Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Journal of Biological Chemistry

Volumn 286, Issue 30, 2011, Pages 26913-26920

  Watanabe, Mitsuhiro ^a   Horai, Yasushi ^a   Houten, Sander M ^b   Morimoto, Kohkichi ^a   Sugizaki, Taichi ^a   Arita, Eri ^a   Mataki, Chikage ^c   Sato, Hiroyuki ^d   Tanigawara, Yusuke ^a   Schoonjans, Kristina ^c   Itoh, Hiroshi ^a   Auwerx, Johan ^c  

^a KEIO UNIVERSITY   (Japan)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c EPFL   (Switzerland)

^d EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; BILE ACID; BODY WEIGHT; ENERGY EXPENDITURE; FARNESOID X RECEPTORS; GLUCOSE INTOLERANCE; HIGH-FAT DIET; INSULIN RESISTANCE; LONG-TERM MANAGEMENT; METABOLIC SYNDROMES; REDUCED ENERGY; WEIGHT GAIN;

BIOCHEMISTRY; BODY FLUIDS; GLUCOSE; MAMMALS; METABOLISM; NUTRITION; TISSUE;

LAKES;

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BILE ACID; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR AGONIST; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; ENERGY EXPENDITURE; ENZYME RECONSTITUTION; GLUCOSE INTOLERANCE; HORMONAL REGULATION; INSULIN RESISTANCE; LIPID DIET; LIPOGENESIS; LIVER; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN;

3T3-L1 CELLS; ANIMALS; BILE ACIDS AND SALTS; BODY WEIGHT; DIABETES MELLITUS; DIETARY FATS; ENERGY METABOLISM; ISOXAZOLES; METABOLIC SYNDROME X; MICE; OBESITY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

ANIMALIA; MUS;

EID: 79960695556     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.248203     Document Type: Article

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