Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults

Gastroenterology

Volumn 139, Issue 2, 2010, Pages 448-455

  Fabbrini, Elisa ^a,b   Tamboli, Robyn A ^c   Magkos, Faidon ^a,d   Marks Shulman, Pamela A ^c   Eckhauser, Aaron W ^c   Richards, William O ^c   Klein, Samuel ^a   Abumrad, Naji N ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HAROKOPIO UNIVERSITY   (Greece)

Author keywords

Insulin Resistance; Intra abdominal Fat; Omentectomy; Portal Hypothesis

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LAPAROSCOPIC SURGERY; LONGITUDINAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OMENTECTOMY; OMENTUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ROUX Y ANASTOMOSIS; SKELETAL MUSCLE; STOMACH BYPASS; BLOOD; CARDIOVASCULAR DISEASE; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; LAPAROSCOPY; LIPECTOMY; LIVER; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; RISK ASSESSMENT; RISK FACTOR; TIME; TREATMENT OUTCOME;

ADULT; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC BYPASS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LAPAROSCOPY; LIPECTOMY; LIVER; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; OMENTUM; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 77955485237     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.04.056     Document Type: Article

References (36)

1. G.A. Bray, K.A. Jablonski, W.Y. Fujimoto, et al. Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program Am J Clin Nutr 87 2008 1212 1218
2. C.S. Fox, J.M. Massaro, and U. Hoffmann Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study Circulation 116 2007 39 48 (Pubitemid 47016245)
3. J.P. Despres Intra-abdominal obesity: an untreated risk factor for type 2 diabetes and cardiovascular disease J Endocrinol Invest 29 2006 77 82
4. M.U. Jakobsen, T. Berentzen, T.I. Sorensen, et al. Abdominal obesity and fatty liver Epidemiol Rev 29 2007 77 87
5. R.N. Bergman, S.P. Kim, K.J. Catalano, et al. Why visceral fat is bad: mechanisms of the metabolic syndrome Obesity (Silver Spring) 14 Suppl 1 2006 16S 19S
6. J.P. Despres, and I. Lemieux Abdominal obesity and metabolic syndrome Nature 444 2006 881 887
7. E. Hansen, T. Hajri, and N.N. Abumrad Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus Surgery 139 2006 711 716
8. K.N. Frayn Visceral fat and insulin resistance - causative or correlative? Br J Nutr 83 2000 S71 S77
9. S.K. Fried, R.L. Leibel, N.K. Edens, et al. Lipolysis in intraabdominal adipose tissues of obese women and men Obes Res 1 1993 443 448
10. M. Rebuffe-Scrive, B. Anderson, L. Olbe, et al. Metabolism of adipose tissue in intraabdominal depots in severely obese men and women Metabolism 39 1990 1021 1025
11. M. Lafontan, and J. Girard Impact of visceral adipose tissue on liver metabolism Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue Diabetes Metab 34 2008 317 327
12. M.M. Ibrahim Subcutaneous and visceral adipose tissue: structural and functional differences Obes Rev 11 2010 11 18
13. D.M. Huffman, and N. Barzilai Role of visceral adipose tissue in aging Biochim Biophys Acta 1790 2009 1117 1123
14. M. Lottati, C.M. Kolka, D. Stefanovski, et al. Greater omentectomy improves insulin sensitivity in nonobese dogs Obesity (Silver Spring) 17 2009 674 680
15. A. Thorne, F. Lonnqvist, J. Apelman, et al. A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding Int J Obes Relat Metab Disord 26 2002 193 199
16. A. Csendes, F. Maluenda, and A.M. Burgos A prospective randomized study comparing patients with morbid obesity submitted to laparotomic gastric bypass with or without omentectomy Obes Surg 19 2009 490 494
17. P.A. Tataranni, and E. Ravussin Use of dual-energy X-ray absorptiometry in obese individuals Am J Clin Nutr 62 1995 730 734
18. S. Camastra, M. Manco, A. Mari, et al. β-Cell function in morbidly obese subjects during free living: long-term effects of weight loss Diabetes 54 2005 2382 2389
19. J.C. Levy, D.R. Matthews, and M.P. Hermans Correct homeostasis model assessment (HOMA) evaluation uses the computer program Diabetes Care 21 1998 2191 2192
20. M. Matsuda, and R.A. DeFronzo Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1999 1462 1470
21. R. Steele, J.S. Wall, R.C. De Bodo, et al. Measurement of size and turnover rate of body glucose pool by the isotope dilution method Am J Physiol 187 1956 15 24
22. K.M. Korenblat, E. Fabbrini, B.S. Mohammed, et al. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects Gastroenterology 134 2008 1369 1375
23. R.C. Boston, D. Stefanovski, P.J. Moate, et al. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test Diabetes Technol Ther 5 2003 1003 1015
24. P.A. Harris, R. Taylor, R. Thielke, et al. Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support J Biomed Inform 42 2009 377 381
25. D.E. Kelley, R. Wing, C. Buonocore, et al. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 77 1993 1287 1293
26. E. Kirk, D.N. Reeds, B.N. Finck, et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction Gastroenterology 136 2009 1552 1560
27. M. Tiikkainen, R. Bergholm, A. Rissanen, et al. Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women Am J Clin Nutr 79 2004 22 30
28. R. Ross, D. Dagnone, P.J. Jones, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men A randomized, controlled trial Ann Intern Med 133 2000 92 103
29. V.B. Schrauwen-Hinderling, M. Mensink, M.K. Hesselink, et al. The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function J Clin Endocrinol Metab 93 2008 2917 2921
30. W. Li, J. Tonelli, P. Kishore, et al. Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle Am J Physiol Endocrinol Metab 292 2007 E1301 E1307
31. D.K. Coletta, A. Sriwijitkamol, E. Wajcberg, et al. Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial Diabetologia 52 2009 723 732
32. G. Boden Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 46 1997 3 10
33. P. Bjorntorp "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes Arteriosclerosis 10 1990 493 496 (Pubitemid 20220571)
34. S. Nielsen, Z. Guo, C.M. Johnson, et al. Splanchnic lipolysis in human obesity J Clin Invest 113 2004 1582 1588
35. S. Klein The case of visceral fat: argument for the defense J Clin Invest 113 2004 1530 1532
36. L.V. Basso, and R.J. Havel Hepatic metabolism of free fatty acids in normal and diabetic dogs J Clin Invest 49 1970 537 547