Mast cells promote atherosclerosis by releasing proinflammatory cytokines

Nature Medicine

Volumn 13, Issue 6, 2007, Pages 719-724

  Sun, Jiusong ^a   Sukhova, Galina K ^a   Wolters, Paul J ^b   Yang, Min ^a,c   Kitamoto, Shiro ^a   Libby, Peter ^a   MacFarlane, Lindsey A ^a   Clair, Jon Mallen St ^b   Shi, Guo Ping ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c FIRST MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYSTEINE PROTEINASE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 6; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VIVO STUDY; LIPID PEROXIDATION; LIPID STORAGE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; WILD TYPE;

ANIMALS; ATHEROSCLEROSIS; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; MALE; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC;

MUS;

EID: 34250014988     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1601     Document Type: Article

References (30)

1. Gurish, M.F. & Austen, K.F. The diverse roles of mast cells. J. Exp. Med. 194, F1-F5 (2001).
2. Galli, S.J. et al. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23, 749-786 (2005).
3. Jeziorska, M., McCollum, C. & Woolley, D.E. Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. J. Pathol. 182, 115-122 (1997).
4. Ishibashi, S., Goldstein, J.L., Brown, M.S., Herz, J. & Burns, D.K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93, 1885-1893 (1994).
5. W-sh sash mice. Clin. Exp. Allergy 35, 82-88 (2005).
6. Libby, P. Inflammation in atherosclerosis. Nature 420, 868-874 (2002).
7. Constantinides, P. Mast cells and susceptibility to experimental atherosclerosis. Science 117, 505-506 (1953).
8. Kaartinen, M., Penttila, A. & Kovanen, P.T. Mast cells in rupture-prone areas of human coronary atheromas produce and store TNF-α. Circulation 94, 2787-2792 (1996).
9. Bradding, P. Human mast cell cytokines. Clin. Exp. Allergy 26, 13-19 (1996).
10. Johnson, J.L., Jackson, C.L., Angelini, G.D. & George, S.J. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 18, 1707-1715 (1998).
11. Tchougounova, E., Pejler, G. & Abrink, M. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J. Exp. Med. 198, 423-431 (2003).
12. sh and Ph mutant mice. Proc. Natl. Acad. Sci. USA 92, 3754-3758 (1995).
13. Coussens, L.M. et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382-1397 (1999).
14. W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am. J. Pathol. 167, 835-848 (2005).
15. Williams, C.M. & Galli, S.J. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J. Exp. Med. 192, 455-462 (2000).
16. Gurish, M.F. et al. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J. Exp. Med. 175, 1003-1012 (1992).
17. Grivennikov, S.I. et al. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22, 93-104 (2005).
18. Luttun, A. et al. Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation 109, 1408-1414 (2004).
19. Sukhova, G.K. et al. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 111, 897-906 (2003).
20. Lutgens, E. et al. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113, 98-107 (2006).
21. Kitamoto, S. et al. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation 115, 2065-2075 (2007).
22. Tchougounova, E. et al. A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J. Biol. Chem. 280, 9291-9296 (2005).
23. Shi, G.P., Munger, J.S., Meara, J.P., Rich, D.H. & Chapman, H.A. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J. Biol. Chem. 267, 7258-7262 (1992).
24. Faggioli, L. et al. Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma. Eur. J. Immunol. 27, 3022-3030 (1997).
25. Biondillo, D.E., Konicek, S.A. & Iwamoto, G.K. Interferon-gamma regulation of interleukin 6 in monocytic cells. Am. J. Physiol. 267, L564-L568 (1994).
26. sh mice that have a normal number of erythrocytes and a normal c-kit coding region. Blood 80, 1448-1453 (1992).
27. Mach, F., Schonbeck, U., Sukhova, G.K., Atkinson, E. & Libby, P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 394, 200-203 (1998).
28. Shi, G.P. et al. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ. Res. 92, 493-500 (2003).
29. Fang, K.C., Raymond, W.W., Lazarus, S.C. & Caughey, G.H. Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. J. Clin. Invest. 97, 1589-1596 (1996).
30. Galis, Z.S., Sukhova, G.K. & Libby, P. Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue. FASEB J. 9, 974-980 (1995).