Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 9, 2014, Pages 1942-1952

  Emanuel, Roy ^a   Sergin, Ismail ^a   Bhattacharya, Somashubhra ^a   Turner, Jaleisa N ^b   Epelman, Slava ^a   Settembre, Carmine ^d,e   Diwan, Abhinav ^a,c   Ballabio, Andrea ^d,e   Razani, Babak ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Pathology and Immunology ^*  (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

atherosclerosis; autophagy; inflammasome; lipid metabolism; lysosomes; macrophages

Indexed keywords

CHLOROQUINE; CHOLESTEROL; INTERLEUKIN 1BETA; LIPID; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYUBIQUITIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; AUTOPHAGY; BIOGENESIS; CELL PH; CELL STRESS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; GENE ACTIVATION; INFLAMMATION; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION;

ATHEROSCLEROSIS; AUTOPHAGY; INFLAMMASOME; LIPID METABOLISM; LYSOSOMES; MACROPHAGES;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL MEMBRANE PERMEABILITY; CHLOROQUINE; CHOLESTEROL; HYDROGEN-ION CONCENTRATION; INCLUSION BODIES; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPIDS; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; PLAQUE, ATHEROSCLEROTIC; POLYUBIQUITIN; PROTEOLYSIS; STEROL ESTERASE; TRANSCRIPTION, GENETIC;

EID: 84906935699     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303342     Document Type: Article

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