Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Abd Elrahman, Ihab ^a   Kosuge, Hisanori ^b,d   Sadan, Tommy Wises ^a   Ben Nun, Yael ^a   Meir, Karen ^c   Rubinstein, Chen ^c   Bogyo, Matthew ^b   McConnell, Michael V ^b   Blum, Galia ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CATHEPSIN S; CATHEPSIN; FLUORESCENT DYE; PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPY; HUMAN; MACROPHAGE; MALE; MOLECULAR CLONING; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY OBSTRUCTION; DIAGNOSTIC IMAGING; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; CAROTID STENOSIS; CATHEPSINS; FLUORESCENT DYES; HUMANS; MACROPHAGES; MALE; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR IMAGING; PLAQUE, ATHEROSCLEROTIC; PROTEASE INHIBITORS;

EID: 84984820187     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160522     Document Type: Article

References (15)

1. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation 1994;90:775-8. PMID: 8044947
2. Li W, Kornmark L, Jonasson L, Forssell C, Yuan X-M. Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis. Atherosclerosis 2009;202:92-102. doi: 10. 1016/j.atherosclerosis. 2008.03.027 PMID: 18495127
3. Skjot-Arkil H, Barascuk N, Register T, Karsdal MA. Macrophage-mediated proteolytic remodeling of the extracellular matrix in atherosclerosis results in neoepitopes: a potential new class of biochemical markers. Assay Drug DevTechnol 2010;8:542-52. doi: 10.1089/adt.2009.0258 PMID: 20662734
4. Abd-Elrahman I, Meir K, Kosuge H, Ben-Nun Y, Weiss Sadan T, Rubinstein C, et al. Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques. Stroke 2016;47:1101-8. doi: 10.1161/STROKEAHA.115.011573 PMID: 26941255
5. Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nature Chemical Biology 2007;3:668-677. PMID: 17828252
6. Blum G, Mullins SR, Keren K, Fonovic M, Jedeszko C, Rice MJ, et al. Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nature Chemical Biology 2005;1:203-209. PMID: 16408036
7. Croons V, Martinet W, De Meyer GRY. Selective Removal of Macrophages in Atherosclerotic Plaques as a Pharmacological Approach for Plaque Stabilization: Benefits Vs. Potential Complications. Current Vascular Pharmacology 2010;8:495-508. PMID: 19485918
8. Salpeter SJ, Pozniak Y, Merquiol E, Ben-Nun Y, Geiger T, Blum G. A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression. Oncogene 2015;34:6066-78. doi: 10. 1038/onc.2015.51 PMID: 25798843
9. Kitagawa T, Kosuge H, Uchida M, Dua MM, Lida Y, Dalman RL, et al. RGD-Conjugated Human Ferritin Nanoparticles for Imaging Vascular Inflammation and Angiogenesis in Experimental Carotid and Aortic Disease. Molecular Imaging and Biology 2012;14:315-324. doi: 10.1007/s11307-011-0495-1 PMID: 21638084
10. Terashima M, Ehara S, Yang E et al. In Vivo Bioluminescence Imaging of Inducible Nitric Oxide Synthase Gene Expression in Vascular Inflammation. Molecular Imaging and Biology 2011;13:1061-1066. doi: 10.1007/s11307-010-0451-5 PMID: 21057879
11. Calfon MA, Vinegoni C, Ntziachristos V, Jaffer FA. Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques. Journal of Biomedical Optics 2010;15.
12. Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999;17:375-8. PMID: 10207887
13. Jaffer FA, Vinegoni C, John MC et al. Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation 2008;118:1802-9. doi: 10.1161/CIRCULATIONAHA.108.785881 PMID: 18852366
14. Ben-Aderet L, Merquiol E, Fahham D, Kumar A, Reich E, Ben-Nun Y, et al. Detecting cathepsin activity in human osteoarthritis via activity-based probes. Arthritis ResTher 2015;17:69. doi: 10.1186/s13075-015-0586-5 PMID: 25889265
15. Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, et al. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife 2016;5.