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Volumn 105, Issue 1, 2017, Pages 10-22

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Author keywords

Absorption; Adme; Flavonoids; Genotype; Health; Metabolism; Microbiome

Indexed keywords

ANTIHISTAMINIC AGENT; BREAST CANCER RESISTANCE PROTEIN; FLAVONOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ORGANIC ANION TRANSPORTER; XENOBIOTIC AGENT; ANTHOCYANIN; FLAVANONE DERIVATIVE; FLAVONOL DERIVATIVE; PLANT EXTRACT;

EID: 85008440879     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.136051     Document Type: Review
Times cited : (368)

References (145)
  • 1
    • 33947095990 scopus 로고    scopus 로고
    • Flavonoids and heart health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC
    • Erdman JW Jr., Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, Harnly J, Hollman P, Keen CL, Mazza G, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr 2007;137(3 Suppl 1):718S-37S.
    • (2007) J Nutr , vol.137 , Issue.3 , pp. 718S-737S
    • Erdman, J.W.1    Balentine, D.2    Arab, L.3    Beecher, G.4    Dwyer, J.T.5    Folts, J.6    Harnly, J.7    Hollman, P.8    Keen, C.L.9    Mazza, G.10
  • 3
    • 84872338139 scopus 로고    scopus 로고
    • High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women
    • Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 2013;127:188-96.
    • (2013) Circulation , vol.127 , pp. 188-196
    • Cassidy, A.1    Mukamal, K.J.2    Liu, L.3    Franz, M.4    Eliassen, A.H.5    Rimm, E.B.6
  • 6
    • 84864452592 scopus 로고    scopus 로고
    • Dietary intakes of berries and flavonoids in relation to cognitive decline
    • Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 2012;72:135-43.
    • (2012) Ann Neurol , vol.72 , pp. 135-143
    • Devore, E.E.1    Kang, J.H.2    Breteler, M.M.3    Grodstein, F.4
  • 7
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81(1 Suppl):230S-42S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.1 , pp. 230S-242S
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 8
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 2005;81(1 Suppl):243S-55S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.1 , pp. 243S-255S
    • Williamson, G.1    Manach, C.2
  • 10
    • 78049432112 scopus 로고    scopus 로고
    • Colonic metabolites of berry polyphenols: The missing link to biological activity?
    • Williamson G, Clifford MN. Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 2010;104(Suppl 3):S48-66.
    • (2010) Br J Nutr , vol.104 , pp. S48-S66
    • Williamson, G.1    Clifford, M.N.2
  • 12
    • 84859080819 scopus 로고    scopus 로고
    • Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: A 1-year, double-blind, randomized, controlled trial
    • Curtis PJ, Sampson M, Potter J, Dhatariya K, Kroon PA, Cassidy A. Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial. Diabetes Care 2012;35:226-32.
    • (2012) Diabetes Care , vol.35 , pp. 226-232
    • Curtis, P.J.1    Sampson, M.2    Potter, J.3    Dhatariya, K.4    Kroon, P.A.5    Cassidy, A.6
  • 13
    • 84883287472 scopus 로고    scopus 로고
    • Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes
    • Jacques PF, Cassidy A, Rogers G, Peterson JJ, Meigs JB, Dwyer JT. Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes. J Nutr 2013;143:1474-80.
    • (2013) J Nutr , vol.143 , pp. 1474-1480
    • Jacques, P.F.1    Cassidy, A.2    Rogers, G.3    Peterson, J.J.4    Meigs, J.B.5    Dwyer, J.T.6
  • 15
    • 77953740445 scopus 로고    scopus 로고
    • Equol: Pharmacokinetics and biological actions
    • Setchell KD, Clerici C. Equol: pharmacokinetics and biological actions. J Nutr 2010;140:1363S-8S.
    • (2010) J Nutr , vol.140 , pp. 1363S-1368S
    • Setchell, K.D.1    Clerici, C.2
  • 16
    • 84966567956 scopus 로고    scopus 로고
    • An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health
    • Zaheer K, Akhtar MH. An updated review of dietary isoflavones: nutrition, processing, bioavailability and impacts on human health. Crit Rev Food Sci Nutr 2015;0.
    • (2015) Crit Rev Food Sci Nutr , pp. 0
    • Zaheer, K.1    Akhtar, M.H.2
  • 18
    • 34548445077 scopus 로고    scopus 로고
    • Interindividual differences in phytochemical metabolism and disposition
    • Lampe JW, Chang JL. Interindividual differences in phytochemical metabolism and disposition. Semin Cancer Biol 2007;17:347-53.
    • (2007) Semin Cancer Biol , vol.17 , pp. 347-353
    • Lampe, J.W.1    Chang, J.L.2
  • 19
    • 4043089112 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of dietary flavonoids in humans
    • Manach C, Donovan JL. Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic Res 2004;38:771-85.
    • (2004) Free Radic Res , vol.38 , pp. 771-785
    • Manach, C.1    Donovan, J.L.2
  • 20
    • 1642528478 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids
    • Walle T. Absorption and metabolism of flavonoids. Free Radic Biol Med 2004;36:829-37.
    • (2004) Free Radic Biol Med , vol.36 , pp. 829-837
    • Walle, T.1
  • 23
    • 0036213863 scopus 로고    scopus 로고
    • Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine
    • Wolffram S, Block M, Ader P. Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. J Nutr 2002;132:630-5.
    • (2002) J Nutr , vol.132 , pp. 630-635
    • Wolffram, S.1    Block, M.2    Ader, P.3
  • 25
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
    • Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 1998;436:71-5.
    • (1998) FEBS Lett , vol.436 , pp. 71-75
    • Day, A.J.1    DuPont, M.S.2    Ridley, S.3    Rhodes, M.4    Rhodes, M.J.5    Morgan, M.R.6    Williamson, G.7
  • 27
    • 0035046914 scopus 로고    scopus 로고
    • Anthocyanins are absorbed in glycated forms in elderly women: A pharmacokinetic study
    • Cao G, Muccitelli HU, Sanchez-Moreno C, Prior RL. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 2001;73:920-6.
    • (2001) Am J Clin Nutr , vol.73 , pp. 920-926
    • Cao, G.1    Muccitelli, H.U.2    Sanchez-Moreno, C.3    Prior, R.L.4
  • 28
  • 29
    • 13244258342 scopus 로고    scopus 로고
    • Transepithelial transport of microbial metabolites of quercetin in intestinal Caco-2 cell monolayers
    • Konishi Y. Transepithelial transport of microbial metabolites of quercetin in intestinal Caco-2 cell monolayers. J Agric Food Chem 2005;53:601-7.
    • (2005) J Agric Food Chem , vol.53 , pp. 601-607
    • Konishi, Y.1
  • 30
    • 84859854410 scopus 로고    scopus 로고
    • Cocoa polyphenols are absorbed in Caco-2 cell model of intestinal epithelium
    • Kosińska A, Andlauer W. Cocoa polyphenols are absorbed in Caco-2 cell model of intestinal epithelium. Food Chem 2012;135:999-1005.
    • (2012) Food Chem , vol.135 , pp. 999-1005
    • Kosińska, A.1    Andlauer, W.2
  • 31
    • 0037154405 scopus 로고    scopus 로고
    • Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450
    • Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.
    • (2002) Chem Biol Interact , vol.139 , pp. 1-21
    • Hodek, P.1    Trefil, P.2    Stiborova, M.3
  • 32
    • 0036146585 scopus 로고    scopus 로고
    • Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9
    • Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos 2002;30:103-5.
    • (2002) Drug Metab Dispos , vol.30 , pp. 103-105
    • Otake, Y.1    Walle, T.2
  • 33
    • 84896324163 scopus 로고    scopus 로고
    • Metabolism of flavonoids in human: A comprehensive review
    • Chen Z, Zheng S, Li L, Jiang H. Metabolism of flavonoids in human: a comprehensive review. Curr Drug Metab 2014;15:48-61.
    • (2014) Curr Drug Metab , vol.15 , pp. 48-61
    • Chen, Z.1    Zheng, S.2    Li, L.3    Jiang, H.4
  • 34
    • 84929659207 scopus 로고    scopus 로고
    • Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease
    • Schär MY, Curtis PJ, Hazim S, Ostertag LM, Kay CD, Potter JF, Cassidy A. Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease. Am J Clin Nutr 2015;101:931-8.
    • (2015) Am J Clin Nutr , vol.101 , pp. 931-938
    • Schär, M.Y.1    Curtis, P.J.2    Hazim, S.3    Ostertag, L.M.4    Kay, C.D.5    Potter, J.F.6    Cassidy, A.7
  • 36
    • 77953245569 scopus 로고    scopus 로고
    • Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes
    • Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, Liu Z, Hu M. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm 2010;7:664-79.
    • (2010) Mol Pharm , vol.7 , pp. 664-679
    • Tang, L.1    Ye, L.2    Singh, R.3    Wu, B.4    Lv, C.5    Zhao, J.6    Liu, Z.7    Hu, M.8
  • 38
    • 70350319524 scopus 로고    scopus 로고
    • Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: The SULT "pie"
    • Riches Z, Stanley EL, Bloomer JC, Coughtrie MW. Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie". Drug Metab Dispos 2009;37:2255-61.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2255-2261
    • Riches, Z.1    Stanley, E.L.2    Bloomer, J.C.3    Coughtrie, M.W.4
  • 39
    • 34249799590 scopus 로고    scopus 로고
    • Identification and localization of soluble sulfotransferases in the human gastrointestinal tract
    • Teubner W, Meinl W, Florian S, Kretzschmar M, Glatt H. Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem J 2007;404:207-15.
    • (2007) Biochem J , vol.404 , pp. 207-215
    • Teubner, W.1    Meinl, W.2    Florian, S.3    Kretzschmar, M.4    Glatt, H.5
  • 40
    • 0036241543 scopus 로고    scopus 로고
    • Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes
    • Otake Y, Hsieh F, Walle T. Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab Dispos 2002;30:576-81.
    • (2002) Drug Metab Dispos , vol.30 , pp. 576-581
    • Otake, Y.1    Hsieh, F.2    Walle, T.3
  • 41
    • 0034812454 scopus 로고    scopus 로고
    • Sulfation of flavonoids and other phenolic dietary compounds by the human cytosolic sulfotransferases
    • Pai TG, Suiko M, Sakakibara Y, Liu MC. Sulfation of flavonoids and other phenolic dietary compounds by the human cytosolic sulfotransferases. Biochem Biophys Res Commun 2001;285:1175-9.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 1175-1179
    • Pai, T.G.1    Suiko, M.2    Sakakibara, Y.3    Liu, M.C.4
  • 43
    • 33645122881 scopus 로고    scopus 로고
    • Pharmacogenetics of human cytosolic sulfotransferases
    • Nowell S, Falany CN. Pharmacogenetics of human cytosolic sulfotransferases. Oncogene 2006;25:1673-8.
    • (2006) Oncogene , vol.25 , pp. 1673-1678
    • Nowell, S.1    Falany, C.N.2
  • 44
    • 34247402170 scopus 로고    scopus 로고
    • Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1
    • Ung D, Nagar S. Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1. Drug Metab Dispos 2007;35:740-6.
    • (2007) Drug Metab Dispos , vol.35 , pp. 740-746
    • Ung, D.1    Nagar, S.2
  • 45
    • 77954631104 scopus 로고    scopus 로고
    • Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers
    • Inoue-Choi M, Yuan JM, Yang CS, Van Den Berg DJ, Lee MJ, Gao YT, Yu MC. Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers. Int J Mol Epidemiol Genet 2010;1:114-23.
    • (2010) Int J Mol Epidemiol Genet , vol.1 , pp. 114-123
    • Inoue-Choi, M.1    Yuan, J.M.2    Yang, C.S.3    Van Den Berg, D.J.4    Lee, M.J.5    Gao, Y.T.6    Yu, M.C.7
  • 47
    • 0038018460 scopus 로고    scopus 로고
    • The stomach as a site for anthocyanins absorption from food
    • Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. The stomach as a site for anthocyanins absorption from food. FEBS Lett 2003;544:210-3.
    • (2003) FEBS Lett , vol.544 , pp. 210-213
    • Passamonti, S.1    Vrhovsek, U.2    Vanzo, A.3    Mattivi, F.4
  • 48
    • 84884798409 scopus 로고    scopus 로고
    • Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: Involvement of bilitranslocase
    • Ziberna L, Kim JH, Auger C, Passamonti S, Schini-Kerth V. Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: involvement of bilitranslocase. Food Funct 2013;4:1452-6.
    • (2013) Food Funct , vol.4 , pp. 1452-1456
    • Ziberna, L.1    Kim, J.H.2    Auger, C.3    Passamonti, S.4    Schini-Kerth, V.5
  • 50
    • 84959283893 scopus 로고    scopus 로고
    • Interplay of breast cancer resistance protein (BCRP) and Metabolizing Enzymes
    • Tian Y, Bian Y, Jiang Y, Qian S, Yu A, Zeng S. Interplay of breast cancer resistance protein (BCRP) and Metabolizing Enzymes. Curr Drug Metab 2015;16:877-93.
    • (2015) Curr Drug Metab , vol.16 , pp. 877-893
    • Tian, Y.1    Bian, Y.2    Jiang, Y.3    Qian, S.4    Yu, A.5    Zeng, S.6
  • 52
    • 79952575127 scopus 로고    scopus 로고
    • Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
    • Wong CC, Botting NP, Orfila C, Al-Maharik N, Williamson G. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochem Pharmacol 2011;81:942-9.
    • (2011) Biochem Pharmacol , vol.81 , pp. 942-949
    • Wong, C.C.1    Botting, N.P.2    Orfila, C.3    Al-Maharik, N.4    Williamson, G.5
  • 53
    • 78649631235 scopus 로고    scopus 로고
    • Bioavailability of dietary flavonoids and phenolic compounds
    • Crozier A, Del Rio D, Clifford MN. Bioavailability of dietary flavonoids and phenolic compounds. Mol Aspects Med 2010;31:446-67.
    • (2010) Mol Aspects Med , vol.31 , pp. 446-467
    • Crozier, A.1    Del Rio, D.2    Clifford, M.N.3
  • 54
    • 77952290522 scopus 로고    scopus 로고
    • The pharmacokinetics of C-glycosyl flavones of Hawthorn leaf flavonoids in rat after single dose oral administration
    • Ma LY, Liu RH, Xu XD, Yu MQ, Zhang Q, Liu HL. The pharmacokinetics of C-glycosyl flavones of Hawthorn leaf flavonoids in rat after single dose oral administration. Phytomedicine 2010;17:640-5.
    • (2010) Phytomedicine , vol.17 , pp. 640-645
    • Ma, L.Y.1    Liu, R.H.2    Xu, X.D.3    Yu, M.Q.4    Zhang, Q.5    Liu, H.L.6
  • 55
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004;56:163-84.
    • (2004) Pharmacol Rev , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couteur, D.G.2
  • 56
    • 0035695389 scopus 로고    scopus 로고
    • Liver function and phase I drug metabolism in the elderly: A paradox
    • Schmucker DL. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging 2001;18:837-51.
    • (2001) Drugs Aging , vol.18 , pp. 837-851
    • Schmucker, D.L.1
  • 57
    • 0030855770 scopus 로고    scopus 로고
    • Effect of aging on mixed-function oxidation and conjugation by isolated perfused rat livers
    • Handler JA, Brian WR. Effect of aging on mixed-function oxidation and conjugation by isolated perfused rat livers. Biochem Pharmacol 1997;54:159-64.
    • (1997) Biochem Pharmacol , vol.54 , pp. 159-164
    • Handler, J.A.1    Brian, W.R.2
  • 58
    • 58149469245 scopus 로고    scopus 로고
    • Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDPglucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
    • Argikar UA, Remmel RP. Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDPglucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos 2009;37:229-36.
    • (2009) Drug Metab Dispos , vol.37 , pp. 229-236
    • Argikar, U.A.1    Remmel, R.P.2
  • 59
    • 0342617629 scopus 로고    scopus 로고
    • The influence of age and some inducers on UDP-glucuronyltransferase activity
    • Plewka A, Kaminski M, Plewka D. The influence of age and some inducers on UDP-glucuronyltransferase activity. Exp Gerontol 1997;32:305-13.
    • (1997) Exp Gerontol , vol.32 , pp. 305-313
    • Plewka, A.1    Kaminski, M.2    Plewka, D.3
  • 60
    • 84862067321 scopus 로고    scopus 로고
    • Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice
    • Fu ZD, Csanaky IL, Klaassen CD. Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice. Drug Metab Dispos 2012;40:1216-25.
    • (2012) Drug Metab Dispos , vol.40 , pp. 1216-1225
    • Fu, Z.D.1    Csanaky, I.L.2    Klaassen, C.D.3
  • 61
    • 84938747867 scopus 로고    scopus 로고
    • Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDPglucuronosyltransferase in female rats
    • Kawase A, Ito A, Yamada A, Iwaki M. Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDPglucuronosyltransferase in female rats. Eur J Drug Metab Pharmacokinet 2015;40:239-44.
    • (2015) Eur J Drug Metab Pharmacokinet , vol.40 , pp. 239-244
    • Kawase, A.1    Ito, A.2    Yamada, A.3    Iwaki, M.4
  • 62
    • 84973594796 scopus 로고    scopus 로고
    • Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes
    • Dai P, Luo F, Wang Y, Jiang H, Wang L, Zhang G, Zhu L, Hu M, Wang X, Lu L, et al. Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Biopharm Drug Dispos 2015;36:622-35.
    • (2015) Biopharm Drug Dispos , vol.36 , pp. 622-635
    • Dai, P.1    Luo, F.2    Wang, Y.3    Jiang, H.4    Wang, L.5    Zhang, G.6    Zhu, L.7    Hu, M.8    Wang, X.9    Lu, L.10
  • 63
    • 77952876426 scopus 로고    scopus 로고
    • The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes
    • Bolling BW, Court MH, Blumberg JB, Chen CY. The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes. J Nutr Biochem 2010;21:498-503.
    • (2010) J Nutr Biochem , vol.21 , pp. 498-503
    • Bolling, B.W.1    Court, M.H.2    Blumberg, J.B.3    Chen, C.Y.4
  • 65
    • 6344265879 scopus 로고    scopus 로고
    • Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain
    • Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004;75:807-21.
    • (2004) Am J Hum Genet , vol.75 , pp. 807-821
    • Chen, J.1    Lipska, B.K.2    Halim, N.3    Ma, Q.D.4    Matsumoto, M.5    Melhem, S.6    Kolachana, B.S.7    Hyde, T.M.8    Herman, M.M.9    Apud, J.10
  • 66
    • 33745703902 scopus 로고    scopus 로고
    • Catechol-omethyltransferase, cognition, and psychosis: Val158Met and beyond
    • Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-omethyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 2006;60:141-51.
    • (2006) Biol Psychiatry , vol.60 , pp. 141-151
    • Tunbridge, E.M.1    Harrison, P.J.2    Weinberger, D.R.3
  • 67
    • 0242442468 scopus 로고    scopus 로고
    • Tea intake, COMT genotype, and breast cancer in Asian-American women
    • Wu AH, Tseng CC, Van Den Berg D, Yu MC. Tea intake, COMT genotype, and breast cancer in Asian-American women. Cancer Res 2003;63:7526-9.
    • (2003) Cancer Res , vol.63 , pp. 7526-7529
    • Wu, A.H.1    Tseng, C.C.2    Van Den Berg, D.3    Yu, M.C.4
  • 68
    • 84862519231 scopus 로고    scopus 로고
    • The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion
    • Miller RJ, Jackson KG, Dadd T, Mayes AE, Brown AL, Lovegrove JA, Minihane AM. The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Mol Nutr Food Res 2012;56:966-75.
    • (2012) Mol Nutr Food Res , vol.56 , pp. 966-975
    • Miller, R.J.1    Jackson, K.G.2    Dadd, T.3    Mayes, A.E.4    Brown, A.L.5    Lovegrove, J.A.6    Minihane, A.M.7
  • 69
    • 84959297337 scopus 로고    scopus 로고
    • Green tea extract and catechol-O-methyltransferase genotype modify fasting serum insulin and plasma adiponectin concentrations in a randomized controlled trial of overweight and obese postmenopausal women
    • Dostal AM, Samavat H, Espejo L, Arikawa AY, Stendell-Hollis NR, Kurzer MS. Green tea extract and catechol-O-methyltransferase genotype modify fasting serum insulin and plasma adiponectin concentrations in a randomized controlled trial of overweight and obese postmenopausal women. J Nutr 2016;146:38-45.
    • (2016) J Nutr , vol.146 , pp. 38-45
    • Dostal, A.M.1    Samavat, H.2    Espejo, L.3    Arikawa, A.Y.4    Stendell-Hollis, N.R.5    Kurzer, M.S.6
  • 70
    • 84945972618 scopus 로고    scopus 로고
    • Influence of UDPglucuronosyltransferase polymorphisms on stable warfarin doses in patients with mechanical cardiac valves
    • An SH, Chang BC, Lee KE, Gwak HS. Influence of UDPglucuronosyltransferase polymorphisms on stable warfarin doses in patients with mechanical cardiac valves. Cardiovasc Ther 2015;33:324-8.
    • (2015) Cardiovasc Ther , vol.33 , pp. 324-328
    • An, S.H.1    Chang, B.C.2    Lee, K.E.3    Gwak, H.S.4
  • 71
    • 0037223551 scopus 로고    scopus 로고
    • Genetic variation of human UDP-glucuronosyltransferase: Implications in disease and drug glucuronidation
    • Burchell B. Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation. Am J Pharmacogenomics 2003;3:37-52.
    • (2003) Am J Pharmacogenomics , vol.3 , pp. 37-52
    • Burchell, B.1
  • 72
    • 34247094146 scopus 로고    scopus 로고
    • UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial
    • Chang JL, Bigler J, Schwarz Y, Li SS, Li L, King IB, Potter JD, Lampe JW. UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial. J Nutr 2007;137:890-7.
    • (2007) J Nutr , vol.137 , pp. 890-897
    • Chang, J.L.1    Bigler, J.2    Schwarz, Y.3    Li, S.S.4    Li, L.5    King, I.B.6    Potter, J.D.7    Lampe, J.W.8
  • 75
    • 0032767352 scopus 로고    scopus 로고
    • ∗2) polymorphisms in Caucasians and Asians: Relationships to serum bilirubin concentrations
    • ∗2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Pharmacogenetics 1999;9:341-9.
    • (1999) Pharmacogenetics , vol.9 , pp. 341-349
    • Lampe, J.W.1    Bigler, J.2    Horner, N.K.3    Potter, J.D.4
  • 77
    • 84941360366 scopus 로고    scopus 로고
    • Impacts of the glucuronidase genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on tamoxifen metabolism in breast cancer patients
    • Romero-Lorca A, Novillo A, Gaibar M, Bandres F, Fernandez-Santander A. Impacts of the glucuronidase genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on tamoxifen metabolism in breast cancer patients. PLoS One 2015;10:e0132269.
    • (2015) PLoS One , vol.10 , pp. e0132269
    • Romero-Lorca, A.1    Novillo, A.2    Gaibar, M.3    Bandres, F.4    Fernandez-Santander, A.5
  • 80
    • 84890561172 scopus 로고    scopus 로고
    • Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review
    • Stingl JC, Bartels H, Viviani R, Lehmann ML, Brockmoller J. Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: a quantitative systematic review. Pharmacol Ther 2014;141:92-116.
    • (2014) Pharmacol Ther , vol.141 , pp. 92-116
    • Stingl, J.C.1    Bartels, H.2    Viviani, R.3    Lehmann, M.L.4    Brockmoller, J.5
  • 83
    • 0036045433 scopus 로고    scopus 로고
    • Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells
    • Basten GP, Bao Y, Williamson G. Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis 2002;23:1399-404.
    • (2002) Carcinogenesis , vol.23 , pp. 1399-1404
    • Basten, G.P.1    Bao, Y.2    Williamson, G.3
  • 84
    • 0026566367 scopus 로고
    • Dietary modification of drugmetabolizing enzyme activities: Dose-response effect of flavonoids
    • Siess MH, Le Bon AM, Suschetet M. Dietary modification of drugmetabolizing enzyme activities: dose-response effect of flavonoids. J Toxicol Environ Health 1992;35:141-52.
    • (1992) J Toxicol Environ Health , vol.35 , pp. 141-152
    • Siess, M.H.1    Le Bon, A.M.2    Suschetet, M.3
  • 85
    • 0035197548 scopus 로고    scopus 로고
    • Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
    • Dai D, Tang J, Rose R, Hodgson E, Bienstock RJ, Mohrenweiser HW, Goldstein JA. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther 2001;299:825-31.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 825-831
    • Dai, D.1    Tang, J.2    Rose, R.3    Hodgson, E.4    Bienstock, R.J.5    Mohrenweiser, H.W.6    Goldstein, J.A.7
  • 86
    • 39049146064 scopus 로고    scopus 로고
    • Effect of dietary flavonoids on pathways involved in drug metabolism
    • Cermak R. Effect of dietary flavonoids on pathways involved in drug metabolism. Expert Opin Drug Metab Toxicol 2008;4:17-35.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 17-35
    • Cermak, R.1
  • 87
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: Effects of flavonoids on ABC transporters
    • Morris ME, Zhang S. Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 2006;78:2116-30.
    • (2006) Life Sci , vol.78 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.2
  • 89
    • 84946104726 scopus 로고    scopus 로고
    • Recent trends in preclinical drug-drug interaction studies of flavonoids-review of case studies, issues and perspectives
    • Srinivas NR. Recent trends in preclinical drug-drug interaction studies of flavonoids-review of case studies, issues and perspectives. Phytother Res 2015;29:1679-91.
    • (2015) Phytother Res , vol.29 , pp. 1679-1691
    • Srinivas, N.R.1
  • 90
    • 0027155665 scopus 로고
    • Grapefruit juice-felodipine interaction: Mechanism, predictability, and effect of naringin
    • Bailey DG, Arnold JM, Munoz C, Spence JD. Grapefruit juice-felodipine interaction: mechanism, predictability, and effect of naringin. Clin Pharmacol Ther 1993;53:637-42.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 637-642
    • Bailey, D.G.1    Arnold, J.M.2    Munoz, C.3    Spence, J.D.4
  • 94
    • 0036165985 scopus 로고    scopus 로고
    • Urinary excretion of catechin metabolites by human subjects after red wine consumption
    • Donovan JL, Kasim-Karakas S, German JB, Waterhouse AL. Urinary excretion of catechin metabolites by human subjects after red wine consumption. Br J Nutr 2002;87:31-7.
    • (2002) Br J Nutr , vol.87 , pp. 31-37
    • Donovan, J.L.1    Kasim-Karakas, S.2    German, J.B.3    Waterhouse, A.L.4
  • 95
    • 84903794302 scopus 로고    scopus 로고
    • Dietary factors affecting polyphenol bioavailability
    • Bohn T. Dietary factors affecting polyphenol bioavailability. Nutr Rev 2014;72:429-52.
    • (2014) Nutr Rev , vol.72 , pp. 429-452
    • Bohn, T.1
  • 96
    • 36348965939 scopus 로고    scopus 로고
    • Effect of pectin enhancement on plasma quercetin and fecal flora in rutinsupplemented mice
    • Tamura M, Nakagawa H, Tsushida T, Hirayama K, Itoh K. Effect of pectin enhancement on plasma quercetin and fecal flora in rutinsupplemented mice. J Food Sci 2007;72:S648-51.
    • (2007) J Food Sci , vol.72 , pp. S648-S651
    • Tamura, M.1    Nakagawa, H.2    Tsushida, T.3    Hirayama, K.4    Itoh, K.5
  • 97
    • 0036481691 scopus 로고    scopus 로고
    • Gastrointestinal transit and drug absorption
    • Kimura T, Higaki K. Gastrointestinal transit and drug absorption. Biol Pharm Bull 2002;25:149-64.
    • (2002) Biol Pharm Bull , vol.25 , pp. 149-164
    • Kimura, T.1    Higaki, K.2
  • 98
    • 2442479970 scopus 로고    scopus 로고
    • Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy
    • Scheidt HA, Pampel A, Nissler L, Gebhardt R, Huster D. Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. Biochim Biophys Acta 2004;1663:97-107.
    • (2004) Biochim Biophys Acta , vol.1663 , pp. 97-107
    • Scheidt, H.A.1    Pampel, A.2    Nissler, L.3    Gebhardt, R.4    Huster, D.5
  • 99
    • 80051831913 scopus 로고    scopus 로고
    • Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream
    • Mullen W, Edwards CA, Serafini M, Crozier A. Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. J Agric Food Chem 2008;56:713-9.
    • (2008) J Agric Food Chem , vol.56 , pp. 713-719
    • Mullen, W.1    Edwards, C.A.2    Serafini, M.3    Crozier, A.4
  • 100
    • 67649886708 scopus 로고    scopus 로고
    • Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model
    • Ortega N, Reguant J, Romero MP, Macia A, Motilva MJ. Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model. J Agric Food Chem 2009;57:5743-9.
    • (2009) J Agric Food Chem , vol.57 , pp. 5743-5749
    • Ortega, N.1    Reguant, J.2    Romero, M.P.3    Macia, A.4    Motilva, M.J.5
  • 101
    • 2642574313 scopus 로고    scopus 로고
    • Bioavailability of quercetin in pigs is influenced by the dietary fat content
    • Lesser S, Cermak R, Wolffram S. Bioavailability of quercetin in pigs is influenced by the dietary fat content. J Nutr 2004;134:1508-11.
    • (2004) J Nutr , vol.134 , pp. 1508-1511
    • Lesser, S.1    Cermak, R.2    Wolffram, S.3
  • 103
    • 76749171209 scopus 로고    scopus 로고
    • Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice
    • Giunta B, Hou H, Zhu Y, Salemi J, Ruscin A, Shytle RD, Tan J. Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neurosci Lett 2010;471:134-8.
    • (2010) Neurosci Lett , vol.471 , pp. 134-138
    • Giunta, B.1    Hou, H.2    Zhu, Y.3    Salemi, J.4    Ruscin, A.5    Shytle, R.D.6    Tan, J.7
  • 104
    • 67649422271 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion
    • Brett GM, Hollands W, Needs PW, Teucher B, Dainty JR, Davis BD, Brodbelt JS, Kroon PA. Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion. Br J Nutr 2009;101:664-75.
    • (2009) Br J Nutr , vol.101 , pp. 664-675
    • Brett, G.M.1    Hollands, W.2    Needs, P.W.3    Teucher, B.4    Dainty, J.R.5    Davis, B.D.6    Brodbelt, J.S.7    Kroon, P.A.8
  • 106
    • 84892171548 scopus 로고    scopus 로고
    • Volunteer stratification is more relevant than technological treatment in orange juice flavanone bioavailability
    • Tomás-Navarro M, Vallejo F, Sentandreu E, Navarro JL, Tomas-Barberan FA. Volunteer stratification is more relevant than technological treatment in orange juice flavanone bioavailability. J Agric Food Chem 2014;62:24-7.
    • (2014) J Agric Food Chem , vol.62 , pp. 24-27
    • Tomás-Navarro, M.1    Vallejo, F.2    Sentandreu, E.3    Navarro, J.L.4    Tomas-Barberan, F.A.5
  • 108
    • 84896338693 scopus 로고    scopus 로고
    • Impact of various factors on pharmacokinetics of bioactive polyphenols: An overview
    • Rubió L, Macia A, Motilva MJ. Impact of various factors on pharmacokinetics of bioactive polyphenols: an overview. Curr Drug Metab 2014;15:62-76.
    • (2014) Curr Drug Metab , vol.15 , pp. 62-76
    • Rubió, L.1    Macia, A.2    Motilva, M.J.3
  • 109
    • 0032819772 scopus 로고    scopus 로고
    • Dietary flavonoids: Intake, health effects and bioavailability
    • Hollman PC, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 1999;37:937-42.
    • (1999) Food Chem Toxicol , vol.37 , pp. 937-942
    • Hollman, P.C.1    Katan, M.B.2
  • 112
    • 78651249150 scopus 로고    scopus 로고
    • The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo
    • Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL. The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med 2011;50:237-44.
    • (2011) Free Radic Biol Med , vol.50 , pp. 237-244
    • Ottaviani, J.I.1    Momma, T.Y.2    Heiss, C.3    Kwik-Uribe, C.4    Schroeter, H.5    Keen, C.L.6
  • 113
    • 78049429506 scopus 로고    scopus 로고
    • Berry flavonoids and phenolics: Bioavailability and evidence of protective effects
    • Del Rio D, Borges G, Crozier A. Crozier A. Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br J Nutr 2010;104(Suppl 3):S67-90.
    • (2010) Br J Nutr , vol.104 , pp. S67-S90
    • Del Rio, D.1    Borges, G.2    Crozier, A.3    Crozier, A.4
  • 115
    • 33645100663 scopus 로고    scopus 로고
    • In vitro degradation of the flavonol quercetin and of quercetin glycosides in the porcine hindgut
    • Cermak R, Breves GM. In vitro degradation of the flavonol quercetin and of quercetin glycosides in the porcine hindgut. Arch Anim Nutr 2006;60:180-9.
    • (2006) Arch Anim Nutr , vol.60 , pp. 180-189
    • Cermak, R.1    Breves, G.M.2
  • 118
    • 33947186284 scopus 로고    scopus 로고
    • Metabolic diversity of the intestinal microbiota: Implications for health and disease
    • Blaut M, Clavel T. Metabolic diversity of the intestinal microbiota: implications for health and disease. J Nutr 2007;137(3 Suppl 2):751S-5S.
    • (2007) J Nutr , vol.137 , Issue.3 , pp. 751S-755S
    • Blaut, M.1    Clavel, T.2
  • 119
    • 20844448924 scopus 로고    scopus 로고
    • Human gut microbial degradation of flavonoids: Structure-function relationships
    • Simons AL, Renouf M, Hendrich S, Murphy PA. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric Food Chem 2005;53:4258-63.
    • (2005) J Agric Food Chem , vol.53 , pp. 4258-4263
    • Simons, A.L.1    Renouf, M.2    Hendrich, S.3    Murphy, P.A.4
  • 120
    • 67650002403 scopus 로고    scopus 로고
    • Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans
    • Roowi S, Mullen W, Edwards CA, Crozier A. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res 2009;53(Suppl 1):S68-75.
    • (2009) Mol Nutr Food Res , vol.53 , pp. S68-S75
    • Roowi, S.1    Mullen, W.2    Edwards, C.A.3    Crozier, A.4
  • 121
    • 0019395189 scopus 로고
    • The excretion of lignans in rats-evidence for an intestinal bacterial source for this new group of compounds
    • Axelson M, Setchell KD. The excretion of lignans in rats-evidence for an intestinal bacterial source for this new group of compounds. FEBS Lett 1981;123:337-42.
    • (1981) FEBS Lett , vol.123 , pp. 337-342
    • Axelson, M.1    Setchell, K.D.2
  • 122
    • 0036898114 scopus 로고    scopus 로고
    • The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
    • Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr 2002;132:3577-84.
    • (2002) J Nutr , vol.132 , pp. 3577-3584
    • Setchell, K.D.1    Brown, N.M.2    Lydeking-Olsen, E.3
  • 123
    • 84888395204 scopus 로고    scopus 로고
    • Dietary factors influence production of the soy isoflavone metabolite s-(-) equol in healthy adults
    • Setchell KD, Brown NM, Summer S, King EC, Heubi JE, Cole S, Guy T, Hokin B. Dietary factors influence production of the soy isoflavone metabolite s-(-) equol in healthy adults. J Nutr 2013;143:1950-8.
    • (2013) J Nutr , vol.143 , pp. 1950-1958
    • Setchell, K.D.1    Brown, N.M.2    Summer, S.3    King, E.C.4    Heubi, J.E.5    Cole, S.6    Guy, T.7    Hokin, B.8
  • 124
    • 65549169095 scopus 로고    scopus 로고
    • Is equol the key to the efficacy of soy foods?
    • Lampe JW. Is equol the key to the efficacy of soy foods? Am J Clin Nutr 2009;89:1664S-7S.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1664S-1667S
    • Lampe, J.W.1
  • 126
    • 84869488302 scopus 로고    scopus 로고
    • Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States
    • Atkinson C, Newton KM, Yong M, Stanczyk FZ, Westerlind KC, Li L, Lampe JW. Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States. Metabolism 2012;61:1678-82.
    • (2012) Metabolism , vol.61 , pp. 1678-1682
    • Atkinson, C.1    Newton, K.M.2    Yong, M.3    Stanczyk, F.Z.4    Westerlind, K.C.5    Li, L.6    Lampe, J.W.7
  • 127
    • 84941633665 scopus 로고    scopus 로고
    • Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: A randomized crossover trial
    • Pawlowski JW, Martin BR, McCabe GP, McCabe L, Jackson GS, Peacock M, Barnes S, Weaver CM. Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial. Am J Clin Nutr 2015;102:695-703.
    • (2015) Am J Clin Nutr , vol.102 , pp. 695-703
    • Pawlowski, J.W.1    Martin, B.R.2    McCabe, G.P.3    McCabe, L.4    Jackson, G.S.5    Peacock, M.6    Barnes, S.7    Weaver, C.M.8
  • 128
    • 84942758923 scopus 로고    scopus 로고
    • Metabolic and microbial modulation of the large intestine ecosystem by non-absorbed diet phenolic compounds: A review
    • Mosele JI, Macia A, Motilva MJ. Metabolic and microbial modulation of the large intestine ecosystem by non-absorbed diet phenolic compounds: a review. Molecules 2015;20:17429-68.
    • (2015) Molecules , vol.20 , pp. 17429-17468
    • Mosele, J.I.1    Macia, A.2    Motilva, M.J.3
  • 133
    • 79952316380 scopus 로고    scopus 로고
    • Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency
    • Spencer MD, Hamp TJ, Reid RW, Fischer LM, Zeisel SH, Fodor AA. Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology 2011;140:976-86.
    • (2011) Gastroenterology , vol.140 , pp. 976-986
    • Spencer, M.D.1    Hamp, T.J.2    Reid, R.W.3    Fischer, L.M.4    Zeisel, S.H.5    Fodor, A.A.6
  • 134
    • 84905046586 scopus 로고    scopus 로고
    • High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites: A randomized clinical trial
    • Boto-Ordóñez M, Urpi-Sarda M, Queipo-Ortuno MI, Tulipani S, Tinahones FJ, Andres-Lacueva C. High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites: a randomized clinical trial. Food Funct 2014;5:1932-8.
    • (2014) Food Funct , vol.5 , pp. 1932-1938
    • Boto-Ordóñez, M.1    Urpi-Sarda, M.2    Queipo-Ortuno, M.I.3    Tulipani, S.4    Tinahones, F.J.5    Andres-Lacueva, C.6
  • 135
    • 84964696945 scopus 로고    scopus 로고
    • Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat dietinduced metabolic syndrome
    • Roopchand DE, Carmody RN, Kuhn P, Moskal K, Rojas-Silva P, Turnbaugh PJ, Raskin I. Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat dietinduced metabolic syndrome. Diabetes 2015;64:2847-58.
    • (2015) Diabetes , vol.64 , pp. 2847-2858
    • Roopchand, D.E.1    Carmody, R.N.2    Kuhn, P.3    Moskal, K.4    Rojas-Silva, P.5    Turnbaugh, P.J.6    Raskin, I.7
  • 136
    • 84934451277 scopus 로고    scopus 로고
    • A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. Population in the gut microbiota of mice
    • Anhê FF, Roy D, Pilon G, Dudonne S, Matamoros S, Varin TV, Garofalo C, Moine Q, Desjardins Y, Levy E, et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 2015;64:872-83.
    • (2015) Gut , vol.64 , pp. 872-883
    • Anhê, F.F.1    Roy, D.2    Pilon, G.3    Dudonne, S.4    Matamoros, S.5    Varin, T.V.6    Garofalo, C.7    Moine, Q.8    Desjardins, Y.9    Levy, E.10
  • 139
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases
    • Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 2013;18:1818-92.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1818-1892
    • Del Rio, D.1    Rodriguez-Mateos, A.2    Spencer, J.P.3    Tognolini, M.4    Borges, G.5    Crozier, A.6
  • 140
    • 84930177527 scopus 로고    scopus 로고
    • Flavonoid metabolites reduce tumor necrosis factor-alpha secretion to a greater extent than their precursor compounds in human THP-1 monocytes
    • di Gesso JL, Kerr JS, Zhang Q, Raheem S, Yalamanchili SK, O'Hagan D, Kay CD, O'Connell MA. Flavonoid metabolites reduce tumor necrosis factor-alpha secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Mol Nutr Food Res 2015;59:1143-54.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 1143-1154
    • Di Gesso, J.L.1    Kerr, J.S.2    Zhang, Q.3    Raheem, S.4    Yalamanchili, S.K.5    O'Hagan, D.6    Kay, C.D.7    O'Connell, M.A.8
  • 141
    • 84930178829 scopus 로고    scopus 로고
    • Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
    • Amin HP, Czank C, Raheem S, Zhang Q, Botting NP, Cassidy A, Kay CD. Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Mol Nutr Food Res 2015;59:1095-106.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 1095-1106
    • Amin, H.P.1    Czank, C.2    Raheem, S.3    Zhang, Q.4    Botting, N.P.5    Cassidy, A.6    Kay, C.D.7
  • 142
    • 44449100218 scopus 로고    scopus 로고
    • Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells
    • Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J Nutr 2008;138:1067-73.
    • (2008) J Nutr , vol.138 , pp. 1067-1073
    • Amasheh, M.1    Schlichter, S.2    Amasheh, S.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6    Schulzke, J.D.7


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