The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

Molecular Nutrition and Food Research

Volumn 56, Issue 6, 2012, Pages 966-975

  Miller, Rosalind J ^a   Jackson, Kim G ^a   Dadd, Tony ^b   Mayes, Andrew E ^b   Brown, A Louise ^b   Lovegrove, Julie A ^a   Minihane, Anne M ^a,c  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Blood pressure; Catechol O methyltransferase; Endothelial function; Flavonoids; Green tea

Indexed keywords

4' O METHYLEPIGALLOCATECHIN; 4'-O-METHYLEPIGALLOCATECHIN; CATECHIN; CATECHOL METHYLTRANSFERASE; DRUG DERIVATIVE; PLANT EXTRACT;

ADOLESCENT; ADULT; ARTICLE; BLOOD; BLOOD PRESSURE; BLOOD VESSEL; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; GENETIC ASSOCIATION; GENETICS; HUMAN; KINETICS; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TEA; URINE;

ADOLESCENT; ADULT; BLOOD PRESSURE; BLOOD VESSELS; CAMELLIA SINENSIS; CATECHIN; CATECHOL O-METHYLTRANSFERASE; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; GENETIC ASSOCIATION STUDIES; HUMANS; KINETICS; MALE; MIDDLE AGED; PLANT EXTRACTS; PLANT LEAVES; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84862519231     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100726     Document Type: Article

References (42)

1. Hu, F. B., Stampfer, M. J., Manson, J. E., Grodstein, F. et al., Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N. Engl. J. Med. 2000, 343, 530-537.
2. Landmesser, U., Hornig, B., Drexler, H., Endothelial function-a critical determinant in atherosclerosis? Circulation 2004, 109, 27-33.
3. Widlansky, M. E., Hamburg, N. M., Anter, E., Holbrook, M. et al., Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J. Am. Coll. Nutr. 2007, 26, 95-102.
4. Kim, W., Jeong, M. H., Cho, S. H., Yun, J. H. et al., Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers. Circ. J. 2006, 70, 1052-1057.
5. Tinahones Madueno, F. J., Rubio, M. A., Garrido Sanchez, L., Ruiz, C. et al., Green tea reduces LDL oxidability and improves vascular function. Atheroscler. Suppl. 2007, 8, 166-166.
6. Jochmann, N., Lorenz, M., Krosigk, A., Martus, P. et al., The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br. J. Nutr. 2008, 99, 863-868.
7. Nagaya, N., Yamamoto, H., Uematsu, M., Itoh, T. et al., Green tea reverses endothelial dysfunction in healthy smokers. Heart 2004, 90, 1485-1486.
8. Ryu, O. H., Lee, J., Lee, K. W., Kim, H. Y. et al., Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res. Clin. Pract. 2006, 71, 356-358.
9. Vlachopoulos, C., Alexopoulos, N., Dima, I., Aznaouridis, K. et al., Acute effect of black and green tea on aortic stiffness and wave reflections. J. Am. Coll. Nutr. 2006, 25, 216-223.
10. Chen, J., Lipska, B. K., Halim, N., Ma, Q. D. et al., Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 2004, 75, 807-821.
11. Shield, A. J., Thomae, B. A., Eckloff, B. W., Wieben, E. D. et al., Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes. Mol. Psychiatry 2004, 9, 151-160.
12. Boudikova, B., Szumlanski, C., Maidak, B., Weinshilboum, R., Human liver catechol-O-methyltransferase pharmacogenetics. Clin. Pharmacol. Ther. 1990, 48, 381-389.
13. Worda, C., Sator, M. O., Schneeberger, C., Jantschev, T. et al., Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women. Hum. Reprod. 2003, 18, 262-266.
14. Miller, R. J., Jackson, K. G., Dadd, T., Mayes, A. E. et al., The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract. Br. J. Nutr. 2011, 105, 1138-1144.
15. Hamburg, N. M., Keyes, M. J., Larson, M. G., Vasan, R. S. et al., Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 2008, 117, 2467-2474.
16. Mulukutla, S. R., Venkitachalam, L., Bambs, C., Kip, K. E. et al., Black race is associated with digital artery endothelial dysfunction: results from the Heart SCORE study. Eur. Heart J. 2010, 31, 2808-2815.
17. Dangardt, F., Osika, W., Chen, Y., Nilsson, U. et al., Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents. Atherosclerosis 2010, 212, 580-585.
18. Fisher, N. D., Hollenberg, N. K., Aging and vascular responses to flavanol-rich cocoa. J. Hypertens 2006, 24, 1575-1580.
19. Millasseau, S. C., Kelly, R. P., Ritter, J. M., Chowienczyk, P. J., Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin. Sci. (Lond) 2002, 103, 371-377.
20. Meng, X., Sang, S., Zhu, N., Lu, H. et al., Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats. Chem. Res. Toxicol. 2002, 15, 1042-1050.
21. Kenward, M. G., Roger, J. H., The use of baseline covariates in crossover studies. Biostatistics 2010, 11, 1-17.
22. Ras, R. T., Zock, P. L., Draijer, R., Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One 2011, 6, e16974.
23. Alexopoulos, N., Vlachopoulos, C., Aznaouridis, K., Baou, K. et al., The acute effect of green tea consumption on endothelial function in healthy individuals. Eur. J. Cardiovasc Prev. Rehabil. 2008, 15, 300-305.
24. Landis-Piwowar, K. R., Wan, S. B., Wiegand, R. A., Kuhn, D. J. et al., Methylation suppresses the proteasome-inhibitory function of green tea polyphenols. J. Cell Physiol. 2007, 213, 252-260.
25. Wu, A. H., Tseng, C. C., Van den Berg, D., Yu, M. C., Tea intake, COMT genotype, and breast cancer in Asian-American women. Cancer Res. 2003, 63, 7526-7529.
26. Landis-Piwowar, K., Chen, D., Chan, T. H., Dou, Q. P., Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG. Oncol. Rep. 2010, 24, 563-569.
27. Duenas, M., Gonzalez-Manzano, S., Gonzalez-Paramas, A., Santos-Buelga, C., Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin. J. Pharm. Biomed. Anal. 2010, 51, 443-449.
28. Pollard, S. E., Kuhnle, G. G., Vauzour, D., Vafeiadou, K. et al., The reaction of flavonoid metabolites with peroxynitrite. Biochem. Biophys. Res. Commun. 2006, 350, 960-968.
29. Lorenz, M., Wessler, S., Follmann, E., Michaelis, W. et al., A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase, cAMP-dependent protein kinase, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J. Biol. Chem. 2004, 279, 6190-6195.
30. Alvarez, E., Campos-Toimil, M., Justiniano-Basaran, H., Lugnier, C. et al., Study of the mechanisms involved in the vasorelaxation induced by (2)-epigallocatechin-3-gallate in rat aorta. Br. J. Pharmacol. 2006, 147, 269-280.
31. Mizugaki, M., Ishizawa, F., Yamazaki, T., Hishinuma, T., Epigallo-catechin gallate increase the prostacyclin production of bovine aortic endothelial cells. Prostaglandins Other Lipid Mediat 2000, 62, 157-164.
32. Actis-Goretta, L., Ottaviani, J. I., Fraga, C. G., Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J. Agric. Food Chem. 2006 54, 229-234.
33. Steffen, Y., Gruber, C., Schewe, T., Sies, H., Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch. Biochem. Biophys. 2008, 469, 209-219.
34. Nagai, M., Conney, A. H., Zhu, B. T., Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Drug. Metab. Dispos. 2004, 32, 497-504.
35. Lu, H., Meng, X. F., Yang, C. S., Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate. Drug Metab. Dispos. 2003, 31, 572-579.
36. Masuda, M., Tsunoda, M., Imai, K., Low catechol-O-methyltransferase activity in the brain and blood pressure regulation. Biol. Pharm. Bull. 2006, 29, 202-205.
37. Hodgson, J. M., Puddey, I. B., Burke, V., Beilin, L. J. et al., Effects on blood pressure of drinking green and black tea. J. Hypertens 1999, 17, 457-463.
38. Basu, A., Sanchez, K., Leyva, M. J., Wu, M. et al., Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J. Am. Coll Nutr. 2010, 29, 31-40.
39. Brown, A. L., Lane, J., Coverly, J., Stocks, J. et al., Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br. J. Nutr. 2009, 101, 886-894.
40. Yang, Y. C., Lu, F. H., Wu, J. S., Wu, C. H. et al., The protective effect of habitual tea consumption on hypertension. Arch. Intern. Med. 2004, 164, 1534-1540.
41. Nagao, T., Hase, T., Tokimitsu, I., A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 2007, 15, 1473-1483.
42. Stensvold, I., Tverdal, A., Solvoll, K., Foss, O. P., Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality. Prev. Med. 1992, 21, 546-553.