Pleiotropic roles of bile acids in metabolism

Cell Metabolism

Volumn 17, Issue 5, 2013, Pages 657-669

  De Aguiar Vallim, Thomas Q ^a,b   Tarling, Elizabeth J ^a,b   Edwards, Peter A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; PREGNANE X RECEPTOR; VITAMIN D RECEPTOR;

BILE ACID METABOLISM; BILE ACID SYNTHESIS; CHOLESTASIS; ENERGY METABOLISM; ENTEROHEPATIC CIRCULATION; GALLBLADDER; GLUCOSE METABOLISM; HUMAN; IMMUNE SYSTEM; INFLAMMATION; INTESTINE; INTESTINE MOTILITY; LIPOPROTEIN METABOLISM; LIVER; LIVER PROTECTION; METABOLISM; MICROBIOME; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; REVIEW;

BILE ACIDS AND SALTS; GENE EXPRESSION; HUMANS; LIPID METABOLISM; RECEPTORS, CELL SURFACE;

BACTERIA (MICROORGANISMS);

EID: 84877581095     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.03.013     Document Type: Review

References (116)

1. F. Alemi, D.P. Poole, J. Chiu, K. Schoonjans, F. Cattaruzza, J.R. Grider, N.W. Bunnett, and C.U. Corvera The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice Gastroenterology 144 2013 145 154
2. K.E. Anderson, E. Kok, and N.B. Javitt Bile acid synthesis in man: metabolism of 7 -hydroxycholesterol- 14 C and 26-hydroxycholesterol- 3 H J. Clin. Invest. 51 1972 112 117
3. B. Angelin, I. Björkhem, K. Einarsson, and S. Ewerth Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum J. Clin. Invest. 70 1982 724 731
4. B. Angelin, T.E. Larsson, and M. Rudling Circulating fibroblast growth factors as metabolic regulators - a critical appraisal Cell Metab. 16 2012 693 705
5. B.J. Bennett, T.Q.A. Vallim, Z. Wang, D. Shih, Y. Meng, J. Gregory, H. Allayee, R. Lee, M. Graham, and R. Crooke Genetic and dietary regulation of trimethylamine-N-oxide, a metabolite associated with atherosclerosis Cell Metab. 17 2013 1 12
6. I. Björkhem, V. Leoni, and S. Meaney Genetic connections between neurological disorders and cholesterol metabolism J. Lipid Res. 51 2010 2489 2503
7. L. Boyer, S. Travaglione, L. Falzano, N.C. Gauthier, M.R. Popoff, E. Lemichez, C. Fiorentini, and A. Fabbri Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes Mol. Biol. Cell 15 2004 1124 1133
8. S. Buch, C. Schafmayer, H. Völzke, C. Becker, A. Franke, H. von Eller-Eberstein, C. Kluck, I. Bässmann, M. Brosch, and F. Lammert A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease Nat. Genet. 39 2007 995 999
9. A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat. Rev. Mol. Cell Biol. 13 2012 213 224
10. B. Cariou, K. van Harmelen, D. Duran-Sandoval, T.H. van Dijk, A. Grefhorst, M. Abdelkarim, S. Caron, G. Torpier, J.C. Fruchart, and F.J. Gonzalez The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice J. Biol. Chem. 281 2006 11039 11049
11. P.C. Cha, H. Zembutsu, A. Takahashi, M. Kubo, N. Kamatani, and Y. Nakamura A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population J. Hum. Genet. 57 2012 235 237
12. R. Chandra, and R.A. Liddle Cholecystokinin Curr. Opin. Endocrinol. Diabetes Obes. 14 2007 63 67
13. J. Cheng, Y.M. Shah, and F.J. Gonzalez Pregnane X receptor as a target for treatment of inflammatory bowel disorders Trends Pharmacol. Sci. 33 2012 323 330
14. J.Y. Chiang Bile acids: regulation of synthesis J. Lipid Res. 50 2009 1955 1966
15. M. Choi, A. Moschetta, A.L. Bookout, L. Peng, M. Umetani, S.R. Holmstrom, K. Suino-Powell, H.E. Xu, J.A. Richardson, and R.D. Gerard Identification of a hormonal basis for gallbladder filling Nat. Med. 12 2006 1253 1255
16. H.K. Chong, A.M. Infante, Y.K. Seo, T.I. Jeon, Y. Zhang, P.A. Edwards, X. Xie, and T.F. Osborne Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1 Nucleic Acids Res. 38 2010 6007 6017
17. P.A. Dawson Bile secretion and the enterohepatic circulation M. Feldman, L.S. Friedman, L.J. Brandt, M.H. Sleisenger, Gastrointestinal and Liver Disease Vol. 1 2010 Saunders Elsevier Philadelphia 1075 1088
18. P.A. Dawson, J. Haywood, A.L. Craddock, M. Wilson, M. Tietjen, K. Kluckman, N. Maeda, and J.S. Parks Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice J. Biol. Chem. 278 2003 33920 33927
19. P.A. Dawson, M.L. Hubbert, and A. Rao Getting the mOST from OST: role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism Biochim. Biophys. Acta. 1801 2010 994 1004
20. L.A. Denson, E. Sturm, W. Echevarria, T.L. Zimmerman, M. Makishima, D.J. Mangelsdorf, and S.J. Karpen The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp Gastroenterology 121 2001 140 147
21. S. Devkota, Y. Wang, M.W. Musch, V. Leone, H. Fehlner-Peach, A. Nadimpalli, D.A. Antonopoulos, B. Jabri, and E.B. Chang Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice Nature 487 2012 104 108
22. W.C. Duane, and N.B. Javitt 27-hydroxycholesterol: production rates in normal human subjects J. Lipid Res. 40 1999 1194 1199
23. B.M. Forman, E. Goode, J. Chen, A.E. Oro, D.J. Bradley, T. Perlmann, D.J. Noonan, L.T. Burka, T. McMorris, and W.W. Lamph Identification of a nuclear receptor that is activated by farnesol metabolites Cell 81 1995 687 693
24. C. Gälman, B. Angelin, and M. Rudling Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19 J. Intern. Med. 270 2011 580 588
25. M.M. Garcia-Barceló, M.Y. Yeung, X.P. Miao, C.S. Tang, G. Cheng, M.T. So, E.S. Ngan, V.C. Lui, Y. Chen, and X.L. Liu Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2 Hum. Mol. Genet. 19 2010 2917 2925
26. G.A. Graf, L. Yu, W.P. Li, R.D. Gerard, P.L. Tuma, J.C. Cohen, and H.H. Hobbs ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion J. Biol. Chem. 278 2003 48275 48282
27. T. Harach, T.W. Pols, M. Nomura, A. Maida, M. Watanabe, J. Auwerx, and K. Schoonjans TGR5 potentiates GLP-1 secretion in response to anionic exchange resins Sci. Rep. 2 2012 430 10.1038/srep00430
28. J.E. Heubi, K.D. Setchell, and K.E. Bove Inborn errors of bile acid metabolism Semin. Liver Dis. 27 2007 282 294
29. H. Higashiyama, M. Kinoshita, and S. Asano Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray Acta Histochem. 110 2008 86 93
30. Hofmann, A.F. (2010). Enterohepatic circulation of bile acids. In Comprehensive Physiology, 567-596.
31. J.A. Holt, G. Luo, A.N. Billin, J. Bisi, Y.Y. McNeill, K.F. Kozarsky, M. Donahee, D.Y. Wang, T.A. Mansfield, and S.A. Kliewer Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis Genes Dev. 17 2003 1581 1591
32. T. Inagaki, M. Choi, A. Moschetta, L. Peng, C.L. Cummins, J.G. McDonald, G. Luo, S.A. Jones, B. Goodwin, and J.A. Richardson Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis Cell Metab. 2 2005 217 225
33. J.H. Iser, and A. Sali Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use Drugs 21 1981 90 119
34. S. Ishibashi, M. Schwarz, P.K. Frykman, J. Herz, and D.W. Russell Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation J. Biol. Chem. 271 1996 18017 18023
35. S. Ito, T. Fujimori, A. Furuya, J. Satoh, Y. Nabeshima, and Y. Nabeshima Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho J. Clin. Invest. 115 2005 2202 2208
36. S.A. Jones Physiology of FGF15/19 Adv. Exp. Med. Biol. 728 2012 171 182
37. N.Y. Kalaany, and D.J. Mangelsdorf LXRS and FXR: the yin and yang of cholesterol and fat metabolism Annu. Rev. Physiol. 68 2006 159 191
38. S. Katsuma, A. Hirasawa, and G. Tsujimoto Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1 Biochem. Biophys. Res. Commun. 329 2005 386 390
39. Y. Kawamata, R. Fujii, M. Hosoya, M. Harada, H. Yoshida, M. Miwa, S. Fukusumi, Y. Habata, T. Itoh, and Y. Shintani A G protein-coupled receptor responsive to bile acids J. Biol. Chem. 278 2003 9435 9440
40. V. Keitel, and D. Häussinger TGR5 in the biliary tree Dig. Dis. 29 2011 45 47
41. V. Keitel, and D. Häussinger Perspective: TGR5 (Gpbar-1) in liver physiology and disease Clin. Res. Hepatol. Gastroenterol. 36 2012 412 419
42. V. Keitel, M. Donner, S. Winandy, R. Kubitz, and D. Häussinger Expression and function of the bile acid receptor TGR5 in Kupffer cells Biochem. Biophys. Res. Commun. 372 2008 78 84
43. V. Keitel, K. Cupisti, C. Ullmer, W.T. Knoefel, R. Kubitz, and D. Häussinger The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders Hepatology 50 2009 861 870
44. V. Keitel, B. Görg, H.J. Bidmon, I. Zemtsova, L. Spomer, K. Zilles, and D. Häussinger The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain Glia 58 2010 1794 1805
45. T.A. Kerr, S. Saeki, M. Schneider, K. Schaefer, S. Berdy, T. Redder, B. Shan, D.W. Russell, and M. Schwarz Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis Dev. Cell 2 2002 713 720
46. S. Kir, S.A. Beddow, V.T. Samuel, P. Miller, S.F. Previs, K. Suino-Powell, H.E. Xu, G.I. Shulman, S.A. Kliewer, and D.J. Mangelsdorf FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis Science 331 2011 1621 1624
47. B. Kong, L. Wang, J.Y. Chiang, Y. Zhang, C.D. Klaassen, and G.L. Guo Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice Hepatology 56 2012 1034 1043
48. B. Lavoie, O.B. Balemba, C. Godfrey, C.A. Watson, G. Vassileva, C.U. Corvera, M.T. Nelson, and G.M. Mawe Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels J. Physiol. 588 2010 3295 3305
49. H. Lee, Y. Zhang, F.Y. Lee, S.F. Nelson, F.J. Gonzalez, and P.A. Edwards FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine J. Lipid Res. 47 2006 201 214
50. F.Y. Lee, T.Q. de Aguiar Vallim, H.K. Chong, Y. Zhang, Y. Liu, S.A. Jones, T.F. Osborne, and P.A. Edwards Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity Mol. Endocrinol. 24 2010 1626 1636
51. P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, and B. Staels Role of bile acids and bile acid receptors in metabolic regulation Physiol. Rev. 89 2009 147 191
52. T. Li, S.R. Holmstrom, S. Kir, M. Umetani, D.R. Schmidt, S.A. Kliewer, and D.J. Mangelsdorf The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling Mol. Endocrinol. 25 2011 1066 1071
53. Y. Liu, J. Binz, M.J. Numerick, S. Dennis, G. Luo, B. Desai, K.I. MacKenzie, T.A. Mansfield, S.A. Kliewer, B. Goodwin, and S.A. Jones Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis J. Clin. Invest. 112 2003 1678 1687
54. X. Liu, P. Invernizzi, Y. Lu, R. Kosoy, Y. Lu, I. Bianchi, M. Podda, C. Xu, G. Xie, and F. Macciardi Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis Nat. Genet. 42 2010 658 660
55. T. Lundåsen, C. Gälman, B. Angelin, and M. Rudling Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man J. Intern. Med. 260 2006 530 536
56. K. Ma, P.K. Saha, L. Chan, and D.D. Moore Farnesoid X receptor is essential for normal glucose homeostasis J. Clin. Invest. 116 2006 1102 1109
57. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365
58. M. Makishima, T.T. Lu, W. Xie, G.K. Whitfield, H. Domoto, R.M. Evans, M.R. Haussler, and D.J. Mangelsdorf Vitamin D receptor as an intestinal bile acid sensor Science 296 2002 1313 1316
59. T. Maruyama, Y. Miyamoto, T. Nakamura, Y. Tamai, H. Okada, E. Sugiyama, T. Nakamura, H. Itadani, and K. Tanaka Identification of membrane-type receptor for bile acids (M-BAR) Biochem. Biophys. Res. Commun. 298 2002 714 719
60. T. Maruyama, K. Tanaka, J. Suzuki, H. Miyoshi, N. Harada, T. Nakamura, Y. Miyamoto, A. Kanatani, and Y. Tamai Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice J. Endocrinol. 191 2006 197 205
61. T. Matsubara, F. Li, and F.J. Gonzalez FXR signaling in the enterohepatic system Mol. Cell. Endocrinol. 368 2013 17 29
62. G.F. Mells, J.A. Floyd, K.I. Morley, H.J. Cordell, C.S. Franklin, S.Y. Shin, M.A. Heneghan, J.M. Neuberger, P.T. Donaldson, D.B. Day UK PBC Consortium; Wellcome Trust Case Control Consortium 3 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nat. Genet. 43 2011 329 332
63. M. Nakamura, N. Nishida, M. Kawashima, Y. Aiba, A. Tanaka, M. Yasunami, H. Nakamura, A. Komori, M. Nakamuta, and M. Zeniya Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population Am. J. Hum. Genet. 91 2012 721 728
64. A. Nguyen, and B. Bouscarel Bile acids and signal transduction: role in glucose homeostasis Cell. Signal. 20 2008 2180 2197
65. M. Nicolaou, E.J. Andress, J.K. Zolnerciks, P.H. Dixon, C. Williamson, and K.J. Linton Canalicular ABC transporters and liver disease J. Pathol. 226 2012 300 315
66. P. Oelkers, L.C. Kirby, J.E. Heubi, and P.A. Dawson Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2) J. Clin. Invest. 99 1997 1880 1887
67. R. Pai, D. French, N. Ma, K. Hotzel, E. Plise, L. Salphati, K.D. Setchell, J. Ware, V. Lauriault, and L. Schutt Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys Toxicol. Sci. 126 2012 446 456
68. D.J. Parks, S.G. Blanchard, R.K. Bledsoe, G. Chandra, T.G. Consler, S.A. Kliewer, J.B. Stimmel, T.M. Willson, A.M. Zavacki, D.D. Moore, and J.M. Lehmann Bile acids: natural ligands for an orphan nuclear receptor Science 284 1999 1365 1368
69. T.W. Pols, M. Nomura, T. Harach, G. Lo Sasso, M.H. Oosterveer, C. Thomas, G. Rizzo, A. Gioiello, L. Adorini, and R. Pellicciari TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading Cell Metab. 14 2011 747 757
70. T.W. Pols, L.G. Noriega, M. Nomura, J. Auwerx, and K. Schoonjans The bile acid membrane receptor TGR5: a valuable metabolic target Dig. Dis. 29 2011 37 44
71. G. Porez, J. Prawitt, B. Gross, and B. Staels Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease J. Lipid Res. 53 2012 1723 1737
72. M.J. Potthoff, J. Boney-Montoya, M. Choi, T. He, N.E. Sunny, S. Satapati, K. Suino-Powell, H.E. Xu, R.D. Gerard, and B.N. Finck FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway Cell Metab. 13 2011 729 738
73. M.J. Potthoff, S.A. Kliewer, and D.J. Mangelsdorf Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Genes Dev. 26 2012 312 324
74. A. Rao, J. Haywood, A.L. Craddock, M.G. Belinsky, G.D. Kruh, and P.A. Dawson The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Proc. Natl. Acad. Sci. USA 105 2008 3891 3896
75. J.M. Ridlon, D.J. Kang, and P.B. Hylemon Bile salt biotransformations by human intestinal bacteria J. Lipid Res. 47 2006 241 259
76. D.W. Russell The enzymes, regulation, and genetics of bile acid synthesis Annu. Rev. Biochem. 72 2003 137 174
77. D.W. Russell Fifty years of advances in bile acid synthesis and metabolism J. Lipid Res. 50 Suppl 2009 S120 S125
78. T. Ruutu, B. Eriksson, K. Remes, E. Juvonen, L. Volin, M. Remberger, T. Parkkali, H. Hägglund, O. Ringdén Nordic Bone Marrow Transplantation Group Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation Blood 100 2002 1977 1983
79. H. Sato, C. Genet, A. Strehle, C. Thomas, A. Lobstein, A. Wagner, C. Mioskowski, J. Auwerx, and R. Saladin Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea Biochem. Biophys. Res. Commun. 362 2007 793 798
80. H. Sato, A. Macchiarulo, C. Thomas, A. Gioiello, M. Une, A.F. Hofmann, R. Saladin, K. Schoonjans, R. Pellicciari, and J. Auwerx Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies J. Med. Chem. 51 2008 1831 1841
81. S.I. Sayin, A. Wahlström, J. Felin, S. Jäntti, H.U. Marschall, K. Bamberg, B. Angelin, T. Hyötyläinen, M. Orešič, and F. Bäckhed Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17 2013 225 235
82. F.G. Schaap Role of fibroblast growth factor 19 in the control of glucose homeostasis Curr. Opin. Clin. Nutr. Metab. Care 15 2012 386 391
83. F.G. Schaap, N.A. van der Gaag, D.J. Gouma, and P.L. Jansen High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis Hepatology 49 2009 1228 1235
84. D.R. Schmidt, S.R. Holmstrom, K. Fon Tacer, A.L. Bookout, S.A. Kliewer, and D.J. Mangelsdorf Regulation of bile acid synthesis by fat-soluble vitamins A and D J. Biol. Chem. 285 2010 14486 14494
85. M. Schwarz, E.G. Lund, K.D. Setchell, H.J. Kayden, J.E. Zerwekh, I. Björkhem, J. Herz, and D.W. Russell Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase J. Biol. Chem. 271 1996 18024 18031
86. M. Schwarz, D.W. Russell, J.M. Dietschy, and S.D. Turley Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding J. Lipid Res. 42 2001 1594 1603
87. F. Selwyn, and C.D. Klaassen Characterization of bile acid homeostasis in germ-free mice FASEB J. 26 2012 1155.1
88. W. Seol, H.S. Choi, and D.D. Moore Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors Mol. Endocrinol. 9 1995 72 85
89. C.J. Sinal, M. Tohkin, M. Miyata, J.M. Ward, G. Lambert, and F.J. Gonzalez Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis Cell 102 2000 731 744
90. J. Sonoda, L. Pei, and R.M. Evans Nuclear receptors: decoding metabolic disease FEBS Lett. 582 2008 2 9
91. B. Staels, Y. Handelsman, and V. Fonseca Bile acid sequestrants for lipid and glucose control Curr. Diab. Rep. 10 2010 70 77
92. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, A. LaTour, Y. Liu, C.D. Klaassen, K.K. Brown, and J. Reinhard The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc. Natl. Acad. Sci. USA 98 2001 3369 3374
93. E. Studer, X. Zhou, R. Zhao, Y. Wang, K. Takabe, M. Nagahashi, W.M. Pandak, P. Dent, S. Spiegel, and R. Shi Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes Hepatology 55 2012 267 276
94. J.Y. Sung, J.W. Costerton, and E.A. Shaffer Defense system in the biliary tract against bacterial infection Dig. Dis. Sci. 37 1992 689 696
95. J.R. Swann, E.J. Want, F.M. Geier, K. Spagou, I.D. Wilson, J.E. Sidaway, J.K. Nicholson, and E. Holmes Systemic gut microbial modulation of bile acid metabolism in host tissue compartments Proc. Natl. Acad. Sci. USA 108 Suppl 1 2011 4523 4530
96. T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M. Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, and C.J. Willer Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 2010 707 713
97. C. Thomas, R. Pellicciari, M. Pruzanski, J. Auwerx, and K. Schoonjans Targeting bile-acid signalling for metabolic diseases Nat. Rev. Drug Discov. 7 2008 678 693
98. C. Thomas, A. Gioiello, L. Noriega, A. Strehle, J. Oury, G. Rizzo, A. Macchiarulo, H. Yamamoto, C. Mataki, and M. Pruzanski TGR5-mediated bile acid sensing controls glucose homeostasis Cell Metab. 10 2009 167 177
99. A.M. Thomas, S.N. Hart, B. Kong, J. Fang, X.B. Zhong, and G.L. Guo Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine Hepatology 51 2010 1410 1419
100. J. Trottier, A. Białek, P. Caron, R.J. Straka, P. Milkiewicz, and O. Barbier Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting PLoS ONE 6 2011 e22094 10.1371/journal.pone.0022094
101. G. Vassileva, A. Golovko, L. Markowitz, S.J. Abbondanzo, M. Zeng, S. Yang, L. Hoos, G. Tetzloff, D. Levitan, and N.J. Murgolo Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation Biochem. J. 398 2006 423 430
102. H. Wang, J. Chen, K. Hollister, L.C. Sowers, and B.M. Forman Endogenous bile acids are ligands for the nuclear receptor FXR/BAR Mol. Cell 3 1999 543 553
103. L. Wang, Y.K. Lee, D. Bundman, Y. Han, S. Thevananther, C.S. Kim, S.S. Chua, P. Wei, R.A. Heyman, M. Karin, and D.D. Moore Redundant pathways for negative feedback regulation of bile acid production Dev. Cell 2 2002 721 731
104. D.Q. Wang, D.E. Cohen, and M.C. Carey Biliary lipids and cholesterol gallstone disease J. Lipid Res. 50 Suppl 2009 S406 S411
105. X.X. Wang, T. Jiang, Y. Shen, L. Adorini, M. Pruzanski, F.J. Gonzalez, P. Scherzer, L. Lewis, S. Miyazaki-Anzai, and M. Levi The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria Am. J. Physiol. Renal Physiol. 297 2009 F1587 F1596
106. Y.D. Wang, W.D. Chen, D. Yu, B.M. Forman, and W. Huang The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice Hepatology 54 2011 1421 1432
107. M. Watanabe, S.M. Houten, L. Wang, A. Moschetta, D.J. Mangelsdorf, R.A. Heyman, D.D. Moore, and J. Auwerx Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c J. Clin. Invest. 113 2004 1408 1418
108. M. Watanabe, S.M. Houten, C. Mataki, M.A. Christoffolete, B.W. Kim, H. Sato, N. Messaddeq, J.W. Harney, O. Ezaki, and T. Kodama Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Nature 439 2006 484 489
109. H.O. Wieland Nobel Prize Lecture (1928): the chemistry of the bile acids Nobel Lectures, Chemistry 1922-1941 1966 Elsevier Publishing Company Amsterdam
110. C. Yu, F. Wang, M. Kan, C. Jin, R.B. Jones, M. Weinstein, C.X. Deng, and W.L. McKeehan Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4 J. Biol. Chem. 275 2000 15482 15489
111. Y. Zhang, and P.A. Edwards FXR signaling in metabolic disease FEBS Lett. 582 2008 10 18
112. Y. Zhang, F.Y. Lee, G. Barrera, H. Lee, C. Vales, F.J. Gonzalez, T.M. Willson, and P.A. Edwards Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice Proc. Natl. Acad. Sci. USA 103 2006 1006 1011
113. Y. Zhang, C.H. Hagedorn, and L. Wang Role of nuclear receptor SHP in metabolism and cancer Biochim. Biophys. Acta 1812 2011 893 908
114. Y.K. Zhang, G.L. Guo, and C.D. Klaassen Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters PLoS ONE 6 2011 e16683 10.1371/journal.pone.0016683
115. Y. Zhang, J.Y. Hong, C.E. Rockwell, B.L. Copple, H. Jaeschke, and C.D. Klaassen Effect of bile duct ligation on bile acid composition in mouse serum and liver Liver Int. 32 2012 58 69
116. G. Zollner, and M. Trauner Molecular mechanisms of cholestasis Wien. Med. Wochenschr. 156 2006 380 385