Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia

Nature Communications

Volumn 5, Issue , 2014, Pages

  Jiang, Haiying ^a,b   Cheng, Xian Wu ^a,b,c   Shi, Guo Ping ^d   Hu, Lina ^a   Inoue, Aiko ^a   Yamamura, Yumiko ^a   Wu, Hongxian ^a   Takeshita, Kyosuke ^a   Li, Xiang ^a,b   Huang, Zhe ^a   Song, Haizhen ^a,e   Asai, Masashi ^f   Hao, Chang Ning ^a   Unno, Kazumasa ^a   Koike, Teruhiro ^a   Oshida, Yoshiharu ^a   Okumura, Kenji ^a   Murohara, Toyoaki ^a   Kuzuya, Masafumi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b YANBIAN UNIVERSITY   (China)

^c Kyung Hee University College of Medicine   (South Korea)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e School of Medicine   (China)

^f NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; CATHEPSIN K INHIBITOR; COLLAGEN TYPE 6; GAMMA SECRETASE; MESSENGER RNA; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR HES 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; CTSK PROTEIN, MOUSE; FLT1 PROTEIN, MOUSE; HES1 PROTEIN, MOUSE; HEY1 PROTEIN, MOUSE; HEY2 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; NOTCH1 PROTEIN, MOUSE; PROTEIN KINASE B; REPRESSOR PROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

CELL ORGANELLE; DISEASE PREVALENCE; ENZYME ACTIVITY; GROWTH; HYPOXIA; PHYSIOLOGICAL RESPONSE; RODENT;

ANGIOGENESIS; ANGIOGENESIS ASSAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CAPILLARY DENSITY; CELL INVASION; CELL PROLIFERATION; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; GENE SILENCING; HINDLIMB; HUMAN; HUMAN CELL; HYPOXIA; LIMB ISCHEMIA; MICROTUBULE ASSEMBLY; MONONUCLEAR CELL; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PROTEIN EXPRESSION; RAT; UMBILICAL VEIN ENDOTHELIAL CELL; ZYMOGRAPHY; ANIMAL; ANOXIA; CAPILLARY; FEMORAL ARTERY; GENETICS; ISCHEMIA; KNOCKOUT MOUSE; LASER DOPPLER FLOWMETRY; LIGATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SURGERY; VASCULARIZATION;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CAPILLARIES; CATHEPSIN K; CELL CYCLE PROTEINS; FEMORAL ARTERY; HINDLIMB; HOMEODOMAIN PROTEINS; ISCHEMIA; LASER-DOPPLER FLOWMETRY; LIGATION; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84901911078     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4838     Document Type: Article

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