Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 8, 2016, Pages 1549-1557

  Wu, Hongxian ^a,b   Cheng, Xian Wu ^b,d,f   Hu, Lina ^b   Takeshita, Kyosuke ^b   Hu, Chen ^c   Du, Qiuna ^a   Li, Xiang ^d   Zhu, Enbo ^d   Huang, Zhe ^e   Yisireyili, Maimaiti ^b   Zhao, Guangxian ^d   Piao, Limei ^d   Inoue, Aiko ^b   Jiang, Haiying ^d   Lei, Yanna ^d   Zhang, Xiaohong ^c   Liu, Shaowen ^a   Dai, Qiuyan ^a   Kuzuya, Masafumi ^b   Shi, Guo Ping ^g   Murohara, Toyoaki ^b   more..

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d YANBIAN UNIVERSITY   (China)

^e UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^f Kyung Hee University   (South Korea)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

cathepsin S; HDAC6; neointimal formation; vascular remodeling

Indexed keywords

CATHEPSIN S; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; TOLL LIKE RECEPTOR 2; TUBASTATIN A; UNCLASSIFIED DRUG; CATHEPSIN; HDAC6 PROTEIN, MOUSE; HISTONE DEACETYLASE; PROTEINASE INHIBITOR; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY INJURY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE SILENCING; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE CELL; VASCULAR SURGERY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL CYCLE CHECKPOINT; CELL MOTION; COMMON CAROTID ARTERY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; GENOTYPE; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; RNA INTERFERENCE; SMOOTH MUSCLE CELL; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE; WOUND HEALING;

ANIMALS; CAROTID ARTERY INJURIES; CAROTID ARTERY, COMMON; CATHEPSINS; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENOTYPE; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; MALE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TRANSFECTION; VASCULAR REMODELING; WOUND HEALING;

EID: 84976563555     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.307110     Document Type: Article

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