Apoptotic death of inflammatory cells in human atheroma

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 7, 2001, Pages 1124-1130

  Li, Wei ^a,d   Dalen, Helge ^b   Eaton, John W ^c   Yuan, Xi Ming ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Atherosclerosis; Lysosomal enzymes; Oxysterols; Plaque instability

Indexed keywords

CASPASE 3; CATHEPSIN B; CATHEPSIN L; OXYSTEROL;

APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MACROPHAGE; PHAGOCYTE; PRIORITY JOURNAL;

EID: 0035722063     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0701.092145     Document Type: Article

References (35)

1. Lipids and oxidised lipids in human atheroma and normal aorta
2. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages
3. Oxysterols in cap and core of human advanced atherosclerotic lesions
4. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: A mechanistic clue to the "response to injury" hypothesis
5. Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein
6. Oxysterols and atherosclerosis
7. Increased plasma 7β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease
8. Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol
9. Macrophages and atherosclerotic plaque stability
10. Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis
11. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
12. Oxidative stress, growth-factor starvation and Fas-activation may all cause apoptosis through lysosomal leak
13. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
14. Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products
15. Induction of cell death by the lysosomotropic detergent MSDH
16. Atractyloside-induced release of cathepsin B a protease with caspase-processing activity
17. Participation of a cathepsin L-type protease in the activation of caspase-3
18. Induction of apoptosis in endothelial cells treated with cholesterol oxides
19. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
20. Macrophage death and the role of apoptosis in human atherosclerosis
21. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64), and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
22. Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages
23. Accumulation and metabolism of low density lipoprotein-derived cholesteryl linoleate hydroperoxide and hydroxide by macrophages
24. Apolipoprotein B of oxidized LDL accumulates in the lysosomes of macrophages
25. Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes: A possible role for 7-ketocholesterol
26. Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: Colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins
27. Photooxidative damage to lysosomes of cultured macrophages by acridine orange
28. Lovastatin enhances the photocytotoxicity of UVA radiation toward cultured N. C. T. C. 2544 human keratinocytes: Prevention by cholesterol supplementation and by a cathepsin inhibitor
29. Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors
30. Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents
31. Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
32. Lysosomal protease pathways to apoptosis: Cleavage of Bid, not pro-caspases, is the most likely route
33. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
34. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
35. Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases