Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

Obesity

Volumn 22, Issue 2, 2014, Pages 390-400

  Myronovych, Andriy ^a   Kirby, Michelle ^a   Ryan, Karen K ^b   Zhang, Wujuan ^a   Jha, Pinky ^a   Setchell, Kenneth Dr ^a   Dexheimer, Phillip J ^a   Aronow, Bruce ^a   Seeley, Randy J ^b   Kohli, Rohit ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BILE ACIDS AND SALTS; CALORIC RESTRICTION; CHOLIC ACID; DIET, HIGH-FAT; DOWN-REGULATION; FATTY LIVER; GASTROPLASTY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; POSTPRANDIAL PERIOD; RANDOM ALLOCATION; TAUROCHENODEOXYCHOLIC ACID; TRIGLYCERIDES; UP-REGULATION; WEIGHT LOSS;

EID: 84895910457     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20548     Document Type: Article

References (35)

1. Giorgio V, Prono F, Graziano F, Nobili V,. Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets. BMC Pediatr 2013; 13: 40.
2. Sturm R, Hattori A,. Morbid obesity rates continue to rise rapidly in the United States. Int J Obes (Lond) 2012 Sep 18. doi: 10.1038/ijo.2012.159. [Epub ahead of print].
3. Noria SF, Grantcharov T,. Biological effects of bariatric surgery on obesity-related comorbidities. Can J Surg 2013; 56: 47-57.
4. Eldar S, Heneghan HM, Brethauer SA, Schauer PR,. Bariatric surgery for treatment of obesity. Int J Obes (Lond) 2011; 35 Suppl 3: S16-S21.
5. Clifton PM,. Bariatric surgery: results in obesity and effects on metabolic parameters. Curr Opin Lipidol 2011; 22: 1-5.
6. Cummings DE, Overduin J, Foster-Schubert KE,. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004; 89: 2608-2615.
7. Shah SS, Todkar JS, Shah PS, Cummings DE,. Diabetes remission and reduced cardiovascular risk after gastric bypass in Asian Indians with body mass index <35 kg/m(2). Surg Obes Relat Dis 2010; 6: 332-338.
8. Chambers AP, Jessen L, Ryan KK, et al. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology 2011; 141: 950-958.
9. Karcz WK, Krawczykowski D, Kuesters S, et al. Influence of sleeve gastrectomy on NASH and type 2 diabetes mellitus. J Obes 2011;2011: 765473.
10. Nakatani H, Kasama K, Oshiro T, Watanabe M, Hirose H, Itoh H,. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism 2009; 58: 1400-1407.
11. Houten SM, Watanabe M, Auwerx J,. Endocrine functions of bile acids. EMBO J 2006; 25: 1419-1425.
12. Watanabe M, Houten SM, Wang L, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004; 113: 1408-1418.
13. Jandacek RJ, Heubi JE, Tso P,. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology 2004; 127: 139-144.
14. Hagio M, Matsumoto M, Fukushima M, Hara H, Ishizuka S,. Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS. J Lipid Res 2009; 50: 173-180.
15. Stefater MA, Perez-Tilve D, Chambers AP, et al. Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology 2010; 138: 2426-2436, 2436 e2421-2423.
16. Chambers AP, Wilson-Perez HE, McGrath S, et al. Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab 2012; 303: E1076-1084.
17. Karmali S, Schauer P, Birch D, Sharma AM, Sherman V,. Laparoscopic sleeve gastrectomy: an innovative new tool in the battle against the obesity epidemic in Canada. Can J Surg 2010; 53: 126-132.
18. Wang L, Lee YK, Bundman D, et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2002; 2: 721-731.
19. del Castillo-Olivares A, Gil G,. Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription. Nucleic Acids Res 2000; 28: 3587-3593.
20. Kohli R, Bradley D, Setchell KD, Eagon JC, Abumrad N, Klein S,. Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab 2013; 98: E708-E712.
21. Patti ME, Houten SM, Bianco AC, et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity 2009; 17: 1671-1677.
22. Pournaras DJ, Glicksman C, Vincent RP, et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology 2012; 153: 3613-3619.
23. Ahmad NN, Pfalzer A, Kaplan LM,. Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int J Obes (Lond) 2013 Apr 9. doi: 10.1038/ijo.2013.38. [Epub ahead of print].
24. Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D,. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 2012; 15: 65-74.
25. Yang JS, Kim JT, Jeon J, et al. Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. PloS ONE 2010; 5: e13858.
26. Yang ZX, Shen W, Sun H,. Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease. Hepatol Int 2010; 4: 741-748.
27. Stylopoulos N, Hoppin AG, Kaplan LM,. Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats. Obesity 2009; 17: 1839-1847.
28. Kang K, Schmahl J, Lee JM, et al. Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption. FASEB J 2012; 26: 259-271.
29. Ishibashi S, Schwarz M, Frykman PK, Herz J, Russell DW,. Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem 1996; 271: 18017-18023.
30. Pandak WM, Bohdan P, Franklund C, et al. Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo. Gastroenterology 2001; 120: 1801-1809.
31. Lu TT, Makishima M, Repa JJ, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000; 6: 507-515.
32. Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000; 6: 517-526.
33. Bellentani S, Hardison WG, Marchegiano P, Zanasi G, Manenti F,. Bile acid inhibition of taurocholate uptake by rat hepatocytes: role of OH groups. Am J Physiol 1987; 252: G339-G344.
34. Eloranta JJ, Jung D, Kullak-Ublick GA,. The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol Endocrinol 2006; 20: 65-79.
35. Rost D, Herrmann T, Sauer P, et al. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Hepatology 2003; 38: 187-195.