NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Nature

Volumn 464, Issue 7293, 2010, Pages 1357-1361

  Duewell, Peter ^a,b   Kono, Hajime ^a   Rayner, Katey J ^c,d   Sirois, Cherilyn M ^a   Vladimer, Gregory ^a   Bauernfeind, Franz G ^e   Abela, George S ^g   Franchi, Luigi ^h   Nũez, Gabriel ^h   Schnurr, Max ^b   Espevik, Terje ⁱ   Lien, Egil ^a   Fitzgerald, Katherine A ^a   Rock, Kenneth L ^a   Moore, Kathryn J ^c,d   Wright, Samuel D ^j   Hornung, Veit ^d   Latz, Eicke ^a,f,i  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c NEW YORK UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e Institute of Clinical Chemistry and Pharmacology   (United States)

^f UNIVERSITY OF BONN   (Germany)

^g MICHIGAN STATE UNIVERSITY   (United States)

^h UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

ⁱ NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^j CSL LIMITED   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CHOLESTEROL; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN;

CARDIOVASCULAR DISEASE; CRYSTAL CHEMISTRY; CRYSTALLIZATION; CYTOLOGY; DISEASE TREATMENT; LESION; PATHOLOGY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BONE MARROW; BONE MARROW TRANSPLANTATION; CHOLESTEROL DIET; CONTROLLED STUDY; CRYSTALLIZATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL;

ANIMALS; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CARRIER PROTEINS; CATHEPSIN B; CATHEPSIN L; CHOLESTEROL; CRYSTALLIZATION; CYTOSKELETAL PROTEINS; DIET, ATHEROGENIC; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-18; LYSOSOMES; MICE; MICE, INBRED C57BL; PERITONEAL CAVITY; PHAGOCYTES; RECEPTORS, LDL; TIME FACTORS;

ANIMALIA; MUS;

EID: 77951800951     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08938     Document Type: Article

References (28)

1. Wright, S. D. et al. Infectious agents are not necessary for murine atherogenesis. J. Exp. Med. 191, 1437-1442 (2000).
2. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
3. Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nature Immunol. 9, 847-856 (2008).
4. Chang, T. Y., Chang, C. C., Ohgami, N. & Yamauchi, Y. Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 22, 129-157 (2006).
5. Small, D. M. George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry. Arteriosclerosis 8, 103-129 (1988).
6. Stary, H. et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler. Thromb. Vasc. Biol. 15, 1512-1531 (1995).
7. Abela, G. S. et al. Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes. Am. J. Cardiol. 103, 959-968 (2009).
8. Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M. & Maeda, N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl Acad. Sci. USA 89, 4471-4475 (1992).
9. Zhang, S. H., Reddick, R. L., Piedrahita, J. A. & Maeda, N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468-471 (1992).
10. Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265 (2009).
11. Bauernfeind, F. G. et al. Cutting edge: NF-kB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791 (2009).
12. Hornung, V. et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518 (2009).
13. Stewart, C. R. et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nature Immunol. 11, 155-161 (2009).
14. Halle, A. et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-b. Nature Immunol. 9, 857-865 (2008).
15. Garin, J. et al. The phagosome proteome: insight into phagosome functions. J. Cell Biol. 152, 165-180 (2001).
16. Yuan, X. M., Li, W., Olsson, A. G. & Brunk, U. T. The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis 133, 153-161 (1997).
17. Chen, C. J. et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nature Med. 13, 851-856 (2007).
18. Guarda, G. et al. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460, 269-273 (2009)
19. Dinarello, C. A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550 (2009).
20. Ishibashi, S., Goldstein, J. L., Brown, M. S., Herz, J. & Burns, D. K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93, 1885-1893 (1994).
21. Blankenberg, S. et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation 106, 24-30 (2002).
22. Dostert, C. et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677 (2008).
23. Mossman, B. T. & Churg, A. Mechanisms in the pathogenesis of asbestosis and silicosis. Am. J. Respir. Crit. Care Med. 157, 1666-1680 (1998).
24. Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. & Dawber, T. R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62, 707-714 (1977).
25. Nissen, S. E. et al. Effect of ACAT inhibition on the progression of coronary atherosclerosis. N. Engl. J. Med. 354, 1253-1263 (2006).
26. Meuwese, M. C. et al. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial. J. Am. Med. Assoc. 301, 1131-1139 (2009).
27. Accad, M. et al. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J. Clin. Invest. 105, 711-719 (2000).
28. Moore, K. J. et al. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J. Clin. Invest. 115, 2192-2201 (2005).