Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation

Circulation

Volumn 113, Issue 1, 2006, Pages 98-107

  Lutgens, E ^a   Lutgens, S P M ^a   Faber, B C G ^a   Heeneman, S ^a   Gijbels, M M J ^a   De Winther, M P J ^a   Frederik, P ^a   Van Der Made, I ^a   Daugherty, A ^b   Sijbers, A M ^c   Fisher, A ^c   Long, C J ^c   Saftig, P ^d   Black, D ^c   Daemen, M J A P ^a   Cleutjens, K B J M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF KENTUCKY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

Atherosclerosis; Cathepsins; Lipids; Pathology; Proteases

Indexed keywords

APOLIPOPROTEIN E; CATHEPSIN K; CD36 ANTIGEN; CHOLESTEROL ESTER; CYSTEINE PROTEINASE; ELASTIN; SCAVENGER RECEPTOR; CATHEPSIN; COLLAGEN; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B LYMPHOCYTE; CELL SIZE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DISEASE COURSE; FOAM CELL; GENE DISRUPTION; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; FIBROSIS; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD36; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CATHEPSINS; CELL SIZE; CELLS, CULTURED; COLLAGEN; DISEASE PROGRESSION; FIBROSIS; FOAM CELLS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, KNOCKOUT;

EID: 33644865170     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.561449     Document Type: Article

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