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Volumn 138, Issue 6, 2008, Pages 1067-1073

Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE 36; CLAUDIN 4; MANNITOL; QUERCETIN; SODIUM 22;

EID: 44449100218     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.6.1067     Document Type: Article
Times cited : (145)

References (61)
  • 1
    • 33751391867 scopus 로고
    • Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
    • Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem. 1992;40:2379-83.
    • (1992) J Agric Food Chem , vol.40 , pp. 2379-2383
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3
  • 2
    • 0347197907 scopus 로고
    • Content of potentially anticarcinogenic flavonoids of tea infusions, wine, and fruit juices
    • Hertog MGL, Hollman PCH, van de Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wine, and fruit juices. J Agric Food Chem. 1993;41:1242-6.
    • (1993) J Agric Food Chem , vol.41 , pp. 1242-1246
    • Hertog, M.G.L.1    Hollman, P.C.H.2    van de Putte, B.3
  • 3
    • 0034658374 scopus 로고    scopus 로고
    • Flavonols, flavones and flavanols: Nature, occurrence and dietary burden
    • Hollman PCA, Arts ICW. Flavonols, flavones and flavanols: nature, occurrence and dietary burden. J Sci Food Agric. 2000;80:1081-93.
    • (2000) J Sci Food Agric , vol.80 , pp. 1081-1093
    • Hollman, P.C.A.1    Arts, I.C.W.2
  • 4
    • 0019917133 scopus 로고
    • Quercetin, flavonoids and the life-span of mice
    • Jones E, Hughes RE. Quercetin, flavonoids and the life-span of mice. Exp Gerontol. 1982;17:213-7.
    • (1982) Exp Gerontol , vol.17 , pp. 213-217
    • Jones, E.1    Hughes, R.E.2
  • 5
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 7
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. 2005;171:939-45.
    • (2005) J Cell Biol , vol.171 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3    Sasaki, H.4    Tsukita, S.5
  • 8
    • 0141644213 scopus 로고    scopus 로고
    • The JAM family of junctional adhesion molecules
    • Bazzoni G. The JAM family of junctional adhesion molecules. Curr Opin Cell Biol. 2003;15:525-30.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 525-530
    • Bazzoni, G.1
  • 9
    • 0032547833 scopus 로고    scopus 로고
    • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    • Furuse M, Sasaki H, Fujimoto K, Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol. 1998;143:391-401.
    • (1998) J Cell Biol , vol.143 , pp. 391-401
    • Furuse, M.1    Sasaki, H.2    Fujimoto, K.3    Tsukita, S.4
  • 10
    • 0033582334 scopus 로고    scopus 로고
    • Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
    • Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA. 1999;96:511-6.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 511-516
    • Morita, K.1    Furuse, M.2    Fujimoto, K.3    Tsukita, S.4
  • 12
    • 33645963995 scopus 로고    scopus 로고
    • Claudins and epithelial paracellular transport
    • Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol. 2006;68:403-29.
    • (2006) Annu Rev Physiol , vol.68 , pp. 403-429
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 13
    • 0037128938 scopus 로고    scopus 로고
    • Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice
    • Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol. 2002;156:1099-111.
    • (2002) J Cell Biol , vol.156 , pp. 1099-1111
    • Furuse, M.1    Hata, M.2    Furuse, K.3    Yoshida, Y.4    Haratake, A.5    Sugitani, Y.6    Noda, T.7    Kubo, A.8    Tsukita, S.9
  • 18
    • 18244431922 scopus 로고    scopus 로고
    • Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene
    • Weber S, Hoffmann K, Jeck N, Saar K, Boeswald M, Kuwertz-Broeking E, Meij II, Knoers NV, Cochat P, et al. Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. Eur J Hum Genet. 2000;8:414-22.
    • (2000) Eur J Hum Genet , vol.8 , pp. 414-422
    • Weber, S.1    Hoffmann, K.2    Jeck, N.3    Saar, K.4    Boeswald, M.5    Kuwertz-Broeking, E.6    Meij, I.I.7    Knoers, N.V.8    Cochat, P.9
  • 21
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S, Bürgel N, Günzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut. 2007;56:61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Bürgel, N.2    Günzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9
  • 22
  • 23
    • 0037466449 scopus 로고    scopus 로고
    • Florian P, Amasheh S, Lessidrensky M, Todt I, Bloedow A, Ernst A, Fromm M, Gitter AH. Claudins in the tight junctions of stria vascularis marginal cells. Biochem Biophys Res Commun. 2003;304:5-10.
    • Florian P, Amasheh S, Lessidrensky M, Todt I, Bloedow A, Ernst A, Fromm M, Gitter AH. Claudins in the tight junctions of stria vascularis marginal cells. Biochem Biophys Res Commun. 2003;304:5-10.
  • 24
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, Schulzke JD. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci. 2000;113:2085-90.
    • (2000) J Cell Sci , vol.113 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6    Schulzke, J.D.7
  • 25
    • 0034866934 scopus 로고    scopus 로고
    • Polyphenolic compounds: Interactions with the gut and implications for human health
    • Gee JM, Johnson IT. Polyphenolic compounds: interactions with the gut and implications for human health. Curr Med Chem. 2001;8:1245-55.
    • (2001) Curr Med Chem , vol.8 , pp. 1245-1255
    • Gee, J.M.1    Johnson, I.T.2
  • 26
    • 33749246068 scopus 로고    scopus 로고
    • Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
    • Perez-Vizcaino F, Duarte J, Andriantsitohaina R. Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res. 2006;40:1054-65.
    • (2006) Free Radic Res , vol.40 , pp. 1054-1065
    • Perez-Vizcaino, F.1    Duarte, J.2    Andriantsitohaina, R.3
  • 29
    • 0035013499 scopus 로고    scopus 로고
    • Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability
    • Van Itallie C, Rahner C, Anderson JM. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest. 2001;107:1319-27.
    • (2001) J Clin Invest , vol.107 , pp. 1319-1327
    • Van Itallie, C.1    Rahner, C.2    Anderson, J.M.3
  • 31
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    • Furuse M, Furuse K, Sasaki H, Tsukita S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol. 2001;153:263-72.
    • (2001) J Cell Biol , vol.153 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 32
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, Parkos CA, Nusrat A. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell. 2005;16:5040-52.
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6    Parkos, C.A.7    Nusrat, A.8
  • 34
    • 0036370718 scopus 로고    scopus 로고
    • Glutamine: Clinical applications and mechanisms of action
    • Neu J, DeMarco V, Li N. Glutamine: clinical applications and mechanisms of action. Curr Opin Clin Nutr Metab Care. 2002;5:69-75.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , pp. 69-75
    • Neu, J.1    DeMarco, V.2    Li, N.3
  • 36
    • 0030926950 scopus 로고    scopus 로고
    • Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model
    • Mariadason JM, Barkla DH, Gibson PR. Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model. Am J Physiol. 1997;272:G705-12.
    • (1997) Am J Physiol , vol.272
    • Mariadason, J.M.1    Barkla, D.H.2    Gibson, P.R.3
  • 38
    • 0027133307 scopus 로고
    • Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C
    • Stenson WF, Easom RA, Riehl TE, Turk J. Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C. Am J Physiol. 1993;265:G955-62.
    • (1993) Am J Physiol , vol.265
    • Stenson, W.F.1    Easom, R.A.2    Riehl, T.E.3    Turk, J.4
  • 39
    • 0024550507 scopus 로고
    • Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
    • Ferriola PC, Cody V, Middleton E Jr. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol. 1989;38:1617-24.
    • (1989) Biochem Pharmacol , vol.38 , pp. 1617-1624
    • Ferriola, P.C.1    Cody, V.2    Middleton Jr., E.3
  • 40
    • 3543005330 scopus 로고    scopus 로고
    • Electrochemical study of quercetin-DNA interactions. Part I. Analysis in incubated solutions
    • Oliveira-Brett AM, Diculescu VC. Electrochemical study of quercetin-DNA interactions. Part I. Analysis in incubated solutions. Bioelectrochemistry. 2004;64:133-41.
    • (2004) Bioelectrochemistry , vol.64 , pp. 133-141
    • Oliveira-Brett, A.M.1    Diculescu, V.C.2
  • 42
    • 17844393395 scopus 로고    scopus 로고
    • Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells
    • Yuan H, Gong A, Young CY. Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells. Carcinogenesis. 2005;26:793-801.
    • (2005) Carcinogenesis , vol.26 , pp. 793-801
    • Yuan, H.1    Gong, A.2    Young, C.Y.3
  • 43
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells
    • Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol. 2000;279:G851-7.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 44
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D, Pedram A, Said HM. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol. 2005;288:G422-30.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 46
    • 0032524982 scopus 로고    scopus 로고
    • Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells
    • Walgren RA, Walle UK, Walle T. Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells. Biochem Pharmacol. 1998;55:1721-7.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1721-1727
    • Walgren, R.A.1    Walle, U.K.2    Walle, T.3
  • 47
    • 0032844221 scopus 로고    scopus 로고
    • The influence of plasma binding on absorption/exsorption in the Caco-2 model of human intestinal absorption
    • Walgren RA, Walle T. The influence of plasma binding on absorption/exsorption in the Caco-2 model of human intestinal absorption. J Pharm Pharmacol. 1999;51:1037-40.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 1037-1040
    • Walgren, R.A.1    Walle, T.2
  • 48
    • 0038730962 scopus 로고    scopus 로고
    • Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells
    • Walle T, Vincent TS, Walle UK. Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells. Biochem Pharmacol. 2003;65:1603-10.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1603-1610
    • Walle, T.1    Vincent, T.S.2    Walle, U.K.3
  • 50
    • 0043063961 scopus 로고    scopus 로고
    • Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism
    • Murota K, Terao J. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys. 2003;417:12-7.
    • (2003) Arch Biochem Biophys , vol.417 , pp. 12-17
    • Murota, K.1    Terao, J.2
  • 51
    • 0034671729 scopus 로고    scopus 로고
    • Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2
    • Murota K, Shimizu S, Chujo H, Moon JH, Terao J. Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. Arch Biochem Biophys. 2000;384:391-7.
    • (2000) Arch Biochem Biophys , vol.384 , pp. 391-397
    • Murota, K.1    Shimizu, S.2    Chujo, H.3    Moon, J.H.4    Terao, J.5
  • 52
    • 3042803764 scopus 로고    scopus 로고
    • Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation
    • Ma ZS, Nguyen TH, Huynh TH, Do PT, Huynh H. Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. J Endocrinol. 2004;181:493-507.
    • (2004) J Endocrinol , vol.181 , pp. 493-507
    • Ma, Z.S.1    Nguyen, T.H.2    Huynh, T.H.3    Do, P.T.4    Huynh, H.5
  • 55
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • Németh K, Plumb GW, Berrin JG, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr. 2003;42:29-42.
    • (2003) Eur J Nutr , vol.42 , pp. 29-42
    • Németh, K.1    Plumb, G.W.2    Berrin, J.G.3    Juge, N.4    Jacob, R.5    Naim, H.Y.6    Williamson, G.7    Swallow, D.M.8    Kroon, P.A.9
  • 56
    • 3142621340 scopus 로고    scopus 로고
    • The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides
    • Arts IC, Sesink AL, Faassen-Peters M, Hollman PC. The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr. 2004;91:841-7.
    • (2004) Br J Nutr , vol.91 , pp. 841-847
    • Arts, I.C.1    Sesink, A.L.2    Faassen-Peters, M.3    Hollman, P.C.4
  • 57
    • 0023548365 scopus 로고
    • Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans
    • Bokkenheuser VD, Shackleton CH, Winter J. Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans. Biochem J. 1987;248:953-6.
    • (1987) Biochem J , vol.248 , pp. 953-956
    • Bokkenheuser, V.D.1    Shackleton, C.H.2    Winter, J.3
  • 58
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
    • Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett. 1998;436:71-5.
    • (1998) FEBS Lett , vol.436 , pp. 71-75
    • Day, A.J.1    DuPont, M.S.2    Ridley, S.3    Rhodes, M.4    Rhodes, M.J.5    Morgan, M.R.6    Williamson, G.7
  • 60
    • 0034494884 scopus 로고    scopus 로고
    • Respective bioavailability of quercetin aglycone and its glycosides in a rat model
    • Morand C, Manach C, Crespy V, Remesy C. Respective bioavailability of quercetin aglycone and its glycosides in a rat model. Biofactors. 2000;12:169-74.
    • (2000) Biofactors , vol.12 , pp. 169-174
    • Morand, C.1    Manach, C.2    Crespy, V.3    Remesy, C.4
  • 61
    • 0347320505 scopus 로고    scopus 로고
    • In vitro studies indicate that miquelianin (quercetin 3-O-beta-D- glucuronopyranoside) is able to reach the CNS from the small intestine
    • Juergenliemk G, Boje K, Huewel S, Lohmann C, Galla HJ, Nahrstedt A. In vitro studies indicate that miquelianin (quercetin 3-O-beta-D- glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Med. 2003;69:1013-7.
    • (2003) Planta Med , vol.69 , pp. 1013-1017
    • Juergenliemk, G.1    Boje, K.2    Huewel, S.3    Lohmann, C.4    Galla, H.J.5    Nahrstedt, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.