Atherosclerosis: The road ahead

Cell

Volumn 104, Issue 4, 2001, Pages 503-516

  Glass, Christopher K ^a,b   Witztum, Joseph L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL ACYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR CELL ADHESION MOLECULE 1; VERY LOW DENSITY LIPOPROTEIN;

ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; FOAM CELL; HUMAN; LIPID OXIDATION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0035936802     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00238-0     Document Type: Review

References (104)

1. Massive zanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:Cholesterol acyltransferase 1
2. Effect of chronic treatment with the inducible nitric oxide synthase inhibitor N-iminoethyl-L-lysine or with L-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits
3. Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture
4. Somatic gene transfer of human apo A-I inhibits atherosclerosis progression in mouse models
5. Mechanism of degradation of the steroid side chain in the formation of bile acids
6. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
7. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice
8. -/- mice reveals a role for chemokines in the initiation of atherosclerosis
9. Mouse models of atherosclerosis
10. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
11. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
12. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
13. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
14. Proteins in cardiovascular aneurysms and rupture: Targets for therapy?
15. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
16. Roles of multiple oxidized lipids in cellular injury
17. P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice
18. Sterol-dependent transactivation of the ABC1 promoter by the liver X Receptor/Retinoid X receptor
19. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
20. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
21. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse
22. Genetic background determines the extent of atherosclerosis in apo E-deficient mice
23. Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage, and smooth muscle cell content
24. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice
25. The Combined role of P- and E-selectins in atherosclerosis
26. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
27. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
28. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
29. The coregulator exchange in transcriptional functions of nuclear receptors
30. The low-density lipoprotein pathway and its relation to atherosclerosis
31. MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
32. Cholesterol reduction yields clinical benefit: Impact of statin trials
33. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein-deficient mice
34. IFN-γ potentiates atherosclerosis in apoE knock-out mice
35. Espression of hte monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: Differential effects of plasma lipoproteins on monocyte function
36. Cell-mediated immunity in atherosclerosis
37. Overexpression of 15-Lipoxygenase in Vascular Endothelium Accelerates Early Atherosclerosis in LDL Receptor-Deficient Mice
38. Oxidants and antioxidants in the pathogenesis of atherosclerosis: Implications for the oxidized low density lipoprotein hypothesis
39. Increasing burden of cardiovascular disease: Current knowledge and future directions for research on risk factors
40. The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein
41. Immunological responses to oxidized LDL
42. Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1
43. The antioxidant vitamins and cardiovascular disease. A critical review of epidemiologic and clinical trial data
44. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
45. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice
46. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)ApoE(-/-) mice are ameliorated by enalapril treatment
47. Gene transfer and hepatic overexpression of the HDL receptor SR-B1 reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse
48. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
49. The unstable atheroma
50. Periosome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
51. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
52. Genomics, gene expression and DNA arrays
53. Identification of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparisons
54. Requirement for CD154 in the progression of atherosclerosis
55. CD40 signaling in vascular cells: A key role in atherosclerosis?
56. Reduction of atherosclerosis in mice by inhibition of CD40 signalling
57. Protective role of interleukin-10 in atherosclerosis
58. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
59. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma
60. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions
61. The yin and yang of oxidation in the development of the fatty streak
62. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
63. Oligoclonal T cell expansion in atheroslcerotic lesions of apoliprotein E-deficient mice
64. Interleukin-10 blocks atherosclerotic events in vitro and in vivo
65. Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression
66. Role of macrophage colony-stimulating factor in atherosclerosis: Studies of osteoporotic mice
67. Tamoxifen decreases cholesterol sevenfold and abolishes lipid lesion development in apolipoprotein E knockout mice
68. Regulation of mouse sterol regulatory element-binding protein-1c (SREBP-1c) by oxysterol receptors LXRα and LXRβ
69. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
70. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
71. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
72. Searching for genetic determinants in the new millennium
73. Selective estrogen receptor modulators and postmenopausal health
74. Atherosclerosis - An inflammatory disease
75. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
76. Role of LXRs in control of lipogenesis
77. Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions
78. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties
79. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
80. Large scale gene expression analysis of cholesterol-loaded macrophages
81. Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet
82. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
83. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1
84. Decreased atherosclerosis in mice deficient in both macrophage colony stimulating factor (op) and apolipoprotein E
85. Gene targeting approaches to complex genetic disease: Atherosclerosis and essential hypertension
86. PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
87. Regulation of apoA-I gene expression by fibrates
88. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators
89. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
90. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
91. 1999 George Lyman Duff memorial lecture: Lipid transfer proteins, HDL metabolism and atherogenesis
92. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice
93. The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis
94. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
95. ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice
96. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits
97. The response-to-retention hypothesis of atherogenesis reinforced
98. The Hyperlipoproteinemias
99. Fibrinogen deficiency is compatible with the development of atherosclerosis in mice
100. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
101. Scavenger receptor family proteins: Roles for atherosclerosis, host defence and disorders of the central nervous system
102. Biomedical discovery with DNA arrays
103. Vitamin E supplementation and cardiovascular events in high-risk patients