-
1
-
-
84959055854
-
Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease
-
Herrington W, Lacey B, Sherliker P, Armitage J & Lewington S (2016) Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ Res 118, 535–546.
-
(2016)
Circ Res
, vol.118
, pp. 535-546
-
-
Herrington, W.1
Lacey, B.2
Sherliker, P.3
Armitage, J.4
Lewington, S.5
-
2
-
-
84928254049
-
Recent insights into the cellular biology of atherosclerosis
-
Tabas I, Garcia-Cardena G & Owens GK (2015) Recent insights into the cellular biology of atherosclerosis. J Cell Biol 209, 13–22.
-
(2015)
J Cell Biol
, vol.209
, pp. 13-22
-
-
Tabas, I.1
Garcia-Cardena, G.2
Owens, G.K.3
-
3
-
-
84944681535
-
Regulation of atherosclerotic plaque inflammation
-
Back M, Weber C & Lutgens E (2015) Regulation of atherosclerotic plaque inflammation. J Intern Med 278, 462–482.
-
(2015)
J Intern Med
, vol.278
, pp. 462-482
-
-
Back, M.1
Weber, C.2
Lutgens, E.3
-
4
-
-
0036463414
-
The potential for novel anti-inflammatory therapies for coronary artery disease
-
Cascieri MA (2002) The potential for novel anti-inflammatory therapies for coronary artery disease. Nat Rev Drug Discov 1, 122–130.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 122-130
-
-
Cascieri, M.A.1
-
5
-
-
17644412023
-
Inflammation, atherosclerosis, and coronary artery disease
-
Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352, 1685–1695.
-
(2005)
N Engl J Med
, vol.352
, pp. 1685-1695
-
-
Hansson, G.K.1
-
6
-
-
84945496884
-
Inflammation and plaque vulnerability
-
Hansson GK, Libby P & Tabas I (2015) Inflammation and plaque vulnerability. J Intern Med 278, 483–493.
-
(2015)
J Intern Med
, vol.278
, pp. 483-493
-
-
Hansson, G.K.1
Libby, P.2
Tabas, I.3
-
7
-
-
84921433970
-
Proteinases and plaque rupture: unblocking the road to translation
-
Newby AC (2014) Proteinases and plaque rupture: unblocking the road to translation. Curr Opin Lipidol 25, 358–366.
-
(2014)
Curr Opin Lipidol
, vol.25
, pp. 358-366
-
-
Newby, A.C.1
-
8
-
-
84965071473
-
Lysosomal cathepsins and their regulation in aging and neurodegeneration
-
Stoka V, Turk V & Turk B (2016) Lysosomal cathepsins and their regulation in aging and neurodegeneration. Ageing Res Rev 32, 22–37.
-
(2016)
Ageing Res Rev
, vol.32
, pp. 22-37
-
-
Stoka, V.1
Turk, V.2
Turk, B.3
-
9
-
-
0035801514
-
Lysosomal cysteine proteases: facts and opportunities
-
Turk V, Turk B & Turk D (2001) Lysosomal cysteine proteases: facts and opportunities. EMBO J 20, 4629–4633.
-
(2001)
EMBO J
, vol.20
, pp. 4629-4633
-
-
Turk, V.1
Turk, B.2
Turk, D.3
-
10
-
-
82755161948
-
Cysteine cathepsins: from structure, function and regulation to new frontiers
-
Turk V, Stoka V, Vasiljeva O, Renko M, Sun T, Turk B & Turk D (2012) Cysteine cathepsins: from structure, function and regulation to new frontiers. Biochim Biophys Acta 1824, 68–88.
-
(2012)
Biochim Biophys Acta
, vol.1824
, pp. 68-88
-
-
Turk, V.1
Stoka, V.2
Vasiljeva, O.3
Renko, M.4
Sun, T.5
Turk, B.6
Turk, D.7
-
11
-
-
17944366493
-
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases
-
Turk D, Janjic V, Stern I, Podobnik M, Lamba D, Dahl SW, Lauritzen C, Pedersen J, Turk V & Turk B (2001) Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. EMBO J 20, 6570–6582.
-
(2001)
EMBO J
, vol.20
, pp. 6570-6582
-
-
Turk, D.1
Janjic, V.2
Stern, I.3
Podobnik, M.4
Lamba, D.5
Dahl, S.W.6
Lauritzen, C.7
Pedersen, J.8
Turk, V.9
Turk, B.10
-
12
-
-
69249140641
-
Lysosomes as “suicide bags” in cell death: myth or reality?
-
Turk B & Turk V (2009) Lysosomes as “suicide bags” in cell death: myth or reality? J Biol Chem 284, 21783–21787.
-
(2009)
J Biol Chem
, vol.284
, pp. 21783-21787
-
-
Turk, B.1
Turk, V.2
-
13
-
-
38649111363
-
Cysteine cathepsins: cellular roadmap to different functions
-
Brix K, Dunkhorst A, Mayer K & Jordans S (2008) Cysteine cathepsins: cellular roadmap to different functions. Biochimie 90, 194–207.
-
(2008)
Biochimie
, vol.90
, pp. 194-207
-
-
Brix, K.1
Dunkhorst, A.2
Mayer, K.3
Jordans, S.4
-
14
-
-
0035881830
-
Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum
-
Wex T, Buhling F, Wex H, Gunther D, Malfertheiner P, Weber E & Bromme D (2001) Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. J Immunol 167, 2172–2178.
-
(2001)
J Immunol
, vol.167
, pp. 2172-2178
-
-
Wex, T.1
Buhling, F.2
Wex, H.3
Gunther, D.4
Malfertheiner, P.5
Weber, E.6
Bromme, D.7
-
15
-
-
84924390096
-
Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S
-
Vizovisek M, Vidmar R, Van Quickelberghe E, Impens F, Andjelkovic U, Sobotic B, Stoka V, Gevaert K, Turk B & Fonovic M (2015) Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S. Proteomics 15, 2479–2490.
-
(2015)
Proteomics
, vol.15
, pp. 2479-2490
-
-
Vizovisek, M.1
Vidmar, R.2
Van Quickelberghe, E.3
Impens, F.4
Andjelkovic, U.5
Sobotic, B.6
Stoka, V.7
Gevaert, K.8
Turk, B.9
Fonovic, M.10
-
16
-
-
82755164012
-
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S
-
Biniossek ML, Nagler DK, Becker-Pauly C & Schilling O (2011) Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. J Proteome Res 10, 5363–5373.
-
(2011)
J Proteome Res
, vol.10
, pp. 5363-5373
-
-
Biniossek, M.L.1
Nagler, D.K.2
Becker-Pauly, C.3
Schilling, O.4
-
17
-
-
33744961634
-
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
-
Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Bromme D, Ellman JA & Craik CS (2006) Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem 281, 12824–12832.
-
(2006)
J Biol Chem
, vol.281
, pp. 12824-12832
-
-
Choe, Y.1
Leonetti, F.2
Greenbaum, D.C.3
Lecaille, F.4
Bogyo, M.5
Bromme, D.6
Ellman, J.A.7
Craik, C.S.8
-
18
-
-
84957846249
-
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
-
Tamhane T, Lllukkumbura R, Lu S, Maelandsmo GM, Haugen MH & Brix K (2016) Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells. Biochimie 122, 208–218.
-
(2016)
Biochimie
, vol.122
, pp. 208-218
-
-
Tamhane, T.1
Lllukkumbura, R.2
Lu, S.3
Maelandsmo, G.M.4
Haugen, M.H.5
Brix, K.6
-
19
-
-
34249893895
-
Protease signalling in cell death: caspases versus cysteine cathepsins
-
Turk B & Stoka V (2007) Protease signalling in cell death: caspases versus cysteine cathepsins. FEBS Lett 581, 2761–2767.
-
(2007)
FEBS Lett
, vol.581
, pp. 2761-2767
-
-
Turk, B.1
Stoka, V.2
-
20
-
-
2542586967
-
Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy
-
Potts W, Bowyer J, Jones H, Tucker D, Freemont AJ, Millest A, Martin C, Vernon W, Neerunjun D, Slynn G et al. (2004) Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. Int J Exp Pathol 85, 85–96.
-
(2004)
Int J Exp Pathol
, vol.85
, pp. 85-96
-
-
Potts, W.1
Bowyer, J.2
Jones, H.3
Tucker, D.4
Freemont, A.J.5
Millest, A.6
Martin, C.7
Vernon, W.8
Neerunjun, D.9
Slynn, G.10
-
21
-
-
18344376711
-
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L
-
Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Monnig G, Haverkamp W, Breithardt G, Schmahl W et al. (2002) Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A 99, 6234–6239.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 6234-6239
-
-
Stypmann, J.1
Glaser, K.2
Roth, W.3
Tobin, D.J.4
Petermann, I.5
Matthias, R.6
Monnig, G.7
Haverkamp, W.8
Breithardt, G.9
Schmahl, W.10
-
22
-
-
84948680310
-
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
-
Olson OC & Joyce JA (2015) Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer 15, 712–729.
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 712-729
-
-
Olson, O.C.1
Joyce, J.A.2
-
23
-
-
77957855881
-
Specialized roles for cysteine cathepsins in health and disease
-
Reiser J, Adair B & Reinheckel T (2010) Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 120, 3421–3431.
-
(2010)
J Clin Invest
, vol.120
, pp. 3421-3431
-
-
Reiser, J.1
Adair, B.2
Reinheckel, T.3
-
24
-
-
84874335249
-
Ready, set, cleave: proteases in action
-
Salpeter SJ & Blum G (2013) Ready, set, cleave: proteases in action. Chem Biol 20, 137–138.
-
(2013)
Chem Biol
, vol.20
, pp. 137-138
-
-
Salpeter, S.J.1
Blum, G.2
-
25
-
-
0032496158
-
pH-induced conformational transitions of the propeptide of human cathepsin L. A role for a molten globule state in zymogen activation
-
Jerala R, Zerovnik E, Kidric J & Turk V (1998) pH-induced conformational transitions of the propeptide of human cathepsin L. A role for a molten globule state in zymogen activation. J Biol Chem 273, 11498–11504.
-
(1998)
J Biol Chem
, vol.273
, pp. 11498-11504
-
-
Jerala, R.1
Zerovnik, E.2
Kidric, J.3
Turk, V.4
-
26
-
-
21344455498
-
Lysosomal cysteine proteases: structural features and their role in apoptosis
-
Stoka V, Turk B & Turk V (2005) Lysosomal cysteine proteases: structural features and their role in apoptosis. IUBMB Life 57, 347–353.
-
(2005)
IUBMB Life
, vol.57
, pp. 347-353
-
-
Stoka, V.1
Turk, B.2
Turk, V.3
-
27
-
-
63049095880
-
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
-
Cavallo-Medved D, Rudy D, Blum G, Bogyo M, Caglic D & Sloane BF (2009) Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res 315, 1234–1246.
-
(2009)
Exp Cell Res
, vol.315
, pp. 1234-1246
-
-
Cavallo-Medved, D.1
Rudy, D.2
Blum, G.3
Bogyo, M.4
Caglic, D.5
Sloane, B.F.6
-
28
-
-
84930644133
-
Cysteine cathepsins activate ELR chemokines and inactivate non-ELR chemokines
-
Repnik U, Starr AE, Overall CM & Turk B (2015) Cysteine cathepsins activate ELR chemokines and inactivate non-ELR chemokines. J Biol Chem 290, 13800–13811.
-
(2015)
J Biol Chem
, vol.290
, pp. 13800-13811
-
-
Repnik, U.1
Starr, A.E.2
Overall, C.M.3
Turk, B.4
-
29
-
-
33749017931
-
Cysteine cathepsins: multifunctional enzymes in cancer
-
Mohamed MM & Sloane BF (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6, 764–775.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 764-775
-
-
Mohamed, M.M.1
Sloane, B.F.2
-
30
-
-
84938905143
-
Proteomic identification of cysteine cathepsin substrates shed from the surface of cancer cells
-
Sobotic B, Vizovisek M, Vidmar R, Van Damme P, Gocheva V, Joyce JA, Gevaert K, Turk V, Turk B & Fonovic M (2015) Proteomic identification of cysteine cathepsin substrates shed from the surface of cancer cells. Mol Cell Proteomics 14, 2213–2228.
-
(2015)
Mol Cell Proteomics
, vol.14
, pp. 2213-2228
-
-
Sobotic, B.1
Vizovisek, M.2
Vidmar, R.3
Van Damme, P.4
Gocheva, V.5
Joyce, J.A.6
Gevaert, K.7
Turk, V.8
Turk, B.9
Fonovic, M.10
-
31
-
-
84920517066
-
Cysteine cathepsin activity regulation by glycosaminoglycans
-
Novinec M, Lenarcic B & Turk B (2014) Cysteine cathepsin activity regulation by glycosaminoglycans. Biomed Res Int 2014, 309718.
-
(2014)
Biomed Res Int
, vol.2014
, pp. 309718
-
-
Novinec, M.1
Lenarcic, B.2
Turk, B.3
-
33
-
-
52049096824
-
Cystatins: biochemical and structural properties, and medical relevance
-
Turk V, Stoka V & Turk D (2008) Cystatins: biochemical and structural properties, and medical relevance. Front Biosci 13, 5406–5420.
-
(2008)
Front Biosci
, vol.13
, pp. 5406-5420
-
-
Turk, V.1
Stoka, V.2
Turk, D.3
-
35
-
-
33750984761
-
The role of cystatins in cells of the immune system
-
Kopitar-Jerala N (2006) The role of cystatins in cells of the immune system. FEBS Lett 580, 6295–6301.
-
(2006)
FEBS Lett
, vol.580
, pp. 6295-6301
-
-
Kopitar-Jerala, N.1
-
36
-
-
0032718590
-
Cystatin C deficiency in human atherosclerosis and aortic aneurysms
-
Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P & Chapman HA (1999) Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 104, 1191–1197.
-
(1999)
J Clin Invest
, vol.104
, pp. 1191-1197
-
-
Shi, G.P.1
Sukhova, G.K.2
Grubb, A.3
Ducharme, A.4
Rhode, L.H.5
Lee, R.T.6
Ridker, P.M.7
Libby, P.8
Chapman, H.A.9
-
37
-
-
17044427960
-
Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice
-
Bengtsson E, To F, Grubb A, Hakansson K, Wittgren L, Nilsson J & Jovinge S (2005) Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice. Atherosclerosis 180, 45–53.
-
(2005)
Atherosclerosis
, vol.180
, pp. 45-53
-
-
Bengtsson, E.1
To, F.2
Grubb, A.3
Hakansson, K.4
Wittgren, L.5
Nilsson, J.6
Jovinge, S.7
-
38
-
-
84943754804
-
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies
-
Weitoft T, Larsson A, Manivel VA, Lysholm J, Knight A & Ronnelid J (2015) Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies. Rheumatology (Oxford) 54, 1923–1928.
-
(2015)
Rheumatology (Oxford)
, vol.54
, pp. 1923-1928
-
-
Weitoft, T.1
Larsson, A.2
Manivel, V.A.3
Lysholm, J.4
Knight, A.5
Ronnelid, J.6
-
40
-
-
30044445997
-
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
-
Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C et al. (2006) Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis 184, 302–311.
-
(2006)
Atherosclerosis
, vol.184
, pp. 302-311
-
-
Liu, J.1
Sukhova, G.K.2
Yang, J.T.3
Sun, J.4
Ma, L.5
Ren, A.6
Xu, W.H.7
Fu, H.8
Dolganov, G.M.9
Hu, C.10
-
41
-
-
0032145836
-
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
-
Sukhova GK, Shi GP, Simon DI, Chapman HA & Libby P (1998) Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 102, 576–583.
-
(1998)
J Clin Invest
, vol.102
, pp. 576-583
-
-
Sukhova, G.K.1
Shi, G.P.2
Simon, D.I.3
Chapman, H.A.4
Libby, P.5
-
42
-
-
33847747817
-
Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis
-
Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR & Jo H (2007) Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. Am J Physiol Heart Circ Physiol 292, H1479–H1486.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
, pp. H1479-H1486
-
-
Platt, M.O.1
Ankeny, R.F.2
Shi, G.P.3
Weiss, D.4
Vega, J.D.5
Taylor, W.R.6
Jo, H.7
-
43
-
-
84987648062
-
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
-
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jae N, Rossbach O, Amrhein C, Sigala F et al. (2016) Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med 22, 1140–1150.
-
(2016)
Nat Med
, vol.22
, pp. 1140-1150
-
-
Stellos, K.1
Gatsiou, A.2
Stamatelopoulos, K.3
Perisic Matic, L.4
John, D.5
Lunella, F.F.6
Jae, N.7
Rossbach, O.8
Amrhein, C.9
Sigala, F.10
-
44
-
-
0036735233
-
Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice
-
Jormsjo S, Wuttge DM, Sirsjo A, Whatling C, Hamsten A, Stemme S & Eriksson P (2002) Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 161, 939–945.
-
(2002)
Am J Pathol
, vol.161
, pp. 939-945
-
-
Jormsjo, S.1
Wuttge, D.M.2
Sirsjo, A.3
Whatling, C.4
Hamsten, A.5
Stemme, S.6
Eriksson, P.7
-
45
-
-
34247190780
-
Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice
-
Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X et al. (2007) Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation 115, 2065–2075.
-
(2007)
Circulation
, vol.115
, pp. 2065-2075
-
-
Kitamoto, S.1
Sukhova, G.K.2
Sun, J.3
Yang, M.4
Libby, P.5
Love, V.6
Duramad, P.7
Sun, C.8
Zhang, Y.9
Yang, X.10
-
46
-
-
0037362831
-
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
-
Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML et al. (2003) Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 111, 897–906.
-
(2003)
J Clin Invest
, vol.111
, pp. 897-906
-
-
Sukhova, G.K.1
Zhang, Y.2
Pan, J.H.3
Wada, Y.4
Yamamoto, T.5
Naito, M.6
Kodama, T.7
Tsimikas, S.8
Witztum, J.L.9
Lu, M.L.10
-
47
-
-
26944475263
-
The lysosome turns fifty
-
de Duve C (2005) The lysosome turns fifty. Nat Cell Biol 7, 847–849.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 847-849
-
-
de Duve, C.1
-
48
-
-
84922789990
-
Nutrient-sensing mechanisms and pathways
-
Efeyan A, Comb WC & Sabatini DM (2015) Nutrient-sensing mechanisms and pathways. Nature 517, 302–310.
-
(2015)
Nature
, vol.517
, pp. 302-310
-
-
Efeyan, A.1
Comb, W.C.2
Sabatini, D.M.3
-
50
-
-
0442323561
-
Autophagy: in sickness and in health
-
Cuervo AM (2004) Autophagy: in sickness and in health. Trends Cell Biol 14, 70–77.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 70-77
-
-
Cuervo, A.M.1
-
51
-
-
69249227502
-
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
-
Saftig P & Klumperman J (2009) Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol 10, 623–635.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 623-635
-
-
Saftig, P.1
Klumperman, J.2
-
52
-
-
84903729995
-
Lysosomal adaptation: how the lysosome responds to external cues
-
Settembre C & Ballabio A (2014) Lysosomal adaptation: how the lysosome responds to external cues. Cold Spring Harb Perspect Biol 6, 1–15.
-
(2014)
Cold Spring Harb Perspect Biol
, vol.6
, pp. 1-15
-
-
Settembre, C.1
Ballabio, A.2
-
53
-
-
84988919442
-
Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis
-
Sergin I, Evans TD & Razani B (2015) Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis. Curr Opin Lipidol 26, 394–404.
-
(2015)
Curr Opin Lipidol
, vol.26
, pp. 394-404
-
-
Sergin, I.1
Evans, T.D.2
Razani, B.3
-
54
-
-
0033775936
-
Metabolism of oxidized LDL by macrophages
-
Jessup W & Kritharides L (2000) Metabolism of oxidized LDL by macrophages. Curr Opin Lipidol 11, 473–481.
-
(2000)
Curr Opin Lipidol
, vol.11
, pp. 473-481
-
-
Jessup, W.1
Kritharides, L.2
-
55
-
-
0031965513
-
Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake
-
&, discussion S54–S75
-
Brown MS & Goldstein JL (1998) Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake. Nutr Rev 56, S1–S3; discussion S54–S75.
-
(1998)
Nutr Rev
, vol.56
, pp. S1-S3
-
-
Brown, M.S.1
Goldstein, J.L.2
-
56
-
-
85006314789
-
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
-
Das A, Brown MS, Anderson DD, Goldstein JL & Radhakrishnan A (2014) Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife 3, 1–16.
-
(2014)
Elife
, vol.3
, pp. 1-16
-
-
Das, A.1
Brown, M.S.2
Anderson, D.D.3
Goldstein, J.L.4
Radhakrishnan, A.5
-
57
-
-
28444479505
-
Role of cholesterol and lipid organization in disease
-
Maxfield FR & Tabas I (2005) Role of cholesterol and lipid organization in disease. Nature 438, 612–621.
-
(2005)
Nature
, vol.438
, pp. 612-621
-
-
Maxfield, F.R.1
Tabas, I.2
-
58
-
-
0033729477
-
Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions
-
Oorni K, Pentikainen MO, Ala-Korpela M & Kovanen PT (2000) Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions. J Lipid Res 41, 1703–1714.
-
(2000)
J Lipid Res
, vol.41
, pp. 1703-1714
-
-
Oorni, K.1
Pentikainen, M.O.2
Ala-Korpela, M.3
Kovanen, P.T.4
-
59
-
-
0035936802
-
Atherosclerosis. the road ahead
-
Glass CK & Witztum JL (2001) Atherosclerosis. the road ahead. Cell 104, 503–516.
-
(2001)
Cell
, vol.104
, pp. 503-516
-
-
Glass, C.K.1
Witztum, J.L.2
-
60
-
-
84907355624
-
LOX-1 and mitochondria: an inflammatory relationship
-
Christ A & Latz E (2014) LOX-1 and mitochondria: an inflammatory relationship. Cardiovasc Res 103, 435–437.
-
(2014)
Cardiovasc Res
, vol.103
, pp. 435-437
-
-
Christ, A.1
Latz, E.2
-
61
-
-
84883158032
-
Scavenger receptors in homeostasis and immunity
-
Canton J, Neculai D & Grinstein S (2013) Scavenger receptors in homeostasis and immunity. Nat Rev Immunol 13, 621–634.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 621-634
-
-
Canton, J.1
Neculai, D.2
Grinstein, S.3
-
62
-
-
4544245056
-
Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro
-
Oorni K, Sneck M, Bromme D, Pentikainen MO, Lindstedt KA, Mayranpaa M, Aitio H & Kovanen PT (2004) Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. J Biol Chem 279, 34776–34784.
-
(2004)
J Biol Chem
, vol.279
, pp. 34776-34784
-
-
Oorni, K.1
Sneck, M.2
Bromme, D.3
Pentikainen, M.O.4
Lindstedt, K.A.5
Mayranpaa, M.6
Aitio, H.7
Kovanen, P.T.8
-
63
-
-
0037387604
-
Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis
-
Han SR, Momeni A, Strach K, Suriyaphol P, Fenske D, Paprotka K, Hashimoto SI, Torzewski M, Bhakdi S & Husmann M (2003) Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis. Arterioscler Thromb Vasc Biol 23, 661–667.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 661-667
-
-
Han, S.R.1
Momeni, A.2
Strach, K.3
Suriyaphol, P.4
Fenske, D.5
Paprotka, K.6
Hashimoto, S.I.7
Torzewski, M.8
Bhakdi, S.9
Husmann, M.10
-
64
-
-
0033995604
-
Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes
-
Brown AJ, Mander EL, Gelissen IC, Kritharides L, Dean RT & Jessup W (2000) Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. J Lipid Res 41, 226–237.
-
(2000)
J Lipid Res
, vol.41
, pp. 226-237
-
-
Brown, A.J.1
Mander, E.L.2
Gelissen, I.C.3
Kritharides, L.4
Dean, R.T.5
Jessup, W.6
-
65
-
-
33748752235
-
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
-
Linke M, Gordon RE, Brillard M, Lecaille F, Lalmanach G & Bromme D (2006) Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins. Biol Chem 387, 1295–1303.
-
(2006)
Biol Chem
, vol.387
, pp. 1295-1303
-
-
Linke, M.1
Gordon, R.E.2
Brillard, M.3
Lecaille, F.4
Lalmanach, G.5
Bromme, D.6
-
66
-
-
80054074025
-
PPARs and lipid ligands in inflammation and metabolism
-
Harmon GS, Lam MT & Glass CK (2011) PPARs and lipid ligands in inflammation and metabolism. Chem Rev 111, 6321–6340.
-
(2011)
Chem Rev
, vol.111
, pp. 6321-6340
-
-
Harmon, G.S.1
Lam, M.T.2
Glass, C.K.3
-
67
-
-
84857653989
-
Regulation of lipid droplet cholesterol efflux from macrophage foam cells
-
Ouimet M & Marcel YL (2012) Regulation of lipid droplet cholesterol efflux from macrophage foam cells. Arterioscler Thromb Vasc Biol 32, 575–581.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 575-581
-
-
Ouimet, M.1
Marcel, Y.L.2
-
68
-
-
38549141572
-
Cellular cholesterol trafficking and compartmentalization
-
Ikonen E (2008) Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol 9, 125–138.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 125-138
-
-
Ikonen, E.1
-
69
-
-
84936757799
-
Liver X receptors at the intersection of lipid metabolism and atherogenesis
-
Lee SD & Tontonoz P (2015) Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis 242, 29–36.
-
(2015)
Atherosclerosis
, vol.242
, pp. 29-36
-
-
Lee, S.D.1
Tontonoz, P.2
-
70
-
-
79958030075
-
Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
-
Ouimet M, Franklin V, Mak E, Liao X, Tabas I & Marcel YL (2011) Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab 13, 655–667.
-
(2011)
Cell Metab
, vol.13
, pp. 655-667
-
-
Ouimet, M.1
Franklin, V.2
Mak, E.3
Liao, X.4
Tabas, I.5
Marcel, Y.L.6
-
71
-
-
33845972298
-
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
-
Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R & Marcel YL (2006) Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux. J Biol Chem 281, 39971–39981.
-
(2006)
J Biol Chem
, vol.281
, pp. 39971-39981
-
-
Haidar, B.1
Kiss, R.S.2
Sarov-Blat, L.3
Brunet, R.4
Harder, C.5
McPherson, R.6
Marcel, Y.L.7
-
72
-
-
75149150355
-
A macrophage sterol-responsive network linked to atherogenesis
-
Becker L, Gharib SA, Irwin AD, Wijsman E, Vaisar T, Oram JF & Heinecke JW (2010) A macrophage sterol-responsive network linked to atherogenesis. Cell Metab 11, 125–135.
-
(2010)
Cell Metab
, vol.11
, pp. 125-135
-
-
Becker, L.1
Gharib, S.A.2
Irwin, A.D.3
Wijsman, E.4
Vaisar, T.5
Oram, J.F.6
Heinecke, J.W.7
-
73
-
-
0026353855
-
Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages
-
Lougheed M, Zhang HF & Steinbrecher UP (1991) Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages. J Biol Chem 266, 14519–14525.
-
(1991)
J Biol Chem
, vol.266
, pp. 14519-14525
-
-
Lougheed, M.1
Zhang, H.F.2
Steinbrecher, U.P.3
-
74
-
-
0033779272
-
Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally
-
Dhaliwal BS & Steinbrecher UP (2000) Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally. J Lipid Res 41, 1658–1665.
-
(2000)
J Lipid Res
, vol.41
, pp. 1658-1665
-
-
Dhaliwal, B.S.1
Steinbrecher, U.P.2
-
75
-
-
17344370810
-
Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation
-
Li W, Yuan XM, Olsson AG & Brunk UT (1998) Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler Thromb Vasc Biol 18, 177–184.
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, pp. 177-184
-
-
Li, W.1
Yuan, X.M.2
Olsson, A.G.3
Brunk, U.T.4
-
76
-
-
0142092678
-
Phospholipids in oxidized low density lipoproteins perturb the ability of macrophages to degrade internalized macromolecules and reduce intracellular cathepsin B activity
-
O'Neil J, Hoppe G & Hoff HF (2003) Phospholipids in oxidized low density lipoproteins perturb the ability of macrophages to degrade internalized macromolecules and reduce intracellular cathepsin B activity. Atherosclerosis 169, 215–224.
-
(2003)
Atherosclerosis
, vol.169
, pp. 215-224
-
-
O'Neil, J.1
Hoppe, G.2
Hoff, H.F.3
-
77
-
-
0030976980
-
Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme
-
O'Neil J, Hoppe G, Sayre LM & Hoff HF (1997) Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme. Free Radic Biol Med 23, 215–225.
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 215-225
-
-
O'Neil, J.1
Hoppe, G.2
Sayre, L.M.3
Hoff, H.F.4
-
78
-
-
0036127167
-
Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues
-
Crabb JW, O'Neil J, Miyagi M, West K & Hoff HF (2002) Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues. Protein Sci 11, 831–840.
-
(2002)
Protein Sci
, vol.11
, pp. 831-840
-
-
Crabb, J.W.1
O'Neil, J.2
Miyagi, M.3
West, K.4
Hoff, H.F.5
-
79
-
-
0344926410
-
Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells
-
Lindstedt L, Lee M, Oorni K, Bromme D & Kovanen PT (2003) Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells. Biochem Biophys Res Commun 312, 1019–1024.
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 1019-1024
-
-
Lindstedt, L.1
Lee, M.2
Oorni, K.3
Bromme, D.4
Kovanen, P.T.5
-
80
-
-
85001976245
-
Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity
-
Dinnes DL, White MY, Kockx M, Traini M, Hsieh V, Kim MJ, Hou L, Jessup W, Rye KA, Thaysen-Andersen M et al. (2016) Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity. FASEB J 30, 4239–4255.
-
(2016)
FASEB J
, vol.30
, pp. 4239-4255
-
-
Dinnes, D.L.1
White, M.Y.2
Kockx, M.3
Traini, M.4
Hsieh, V.5
Kim, M.J.6
Hou, L.7
Jessup, W.8
Rye, K.A.9
Thaysen-Andersen, M.10
-
81
-
-
58149345643
-
T-cell costimulation and coinhibition in atherosclerosis
-
Gotsman I, Sharpe AH & Lichtman AH (2008) T-cell costimulation and coinhibition in atherosclerosis. Circ Res 103, 1220–1231.
-
(2008)
Circ Res
, vol.103
, pp. 1220-1231
-
-
Gotsman, I.1
Sharpe, A.H.2
Lichtman, A.H.3
-
82
-
-
79955535643
-
Macrophages in the pathogenesis of atherosclerosis
-
Moore KJ & Tabas I (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145, 341–355.
-
(2011)
Cell
, vol.145
, pp. 341-355
-
-
Moore, K.J.1
Tabas, I.2
-
83
-
-
0028060607
-
Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages
-
Hoppe G, O'Neil J & Hoff HF (1994) Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages. J Clin Invest 94, 1506–1512.
-
(1994)
J Clin Invest
, vol.94
, pp. 1506-1512
-
-
Hoppe, G.1
O'Neil, J.2
Hoff, H.F.3
-
84
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M et al. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357–1361.
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
Bauernfeind, F.G.6
Abela, G.S.7
Franchi, L.8
Nunez, G.9
Schnurr, M.10
-
85
-
-
75649087741
-
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
-
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11, 155–161.
-
(2010)
Nat Immunol
, vol.11
, pp. 155-161
-
-
Stewart, C.R.1
Stuart, L.M.2
Wilkinson, K.3
van Gils, J.M.4
Deng, J.5
Halle, A.6
Rayner, K.J.7
Boyer, L.8
Zhong, R.9
Frazier, W.A.10
-
86
-
-
84880777411
-
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
-
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT et al. (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol 14, 812–820.
-
(2013)
Nat Immunol
, vol.14
, pp. 812-820
-
-
Sheedy, F.J.1
Grebe, A.2
Rayner, K.J.3
Kalantari, P.4
Ramkhelawon, B.5
Carpenter, S.B.6
Becker, C.E.7
Ediriweera, H.N.8
Mullick, A.E.9
Golenbock, D.T.10
-
87
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA & Latz E (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9, 847–856.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
88
-
-
84938909778
-
Multiple cathepsins promote Pro-IL-1beta synthesis and NLRP3-mediated IL-1beta activation
-
Orlowski GM, Colbert JD, Sharma S, Bogyo M, Robertson SA & Rock KL (2015) Multiple cathepsins promote Pro-IL-1beta synthesis and NLRP3-mediated IL-1beta activation. J Immunol 195, 1685–1697.
-
(2015)
J Immunol
, vol.195
, pp. 1685-1697
-
-
Orlowski, G.M.1
Colbert, J.D.2
Sharma, S.3
Bogyo, M.4
Robertson, S.A.5
Rock, K.L.6
-
89
-
-
84959420149
-
NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria
-
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR et al. (2016) NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164, 896–910.
-
(2016)
Cell
, vol.164
, pp. 896-910
-
-
Zhong, Z.1
Umemura, A.2
Sanchez-Lopez, E.3
Liang, S.4
Shalapour, S.5
Wong, J.6
He, F.7
Boassa, D.8
Perkins, G.9
Ali, S.R.10
-
90
-
-
84859448447
-
Autophagy links inflammasomes to atherosclerotic progression
-
Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB & Semenkovich CF (2012) Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 15, 534–544.
-
(2012)
Cell Metab
, vol.15
, pp. 534-544
-
-
Razani, B.1
Feng, C.2
Coleman, T.3
Emanuel, R.4
Wen, H.5
Hwang, S.6
Ting, J.P.7
Virgin, H.W.8
Kastan, M.B.9
Semenkovich, C.F.10
-
91
-
-
77955956764
-
Impaired turnover of autophagolysosomes in cathepsin L deficiency
-
Dennemarker J, Lohmuller T, Muller S, Aguilar SV, Tobin DJ, Peters C & Reinheckel T (2010) Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem 391, 913–922.
-
(2010)
Biol Chem
, vol.391
, pp. 913-922
-
-
Dennemarker, J.1
Lohmuller, T.2
Muller, S.3
Aguilar, S.V.4
Tobin, D.J.5
Peters, C.6
Reinheckel, T.7
-
92
-
-
84860491083
-
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation
-
Pan L, Li Y, Jia L, Qin Y, Qi G, Cheng J, Qi Y, Li H & Du J (2012) Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. PLoS One 7, e35315.
-
(2012)
PLoS One
, vol.7
-
-
Pan, L.1
Li, Y.2
Jia, L.3
Qin, Y.4
Qi, G.5
Cheng, J.6
Qi, Y.7
Li, H.8
Du, J.9
-
93
-
-
84906935699
-
Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae
-
Emanuel R, Sergin I, Bhattacharya S, Turner JN, Epelman S, Settembre C, Diwan A, Ballabio A & Razani B (2014) Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae. Arterioscler Thromb Vasc Biol 34, 1942–1952.
-
(2014)
Arterioscler Thromb Vasc Biol
, vol.34
, pp. 1942-1952
-
-
Emanuel, R.1
Sergin, I.2
Bhattacharya, S.3
Turner, J.N.4
Epelman, S.5
Settembre, C.6
Diwan, A.7
Ballabio, A.8
Razani, B.9
-
94
-
-
84955466400
-
Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(–/–) mice
-
Sun M, Tian X, Liu Y, Zhu N, Li Y, Yang G, Peng C, Yan C & Han Y (2015) Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(–/–) mice. J Mol Cell Cardiol 86, 32–41.
-
(2015)
J Mol Cell Cardiol
, vol.86
, pp. 32-41
-
-
Sun, M.1
Tian, X.2
Liu, Y.3
Zhu, N.4
Li, Y.5
Yang, G.6
Peng, C.7
Yan, C.8
Han, Y.9
-
95
-
-
66349092815
-
Mechanisms and consequences of macrophage apoptosis in atherosclerosis
-
Seimon T & Tabas I (2009) Mechanisms and consequences of macrophage apoptosis in atherosclerosis. J Lipid Res 50 (Suppl), S382–S387.
-
(2009)
J Lipid Res
, vol.50
, pp. S382-S387
-
-
Seimon, T.1
Tabas, I.2
-
96
-
-
84994573306
-
NLRP3 inflammasome expression and activation in human atherosclerosis
-
Paramel Varghese G, Folkersen L, Strawbridge RJ, Halvorsen B, Yndestad A, Ranheim T, Krohg-Sorensen K, Skjelland M, Espevik T, Aukrust P et al. (2016) NLRP3 inflammasome expression and activation in human atherosclerosis. J Am Heart Assoc 5, 1–11.
-
(2016)
J Am Heart Assoc
, vol.5
, pp. 1-11
-
-
Paramel Varghese, G.1
Folkersen, L.2
Strawbridge, R.J.3
Halvorsen, B.4
Yndestad, A.5
Ranheim, T.6
Krohg-Sorensen, K.7
Skjelland, M.8
Espevik, T.9
Aukrust, P.10
-
97
-
-
84875145230
-
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants
-
Jacobson LS, Lima H Jr, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K et al. (2013) Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. J Biol Chem 288, 7481–7491.
-
(2013)
J Biol Chem
, vol.288
, pp. 7481-7491
-
-
Jacobson, L.S.1
Lima, H.2
Goldberg, M.F.3
Gocheva, V.4
Tsiperson, V.5
Sutterwala, F.S.6
Joyce, J.A.7
Gapp, B.V.8
Blomen, V.A.9
Chandran, K.10
-
98
-
-
84928162724
-
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
-
Brojatsch J, Lima H Jr, Palliser D, Jacobson LS, Muehlbauer SM, Furtado R, Goldman DL, Lisanti MP & Chandran K (2015) Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents. Cell Cycle 14, 964–972.
-
(2015)
Cell Cycle
, vol.14
, pp. 964-972
-
-
Brojatsch, J.1
Lima, H.2
Palliser, D.3
Jacobson, L.S.4
Muehlbauer, S.M.5
Furtado, R.6
Goldman, D.L.7
Lisanti, M.P.8
Chandran, K.9
-
99
-
-
84982844535
-
Heart disease: death-defying plaque cells
-
Tabas I (2016) Heart disease: death-defying plaque cells. Nature 536, 32–33.
-
(2016)
Nature
, vol.536
, pp. 32-33
-
-
Tabas, I.1
-
100
-
-
27644537437
-
Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency
-
Tabas I (2005) Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol 25, 2255–2264.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2255-2264
-
-
Tabas, I.1
-
101
-
-
0033756474
-
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
-
Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH & Gores GJ (2000) Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106, 1127–1137.
-
(2000)
J Clin Invest
, vol.106
, pp. 1127-1137
-
-
Guicciardi, M.E.1
Deussing, J.2
Miyoshi, H.3
Bronk, S.F.4
Svingen, P.A.5
Peters, C.6
Kaufmann, S.H.7
Gores, G.J.8
-
102
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ & Gores GJ (2004) Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 40, 185–194.
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
Burgart, L.J.7
Gores, G.J.8
-
103
-
-
15044344243
-
Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis
-
Li W & Yuan XM (2004) Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis. Ann N Y Acad Sci 1030, 427–433.
-
(2004)
Ann N Y Acad Sci
, vol.1030
, pp. 427-433
-
-
Li, W.1
Yuan, X.M.2
-
104
-
-
84922561993
-
Chylomicron remnant model emulsions induce intracellular cholesterol accumulation and cell death due to lysosomal destabilization
-
Wakita K, Morita SY, Okamoto N, Takata E, Handa T & Nakano M (2015) Chylomicron remnant model emulsions induce intracellular cholesterol accumulation and cell death due to lysosomal destabilization. Biochim Biophys Acta 1851, 598–604.
-
(2015)
Biochim Biophys Acta
, vol.1851
, pp. 598-604
-
-
Wakita, K.1
Morita, S.Y.2
Okamoto, N.3
Takata, E.4
Handa, T.5
Nakano, M.6
-
106
-
-
57649183693
-
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
-
Li W, Kornmark L, Jonasson L, Forssell C & Yuan XM (2009) Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis. Atherosclerosis 202, 92–102.
-
(2009)
Atherosclerosis
, vol.202
, pp. 92-102
-
-
Li, W.1
Kornmark, L.2
Jonasson, L.3
Forssell, C.4
Yuan, X.M.5
-
107
-
-
84973397896
-
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
-
Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G & Tabas I (2016) MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A 113, 6526–6531.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. 6526-6531
-
-
Cai, B.1
Thorp, E.B.2
Doran, A.C.3
Subramanian, M.4
Sansbury, B.E.5
Lin, C.S.6
Spite, M.7
Fredman, G.8
Tabas, I.9
-
108
-
-
84982806125
-
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
-
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ et al. (2016) CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 536, 86–90.
-
(2016)
Nature
, vol.536
, pp. 86-90
-
-
Kojima, Y.1
Volkmer, J.P.2
McKenna, K.3
Civelek, M.4
Lusis, A.J.5
Miller, C.L.6
Direnzo, D.7
Nanda, V.8
Ye, J.9
Connolly, A.J.10
-
109
-
-
84862791715
-
Macrophage autophagy plays a protective role in advanced atherosclerosis
-
Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J & Tabas I (2012) Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab 15, 545–553.
-
(2012)
Cell Metab
, vol.15
, pp. 545-553
-
-
Liao, X.1
Sluimer, J.C.2
Wang, Y.3
Subramanian, M.4
Brown, K.5
Pattison, J.S.6
Robbins, J.7
Martinez, J.8
Tabas, I.9
-
110
-
-
84903549575
-
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans
-
Xu M, Liu Y, Zhao L, Gan Q, Wang X & Yang C (2014) The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Mol Biol Cell 25, 2071–2083.
-
(2014)
Mol Biol Cell
, vol.25
, pp. 2071-2083
-
-
Xu, M.1
Liu, Y.2
Zhao, L.3
Gan, Q.4
Wang, X.5
Yang, C.6
-
111
-
-
79956319051
-
Progress and challenges in translating the biology of atherosclerosis
-
Libby P, Ridker PM & Hansson GK (2011) Progress and challenges in translating the biology of atherosclerosis. Nature 473, 317–325.
-
(2011)
Nature
, vol.473
, pp. 317-325
-
-
Libby, P.1
Ridker, P.M.2
Hansson, G.K.3
-
112
-
-
84903543514
-
Cysteine cathepsins and extracellular matrix degradation
-
Fonovic M & Turk B (2014) Cysteine cathepsins and extracellular matrix degradation. Biochim Biophys Acta 1840, 2560–2570.
-
(2014)
Biochim Biophys Acta
, vol.1840
, pp. 2560-2570
-
-
Fonovic, M.1
Turk, B.2
-
113
-
-
84874300261
-
Effects of cysteine proteases on the structural and mechanical properties of collagen fibers
-
Panwar P, Du X, Sharma V, Lamour G, Castro M, Li H & Bromme D (2013) Effects of cysteine proteases on the structural and mechanical properties of collagen fibers. J Biol Chem 288, 5940–5950.
-
(2013)
J Biol Chem
, vol.288
, pp. 5940-5950
-
-
Panwar, P.1
Du, X.2
Sharma, V.3
Lamour, G.4
Castro, M.5
Li, H.6
Bromme, D.7
-
114
-
-
0037047275
-
Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate
-
Li Z, Hou WS, Escalante-Torres CR, Gelb BD & Bromme D (2002) Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate. J Biol Chem 277, 28669–28676.
-
(2002)
J Biol Chem
, vol.277
, pp. 28669-28676
-
-
Li, Z.1
Hou, W.S.2
Escalante-Torres, C.R.3
Gelb, B.D.4
Bromme, D.5
-
115
-
-
84918557552
-
Structural basis of collagen fiber degradation by cathepsin K
-
Aguda AH, Panwar P, Du X, Nguyen NT, Brayer GD & Bromme D (2014) Structural basis of collagen fiber degradation by cathepsin K. Proc Natl Acad Sci U S A 111, 17474–17479.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 17474-17479
-
-
Aguda, A.H.1
Panwar, P.2
Du, X.3
Nguyen, N.T.4
Brayer, G.D.5
Bromme, D.6
-
116
-
-
0037007965
-
Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity
-
Lecaille F, Choe Y, Brandt W, Li Z, Craik CS & Bromme D (2002) Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity. Biochemistry 41, 8447–8454.
-
(2002)
Biochemistry
, vol.41
, pp. 8447-8454
-
-
Lecaille, F.1
Choe, Y.2
Brandt, W.3
Li, Z.4
Craik, C.S.5
Bromme, D.6
-
117
-
-
4344670363
-
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages
-
Yasuda Y, Li Z, Greenbaum D, Bogyo M, Weber E & Bromme D (2004) Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem 279, 36761–36770.
-
(2004)
J Biol Chem
, vol.279
, pp. 36761-36770
-
-
Yasuda, Y.1
Li, Z.2
Greenbaum, D.3
Bogyo, M.4
Weber, E.5
Bromme, D.6
-
118
-
-
84889060938
-
Elastin degradation by cathepsin V requires two exosites
-
Du X, Chen NL, Wong A, Craik CS & Bromme D (2013) Elastin degradation by cathepsin V requires two exosites. J Biol Chem 288, 34871–34881.
-
(2013)
J Biol Chem
, vol.288
, pp. 34871-34881
-
-
Du, X.1
Chen, N.L.2
Wong, A.3
Craik, C.S.4
Bromme, D.5
-
119
-
-
4043106252
-
Lysosomal cysteine proteases in atherosclerosis
-
Liu J, Sukhova GK, Sun JS, Xu WH, Libby P & Shi GP (2004) Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol 24, 1359–1366.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1359-1366
-
-
Liu, J.1
Sukhova, G.K.2
Sun, J.S.3
Xu, W.H.4
Libby, P.5
Shi, G.P.6
-
120
-
-
34250014988
-
Mast cells promote atherosclerosis by releasing proinflammatory cytokines
-
Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J & Shi GP (2007) Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13, 719–724.
-
(2007)
Nat Med
, vol.13
, pp. 719-724
-
-
Sun, J.1
Sukhova, G.K.2
Wolters, P.J.3
Yang, M.4
Kitamoto, S.5
Libby, P.6
MacFarlane, L.A.7
Mallen-St Clair, J.8
Shi, G.P.9
-
121
-
-
77955228071
-
Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe–/– mice
-
Samokhin AO, Lythgo PA, Gauthier JY, Percival MD & Bromme D (2010) Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe–/– mice. J Cardiovasc Pharmacol 56, 98–105.
-
(2010)
J Cardiovasc Pharmacol
, vol.56
, pp. 98-105
-
-
Samokhin, A.O.1
Lythgo, P.A.2
Gauthier, J.Y.3
Percival, M.D.4
Bromme, D.5
-
122
-
-
59449092755
-
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis
-
de Nooijer R, Bot I, von der Thusen JH, Leeuwenburgh MA, Overkleeft HS, Kraaijeveld AO, Dorland R, van Santbrink PJ, van Heiningen SH, Westra MM et al. (2009) Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arterioscler Thromb Vasc Biol 29, 188–194.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 188-194
-
-
de Nooijer, R.1
Bot, I.2
von der Thusen, J.H.3
Leeuwenburgh, M.A.4
Overkleeft, H.S.5
Kraaijeveld, A.O.6
Dorland, R.7
van Santbrink, P.J.8
van Heiningen, S.H.9
Westra, M.M.10
-
123
-
-
33644865170
-
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
-
Lutgens E, Lutgens SP, Faber BC, Heeneman S, Gijbels MM, de Winther MP, Frederik P, van der Made I, Daugherty A, Sijbers AM et al. (2006) Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113, 98–107.
-
(2006)
Circulation
, vol.113
, pp. 98-107
-
-
Lutgens, E.1
Lutgens, S.P.2
Faber, B.C.3
Heeneman, S.4
Gijbels, M.M.5
de Winther, M.P.6
Frederik, P.7
van der Made, I.8
Daugherty, A.9
Sijbers, A.M.10
-
124
-
-
58449106519
-
Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice
-
Guo J, Bot I, de Nooijer R, Hoffman SJ, Stroup GB, Biessen EA, Benson GM, Groot PH, Van Eck M & Van Berkel TJ (2009) Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice. Cardiovasc Res 81, 278–285.
-
(2009)
Cardiovasc Res
, vol.81
, pp. 278-285
-
-
Guo, J.1
Bot, I.2
de Nooijer, R.3
Hoffman, S.J.4
Stroup, G.B.5
Biessen, E.A.6
Benson, G.M.7
Groot, P.H.8
Van Eck, M.9
Van Berkel, T.J.10
-
125
-
-
77951045600
-
Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
-
Barascuk N, Skjot-Arkil H, Register TC, Larsen L, Byrjalsen I, Christiansen C & Karsdal MA (2010) Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes. BMC Cardiovasc Disord 10, 19.
-
(2010)
BMC Cardiovasc Disord
, vol.10
, pp. 19
-
-
Barascuk, N.1
Skjot-Arkil, H.2
Register, T.C.3
Larsen, L.4
Byrjalsen, I.5
Christiansen, C.6
Karsdal, M.A.7
-
126
-
-
84930672493
-
Vasa vasorum in atherosclerosis and clinical significance
-
Xu J, Lu X & Shi GP (2015) Vasa vasorum in atherosclerosis and clinical significance. Int J Mol Sci 16, 11574–11608.
-
(2015)
Int J Mol Sci
, vol.16
, pp. 11574-11608
-
-
Xu, J.1
Lu, X.2
Shi, G.P.3
-
127
-
-
0344921396
-
Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
-
Moulton KS, Vakili K, Zurakowski D, Soliman M, Butterfield C, Sylvin E, Lo KM, Gillies S, Javaherian K & Folkman J (2003) Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A 100, 4736–4741.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4736-4741
-
-
Moulton, K.S.1
Vakili, K.2
Zurakowski, D.3
Soliman, M.4
Butterfield, C.5
Sylvin, E.6
Lo, K.M.7
Gillies, S.8
Javaherian, K.9
Folkman, J.10
-
128
-
-
84892935256
-
Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies
-
Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E & Soehnlein O (2014) Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circ Res 114, 214–226.
-
(2014)
Circ Res
, vol.114
, pp. 214-226
-
-
Silvestre-Roig, C.1
de Winther, M.P.2
Weber, C.3
Daemen, M.J.4
Lutgens, E.5
Soehnlein, O.6
-
129
-
-
84987811322
-
Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization
-
de Vries MR & Quax PH (2016) Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization. Curr Opin Lipidol 27, 499–506.
-
(2016)
Curr Opin Lipidol
, vol.27
, pp. 499-506
-
-
de Vries, M.R.1
Quax, P.H.2
-
130
-
-
0037459360
-
Deficiency of the cysteine protease cathepsin S impairs microvessel growth
-
Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A et al. (2003) Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res 92, 493–500.
-
(2003)
Circ Res
, vol.92
, pp. 493-500
-
-
Shi, G.P.1
Sukhova, G.K.2
Kuzuya, M.3
Ye, Q.4
Du, J.5
Zhang, Y.6
Pan, J.H.7
Lu, M.L.8
Cheng, X.W.9
Iguchi, A.10
-
131
-
-
33646827205
-
Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
-
Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R & Shi GP (2006) Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem 281, 6020–6029.
-
(2006)
J Biol Chem
, vol.281
, pp. 6020-6029
-
-
Wang, B.1
Sun, J.2
Kitamoto, S.3
Yang, M.4
Grubb, A.5
Chapman, H.A.6
Kalluri, R.7
Shi, G.P.8
-
132
-
-
84926610229
-
Cathepsin S activity controls ischemia-induced neovascularization in mice
-
Li X, Cheng XW, Hu L, Wu H, Guo P, Hao CN, Jiang H, Zhu E, Huang Z, Inoue A et al. (2015) Cathepsin S activity controls ischemia-induced neovascularization in mice. Int J Cardiol 183, 198–208.
-
(2015)
Int J Cardiol
, vol.183
, pp. 198-208
-
-
Li, X.1
Cheng, X.W.2
Hu, L.3
Wu, H.4
Guo, P.5
Hao, C.N.6
Jiang, H.7
Zhu, E.8
Huang, Z.9
Inoue, A.10
-
133
-
-
84976563555
-
Cathepsin S activity controls injury-related vascular repair in mice via the TLR2-mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling pathway
-
Wu H, Cheng XW, Hu L, Takeshita K, Hu C, Du Q, Li X, Zhu E, Huang Z, Yisireyili M et al. (2016) Cathepsin S activity controls injury-related vascular repair in mice via the TLR2-mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling pathway. Arterioscler Thromb Vasc Biol 36, 1549–1557.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, pp. 1549-1557
-
-
Wu, H.1
Cheng, X.W.2
Hu, L.3
Takeshita, K.4
Hu, C.5
Du, Q.6
Li, X.7
Zhu, E.8
Huang, Z.9
Yisireyili, M.10
-
134
-
-
20044373820
-
Cathepsin L is required for endothelial progenitor cell-induced neovascularization
-
Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA et al. (2005) Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 11, 206–213.
-
(2005)
Nat Med
, vol.11
, pp. 206-213
-
-
Urbich, C.1
Heeschen, C.2
Aicher, A.3
Sasaki, K.4
Bruhl, T.5
Farhadi, M.R.6
Vajkoczy, P.7
Hofmann, W.K.8
Peters, C.9
Pennacchio, L.A.10
-
135
-
-
84894454739
-
Cathepsin K activity controls injury-related vascular repair in mice
-
Hu L, Cheng XW, Song H, Inoue A, Jiang H, Li X, Shi GP, Kozawa E, Okumura K & Kuzuya M (2014) Cathepsin K activity controls injury-related vascular repair in mice. Hypertension 63, 607–615.
-
(2014)
Hypertension
, vol.63
, pp. 607-615
-
-
Hu, L.1
Cheng, X.W.2
Song, H.3
Inoue, A.4
Jiang, H.5
Li, X.6
Shi, G.P.7
Kozawa, E.8
Okumura, K.9
Kuzuya, M.10
-
136
-
-
84901911078
-
Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia
-
Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z et al. (2014) Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun 5, 3838.
-
(2014)
Nat Commun
, vol.5
, pp. 3838
-
-
Jiang, H.1
Cheng, X.W.2
Shi, G.P.3
Hu, L.4
Inoue, A.5
Yamamura, Y.6
Wu, H.7
Takeshita, K.8
Li, X.9
Huang, Z.10
-
137
-
-
84958933712
-
Gene expression signatures, pathways and networks in carotid atherosclerosis
-
Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, Lengquist M, Akesson S, Wheelock CE, Maegdefessel L et al. (2016) Gene expression signatures, pathways and networks in carotid atherosclerosis. J Intern Med 279, 293–308.
-
(2016)
J Intern Med
, vol.279
, pp. 293-308
-
-
Perisic, L.1
Aldi, S.2
Sun, Y.3
Folkersen, L.4
Razuvaev, A.5
Roy, J.6
Lengquist, M.7
Akesson, S.8
Wheelock, C.E.9
Maegdefessel, L.10
-
138
-
-
84960194141
-
Characterizing cathepsin activity and macrophage subtypes in excised human carotid plaques
-
Abd-Elrahman I, Meir K, Kosuge H, Ben-Nun Y, Weiss Sadan T, Rubinstein C, Samet Y, McConnell MV & Blum G (2016) Characterizing cathepsin activity and macrophage subtypes in excised human carotid plaques. Stroke 47, 1101–1108.
-
(2016)
Stroke
, vol.47
, pp. 1101-1108
-
-
Abd-Elrahman, I.1
Meir, K.2
Kosuge, H.3
Ben-Nun, Y.4
Weiss Sadan, T.5
Rubinstein, C.6
Samet, Y.7
McConnell, M.V.8
Blum, G.9
-
140
-
-
84958046387
-
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
-
Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC & Bogyo M (2016) Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature 530, 233–236.
-
(2016)
Nature
, vol.530
, pp. 233-236
-
-
Li, H.1
O'Donoghue, A.J.2
van der Linden, W.A.3
Xie, S.C.4
Yoo, E.5
Foe, I.T.6
Tilley, L.7
Craik, C.S.8
da Fonseca, P.C.9
Bogyo, M.10
-
141
-
-
50249145214
-
Use of fluorescent imaging to investigate pathological protease activity
-
Blum G (2008) Use of fluorescent imaging to investigate pathological protease activity. Curr Opin Drug Discov Devel 11, 708–716.
-
(2008)
Curr Opin Drug Discov Devel
, vol.11
, pp. 708-716
-
-
Blum, G.1
-
142
-
-
34548230533
-
Molecular imaging of cardiovascular disease
-
Jaffer FA, Libby P & Weissleder R (2007) Molecular imaging of cardiovascular disease. Circulation 116, 1052–1061.
-
(2007)
Circulation
, vol.116
, pp. 1052-1061
-
-
Jaffer, F.A.1
Libby, P.2
Weissleder, R.3
-
143
-
-
84957851359
-
Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside
-
Hughes CS, Burden RE, Gilmore BF & Scott CJ (2016) Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside. Biochimie 122, 48–61.
-
(2016)
Biochimie
, vol.122
, pp. 48-61
-
-
Hughes, C.S.1
Burden, R.E.2
Gilmore, B.F.3
Scott, C.J.4
-
144
-
-
83055180536
-
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes
-
Edgington LE, Verdoes M & Bogyo M (2011) Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Curr Opin Chem Biol 15, 798–805.
-
(2011)
Curr Opin Chem Biol
, vol.15
, pp. 798-805
-
-
Edgington, L.E.1
Verdoes, M.2
Bogyo, M.3
-
145
-
-
0032951071
-
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
-
Weissleder R, Tung CH, Mahmood U & Bogdanov A Jr (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 17, 375–378.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 375-378
-
-
Weissleder, R.1
Tung, C.H.2
Mahmood, U.3
Bogdanov, A.4
-
146
-
-
0037062686
-
In vivo imaging of proteolytic activity in atherosclerosis
-
Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL & Weissleder R (2002) In vivo imaging of proteolytic activity in atherosclerosis. Circulation 105, 2766–2771.
-
(2002)
Circulation
, vol.105
, pp. 2766-2771
-
-
Chen, J.1
Tung, C.H.2
Mahmood, U.3
Ntziachristos, V.4
Gyurko, R.5
Fishman, M.C.6
Huang, P.L.7
Weissleder, R.8
-
147
-
-
34247575810
-
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
-
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P & Weissleder R (2007) Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation 115, 2292–2298.
-
(2007)
Circulation
, vol.115
, pp. 2292-2298
-
-
Jaffer, F.A.1
Kim, D.E.2
Quinti, L.3
Tung, C.H.4
Aikawa, E.5
Pande, A.N.6
Kohler, R.H.7
Shi, G.P.8
Libby, P.9
Weissleder, R.10
-
148
-
-
56549095624
-
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
-
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P & Weissleder R (2008) Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation 118, 1802–1809.
-
(2008)
Circulation
, vol.118
, pp. 1802-1809
-
-
Jaffer, F.A.1
Vinegoni, C.2
John, M.C.3
Aikawa, E.4
Gold, H.K.5
Finn, A.V.6
Ntziachristos, V.7
Libby, P.8
Weissleder, R.9
-
149
-
-
84903945525
-
Quantitative longitudinal imaging of vascular inflammation and treatment by ezetimibe in apoE mice by FMT using new optical imaging biomarkers of cathepsin activity and alpha(v)beta(3) integrin
-
Lin SA, Patel M, Suresch D, Connolly B, Bao B, Groves K, Rajopadhye M, Peterson JD, Klimas M, Sur C et al. (2012) Quantitative longitudinal imaging of vascular inflammation and treatment by ezetimibe in apoE mice by FMT using new optical imaging biomarkers of cathepsin activity and alpha(v)beta(3) integrin. Int J Mol Imaging 2012, 189254.
-
(2012)
Int J Mol Imaging
, vol.2012
, pp. 189254
-
-
Lin, S.A.1
Patel, M.2
Suresch, D.3
Connolly, B.4
Bao, B.5
Groves, K.6
Rajopadhye, M.7
Peterson, J.D.8
Klimas, M.9
Sur, C.10
-
150
-
-
68149166462
-
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity
-
Blum G, Weimer RM, Edgington LE, Adams W & Bogyo M (2009) Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. PLoS One 4, e6374.
-
(2009)
PLoS One
, vol.4
-
-
Blum, G.1
Weimer, R.M.2
Edgington, L.E.3
Adams, W.4
Bogyo, M.5
-
151
-
-
84904438282
-
In vivo imaging of mouse tumors by a lipidated cathepsin S substrate
-
Hu HY, Vats D, Vizovisek M, Kramer L, Germanier C, Wendt KU, Rudin M, Turk B, Plettenburg O & Schultz C (2014) In vivo imaging of mouse tumors by a lipidated cathepsin S substrate. Angew Chem Int Ed Engl 53, 7669–7673.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 7669-7673
-
-
Hu, H.Y.1
Vats, D.2
Vizovisek, M.3
Kramer, L.4
Germanier, C.5
Wendt, K.U.6
Rudin, M.7
Turk, B.8
Plettenburg, O.9
Schultz, C.10
-
152
-
-
33644825565
-
Dynamic imaging of protease activity with fluorescently quenched activity-based probes
-
Blum G, Mullins SR, Keren K, Fonovic M, Jedeszko C, Rice MJ, Sloane BF & Bogyo M (2005) Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol 1, 203–209.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 203-209
-
-
Blum, G.1
Mullins, S.R.2
Keren, K.3
Fonovic, M.4
Jedeszko, C.5
Rice, M.J.6
Sloane, B.F.7
Bogyo, M.8
-
153
-
-
34548666006
-
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes
-
Blum G, von Degenfeld G, Merchant MJ, Blau HM & Bogyo M (2007) Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol 3, 668–677.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 668-677
-
-
Blum, G.1
von Degenfeld, G.2
Merchant, M.J.3
Blau, H.M.4
Bogyo, M.5
-
154
-
-
84984820187
-
Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion
-
Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV & Blum G (2016) Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion. PLoS One 11, e0160522.
-
(2016)
PLoS One
, vol.11
-
-
Abd-Elrahman, I.1
Kosuge, H.2
Wises Sadan, T.3
Ben-Nun, Y.4
Meir, K.5
Rubinstein, C.6
Bogyo, M.7
McConnell, M.V.8
Blum, G.9
-
155
-
-
84965082269
-
A bright future for precision medicine: advances in fluorescent chemical probe design and their clinical application
-
Garland M, Yim JJ & Bogyo M (2016) A bright future for precision medicine: advances in fluorescent chemical probe design and their clinical application. Cell Chem Biol 23, 122–136.
-
(2016)
Cell Chem Biol
, vol.23
, pp. 122-136
-
-
Garland, M.1
Yim, J.J.2
Bogyo, M.3
-
156
-
-
81455127363
-
Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe
-
Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS et al. (2011) Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe. PLoS One 6, e28029.
-
(2011)
PLoS One
, vol.6
-
-
Ren, G.1
Blum, G.2
Verdoes, M.3
Liu, H.4
Syed, S.5
Edgington, L.E.6
Gheysens, O.7
Miao, Z.8
Jiang, H.9
Gambhir, S.S.10
-
157
-
-
84991384034
-
Dual-modality activity-based probes as molecular imaging agents for vascular inflammation
-
Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M et al. (2016) Dual-modality activity-based probes as molecular imaging agents for vascular inflammation. J Nucl Med 57, 1583–1590.
-
(2016)
J Nucl Med
, vol.57
, pp. 1583-1590
-
-
Withana, N.P.1
Saito, T.2
Ma, X.3
Garland, M.4
Liu, C.5
Kosuge, H.6
Amsallem, M.7
Verdoes, M.8
Ofori, L.O.9
Fischbein, M.10
-
158
-
-
84955451151
-
Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes
-
Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K et al. (2016) Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes. Sci Rep 6, 19755.
-
(2016)
Sci Rep
, vol.6
, pp. 19755
-
-
Withana, N.P.1
Ma, X.2
McGuire, H.M.3
Verdoes, M.4
van der Linden, W.A.5
Ofori, L.O.6
Zhang, R.7
Li, H.8
Sanman, L.E.9
Wei, K.10
-
159
-
-
84959056312
-
Imaging atherosclerosis
-
Tarkin JM, Dweck MR, Evans NR, Takx RA, Brown AJ, Tawakol A, Fayad ZA & Rudd JH (2016) Imaging atherosclerosis. Circ Res 118, 750–769.
-
(2016)
Circ Res
, vol.118
, pp. 750-769
-
-
Tarkin, J.M.1
Dweck, M.R.2
Evans, N.R.3
Takx, R.A.4
Brown, A.J.5
Tawakol, A.6
Fayad, Z.A.7
Rudd, J.H.8
-
160
-
-
84925324732
-
Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease
-
Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W et al. (2015) Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol 185, 1156–1166.
-
(2015)
Am J Pathol
, vol.185
, pp. 1156-1166
-
-
Figueiredo, J.L.1
Aikawa, M.2
Zheng, C.3
Aaron, J.4
Lax, L.5
Libby, P.6
de Lima Filho, J.L.7
Gruener, S.8
Fingerle, J.9
Haap, W.10
-
161
-
-
50949115875
-
PhotoPoint photodynamic therapy promotes stabilization of atherosclerotic plaques and inhibits plaque progression
-
Waksman R, McEwan PE, Moore TI, Pakala R, Kolodgie FD, Hellinga DG, Seabron RC, Rychnovsky SJ, Vasek J, Scott RW et al. (2008) PhotoPoint photodynamic therapy promotes stabilization of atherosclerotic plaques and inhibits plaque progression. J Am Coll Cardiol 52, 1024–1032.
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 1024-1032
-
-
Waksman, R.1
McEwan, P.E.2
Moore, T.I.3
Pakala, R.4
Kolodgie, F.D.5
Hellinga, D.G.6
Seabron, R.C.7
Rychnovsky, S.J.8
Vasek, J.9
Scott, R.W.10
-
162
-
-
84941312661
-
Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy
-
Ben-Nun Y, Merquiol E, Brandis A, Turk B, Scherz A & Blum G (2015) Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy. Theranostics 5, 847–862.
-
(2015)
Theranostics
, vol.5
, pp. 847-862
-
-
Ben-Nun, Y.1
Merquiol, E.2
Brandis, A.3
Turk, B.4
Scherz, A.5
Blum, G.6
-
163
-
-
84879126791
-
Photodynamic therapy using a protease-mediated theranostic agent reduces cathepsin-B activity in mouse atheromata in vivo
-
Shon SM, Choi Y, Kim JY, Lee DK, Park JY, Schellingerhout D & Kim DE (2013) Photodynamic therapy using a protease-mediated theranostic agent reduces cathepsin-B activity in mouse atheromata in vivo. Arterioscler Thromb Vasc Biol 33, 1360–1365.
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 1360-1365
-
-
Shon, S.M.1
Choi, Y.2
Kim, J.Y.3
Lee, D.K.4
Park, J.Y.5
Schellingerhout, D.6
Kim, D.E.7
-
164
-
-
85013167848
-
Merck & Co. drops osteoporosis drug odanacatib
-
Mullard A (2016) Merck & Co. drops osteoporosis drug odanacatib. Nat Rev Drug Discov 15, 669.
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 669
-
-
Mullard, A.1
-
165
-
-
84979782459
-
TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors
-
Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC et al. (2016) TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors. Cell Rep 16, 1762–1773.
-
(2016)
Cell Rep
, vol.16
, pp. 1762-1773
-
-
Prudova, A.1
Gocheva, V.2
Auf dem Keller, U.3
Eckhard, U.4
Olson, O.C.5
Akkari, L.6
Butler, G.S.7
Fortelny, N.8
Lange, P.F.9
Mark, J.C.10
-
166
-
-
0039547996
-
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
-
Guncar G, Pungercic G, Klemencic I, Turk V & Turk D (1999) Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. EMBO J 18, 793–803.
-
(1999)
EMBO J
, vol.18
, pp. 793-803
-
-
Guncar, G.1
Pungercic, G.2
Klemencic, I.3
Turk, V.4
Turk, D.5
|