Structure of human dipeptidyl peptidase I (cathepsin C): Exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6570-6582

  Turk, Dušan ^a   Janjić, Vojko ^e   Štern, Igor ^a   Podobnik, Marjetka ^b   Lamba, Doriano ^c   Dahl, Søren Weis ^d   Lauritzen, Connie ^d   Pedersen, John ^d   Turk, Vito ^a   Turk, Boris ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b ROCKEFELLER UNIVERSITY   (United States)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^d Unizyme Laboratories A/S   (Denmark)

^e NONE

Author keywords

Apoptosis; Cysteine protease; Granzyme; Inflammation; Zymogen activation

Indexed keywords

DIPEPTIDYL PEPTIDASE I; SERINE PROTEINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; KERATOSIS PALMOPLANTARIS; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; BINDING SITES; CELL LINE; DIMERIZATION; DIPEPTIDYL PEPTIDASE I; ENDOPEPTIDASES; HUMANS; INSECTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PAPILLON-LEFEVRE DISEASE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; SYNDROME;

EID: 17944366493     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6570     Document Type: Article

References (62)

1. Cathepsin C gene: First compound heterozygous patient with Papillon-Lefevre syndrome and novel symptomless mutation
2. Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi
3. Ribbons 2
4. Stoichiometry and heterogeneity of the pro-region chain in tetrameric human cathepsin C
5. The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme
6. Structure of rat procathepsin B: Model for inhibition of cysteine protease activity by the proregion
7. Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing
8. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
9. Maximum-likelihood heavyatom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
10. Oligomeric structure and substrate induced inhibition of human cathepsin C
11. Interaction of human cathepsin C with chicken cystatin
12. Binding chloromethyl ketone substrate analogues to crystalline papain
13. Accurate bond and angle parameters for X-ray protein structure refinement
14. Studies of beef spleen cathepsin C
15. Structure of 20S proteasome from yeast at 2.4 Å resolution
16. Crystal structure of porcine cathepsin H determined at 2.1 Å resolution: Location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
17. Crystal structure of cathepsin X: A flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease
18. On the proteolytic enzymes of animal tissues VIII: An intracellular enzyme related to chymotrypsin
19. Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome
20. Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C
21. Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation
22. Mapping the protein universe
23. Errors in protein structures
24. Arginine-based structures are specific inhibitors of cathepsin C
25. Role of the occluding loop in cathepsin B activity
26. Crystal structure of a conserved protease that binds DNA: The bleomycin hydrolase, Gal6
27. Rapid automated molecular replacement by evolutionary search
28. Mechanisms mediating caspase activation in cell death
29. Crystal structure of the 20S proteasome from the archaeon T.acidophilum at 3.4 Å resolution
30. Thrombin-independent activation of platelet factor XIII by endogenous platelet acid protease
31. Cathepsin C: A chloride-requiring enzyme
32. Purification and characterization of dipeptidyl peptidase I from human spleen
33. The lysosomal cysteine proteases
34. Raster3D: Photorealistic molecular graphics
35. Processing and transport of the precursor of cathepsin C during its transfer into lysosomes
36. The refined 2.15 Å X-ray crystal structure of human liver cathepsin B: The structural basis for its specificity
37. Activation of thrombin-inactivated single-chain urokinase-type plasminogen activator by dipeptidyl peptidase I (cathepsin C)
38. Evolution of proteolytic enzymes
39. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
40. Paths of glorious proteases
41. Processing of X-ray diffraction data collected in oscillation mode
42. Molecular cloning and sequence analysis of human preprocathepsin C
43. Human β-tryptase is a ring-like tetramer with active sites facing a central pore
44. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
45. The catalytic properties of cathepsin C
46. How to induce involuntary suicide: The need for dipeptidyl peptidase I
47. Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen
48. Rat procathepsin B. Proteolytic processing to the mature form in vitro
49. How do cytotoxic lymphocytes kill their targets?
50. Granzyme A initiates an alternative pathway for granule-mediated apoptosis
51. Structure, function and control of neutrophil proteinases
52. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis
53. Dipeptidyl-peptidase I.
54. Lysosomal cysteine proteases: More than scavengers
55. Crystal structure of cathepsin B inhibited with CA030 at 2 Å resolution: A basis for the design of specific epoxysuccinyl inhibitors
56. Crystal structures of human procathepsin B at 3.2 and 3.3 A resolution reveal an interaction motif between a papain like cysteine protease and its propeptide
57. Revised definition of substrate binding sites of papain-like cysteine proteases
58. Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways
59. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice