Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity

FASEB Journal

Volumn 30, Issue 12, 2016, Pages 4239-4255

  Dinnes, Donna Lee M ^a   White, Melanie Y ^a   Kockx, Maaike ^a   Traini, Mathew ^a   Hsieh, Victar ^b   Kim, Mi Jurng ^c   Hou, Liming ^c   Jessup, Wendy ^a   Rye, Kerry Anne ^c   Thaysen Andersen, Morten ^d   Cordwell, Stuart J ^a   Kritharides, Leonard ^a,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d MACQUARIE UNIVERSITY   (Australia)

^e ANZAC Research Institute   (Australia)

Author keywords

Atherosclerosis; Coronary artery disease; High density lipoprotein; Proteolysis

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CALPEPTIN; CATHEPSIN B; CHOLESTEROL; ILOMASTAT; LEUPEPTIN; PEPSTATIN; SMALL INTERFERING RNA; ABC TRANSPORTER; APOA1 PROTEIN, HUMAN; SERINE;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; CAROTID ATHEROSCLEROSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; ISOELECTRIC POINT; MACROPHAGE; MASS SPECTROMETRY; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ATHEROSCLEROSIS; FOAM CELL; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; TRANSPORT AT THE CELLULAR LEVEL;

APOLIPOPROTEIN A-I; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CATHEPSIN B; CHOLESTEROL; FOAM CELLS; HUMANS; MACROPHAGES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; SERINE;

EID: 85001976245     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201600508R     Document Type: Article

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