메뉴 건너뛰기




Volumn 15, Issue 1, 2012, Pages 65-74

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYLATED BILE ACID DERIVATIVE; BILE ACID; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 8B1; GLUCOSE; INSULIN; LIPID; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84855427221     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.11.010     Document Type: Article
Times cited : (111)

References (62)
  • 1
    • 0023030762 scopus 로고
    • Cholesterol gallstones in alloxan-diabetic mice
    • T. Akiyoshi, K. Uchida, H. Takase, Y. Nomura, and N. Takeuchi Cholesterol gallstones in alloxan-diabetic mice J. Lipid Res. 27 1986 915 924 (Pubitemid 17179133)
    • (1986) Journal of Lipid Research , vol.27 , Issue.9 , pp. 915-924
    • Akiyoshi, T.1    Uchida, K.2    Takase, H.3
  • 2
    • 52149119846 scopus 로고    scopus 로고
    • Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS
    • Y. Alnouti, I.L. Csanaky, and C.D. Klaassen Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 873 2008 209 217
    • (2008) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.873 , pp. 209-217
    • Alnouti, Y.1    Csanaky, I.L.2    Klaassen, C.D.3
  • 3
    • 0018132578 scopus 로고
    • Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia
    • B. Angelin, K. Einarsson, K. Hellström, and B. Leijd Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia J. Lipid Res. 19 1978 1017 1024 (Pubitemid 9059813)
    • (1978) Journal of Lipid Research , vol.19 , Issue.8 , pp. 1017-1024
    • Angelin, B.1    Einarsson, K.2    Hellstrom, K.3    Leijd, B.4
  • 7
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus Total Insulin Resistance: A Pathogenic Paradox
    • DOI 10.1016/j.cmet.2007.12.009, PII S1550413107003828
    • M.S. Brown, and J.L. Goldstein Selective versus total insulin resistance: a pathogenic paradox Cell Metab. 7 2008 95 96 (Pubitemid 351168559)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 8
    • 77957960122 scopus 로고    scopus 로고
    • Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism
    • G. Brufau, F. Stellaard, K. Prado, V.W. Bloks, E. Jonkers, R. Boverhof, F. Kuipers, and E.J. Murphy Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism Hepatology 2010
    • (2010) Hepatology
    • Brufau, G.1    Stellaard, F.2    Prado, K.3    Bloks, V.W.4    Jonkers, E.5    Boverhof, R.6    Kuipers, F.7    Murphy, E.J.8
  • 9
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • J.Y. Chiang Bile acids: regulation of synthesis J. Lipid Res. 50 2009 1955 1966
    • (2009) J. Lipid Res. , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 10
    • 80052388637 scopus 로고    scopus 로고
    • Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
    • S.H. Choi, and H.N. Ginsberg Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance Trends Endocrinol. Metab. 22 2011 353 363
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 353-363
    • Choi, S.H.1    Ginsberg, H.N.2
  • 11
    • 77955657267 scopus 로고    scopus 로고
    • Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links. The Claude Bernard Lecture 2009
    • R.A. DeFronzo Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009 Diabetologia 53 2010 1270 1287
    • (2010) Diabetologia , vol.53 , pp. 1270-1287
    • Defronzo, R.A.1
  • 12
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
    • DOI 10.1016/j.cmet.2008.06.006, PII S1550413108001770
    • X.C. Dong, K.D. Copps, S. Guo, Y. Li, R. Kollipara, R.A. DePinho, and M.F. White Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation Cell Metab. 8 2008 65 76 (Pubitemid 351863393)
    • (2008) Cell Metabolism , vol.8 , Issue.1 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 13
    • 60849139395 scopus 로고    scopus 로고
    • GOrilla: A tool for discovery and visualization of enriched GO terms in ranked gene lists
    • E. Eden, R. Navon, I. Steinfeld, D. Lipson, and Z. Yakhini GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists BMC Bioinformatics 10 2009 48
    • (2009) BMC Bioinformatics , vol.10 , pp. 48
    • Eden, E.1    Navon, R.2    Steinfeld, I.3    Lipson, D.4    Yakhini, Z.5
  • 15
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J. Biol. Chem. 226 1957 497 509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 17
    • 0033106423 scopus 로고    scopus 로고
    • Structure and chromosomal assignment of the sterol 12α-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns
    • DOI 10.1006/geno.1998.5606
    • M. Gfvels, M. Olin, B.P. Chowdhary, T. Raudsepp, U. Andersson, B. Persson, M. Jansson, I. Björkhem, and G. Eggertsen Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns Genomics 56 1999 184 196 (Pubitemid 29141149)
    • (1999) Genomics , vol.56 , Issue.2 , pp. 184-196
    • Gafvels, M.1    Olin, M.2    Chowdhary, B.P.3    Raudsepp, T.4    Andersson, U.5    Persson, B.6    Jansson, M.7    Bjorkhem, I.8    Eggertsen, G.9
  • 20
    • 45549104962 scopus 로고    scopus 로고
    • The Double Life of Irs
    • DOI 10.1016/j.cmet.2008.06.010, PII S1550413108001812
    • R.A. Haeusler, and D. Accili The double life of Irs Cell Metab. 8 2008 7 9 (Pubitemid 351859234)
    • (2008) Cell Metabolism , vol.8 , Issue.1 , pp. 7-9
    • Haeusler, R.A.1    Accili, D.2
  • 21
    • 77956244443 scopus 로고    scopus 로고
    • Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia
    • R.A. Haeusler, S. Han, and D. Accili Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia J. Biol. Chem. 285 2010 26861 26868
    • (2010) J. Biol. Chem. , vol.285 , pp. 26861-26868
    • Haeusler, R.A.1    Han, S.2    Accili, D.3
  • 22
    • 78149272381 scopus 로고    scopus 로고
    • FoxOs function synergistically to promote glucose production
    • R.A. Haeusler, K.H. Kaestner, and D. Accili FoxOs function synergistically to promote glucose production J. Biol. Chem. 285 2010 35245 35248
    • (2010) J. Biol. Chem. , vol.285 , pp. 35245-35248
    • Haeusler, R.A.1    Kaestner, K.H.2    Accili, D.3
  • 23
    • 0024318186 scopus 로고
    • Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions
    • D.M. Heuman Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions J. Lipid Res. 30 1989 719 730 (Pubitemid 19144779)
    • (1989) Journal of Lipid Research , vol.30 , Issue.5 , pp. 719-730
    • Heuman, D.M.1
  • 24
    • 0024373642 scopus 로고
    • Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat
    • D.M. Heuman, P.B. Hylemon, and Z.R. Vlahcevic Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat J. Lipid Res. 30 1989 1161 1171 (Pubitemid 19213256)
    • (1989) Journal of Lipid Research , vol.30 , Issue.8 , pp. 1161-1171
    • Heuman, D.M.1    Hylemon, P.B.2    Vlahcevic, Z.R.3
  • 26
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • N.Y. Kalaany, and D.J. Mangelsdorf LXRS and FXR: the yin and yang of cholesterol and fat metabolism Annu. Rev. Physiol. 68 2006 159 191
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 28
  • 29
    • 59149106502 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    • B. Kong, J.P. Luyendyk, O. Tawfik, and G.L. Guo Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet J. Pharmacol. Exp. Ther. 328 2009 116 122
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 116-122
    • Kong, B.1    Luyendyk, J.P.2    Tawfik, O.3    Guo, G.L.4
  • 31
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, and B. Staels Role of bile acids and bile acid receptors in metabolic regulation Physiol. Rev. 89 2009 147 191
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 32
    • 33749386425 scopus 로고    scopus 로고
    • Insulin regulation of cholesterol 7α-hydroxylase expression in human hepatocytes: Roles of forkhead box O1 and sterol regulatory element-binding protein 1c
    • DOI 10.1074/jbc.M605815200
    • T. Li, X. Kong, E. Owsley, E. Ellis, S. Strom, and J.Y. Chiang Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c J. Biol. Chem. 281 2006 28745 28754 (Pubitemid 44507017)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28745-28754
    • Li, T.1    Kong, X.2    Owsley, E.3    Ellis, E.4    Strom, S.5    Chiang, J.Y.L.6
  • 33
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • S. Li, M.S. Brown, and J.L. Goldstein Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis Proc. Natl. Acad. Sci. USA 107 2010 3441 3446
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 35
    • 79959962745 scopus 로고    scopus 로고
    • Hormonal regulation of hepatic glucose production in health and disease
    • H.V. Lin, and D. Accili Hormonal regulation of hepatic glucose production in health and disease Cell Metab. 14 2011 9 19
    • (2011) Cell Metab. , vol.14 , pp. 9-19
    • Lin, H.V.1    Accili, D.2
  • 40
    • 34547111086 scopus 로고    scopus 로고
    • A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor
    • DOI 10.1074/jbc.M702895200
    • K.E. Matsukuma, L. Wang, M.K. Bennett, and T.F. Osborne A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor J. Biol. Chem. 282 2007 20164 20171 (Pubitemid 47099984)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.28 , pp. 20164-20171
    • Matsukuma, K.E.1    Wang, L.2    Bennett, M.K.3    Osborne, T.F.4
  • 41
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • DOI 10.1172/JCI27047
    • M. Matsumoto, S. Han, T. Kitamura, and D. Accili Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism J. Clin. Invest. 116 2006 2464 2472 (Pubitemid 44330145)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.9 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3    Accili, D.4
  • 42
    • 34548349302 scopus 로고    scopus 로고
    • Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver
    • DOI 10.1016/j.cmet.2007.08.006, PII S1550413107002288
    • M. Matsumoto, A. Pocai, L. Rossetti, R.A. Depinho, and D. Accili Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver Cell Metab. 6 2007 208 216 (Pubitemid 47336849)
    • (2007) Cell Metabolism , vol.6 , Issue.3 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    DePinho, R.A.4    Accili, D.5
  • 43
    • 33746866442 scopus 로고
    • Chemical characterization of inbred-strain mouse milk. I. Gross composition and amino acid analysis
    • H. Meier, W.G. Hoag, and J.J. McBurney Chemical characterization of inbred-strain mouse milk. I. Gross composition and amino acid analysis J. Nutr. 85 1965 305 308
    • (1965) J. Nutr. , vol.85 , pp. 305-308
    • Meier, H.1    Hoag, W.G.2    McBurney, J.J.3
  • 44
    • 0016201510 scopus 로고
    • Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia
    • N.E. Miller, and P.J. Nestel Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia Lancet 2 1974 929 931
    • (1974) Lancet , vol.2 , pp. 929-931
    • Miller, N.E.1    Nestel, P.J.2
  • 46
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • J. Nakae, W.H. Biggs III, T. Kitamura, W.K. Cavenee, C.V. Wright, K.C. Arden, and D. Accili Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nat. Genet. 32 2002 245 253
    • (2002) Nat. Genet. , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs Iii, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 49
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • DOI 10.1194/jlr.R500013-JLR200
    • J.M. Ridlon, D.J. Kang, and P.B. Hylemon Bile salt biotransformations by human intestinal bacteria J. Lipid Res. 47 2006 241 259 (Pubitemid 43276911)
    • (2006) Journal of Lipid Research , vol.47 , Issue.2 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.-J.2    Hylemon, P.B.3
  • 50
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • D.W. Russell Fifty years of advances in bile acid synthesis and metabolism J. Lipid Res. 50 Suppl 2009 S120 S125
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Russell, D.W.1
  • 51
    • 66449085572 scopus 로고    scopus 로고
    • FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    • D.J. Shin, and T.F. Osborne FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action J. Biol. Chem. 284 2009 11110 11120
    • (2009) J. Biol. Chem. , vol.284 , pp. 11110-11120
    • Shin, D.J.1    Osborne, T.F.2
  • 52
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • C.J. Sinal, M. Tohkin, M. Miyata, J.M. Ward, G. Lambert, and F.J. Gonzalez Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis Cell 102 2000 731 744
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 53
    • 80052881506 scopus 로고    scopus 로고
    • Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men
    • L.P. Sørensen, E. Søndergaard, B. Nellemann, J.S. Christiansen, L.C. Gormsen, and S. Nielsen Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men Diabetes 60 2011 2257 2264
    • (2011) Diabetes , vol.60 , pp. 2257-2264
    • Sørensen, L.P.1    Søndergaard, E.2    Nellemann, B.3    Christiansen, J.S.4    Gormsen, L.C.5    Nielsen, S.6
  • 54
    • 34347401852 scopus 로고    scopus 로고
    • Bile acid sequestrants and the treatment of type 2 diabetes mellitus
    • DOI 10.2165/00003495-200767100-00001
    • B. Staels, and F. Kuipers Bile acid sequestrants and the treatment of type 2 diabetes mellitus Drugs 67 2007 1383 1392 (Pubitemid 47026388)
    • (2007) Drugs , vol.67 , Issue.10 , pp. 1383-1392
    • Staels, B.1    Kuipers, F.2
  • 55
    • 74049093243 scopus 로고    scopus 로고
    • The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression
    • I. Tabas, A. Tall, and D. Accili The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression Circ. Res. 106 2010 58 67
    • (2010) Circ. Res. , vol.106 , pp. 58-67
    • Tabas, I.1    Tall, A.2    Accili, D.3
  • 57
    • 0021998704 scopus 로고
    • Altered bile acid metabolism in nonobese, spontaneously diabetic (NOD) mice
    • K. Uchida, S. Makino, and T. Akiyoshi Altered bile acid metabolism in nonobese, spontaneously diabetic (NOD) mice Diabetes 34 1985 79 83 (Pubitemid 15192856)
    • (1985) Diabetes , vol.34 , Issue.1 , pp. 79-83
    • Uchida, K.1    Makino, S.2    Akiyoshi, T.3
  • 60
    • 0041965752 scopus 로고    scopus 로고
    • Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: Studies in the gallstone-susceptible mouse
    • D.Q. Wang, S. Tazuma, D.E. Cohen, and M.C. Carey Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse Am. J. Physiol. Gastrointest. Liver Physiol. 285 2003 G494 G502
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285
    • Wang, D.Q.1    Tazuma, S.2    Cohen, D.E.3    Carey, M.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.