Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice

Journal of Biological Chemistry

Volumn 278, Issue 36, 2003, Pages 33920-33927

  Dawson, Paul A ^a   Haywood, Jamie ^a   Craddock, Ann L ^a   Wilson, Martha ^a   Tietjen, Mary ^a   Kluckman, Kimberly ^b   Maeda, Nobuyo ^b   Parks, John S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; BIOSYNTHESIS; DISEASES; ESTERS; GENES;

MUTATIONS;

BIOCHEMISTRY;

BILE ACID; CARRIER PROTEIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ESTER; COMPLEMENTARY DNA; COTRANSPORTER; ORGANIC ANION TRANSPORTER; RNA; SODIUM; SODIUM BILE ACID COTRANSPORTER; SODIUM-BILE ACID COTRANSPORTER;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APICAL MEMBRANE; ARTICLE; BILE ACID METABOLISM; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENTEROHEPATIC CIRCULATION; GENE; GENE DELETION; GENE DISRUPTION; GENE MUTATION; GENE TARGETING; MALABSORPTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SLC10A2 GENE; SMALL INTESTINE ABSORPTION; STEATORRHEA; ALLELE; ANIMAL; BLOOD; C57BL MOUSE; FEMALE; GENETIC RECOMBINATION; GENETICS; LIVER; MALE; METABOLISM; MOLECULAR GENETICS; MUTATION; NORTHERN BLOTTING; PHYSIOLOGY; SEX DIFFERENCE; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA;

ALLELES; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL ESTERS; DNA, COMPLEMENTARY; FEMALE; GENE DELETION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RECOMBINATION, GENETIC; RNA; SEX FACTORS; SODIUM; SYMPORTERS;

EID: 0141818009     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306370200     Document Type: Article

References (64)

1. Hofmann, A. F. (1994) in The Liver: Biology and Pathobiology (Arias, I. M., Boyer, J. L., Fausto, N., Jakoby, W. B., Schachter, D. A., and Shafritz, D. A., eds) pp. 677-717, Raven Press, New York
2. Hofmann, A. F. (1994) in Physiology of the Gastrointestinal Tract (Johnson, L. R., ed) pp. 1845-1865, Raven Press, New York
3. Shneider, B. L. (2001) J. Ped. Gastroenterol. Nutr. 32, 407-417
4. Dawson, P. A. (2002) in Sleisenger and Fordtran's Gastrointestinal and Liver Disease (Feldman, M., Friedman, L. S., and Sleisenger, M. H., eds) pp. 1051-1064, W. B. Saunders, Co., Philadelphia, PA
5. Hepner, G. W., and Demers, L. M. (1977) Gastroenterology 72, 499-510
6. Hofmann, A. F., and Poley, J. R. (1972) Gastroenterology 62, 918-934
7. Marcus, S. N., Schteingart, C. D., Marquez, M. L., Hofmann, A. F., Xia, Y., Steinbach, J. H., Ton-Nu, H.-T., Lillienau, J., Angellotti, M. A., and Schassmann, A. (1991) Gastroenterology 100, 212-221
8. Aldini, R., Roda, A., Montagnani, M., Polimeni, C., Lenzi, P. L., Cerre, C., Galletti, G., and Roda, E. (1994) Eur. J. Clin. Invest. 24, 691-697
9. Aldini, R., Montagnani, M., Roda, A., Hrelia, S., Biagi, P. L., and Roda, E. (1996) Gastroenterology 110, 459-468
10. Oelkers, P., Kirby, L. C., Heubi, J. E., and Dawson, P. A. (1997) J. Clin. Invest. 99, 1880-1887
11. Heubi, J. E., Balistreri, W. F., Fondacaro, J. D., Partin, J. C., and Schubert, W. K. (1982) Gastroenterology 83, 804-811
12. Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C. (1991) Cell 65, 1153-1163
13. Koller, B. H., Kim, H., Latour, A. M., Brigman, K., Boucher, R. C., Scambler, P., Wainwright, B., and Smithies, O. (1991) Proc. Natl. Acad. Sci. 88, 10730-10734
14. Rudel, L. L., Kelley, K., Sawyer, J. K., Shah, R., and Wilson, M. D. (1998) Arterioscler. Thremb. Vasc. Biol. 18, 1818-1827
15. Kessler, M., Acuto, O., Storelli, C., Murer, H., Muller, M., and Semenza, G. (1978) Biochim. Biophys. Acta 506, 136-154
16. Moyer, M. S., Heubi, J. E., Goodrich, A. L., Balistreri, W. F., and Suchy, F. J. (1986) Gastroenterology 90, 1188-1196
17. Wong, M. H., Oelkers, P., and Dawson, P. A. (1995) J. Biol. Chem. 270, 27228-27234
18. Turley, S. D., Daggy, B. P., and Dietschy, J. M. (1996) J. Cardiovase. Phar. macol. 27, 71-79
19. Mashige, F., Tanaka, N., Maki, A., Kamei, S., and Manabu, Y. (1981) Clin. Chem. 27, 1352-1356
20. Hagey, L. R., Schteingart, C. D., Ton-Nu, H.-T., and Hofmann, A. F. (2002) J. Lipid Res. 43, 685-690
21. Gillotte, K. L., Lund-Katz, S., de la Llera-Moya, M., Parks, J. S., Rudel, L. L., Rothblat, G. H., and Phillips, M. C. (1998) J. Lipid Res. 39, 2065-2075
22. Turley, S. D., Daggy, B. P., and Dietschy, J. M. (1994) Gastroenterology 107, 444-452
23. Schwarz, M., Russell, D. W., Dietschy, J. M., and Turley, S. D. (1998) J. Lipid Res. 39, 1833-1843
24. Rossi S. S., Converse, J. L., and Hofmann, A. F. (1987) J. Lipid Res. 28, 589-595
25. Repa, J. J., Dietschy, J. M., and Turley, S. D. (2002) J. Lipid Res. 43, 1864-1874
26. Rudel, L. L., Deckelman, C., Wilson, M., Scobey, M., and Anderson, R. (1994) J. Clin. Invest. 93, 2463-2472
27. Shelness, G. S., Lin, L., and Nicchitta, C. V. (1993) J. Biol. Chem. 268, 5201-5208
28. Chiang, J. Y. L. (1991) Methods Enzymel. 206, 483-491
29. Carr, T. P., Parks, J. S., and Rudel, L. L. (1992) Arterioscler. Thromb. 12, 1274-1283
30. Wong, M. H., Oelkers, P., Craddock, A. L., and Dawson, P. A. (1994) J. Biol. Chem. 269, 1340-1347
31. Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18017-18023
32. Schwarz, M., Lund, E. G., Setchell, K. D. R., Kayden, H. J., Zerwekh, J. E., Björkem, I., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18024-18031
33. Russell, D. W. (2003) Ann Rev. Biochem. 72, 137-174
34. Jolley, C. D., Dietschy, J. M., and Turley, S. D. (2001) Hepatology 32, 1309-1316
35. Schwarz, M., Russell, D. W., Dietschy, J. M., and Turley, S. D. (2001) J. Lipid Res. 42, 1594-1603
36. Li-Hawkins, J., Gafvels, M., Olin, M., Lund, E. G., Andersson, U., Schuster, G., Björkhem, I., Russell, D. W., and Eggertsen, G. (2002) J. Clin. Invest. 110, 1191-1200
37. Wang, D. Q.-H., and Tazuma, S. (2002) J. Lipid Res. 43, 1960-1968
38. Amelsburg, A., Schteingart, C. D., Ton-Nu, H.-T., and Hofmann, A. F. (1996) Gastroenterology 110, 1098-1106
39. Amelsburg, A., Jochims, C., Richter, C. P., Nitsche, R., and Fölsch, U. (1999) Am. J. Physiol. Gastrointest. Liver Physiol. 276, G737-G742
40. Gui, X., and Carraway, R. E. (2001) Gastroenterology 120, 151-160
41. Gui, X., Dobner, P. R., and Carraway, R. E. (2001) Am. J. Physiol. Gastrointest. Liver Physiol. 281, G1413-G1422
42. Walters, H. C., Craddock, A. L., Fusegawa, H., Willingham, M. C., and Dawson, P. A. (2000) Am. J. Physiol. Gastrointest. Liver Physiol. 279, G1188-G1200
43. Hylemon, P. B., and Harder, J. (1998) FEMS Microbiol. Rev. 22, 475-488
44. Mekhjian, H. S., Phillips, S. F., and Hofmann, A. F. (1979) Dig. Dis. Sci. 24, 545-550
45. Dietschy, J. M. (1968) J. Lipid Res. 9, 297-309
46. Hofmann, A. F., Cravetto, C., Molino, G., Belforte, G., and Bona, B. (1987) Gastroenterology 93, 693-709
47. Thomas, L. A., Versey, M. J., Bathgate, T., King, A., French, G., Smeeton, N. C., Murphy, G. M., and Dowling, R. H. (2000) Gastroenterology 119, 806-815
48. Floch, M. H., Gershengoren, W., Elliot, S., and Spiro, H. M. (1971) Gastroenterology 61, 228-233
49. Lorenzo-Zuñiga, V., Bartoli, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernandez, J. M., Mañé, J., Alvarez, M. A., Ausina, V., and Gassull, M. A. (2003) Hepatology 37, 551-557
50. Lambert, G., Amar, M. J. A., Guo, G., Brewer, H. B., Gonzalez, F. J., and Sinal, C. J. (2003) J. Biol. Chem. 278, 2563-2570
51. Claudel, T., Sturm, E., Duez, H., Pineda, I., Sirvent, A., Kosykh, V., Fruchart, J.-C., Dallongeville, J., Hum, D. W., Kuipers, F., and Staels, B. (2002) J. Clin. Invest. 109, 961-971
52. Srivastava, R. A. K., Srivastava, N., and Averna, M. (2000) Eur. J. Biochem. 267, 4272-4280
53. Grundy, S. M., Ahrens, E. H., and Salen, G. (1971) J. Lab. Clin. Med. 78, 94-121
54. Angelin, B., Einarsson, K., Hellstrom, K., and Leijd, B. (1978) J. Lipid Res. 19, 1017-1024
55. Akerlund, J. E., Björkem, I., Angelin, B., L. Liljeqvist, and K. Einarsson. (1994) Gut 35, 1116-1120
56. Schoenfield, L. J., and Lachin, J. M. (1981) Ann. Intern. Med. 95, 257-282
57. Miller, N. E., and Nestel, P. J. (1974) Lancet 2, 929-931
58. Angelin, B., Hershon, K. S., and Brunzell, J. D. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5434-5438
59. Love, M. W., Craddock, A. L., Angelin, B., Brunzell, J. D., Duane, W. C., and Dawson, P. A. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 2039-2045
60. Duane, W. C., Hartrich, L. A., Bartman, A. E., and Ho, S. B. (2000) J. Lipid Res. 41, 1341-1389
61. Tint, G. S., Ginsberg, H., Salen, G., Lee, N. A., and Shafer, S. (1989) J. Lipid Res. 30, 633-640
62. Pullinger, C. R., Eng, C., Salen, G., Shafer, S., Batta, A. K., Erickson, S. K., Verhagen, A., Rivera, C. R., Mulvihill, S. J., Malloy, M. J., and Kane, J. P. (2002) J. Clin. Invest. 110, 109-117
63. Repa, J. J., Lund, E. G., Horton, J. D., Leitersdorf, E., Russell, D. W., Dietschy, J. M., and Turley, S. D. (2000) J. Biol. Chem. 275, 39685-39692
64. Elzinga, B. M., Havinga, R., Baller, J. F. W., Wolters, H., Bloks, V., Mensenkamp, A. R., Kuipers, F., and Verkade, H. J. (2002) Biochim. Biophys. Acta 1573, 9-20