Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells: Accumulation of oxidized esters in lysosomes

Journal of Lipid Research

Volumn 41, Issue 2, 2000, Pages 226-236

  Brown, Andrew J ^a   Mander, Erin L ^a,b   Gelissen, Ingrid C ^a   Kritharides, Leonard ^a   Dean, Roger T ^a   Jessup, Wendy ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

^b Novogen Limited   (Australia)

Author keywords

7 ketocholesterol; Atherosclerosis; Cholesterol; Foam cell; Low density lipoprotein; Macrophage; Oxidation

Indexed keywords

7 OXOCHOLESTEROL; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; OXYSTEROL;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELLULAR DISTRIBUTION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FOAM CELL; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

ANIMALS; ARTERIOSCLEROSIS; CELL LINE; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL ESTERS; ESTERIFICATION; FOAM CELLS; HUMANS; KETOCHOLESTEROLS; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES, PERITONEAL; MICE; OXIDATION-REDUCTION; STEROL O-ACYLTRANSFERASE; STEROLS; SUBCELLULAR FRACTIONS;

EID: 0033995604     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Stary, H. C., A. B. Chandler, S. Glagov, J. R. Guyton, W. Insull, Jr., M. E. Rosenfeld, S. A. Schaffer, C. J. Schwartz, W. D. Wagner, and R. W. Wissler. 1994. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis. American Heart Association. Circulation. 89: 2462-2478.
2. Goldstein, J. L., Y. K. Ho, S. K. Basu, and M. S. Brown. 1979. Binding site on macrophages that mediates the uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA. 76: 333-337.
3. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity [see comments]. N. Engl. J. Med. 320: 915-924.
4. Jialal, I., and A. Chait. 1989. Differences in the metabolism of oxidatively modified low density lipoprotein and acetylaeed low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein. J. Lipid Res. 30: 1561-1568.
5. Roma, P., A. L. Catapano, S. M. Bertulli, L. Varesi, R. Fumagalli, and K. Bernini. 1990. Oxidized LDL increase free cholesterol and fail to stimulate cholesterol esterification in murine macrophages. Biochem. Biophys. Res. Commun 171: 123-131.
6. Longheed, M., H. F. Zhang, and U. P. Steinbrecher. 1991. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages. J. Biol. Chem. 266: 14519-14525.
7. Jessup, W., E. L. Mander, and R. T. Dean. 1992. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages. Biochim. Biophys. Acta. 1126: 167-177.
8. Hoppe, G., J. O'Neil, and H. F. Hoff. 1991. Inactivation of lysosomal proteases by oxidized LDL is partially responsible for its poor degradation by mouse peritoneal macrophages. J. Clin. Invest. 94: 1506-1512.
9. Dean, R. T., S. Fu, R. Stocker, and M. J. Davies, 1997. The biochemistry and pathology of radical-mediated protein oxidation. Biochem. J. 324: 1-18.
10. Fu, S., L. Hick, M. M. Shiel, and R. T. Dean. 1995. Structural identification of valine hydroperoxides and hydroxides on radical-damaged amino acid, peptide and protein molecules. Free Radical Biol. Med. 19: 281-292.
11. Dean, R. T., S. P. Gieseg, and M. J. Davies. 1993. Reactive species and their accumulation on radical-damaged proteins. Trends Biochem. Sci. 18: 437-441.
12. Grant, A. J., W. Jessup, and R. T. Dean. 1993. Inefficient degradation of oxidized regions of protein molecules. Free Radical Res. Commun. 18: 259-267.
13. Grant, A. J., W. Jessup, and R. T. Dean. 1992. Accelerated endocytosis and incomplete calabolism of radical-damaged protein. Biochim. Biophys. Acta. 1134: 203-209.
14. Mander, E. L., R. T. Dean, K. K. Stanley, and W. Jessup. 1994. Apolipoprotein B of oxidized LDL, accumulates in the lysosomes of macrophages. Biochim. Biophys. Acta. 1212: 80-92.
15. Rosenfeld, M. E., W. Palinski, H. S. Yla, S. Butler, and J. L. Witztum. 1990. Distribution of Oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying-severity from WHHL rabbits. Arteriosclerosis. 10: 336-349.
16. Zhang, H. F., H. J. Basra, and U. P. Steinbrecher. 1990. Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages. J. Lipid Res. 31: 1361-1369.
17. Maor, I., and M. Aviram. 1991. Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. J. Lipid Res. 35: 803-819.
18. Kritharides, K., W. Jessup, E. L. Mander, and R. T. Dean. 1995. Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages. Arterioscler. Thromb. 15: 276-289.
19. Maor, I., H. Mandel, and M. Aviram. 1995. Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-ketocholesterol. Arterioscler. Thromb. Vasc. Biol. 15: 1378-1387.
20. Greenspan, P., H. Yu, F. Mao, and R. L. Gutman. 1997. Cholesterol deposition in macrophages: foam cell formation mediated by cholesterol-enriched oxidized low density lipoprotein. J. Lipid Res. 38: 101-109.
21. Yancey, P. G., and W. G. Jerome. 1998. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. J. Lipid Res. 39: 1349-1361.
22. Brown, A., R. Dean, and W. Jessup. 1996. Free and esterfied oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. J. Lipid Res. 37: 320-335.
23. Gelissen, L., A. J. Brown, E. L. Mander, F. Kritharides, R. T. Dean, and W. Jessup. 1996. Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. J. Biol. Chem. 271: 17852-17860.
24. Jessup, W., U. V. Darley, V. O'Leary, and S. Bedwell. 1991. 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochem. J. 278: 163-169.
25. Jessup, W., G. Jingens, J. Lang, H. Esterbauer, and R. T. Dean. 1986. Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor. Biochem. J. 234: 245-218.
26. van Reyk, D. M., A. J. Brown, W. Jessup, and R. T. Dean. 1995. Batch-to batch variation of Chelex-100 confounds metal-catalysed oxidation. Leaching of inhibitory compounds from a batch of Chelex-100 and their removal by a pre-washing procedure. Free Radical Res. 6: 533-535.
27. Kritharides, L., W. Jessup, and R. T. Dean. 1993. A method for staging the degree of LDL oxidation by the separation of cholesterol and cholesteryl ester oxidation products using HPLC. Anal. Biochem. 213: 79-89.
28. Jessup, W., S. M. Rankin, W. C. De, J. R. Hoult, J. Scott, and D. S. Leake. 1990. Alpha-tocopherol consumption during low-density-lipoprotein oxidation. Biochem. J. 265: 399-405.
29. Goldstein, J. L., S. K. Basu, and M. S. Brown. 1983. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98: 241-260.
30. Kritharides, L. 1994. The oxidation and metabolism of low density lipoproteins by macrophages. Ph.D Thesis, University of Sydney, Sydney, Australia.
31. Deykin, D., and D. S. Goodman. 1962. The hydrolysis of long-chain fatty acids of cholesterol with fat liver enzymes. J. Biol. Chem. 237: 3649-3656.
32. Gelissen, I., T. Hochgrebe, M. Wilson, S. Fasterbrook-Smith, W. Jessup, R. T. Dean, and A. J. Brown. 1998. Apolipoprotein J (clusterin) induces cholesterol efflux from macrophage-foam cells: a potential anti-atherogenic function. Biochem. J. 331: 231-237.
33. Balch, W. E., W. G. Dunphy, W. A. Braell, and J. E. Rothman. 1984. Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine. Cell. 39: 405-416.
34. Branch, W. J., B. M. Mullock, and J. P. Luzio. 1987. Rapid subcellular fractionation of the rat liver endocylic compartments involved in transcytosis of polymeric immunoglobulin A and endocytosis of asialofetuin. Biochem. J. 244: 311-315.
35. Ukkonen, P., V. Lewis, M. Marsh, A. Helenius, and I. Mellman. 1986. Transport of macrophages Fc receptors and Fc receptor-bound ligands to lysosomes. J. Exp. Med. 163: 952-971.
36. Shio, H., N. J. Haley, and S. Fowler. 1979. Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester. Lab. Invest. 41: 160-167.
37. Longheed, M., K. Moore, D. Scriven, and U. Steinbrecher. 1999. Uptake of oxidized LDL by macrophages differs from that of acetyl LDL and leads to expansion of an acidic endolysosomal compartment. Arterioscler. Thromb. Vasc. Biol. 19: 1881-1890.
38. Coleman, R., and J. B. Finean. 1967. A purified plasma membrane fraction isolated from rat liver under isotonic conditions. Biochim. Biophys. Acta. 125: 573-579.
39. Lange, Y., M. H. Swaisgood, B. V. Ramos, and T. L. Steck. 1989. Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts. J. Biol. Chem. 264: 3786-3793.
40. Suarna, C., R. T. Dean, J. May, and R. Stocker. 1995. Human atheroclerotic plaque contains both oxidized lipids and relatively large amounts of α-tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15: 1616-1624.
41. Chan, H.W-S. 1987. Autoxidation of Unsaturated Lipids. Academic Press, Orlando, FL.
42. Tangirala, R. K., F. H. Mahlberg, J. M. Glick, W. G. Jerome, and G. H. Rothblat. 1993. Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. J. Biol. Chem. 268: 9653-9660.
43. O'Neil, J., G. Hoppe, L. M. Sayre, and H. F. Hoff. 1997. Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme. Free Radical Biol. Med. 23: 215-225.
44. Hoppe, G., A. Ravandi, D. Herrera, A. Kuksis, and H. F. Hoff. 1997. Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J. Lipid Res. 38: 1347-1360.
45. Ryu, B. H., F. W. Mao, P. Lou, R. L. Gutman, and P. Greenspan. 1995. Cholesteryl ester accumulation in macrophages treated with oxidized low density lipoprotein. Biosci. Biotechnol. Biochem. 59: 1619-1622.
46. Kaur, K., R. G. Salomon, J. O'Neil, and H. F. Hoff. 1997. (Carboxyalkyl) pyrroles in human plasma and oxidized low-densily lipoproteins. Chem. Res. Toxicol. 10: 1387-1396.
47. Salomon, R. G., G. Subbanagounder, U. Singh, J. O'Neil, and H. F. Hoff. 1997. Oxidation of low-density lipoproteins produces levuglandin-protein adducts. Chem. Res. Toxicol. 10: 750-759.
48. Karten, B., H. Boechzelt, P. Abuja, M. Mittelbach, K. Oettl, and W. Sattler. 1998. Femtomole analysis of 9-oxononanoyl cholesterol by high performance liquid chromatography. J. Lipid Res. 39: 1508-1519.
49. Kritharides, L., J. Upston, W. Jessup, and R. T. Dean. 1998. Accumulation and metabolism of cholesteryl linoleate hydroperoxide and hydroxide by macrophages. J. Lipid Res. 39: 2394-2405.
50. Gelissen, I., K-A. Rye, A. Brown, R. Dean, and W. Jessup. 1999. Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. J. Lipid Res. 40: 1636-1646.
51. Leoni, P., R. T. Dean, and W. Jessup. 1985. Secretion of lysosomal hydrolases by mononuclear phagocytes. In Mononuclear Phagocytes: Physiology and Pathology. R. Dean and W. Jessup, editors. Elsevier, Amsterdam. 181-202.