • The Continuing Importance of Bile Acids in Liver and Intestinal Disease
    • 10.1001/archinte.159.22.2647, 10597755
    • Hofmann AF. The Continuing Importance of Bile Acids in Liver and Intestinal Disease. Arch Intern Med 1999, 159:2647-2658. 10.1001/archinte.159.22.2647, 10597755.
    • (1999) Arch Intern Med , vol.159 , pp. 2647-2658
    • Hofmann, A.F.1
  • 15
    • 0021739393 scopus 로고
    • Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem
    • Hofmann AF, Rods AA. Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem. J Lipid Res 1984, 25:1477-1489.
    • (1984) J Lipid Res , vol.25 , pp. 1477-1489
    • Hofmann, A.F.1    Rods, A.A.2
  • 16
    • 0015689691 scopus 로고
    • Nutrition, development, and population growth
    • Berg A. Nutrition, development, and population growth. Popul Bull 1973, 29:3-37.
    • (1973) Popul Bull , vol.29 , pp. 3-37
    • Berg, A.1
  • 17
    • 78049511815 scopus 로고    scopus 로고
    • Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study
    • 10.1136/bmj.c5504, 2965150, 20978063
    • Kirkegaard H, Johnsen NF, Christensen J. Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study. BMJ 2010, 341:c5504. 10.1136/bmj.c5504, 2965150, 20978063.
    • (2010) BMJ , vol.341
    • Kirkegaard, H.1    Johnsen, N.F.2    Christensen, J.3
  • 19
    • 0028831047 scopus 로고
    • Unconjugated secondary bile acids in the serum of patients with colorectal adenomas
    • 10.1136/gut.36.2.268, 1382415, 7883228
    • Bayerdörffer E, Mannes GA, Ochsenkühn T, Dirschedl P, Wiebecke B, Paumgartner G. Unconjugated secondary bile acids in the serum of patients with colorectal adenomas. Gut 1995, 36:268-273. 10.1136/gut.36.2.268, 1382415, 7883228.
    • (1995) Gut , vol.36 , pp. 268-273
    • Bayerdörffer, E.1    Mannes, G.A.2    Ochsenkühn, T.3    Dirschedl, P.4    Wiebecke, B.5    Paumgartner, G.6
  • 20
    • 84897113200 scopus 로고    scopus 로고
    • Physiology and Pathophysiology of the Biliary Tract: The Gallbladder and Sphincter of Oddi
    • Article ID 837630
    • Behar J. Physiology and Pathophysiology of the Biliary Tract: The Gallbladder and Sphincter of Oddi. Rev ISRN Physiol 2013, 2013:Article ID 837630.
    • (2013) Rev ISRN Physiol , vol.2013
    • Behar, J.1
  • 21
    • 2342475205 scopus 로고    scopus 로고
    • Deoxycholic Acid Activates -Catenin Signaling Pathway and Increases Colon Cell Cancer Growth and Invasiveness
    • 10.1091/mbc.E03-12-0894, 404012, 15004225
    • Pai R, Tarnawski AS, Tran T. Deoxycholic Acid Activates -Catenin Signaling Pathway and Increases Colon Cell Cancer Growth and Invasiveness. Mol Biol Cell 2004, 15:2156-2163. 10.1091/mbc.E03-12-0894, 404012, 15004225.
    • (2004) Mol Biol Cell , vol.15 , pp. 2156-2163
    • Pai, R.1    Tarnawski, A.S.2    Tran, T.3
  • 22
    • 0037422401 scopus 로고    scopus 로고
    • Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis
    • 10.1016/S0009-2797(02)00162-X, 12606154
    • Crowley-Weber CL, Dvorakova K, Crowley C, Bernstein H, Bernstein C, Garewal H, Payne CM. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chem Biol Interact 2003, 145:53-66. 10.1016/S0009-2797(02)00162-X, 12606154.
    • (2003) Chem Biol Interact , vol.145 , pp. 53-66
    • Crowley-Weber, C.L.1    Dvorakova, K.2    Crowley, C.3    Bernstein, H.4    Bernstein, C.5    Garewal, H.6    Payne, C.M.7
  • 24
    • 58949091455 scopus 로고    scopus 로고
    • Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer
    • 2722141, 19017685
    • Newmark HL, Yang K, Kurihara N, Fan K, Augenlicht LH, Lipkin M. Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer. Carcinogenesis 2009, 30:88-92. 2722141, 19017685.
    • (2009) Carcinogenesis , vol.30 , pp. 88-92
    • Newmark, H.L.1    Yang, K.2    Kurihara, N.3    Fan, K.4    Augenlicht, L.H.5    Lipkin, M.6
  • 25
    • 33847785834 scopus 로고    scopus 로고
    • Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake
    • Lorenzen JK, Nielsen S, Holst JJ, Tetens I, Rehfeld JF, Astrup A. Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake. Am J Clin Nutr 2007, 85:678-687.
    • (2007) Am J Clin Nutr , vol.85 , pp. 678-687
    • Lorenzen, J.K.1    Nielsen, S.2    Holst, J.J.3    Tetens, I.4    Rehfeld, J.F.5    Astrup, A.6
  • 26
    • 33744960773 scopus 로고    scopus 로고
    • Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations
    • 10.1074/jbc.M506710200, 16547009
    • Jean-Louis S, Akare S, Ali MA, Mash EA, Meuillet E, Martinez JD. Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations. J Biol Chem 2006, 281:14948-14960. 10.1074/jbc.M506710200, 16547009.
    • (2006) J Biol Chem , vol.281 , pp. 14948-14960
    • Jean-Louis, S.1    Akare, S.2    Ali, M.A.3    Mash, E.A.4    Meuillet, E.5    Martinez, J.D.6
  • 27
    • 0037147320 scopus 로고    scopus 로고
    • Cholesterol Depletion from the Plasma Membrane Triggers Ligand-independent Activation of the Epidermal Growth Factor Receptor
    • Chen X, Resh MD. Cholesterol Depletion from the Plasma Membrane Triggers Ligand-independent Activation of the Epidermal Growth Factor Receptor. J Biol Chem 2002, 227:49631-49637.
    • (2002) J Biol Chem , vol.227 , pp. 49631-49637
    • Chen, X.1    Resh, M.D.2
  • 28
    • 0027192272 scopus 로고
    • Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts
    • Sagawa H, Tazuma S, Kajiyama G. Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts. Am J Physiology 1993, 264:G835-G839.
    • (1993) Am J Physiology , vol.264
    • Sagawa, H.1    Tazuma, S.2    Kajiyama, G.3
  • 29
    • 84858017794 scopus 로고    scopus 로고
    • High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids
    • 10.3748/wjg.v18.i9.923, 3297051, 22408351
    • Stenman LK, Holma R, Korpela R. High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids. World J Gastroenterol 2012, 18:923-929. 10.3748/wjg.v18.i9.923, 3297051, 22408351.
    • (2012) World J Gastroenterol , vol.18 , pp. 923-929
    • Stenman, L.K.1    Holma, R.2    Korpela, R.3
  • 31
    • 69449095892 scopus 로고    scopus 로고
    • Bile acids as regulatory molecules
    • 10.1194/jlr.R900007-JLR200, 2724047, 19346331
    • Hylemon PB, Zhou H, Dent P. Bile acids as regulatory molecules. J Lipid Res 2009, 50:1509-1520. 10.1194/jlr.R900007-JLR200, 2724047, 19346331.
    • (2009) J Lipid Res , vol.50 , pp. 1509-1520
    • Hylemon, P.B.1    Zhou, H.2    Dent, P.3
  • 32
    • 0031459956 scopus 로고    scopus 로고
    • Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation
    • Rao YP, Stravitz RT, Vlahcevic ZR, Gurley EC, Sando JJ, Hylemon PB. Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. J Lipid Res 1997, 38:2446-2454.
    • (1997) J Lipid Res , vol.38 , pp. 2446-2454
    • Rao, Y.P.1    Stravitz, R.T.2    Vlahcevic, Z.R.3    Gurley, E.C.4    Sando, J.J.5    Hylemon, P.B.6
  • 33
    • 44449138033 scopus 로고    scopus 로고
    • Nuclear receptors, intestinal architecture and colon cancer: an intriguing link
    • 10.1007/s00018-008-7552-1, 18278436
    • D'Errico I, Moschetta A. Nuclear receptors, intestinal architecture and colon cancer: an intriguing link. Cell Mol Life Sci 2008, 65:1523-1543. 10.1007/s00018-008-7552-1, 18278436.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1523-1543
    • D'Errico, I.1    Moschetta, A.2
  • 34
    • 70349563339 scopus 로고    scopus 로고
    • Bile acids as endogenous etiologic agents in gastrointestinal cancer
    • 10.3748/wjg.15.3329, 2712893, 19610133
    • Bernstein H, Bernstein C, Payne CM, Dvorak K. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterol 2009, 15:3329-3340. 10.3748/wjg.15.3329, 2712893, 19610133.
    • (2009) World J Gastroenterol , vol.15 , pp. 3329-3340
    • Bernstein, H.1    Bernstein, C.2    Payne, C.M.3    Dvorak, K.4
  • 35
    • 79958273142 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR in the hepatic regeneration
    • 10.1016/j.bbadis.2010.12.006, 21167938
    • Chen WD, Wang YD, Meng Z, Zhang L, Huang W. Nuclear bile acid receptor FXR in the hepatic regeneration. Biochim Biophys Acta 2011, 1812:888-892. 10.1016/j.bbadis.2010.12.006, 21167938.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 888-892
    • Chen, W.D.1    Wang, Y.D.2    Meng, Z.3    Zhang, L.4    Huang, W.5
  • 38
    • 61549104490 scopus 로고    scopus 로고
    • PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics
    • 10.2217/14622416.9.11.1695, 2593625, 19018724
    • Zhang B, Xie W, Krasowski MD. PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics 2008, 9:1695-1709. 10.2217/14622416.9.11.1695, 2593625, 19018724.
    • (2008) Pharmacogenomics , vol.9 , pp. 1695-1709
    • Zhang, B.1    Xie, W.2    Krasowski, M.D.3
  • 40
    • 57149118460 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
    • Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Res Cancer 2008, 68:9589-9594.
    • (2008) Res Cancer , vol.68 , pp. 9589-9594
    • Modica, S.1    Murzilli, S.2    Salvatore, L.3    Schmidt, D.R.4    Moschetta, A.5
  • 42
    • 0028235387 scopus 로고
    • Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -C loci
    • 10.1016/0161-5890(94)90168-6, 8196671
    • Arvind P, Papavassiliou ED, Tsioulias GJ, Duceman BW, Lovelace CI, Geng W, Staiano-Coico L, Rigas B. Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -C loci. Mol Immunol 1994, 31:607-614. 10.1016/0161-5890(94)90168-6, 8196671.
    • (1994) Mol Immunol , vol.31 , pp. 607-614
    • Arvind, P.1    Papavassiliou, E.D.2    Tsioulias, G.J.3    Duceman, B.W.4    Lovelace, C.I.5    Geng, W.6    Staiano-Coico, L.7    Rigas, B.8
  • 43
    • 11844262660 scopus 로고    scopus 로고
    • Bile acids as carcinogens in human gastrointestinal cancers
    • 10.1016/j.mrrev.2004.08.001, 15652226
    • Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 2005, 589:47-65. 10.1016/j.mrrev.2004.08.001, 15652226.
    • (2005) Mutat Res , vol.589 , pp. 47-65
    • Bernstein, H.1    Bernstein, C.2    Payne, C.M.3    Dvorakova, K.4    Garewal, H.5
  • 44
    • 22844440003 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
    • 10.1074/jbc.M414361200, 15917250
    • Reinehr R, Becker S, Eberle A, Grether-Beck S, Haussinger D. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem 2005, 280:27179-27194. 10.1074/jbc.M414361200, 15917250.
    • (2005) J Biol Chem , vol.280 , pp. 27179-27194
    • Reinehr, R.1    Becker, S.2    Eberle, A.3    Grether-Beck, S.4    Haussinger, D.5
  • 45
    • 0037975615 scopus 로고    scopus 로고
    • NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury
    • 1514469, 12677145
    • Strauch ED, Bass BL, Rao JN, Vann JA, Wang JY. NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury. Ann Surg 2003, 237:494-501. 1514469, 12677145.
    • (2003) Ann Surg , vol.237 , pp. 494-501
    • Strauch, E.D.1    Bass, B.L.2    Rao, J.N.3    Vann, J.A.4    Wang, J.Y.5
  • 46
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • 2773649, 20066113
    • Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009, 1:a000141. 2773649, 20066113.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Karin, M.1
  • 47
    • 0036258704 scopus 로고    scopus 로고
    • Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1
    • Glinghammar B, Inoue H, Rafter JJ. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1. Oxford J 2002, 23:839-845.
    • (2002) Oxford J , vol.23 , pp. 839-845
    • Glinghammar, B.1    Inoue, H.2    Rafter, J.J.3
  • 48
    • 0035251866 scopus 로고    scopus 로고
    • Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53
    • 10.1016/S1357-2725(00)00080-7, 11240376
    • Powolny A, Xu J, Loo G. Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53. Int J Biochem Cell Biol 2001, 33:193-203. 10.1016/S1357-2725(00)00080-7, 11240376.
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 193-203
    • Powolny, A.1    Xu, J.2    Loo, G.3
  • 50
    • 80052771111 scopus 로고    scopus 로고
    • Palasciano G Bile acids and colon cancer: Solving the puzzle with nuclear receptors
    • 10.1016/j.molmed.2011.05.010, 21724466
    • Degirolamo C, Modica S. Palasciano G Bile acids and colon cancer: Solving the puzzle with nuclear receptors. Trends Mol Med 2011, 17:564-572. 10.1016/j.molmed.2011.05.010, 21724466.
    • (2011) Trends Mol Med , vol.17 , pp. 564-572
    • Degirolamo, C.1    Modica, S.2
  • 51
    • 0033818372 scopus 로고    scopus 로고
    • K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid
    • 10.1002/1097-0215(20001015)88:2<157::AID-IJC2>3.0.CO;2-B, 11004662
    • Narahara H, Tatsuta M, Iishi H, Baba M, Uedo N, Sakai N, Yano H, Ishiguro S. K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid. Int J Cancer 2000, 88:157-161. 10.1002/1097-0215(20001015)88:2<157::AID-IJC2>3.0.CO;2-B, 11004662.
    • (2000) Int J Cancer , vol.88 , pp. 157-161
    • Narahara, H.1    Tatsuta, M.2    Iishi, H.3    Baba, M.4    Uedo, N.5    Sakai, N.6    Yano, H.7    Ishiguro, S.8
  • 53
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • 10.3748/wjg.15.1677, 2668773, 19360911
    • Perez MJ, Briz O. Bile-acid-induced cell injury and protection. World J Gastroenterol 2009, 15:1677-1689. 10.3748/wjg.15.1677, 2668773, 19360911.
    • (2009) World J Gastroenterol , vol.15 , pp. 1677-1689
    • Perez, M.J.1    Briz, O.2
  • 54
    • 67649410738 scopus 로고    scopus 로고
    • Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells
    • 10.1080/01635580802582744, 19373611
    • Yui S, Kanamoto R, Saeki T. Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells. Nutr Cancer 2009, 61:374-380. 10.1080/01635580802582744, 19373611.
    • (2009) Nutr Cancer , vol.61 , pp. 374-380
    • Yui, S.1    Kanamoto, R.2    Saeki, T.3
  • 55
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe SW, Lin AW. Apoptosis in cancer. Oxford J 1999, 21:485-495.
    • (1999) Oxford J , vol.21 , pp. 485-495
    • Lowe, S.W.1    Lin, A.W.2
  • 56
    • 38749092227 scopus 로고    scopus 로고
    • Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax
    • Yui S, Kanamoto R, Saeki T. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutr Cancer 2007, 60:91-96.
    • (2007) Nutr Cancer , vol.60 , pp. 91-96
    • Yui, S.1    Kanamoto, R.2    Saeki, T.3
  • 57
    • 0029945789 scopus 로고    scopus 로고
    • Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas
    • Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 1996, 56:2422-2427.
    • (1996) Cancer Res , vol.56 , pp. 2422-2427
    • Krajewska, M.1    Moss, S.F.2    Krajewski, S.3    Song, K.4    Holt, P.R.5    Reed, J.C.6


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