Structure-and function-based design of Plasmodium-selective proteasome inhibitors

Nature

Volumn 530, Issue 7589, 2016, Pages 233-236

  Li, Hao ^a   O'Donoghue, Anthony J ^b   Van Der Linden, Wouter A ^a   Xie, Stanley C ^c   Yoo, Euna ^a   Foe, Ian T ^a   Tilley, Leann ^c   Craik, Charles S ^b   Da Fonseca, Paula C A ^d   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARTEMISININ; PROTEASOME; PROTEASOME INHIBITOR; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PROTEIN SUBUNIT;

ANTIGEN; ANTIMALARIAL AGENT; ENZYME; EXPERIMENTAL STUDY; INHIBITOR; MALARIA; PARASITE; PATHOGEN; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROBIAL ATTENUATION; MICROBIAL GROWTH; MOUSE; NONHUMAN; PLASMODIUM CHABAUDI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE DRUG DOSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; PLASMODIUM; PLASMODIUM CHABAUDI; PROTEIN SUBUNIT; SPECIES DIFFERENCE; ULTRASTRUCTURE;

MAMMALIA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CATALYTIC DOMAIN; CRYOELECTRON MICROSCOPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE; DRUG SYNERGISM; ENZYME ACTIVATION; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PLASMODIUM; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN SUBUNITS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 84958046387     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16936     Document Type: Article

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