Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Ren, Gang ^a,d   Blum, Galia ^c,e   Verdoes, Martijn ^c   Liu, Hongguang ^a,d   Syed, Salahuddin ^c   Edgington, Laura E ^c   Gheysens, Olivier ^a,d   Miao, Zheng ^a,d   Jiang, Han ^a,d   Gambhir, Sanjiv Sam ^a,b,d   Bogyo, Matthew ^a,c,d   Cheng, Zhen ^a,d  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY   (United States)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ACYLOXYMETHYL KETONE; CATHEPSIN B; CATHEPSIN L; COPPER 64; CYSTINE; KETONE DERIVATIVE; UNCLASSIFIED DRUG; CATHEPSIN; COPPER; CYSTEINE; DIAGNOSTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SOLID TUMOR; TISSUE DISTRIBUTION; ANIMAL; CHEMISTRY; DISEASE MODEL; METABOLISM; METHODOLOGY; NEOPLASM; SCINTISCANNING; STAINING; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; CATHEPSINS; CELL LINE, TUMOR; COPPER RADIOISOTOPES; CYSTEINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MOLECULAR PROBES; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 81455127363     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028029     Document Type: Article

References (31)

1. Cavallo-Medved D, Sloane BF, (2003) Cell-surface cathepsin B: understanding its functional significance. Curr Top Dev Biol 54: 313-341.
2. Jedeszko C, Sloane BF, (2004) Cysteine cathepsins in human cancer. Biol Chem 385: 1017-1027.
3. Koblinski JE, Ahram M, Sloane BF, (2000) Unraveling the role of proteases in cancer. Clin Chim Acta 291: 113-135.
4. Mohamed MM, Sloane BF, (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6: 764-775.
5. Sloane BF, Sameni M, Podgorski I, Cavallo-Medved D, Moin K, (2006) Functional imaging of tumor proteolysis. Annu Rev Pharmacol Toxicol 46: 301-315.
6. Sloane BF, Yan S, Podgorski I, Linebaugh BE, Cher ML, et al. (2005) Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol 15: 149-157.
7. Joyce JA, Hanahan D, (2004) Multiple roles for cysteine cathepsins in cancer. Cell Cycle 3: 1516-1619.
8. Blum G, Mullins SR, Keren K, Fonovic M, Jedeszko C, et al. (2005) Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol 1: 203-209.
9. Campo E, Munoz J, Miquel R, Palacin A, Cardesa A, et al. (1994) Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival. Am J Pathol 145: 301-309.
10. Figueiredo JL, Alencar H, Weissleder R, Mahmood U, (2006) Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer. Int J Cancer 118: 2672-2677.
11. Gambhir SS, (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2: 683-693.
12. Berger AB, Vitorino PM, Bogyo M, (2004) Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery. Am J Pharmacogenomics 4: 371-381.
13. Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R, (2002) Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia 4: 228-236.
14. Baruch A, Jeffery DA, Bogyo M, (2004) Enzyme activity-it's all about image. Trends Cell Biol 14: 29-35.
15. Bremer C, Tung CH, Bogdanov A Jr, Weissleder R, (2002) Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology 222: 814-818.
16. Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R, (1999) Near-infrared optical imaging of protease activity for tumor detection. Radiology 213: 866-870.
17. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, et al. (2004) Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A 101: 17867-17872.
18. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, et al. (2009) In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb) 1: 382-393.
19. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, et al. (2010) Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A 107: 4311-4316.
20. Kato D, Boatright KM, Berger AB, Nazif T, Blum G, et al. (2005) Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1: 33-38.
21. Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M, (2007) Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol 3: 668-677.
22. Edgington LE, Berger AB, Blum G, Albrow VE, Paulick MG, et al. (2009) Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med 15: 967-973.
23. Lee M, Fridman R, Mobashery S, (2004) Extracellular proteases as targets for treatment of cancer metastases. Chem Soc Rev 33: 401-409.
24. Lim IT, Meroueh SO, Lee M, Heeg MJ, Mobashery S, (2004) Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis. J Am Chem Soc 126: 10271-10277.
25. Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, et al. (2004) Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5: 443-453.
26. D'Orazi G, Marchetti A, Crescenzi M, Coen S, Sacchi A, et al. (2000) Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: implications for cancer gene therapy without tumor targeting. J Gene Med 2: 11-21.
27. Eijan AM, Sandes EO, Riveros MD, Thompson S, Pasik L, et al. (2003) High expression of cathepsin B in transitional bladder carcinoma correlates with tumor invasion. Cancer 98: 262-268.
28. Cheng Z, Xiong Z, Subbarayan M, Chen X, Gambhir SS, (2007) 64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression. Bioconjug Chem 18: 765-772.
29. Anderson CJ, Dehdashti F, Cutler PD, Schwarz SW, Laforest R, et al. (2001) 64Cu-TETA-octreotide as a PET imaging agent for patients with neuroendocrine tumors. J Nucl Med 42: 213-221.
30. Sun X, Kim J, Martell AE, Welch MJ, Anderson CJ, (2004) In vivo evaluation of copper-64-labeled monooxo-tetraazamacrocyclic ligands. Nucl Med Biol 31: 1051-1059.
31. Boswell CA, Sun X, Niu W, Weisman GR, Wong EH, et al. (2004) Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem 47: 1465-1474.