GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Lou, Guiyu ^a,b   Ma, Xiaoxiao ^b   Fu, Xianghui ^b   Meng, Zhipeng ^b   Zhang, Wenyu ^b   Wang, Yan Dong ^b   Van Ness, Carl ^b   Yu, Donna ^b   Xu, Rongzhen ^c   Huang, Wendong ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; CYTOKINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR TGR5; INTERLEUKIN 1BETA; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ATF2 PROTEIN, MOUSE; AUTACOID; CULTURE MEDIUM; GPBAR1 PROTEIN, MOUSE; OLEANOLIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA BINDING; ENZYME INHIBITION; GENE ACTIVATION; GENE EXPRESSION; GENE INTERACTION; KUPFFER CELL; LIVER CELL; LIVER LEVEL; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TGR5 GENE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; LIVER; METABOLISM; PHARMACOLOGY; PHOSPHORYLATION; PROMOTER REGION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; BILE ACIDS AND SALTS; CELL LINE; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CULTURE MEDIA; CYTOKINES; GENE EXPRESSION REGULATION; HEK293 CELLS; HEPATOCYTES; HUMANS; INFLAMMATION MEDIATORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KUPFFER CELLS; LIVER; MICE, INBRED C57BL; OLEANOLIC ACID; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, G-PROTEIN-COUPLED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899672635     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093567     Document Type: Article

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