Seventeenth Marabou Symposium on Diet and Genetic Interactions: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake

Nutrition Reviews

Volumn 56, Issue 2 II, 1998, Pages

  Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CHOLESTEROL; FATTY ACID; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL;

CELL MEMBRANE; CONFERENCE PAPER; FEEDBACK SYSTEM; GENETIC TRANSCRIPTION; HUMAN; LIPID METABOLISM; LIPOGENESIS;

EID: 0031965513     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997;89:331-40
2. Duncan EA, Brown MS, Goldstein JL, Sakai J. Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in lumenal loop of sterol regulatory element binding protein-2. J Biol Chem 1997;272:12778-85
3. Sakai J, Duncan EA, Rawson RB, et al. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 1996;85:1037-46
4. Wang X, Sato R, Brown MS, et al. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 1994;77:53-62
5. Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP). Cell 1996;87:415-26
6. Gil G, Faust JR, Chin DJ, et al. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 1985;41:249-58
7. Sakai J, Nohturfft A, Cheng D, et al. Identification of complexes between the COOH-terminal domains of Sterol Regulatory Element Binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein (SCAP). J Biol Chem 1997;272:20213-21
8. Kim JB, Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 1996;10:1096-107
9. Osborne TF. Transcriptional control mechanisms in the regulation of cholesterol balance. Crit Rev Eukar Gene Expr 1995;5:317-35
10. Shimano H, Horton JD, Hammer RE, et al. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 1996;98:1575-84