Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

Journal of Biological Chemistry

Volumn 281, Issue 18, 2006, Pages 12824-12832

  Choe, Youngchool ^a   Leonetti, Francesco ^b   Greenbaum, Doron C ^a   Lecaille, Fabien ^c   Bogyo, Matthew ^a   Brömme, Dieter ^c   Ellman, Jonathan A ^b   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME KINETICS; PATHOLOGY; PHYSIOLOGY; SUBSTRATES; SYNTHESIS (CHEMICAL);

PARASITIC ORIGIN; POSITIONAL SCANNING; SELECTIVE CHEMICAL PROBES; TETRAPEPTIDE SUBSTRATE SEQUENCES;

PROTEINS;

BROMELAIN; CATHEPSIN B; CATHEPSIN F; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; ENZYME INHIBITOR; GLYCINE; PAPAIN; PEPTIDE LIBRARY; PROLINE; RECOMBINANT ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CLUSTER ANALYSIS; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; MICROTITER PLATE ASSAY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

ANIMALS; BINDING, COMPETITIVE; CATHEPSINS; COUMARINS; CYSTEINE; HUMANS; KETONES; KINETICS; MODELS, CHEMICAL; PEPTIDES; PHYLOGENY; SUBSTRATE SPECIFICITY;

EID: 33744961634     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513331200     Document Type: Article

References (38)

1. Rawlings, N. D., Tolle, D. P., and Barrett, A. J. (2004) Nucleic Acids Res. 32, D160-D164
2. Marnett, A. B., and Craik, C. S. (2005) Trends Biotechnol. 23, 59-64
3. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
4. Harris, J. L., Backes, B. J., Leonetti, F., Mahrus, S., Ellman, J. A., and Craik, C. S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7754-7759
5. Takeuchi, T., Harris, J. L., Huang, W., Yan, K. W., Coughlin, S. R., and Craik, C. S. (2000) J. Biol. Chem. 275, 26333-26342
6. Harris, J. L., Niles, A., Burdick, K., Maffitt, M., Backes, B. J., Ellman, J. A., Kuntz, I., Haak-Frendscho, M., and Craik, C. S. (2001) J. Biol. Chem. 276, 34941-34947
7. Salter, J. P., Choe, Y., Albrecht, H., Franklin, C., Lim, K. C., Craik, C. S., and McKerrow, J. H. (2002) J. Biol. Chem. 277, 24618-24624
8. Lecaille, F., Kaleta, J., and Brömme, D. (2002) Chem. Rev. 102, 4459-4488
9. Brömme, D., and Kaleta, J. (2002) Curr. Pharm. Des. 8, 1639-1658
10. Sajid, M., and McKerrow, J. H. (2002) Mol. Biochem. Parasitol. 120, 1-21
11. Rosenthal, P. J. (2004) Int. J. Parasitol. 34, 1489-1499
12. Brömme, D., Okamoto, K., Wang, B. B., and Biroc, S. (1996) J. Biol. Chem. 271, 2126-2132
13. Berger, A., and Schechter, I. (1970) Philos. Trans. R. Soc. Lond. B Biol. Sci. 257, 249-264
14. Turk, D., Guncar, G., Podobnik, M., and Turk, B. (1998) Biol. Chem. 379, 137-147
15. Brömme, D., and McGrath, M. E. (1996) Protein Sci. 5, 789-791
16. Smith, S. M., and Gottesman, M. M. (1989) J. Biol. Chem. 264, 20487-20495
17. Brömme, D., Li, Z., Barnes, M., and Mehler, E. (1999) Biochemistry 38, 2377-2385
18. Caffrey, C. R., Hansell, E., Lucas, K. D., Brinen, L. S., Alvarez Hernandez, A., Cheng, J., Gwaltney, S. L., II, Roush, W. R., Stierhof, Y. D., Bogyo, M., Steverding, D., and McKerrow, J. H. (2001) Mol. Biochem. Parasitol. 118, 61-73
19. Eakin, A. E., Mills, A. A., Harth, G., McKerrow, J. H., and Craik, C. S. (1992) J. Biol. Chem. 267, 7411-7420
20. Backes, B. J., Harris, J. L., Leonetti, F., Craik, C. S., and Ellman, J. A. (2000) Nat. Biotechnol. 18, 187-193
21. Maly, D. J., Leonetti, F., Backes, B. J., Dauber, D. S., Harris, J. L., Craik, C. S., and Ellman, J. A. (2002) J. Org. Chem. 67, 910-915
22. Bunin, B. A. (1998) The Combinatorial Index, p. 6, Academic Press, San Diego, CA
23. Ostresh, J. M., Winkle, J. H., Hamashin, V. T., and Houghten, R. A. (1994) Biopolymers 34, 1681-1689
24. Wagner, B. M., Smith, R. A., Coles, P. J., Copp, L. J., Ernest, M. J., and Krantz, A. (1994) J. Med. Chem. 37, 1833-1840
25. Brömme, D., Smith, R. A., Coles, P. J., Kirschke, H., Storer, A. C., and Krantz, A. (1994) Biol. Chem. Hoppe-Seyler 375, 343-347
26. Eisen, M. B., Spellman, P. T., Brown, P. O., and Botstein, D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 14863-14868
27. Greenbaum, D., Medzihradszky, K. F., Burlingame, A., and Bogyo, M. (2000) Chem. Biol. 7, 569-581
28. McGrath, M. E., Palmer, J. T., Brömme, D., and Somoza, J. R. (1998) Protein Sci. 7, 1294-1302
29. Puzer, L., Cotrin, S. S., Alves, M. F., Egborge, T., Araujo, M. S., Juliano, M. A., Juliano, L., Brömme, D., and Carmona, A. K. (2004) Arch. Biochem. Biophys. 430, 274-283
30. Cotrin, S. S., Puzer, L., de Souza Judice, W. A., Juliano, L., Carmona, A. K., and Juliano, M. A. (2004) Anal. Biochem. 335, 244-252
31. Xia, L., Kilb, J., Wex, H., Li, Z., Lipyansky, A., Breuil, V., Stein, L., Palmer, J. T., Dempster, D. W., and Brömme, D. (1999) Biol. Chem. 380, 679-687
32. Kafienah, W., Brömme, D., Buttle, D. J., Croucher, L. J., and Hollander, A. P. (1998) Biochem. J. 331, 727-732
33. Villadangos, J. A., Riese, R. J., Peters, C., Chapman, H. A., and Ploegh, H. L. (1997) J. Exp. Med. 186, 549-560
34. Turk, B., Turk, D., and Turk, V. (2000) Biochim. Biophys. Acta 1477, 98-111
35. Turk, V., Turk, B., and Turk, D. (2001) EMBO J. 20, 4629-4633
36. Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J. A., Ploegh, H., Peters, C., and Rudensky, A. Y. (1998) Science 280, 450-453
37. Yasuda, Y., Kaleta, J., and Brömme, D. (2005) Adv. Drug Delivery Rev. 57, 973-993
38. Barrett, A. J., Rawlings, N. D., and Woessner, J. F. (2004) Handbook of Proteolytic Enzymes, Second Ed., p. 1105, Academic Press, London