Potential Risks Resulting from Fruit/Vegetable-Drug Interactions: Effects on Drug-Metabolizing Enzymes and Drug Transporters

Journal of Food Science

Volumn 76, Issue 4, 2011, Pages

  Rodríguez Fragoso, Lourdes ^a   Martínez Arismendi, José Luis ^a   Orozco Bustos, Danae ^a   Reyes Esparza, Jorge ^a   Torres, Eliseo ^b   Burchiel, Scott W ^c  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Drug; Drug metabolizing enzymes; Fruit; Transporters; Vegetables

Indexed keywords

PLANT EXTRACT;

ARTICLE; BIOAVAILABILITY; CITRUS; DRUG DETOXIFICATION; FOOD DRUG INTERACTION; FRUIT; GRAPEFRUIT; HUMAN; LYTHRACEAE; MALUS; METABOLISM; MORUS; NUTRITIONAL VALUE; RISK FACTOR; SWEET ORANGE; TRADITIONAL MEDICINE; TRANSPORT AT THE CELLULAR LEVEL; VEGETABLE; VITIS;

BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CITRUS; CITRUS PARADISI; CITRUS SINENSIS; FOOD-DRUG INTERACTIONS; FRUIT; HUMANS; MALUS; MEDICINE, TRADITIONAL; METABOLIC DETOXICATION, DRUG; MORUS; NUTRITIVE VALUE; PLANT EXTRACTS; PUNICACEAE; RISK FACTORS; VEGETABLES; VITIS;

BRASSICA OLERACEA VAR. BOTRYTIS; BRASSICA OLERACEA VAR. ITALICA; CITRUS RETICULATA; CITRUS X PARADISI; DAUCUS CAROTA; LYCOPERSICON ESCULENTUM; LYTHRACEAE; MALUS X DOMESTICA; MORUS (ANGIOSPERM); MORUS NIGRA; NASTURTIUM OFFICINALE; PERSEA AMERICANA; PSIDIUM; RUBUS GLAUCUS; RUBUS OCCIDENTALIS; SPINACIA OLERACEA; VACCINIUM MACROCARPON; VITACEAE;

EID: 79955593489     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2011.02155.x     Document Type: Article

References (153)

1. Alvarez AI, Real R, Perez M, Mendoza G, Prieto JG, Merino G. 2010. Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response. Pharm Sci 99:598-617.
2. Amory JK, Amory DW. 2005. Oral erythromycin and the risk of sudden death. N Engl J Med 352:301-4.
3. Anwar-Mohamed A, El-Kadi AO. 2009. Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. Cancer Lett 275:93-101.
4. Ayrton A, Morgan P. 2001. Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 8:469-97.
5. Backman JT, Maenppa J, Belle DJ, Wrighton SA, Kivisto KT, Neuvonen PJ. 2000. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 67:382-90.
6. Bailey DG, Dresser GK. 2004. Interactions between grapefruit juice and cardiovascular drugs. Am J Cardiovasc Drugs 4:281-97.
7. Berardini N, Fezer R, Conrad J, Beifuss U, Carle R, Schieber A. 2005. Screening of mango (Mangifera indicaL.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. J Agric Food Chem 53:1563-70.
8. Bergquist SA, Gertsson UE, Knuthsen P, Olsson ME. 2005. Flavonoids in baby spinach (Spinacia oleraceaL.): changes during plant growth and storage. J Agric Food Chem 53:9459-64.
9. Bergman M, Varshavsky L, Gottlieb HE, Grossman S. 2001. The antioxidant activity of aqueous spinach extract: chemical identification of active fractions. Phytochemistry 58:143-52.
10. Bischoff SC. 2008. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11:733-40.
11. Blickstein D, Shaklai M, Inbal A. 1991. Warfarin antagonism by avocado. Lancet 337:914-15.
12. Bradfield CA, Chang Y, Bjeldanes LF. 1985. Effects of commonly consumed vegetables on hepatic xenobiotic-metabolizing enzymes in the mouse. Food Chem Toxicol 23:899-904.
13. Bressler R. 2006. Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs. Geriatrics 61:12-8.
14. Cartea ME, Francisco M, Soengas P, Velasco P. 2010. Phenolic compounds in Brassica vegetables. Molecules 16:251-80.
15. Côté J, Caillet S, Doyon G, Sylvain JF, Lacroix M. 2010. Bioactive compounds in cranberries and their biological properties. Crit Rev Food Sci Nutr 50:666-79.
16. Cuciureanu M, Vlase L, Muntean D, Varlan I, Cuciureanu R. 2010. Grapefruit juice-drug interactions: importance for pharmacotherapy. Rev Med Chir Soc Med Nat Iasi 114:885-91.
17. Custodio JM, Wu CY, Benet LZ. 2008. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev 60:717-33.
18. Chan LN. 2006. Drug-nutrient interactions. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and sisease. Baltimore Lippincott Williams & Wilkins. p 1540-53.
19. Chan WK, Delucchi BA. 2000. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 67:3103-12.
20. Chieli E, Romiti N, Rodeiro I, Garrido G. 2009. In vitro effects ofMangifera indicaand polyphenols derived on ABCB1/P-glycoprotein activity. Food Chem Toxicol 47:2703-10.
21. Dangour AD, Lock K, Hayter A, Aikenhead A, Allen E, Uauy R. 2010. Nutrition-related health effects of organic foods: a systematic review. Am J Clin Nutr 92:203-10.
22. de Wet H, Nkwanyana MN, van Vuuren SF. 2010. Medicinal plants used for the treatment of diarrhoea in northern Maputaland, KwaZulu-Natal Province, South Africa. J Ethnopharmacol 130(2):284-9.
23. Del Rio D, Borges G, Crozier A. 2010. Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br J Nutr 104:S67-90.
24. Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. 2002. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake. Clin Pharmacol Ther 71:11-20.
25. Dresser GK, Kim RB, Bailey DG. 2005. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 77:170-7.
26. Duester KC. 2001. Avocado fruit is a rich source of beta-sitosterol. J Am Diet Assoc 101:404-5.
27. Ellinger S, Ellinger J, Stehle P. 2006. Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies? Curr Opin Clin Nutr Metab Care 9:722-7.
28. Engels C, Knodler M, Zhao YY, Carle R, Ganzle MG, Schieber A. 2009. Antimicrobial activity of gallotannins isolated from mango (Mangifera indicaL.) kernels. J Agric Food Chem 57:7712-8.
29. Ernst E. 2003. Avocado-soybean unsaponifiables (ASU) for osteoarthritis-a systematic review. Clin Rheumatol 22:285-8.
30. Farkas D, Greenblatt DJ. 2008. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 4:381-93.
31. Fimognari C, Lenzi M, Hrelia P. 2008. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab 9:668-78.
32. Flanagan D. 2005. Understanding the grapefruit-drug interaction. Gen Dent 53:282-5.
33. Foti RS, Wienkers LC, Wahlstrom JL. 2010. Application of cytochrome P450 drug interaction screening in drug discovery. Comb Chem High Throughput Screen 13:145-58.
34. Franco OH, Bonneux L, de Laet C, Peeters A, Steyerberg EW, Mackenbach JP. 2004. The polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%. BMJ 329(7480):1447-50.
35. Genser D. 2008. Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 52:29-32.
36. Gerhauser C. 2008. Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med 74:1608-24.
37. Getahun SM, Chung FL. 1999. Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomarkers Prev 8:447-51.
38. Greenblatt DJ. 2009. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 49:1403-7.
39. Hagenbuch B, Gui C. 2008. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38:778-801.
40. Hanley MJ, Cancalon P, Widmer WW, Greenblatt DJ. 2011. The effect of grapefruit juice on drug disposition. Expert Opin Drug Metab Toxicol 7:267-86.
41. Harris KE, Jeffery EH. 2008. Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines. J Nutr Biochem 19:246-54.
42. Heber D. 2004. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 50:145-9.
43. Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. 2005. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 33:644-8.
44. Ho PC, Saville DJ, Coville PF, Wanwimolruk S. 2000. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv 74:379-85.
45. Hofmann T, Kuhnert A, Schubert A, Gill C, Rowland IR, Pool-Zobel BL, Glei M. 2009. Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells. Eur J Nutr 48:483-91.
46. Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y. 2004. Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol 143:856-64. PMID: 15504753
47. Huang SM Hall SD, Watkins P, Love LA, Serabjit-Singh C, Betz JM, Hoffman FA, Honig P, Coates PM, Bull J, Chen ST, Kearms GL, Murray MD. 2004. Drug interactions with herbal products & grapefruit juice: a conference report. Clin Pharmacol Ther 75:1-12.
48. Huang SM, Strong JM, Zhang L, Reynolds KS, Nallani S, Temple R, Abraham S, Habet SA, Baweja RK, Burckart GJ, Chung S, Colangelo P, Frucht D, Green MD, Hepp P, Karnaukhova E, Ko HS, Lee JI, Marroum PJ, Norden JM, Qiu W, Rahman A, Sobel S, Stifano T, Thummel K, Wei XX, Yasuda S, Zheng JH, Zhao H, Lesko LJ. 2008. New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process. J Clin Pharmacol 48:662-70.
49. International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. 2010. Membrane transporters in drug development. Nature Reviews Drug Discovery 9:215-36.
50. Iyanagi T. 2007. Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. Int Rev Cytol 260:35-112.
51. Izzo AA. 2005. Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharmacol 19:1-16.
52. Jouad H, Haloui M, Rhiouani H, El Hilaly J, Eddouks M. 2001. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez-Boulemane). J Ethnopharmacol 77:175-82.
53. Junyaprasert VB, Soonthornchareonnon N, Thongpraditchote S, Murakami T, Takano M. 2006. Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux. Phytother Res 20:79-81.
54. Juranic Z, Zixack Z. 2005. Biological activities of berries: from antioxidant capacity to anti-cancer effects. BioFactors 23:207-11.
55. Kamath AV, Yao M, Zhang Y, Chon S. 2005. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 94:233-9.
56. Kiani J, Imam S. 2007. Medicinal importance of grapefruit juice and its interaction with various drugs. Nutr J 6:33-5.
57. Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. 2006. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos 34:521-3.
58. Kimura Y, Ito H, Ohnishi R, Hatano T. 2010. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity. Food Chem Toxicol 48:429-35.
59. Knodler M, Conrad J, Wenzig EM, Bauer R, Lacorn M, Beifuss U, Carle R, Schieber A. 2008. Anti-inflammatory 5-(11'Z-heptadecenyl)- and 5-(8'Z, 11'Z-heptadecadienyl)-resorcinols from mango (Mangifera indicaL.) peels. Phytochemistry 69:988-93.
60. Kohl C. 2009. Transporters-the view from industry. Chem Biodivers 6:1988-99.
61. Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S, Sakuda SH, Nagasawa H, Shimizu M. 2004. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol 143:379-87.
62. Lambert JD, Sang S, Lu AY, Yang CS 2007. Metabolism of dietary polyphenols and possible interactions with drugs. Curr Drug Metab 8:499-507.
63. Lampe JW, King IB, Li S, Grate MT, Barale KV, Chen C, Feng Z, Potter JD. 2000. Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis 21:1157-62.
64. Leclercq I, Desager JP, Horsmans Y. 1998. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 64:144-9.
65. Lewis N, Ruud J. 2004. Apples in the American diet. Nutr Clin Care 7:82-8.
66. Lhoste EF, Gloux K, De Waziers I, Garrido S, Lory S, Philippe C, Rabot S, Knasmüller S. 2004. The activities of several detoxication enzymes are differentially induced by juices of garden cress, water cress and mustard in human HepG2 cells. Chem Biol Interact 150:211-9.
67. Li P, Wang GJ, Robertson TA, Roberts MS 2009. Liver transporters in hepatic drug disposition: an update. Curr Drug Metab 10:482-98.
68. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. 2004. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 75:184-90.
69. Lilja JJ, Raaska K, Neuvonen PJ. 2005. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol 61:337-40.
70. Liu RH. 2003. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78:517S-20S.
71. Liu RH. 2004. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134:3479S-85S.
72. Lomnitski L, Bergman M, Nyska A, Ben-Shaul V, Grossman S. 2003. Composition, efficacy, and safety of spinach extracts. Nutr Cancer 46:222-31.
73. Lu QY, Arteaga JR, Zhang Q, Huerta S, Go V L, Heber D. 2005. Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances J Nutr Biochem 16:23-30.
74. Malhotra S, Bailey DG, Paine MF, Watkins PB. 2001. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 69:14-23.
75. Mandlekar S, Hong JL, Kong AN. 2006. Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. Curr Drug Metab 7:661-75.
76. Meijerman I, Beijnen JH, Schellensa JH. 2006. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncol 11:742-52.
77. Milner JA. 2004. Molecular targets for bioactive food components. J Nutr 134:2492s-98s. PMID: 15333748
78. Muntané J. 2009. Regulation of drug metabolism and transporters. Curr Drug Metab 10:932-95.
79. Nagata M, Hidaka M, Sekiya H, Kawano Y, Yamasaki K, Okumura M, Arimori K. 2007. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 35:302-5.
80. Nahrstedt A, Butterweck V. 2010. Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). J Nat Prod 28:1015-21.
81. Nowack R. 2008. Review article: cytochrome P450 enzyme, and transport protein mediated herb-drug interactions in renal transplant patients: grapefruit juice, St John's Wort - and beyond! Nephrology 13:337-47.
82. Obermeier MT, White RE, Yang CS. 1995. Effects of bioflavonoids on hepatic P450 activities. Xenobiotica 25:575-84.
83. Oliveira RA, Narciso CD, Bisinotto RS, Perdomo MC, Ballou MA, Dreher M, Santos JE. 2010. Effects of feeding polyphenols from pomegranate extract on health, growth, nutrient digestion, and immunocompetence of calves. J Dairy Sci 93:4280-91.
84. Ortega RM. 2006. Importance of functional foods in the Mediterranean diet. Public Health Nutr 9(8A):1136-40.
85. Paine MF, Widmer WW, Pusek SN, Beavers KL, Criss AB, Snyder J, Watkins PB. 2008. Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine. Am J Clin Nutr 87:863-71.
86. Palaniswamy UR, McAvoy RJ, Bible BB, Stuar JD. 2003. Ontogenic variations of ascorbic acid and phenethyl isothiocyanate concentrations in watercress (Nasturtium officinaleR.Br.) leaves. J Agric Food Chem 51:5504-9.
87. Patel AV, Rojas-Vera J, Dacke CG. 2004. Therapeutic constituents and actions ofRubusspecies. Curr Med Chem 11:1501-12.
88. Pawełczyk T, Kłoszewska I. 2008. Grapefruit juice interactions with psychotropic drugs: advantages and potential risk. Przegl Lek 65:92-5.
89. Pham DQ, Pham AQ. 2007. Interaction potential between cranberry juice and warfarin. Am J Health Syst Pharm 64:490-4.
90. Pillai U, Muzaffar J, Sen S, Yancey A. 2009. Grapefruit juice and verapamil: a toxic cocktail. South Med J 102:308-9.
91. Piver B, Berthou F, Dreano Y, Lucas D. 2001. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 125:83-91.
92. Platt KL, Edenharder R, Aderhold S, Muckel E, Glatt H. 2010. Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells. Mutat Res 703:90-8.
93. Plaza L, Sánchez-Moreno C, de Pascual-Teresa S, de Ancos B, Cano MP. 2009. Fatty acids, sterols, and antioxidant activity in minimally processed avocados during refrigerated storage. J Agric Food Chem 57:3204-9.
94. Pohl C, Will F, Dietrich H, Schrenk D. 2006. Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols. J Agric Food Chem 54:10262-8.
95. Qian H, Nihorimbere V. 2004. Antioxidant power of phytochemicals fromPsidium guajavaleaf. J Zhejiang Univ Sci 5:676-83.
96. Rao AV, Rao LG. 2007. Carotenoids and human health. Pharmacol Res 55:207-16.
97. Reamy BV, Stephens MB. 2007. The grapefruit-drug interaction debate: role of statins. Am Fam Phys 76:190-2.
98. Rendic S. 2002. Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev 34:83-448. PMID: 11996015
99. Riccioni G, Mancini B, Di Ilio E, Bucciarelli T, D'Orazio N. 2008. Protective effect of lycopene in cardiovascular disease. Eur Rev Med Pharmacol Sci 12:183-90.
100. Roberts SS. 2007. Good, bad, and ugly. The inside story of blood lipids and your body. Diabetes Forecast 60:36-7.
101. Rodeiro I, Donato MT, Jimenez N, Garrido G, Molina-Torres J, Menendez R, Castell JV, Gómez-Lechón MJ. 2009. Inhibition of human P450 enzymes by natural extracts used in traditional medicine. Phytother Res 23:279-82.
102. Rodeiro I, Donato MT, Lahoz A, Garrido G, Delgado R, Gómez-Lechón MJ. 2008. Interactions of polyphenols with the P450 system: possible implications on human therapeutics. Mini Rev Med Chem 8:97-106.
103. Ross SM. 2009. Pomegranate: its role in cardiovascular health. Holist Nurs Pract 23:195-7.
104. Rossi R, Porta S, Canovi B. 2010. Overview on cranberry and urinary tract infections in females. J Clin Gastroenterol 44:S61-2.
105. Rushmore TH, Kong AN. 2002. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 3:481-90.
106. Sai Y. 2005. Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition. Drug Metab Pharmacokinet 20:91-9.
107. Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R. 2005. Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies. Drug Saf 28:677-94.
108. Santos CA, Boullata JI. 2005. An approach to evaluating drug-nutrient interactions. Pharmacother 25:1789-800.
109. Saruwatari A, Okamura S, Nakajima Y, Narukawa Y, Takeda T, Tamura H. 2008. Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells. J Med Food 11:623-8.
110. Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y. 2005. Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 33:518-23.
111. Saxena A, Tripathi KP, Roy S, Khan F, Sharma A. 2008. Pharmacovigilance: effects of herbal components on human drugs interactions involving cytochrome P450. Bioinformation 3:198-204.
112. Schieber A, Berardini N, Carle R. 2003. Identification of flavonol and xanthone glycosides from mango (Mangifera indicaL. Cv. "Tommy Atkins") peels by high-performance liquid chromatography-electrospray ionization mass spectrometry. J Agric Food Chem 51:5006-11.
113. Schinkel AH, Jonker JW. 2003. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3-29.
114. Schirrmacher G, Skurk T, Hauner H, Grassmann J. 2010. Effect ofSpinacia oleraceaeL. andPerilla frutescensL. on antioxidants and lipid peroxidation in an intervention study in healthy individuals. Plant Foods Hum Nutr 65:71-6.
115. Schmidt LE, Dalhoff K. 2002. Food-drug interactions. Drugs 62:1481-502.
116. Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D. 2006. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 54:9329-39.
117. Seeram NP. 2008. Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. Agric Food Chem 56:627-9.
118. Shabtay A, Eitam H, Tadmor Y, Orlov A, Meir A, Weinberg P, Weinberg ZG, Chen Y, Brosh A, Izhaki I, Kerem Z. 2008. Nutritive and antioxidative potential of fresh and stored pomegranate industrial byproduct as a novel beef cattle feed. J Agric Food Chem 56:10063-70.
119. Sica DA. 2006. Interaction of grapefruit juice and calcium channel blockers. Am J Hypertens 19:768-73.
120. Sikora M, Hallmann E, Rembiałkowska E. 2009. The content of bioactive compounds in carrots from organic and conventional production in the context of health prevention. Rocz Panstw Zakl Hig 60:217-20
121. Singh BN. 1999. Effects of food on clinical pharmacokinetics. Clin Pharmacokinet 37:213-55.
122. Singh BN, Malhotra BK. 2004. Effects of food on the clinical pharmacokinetics of anticancer agents: underlying mechanisms and implications for oral chemotherapy. Clin Pharmacokinet 43:1127-56.
123. Sun T, Simon PW, Tanumihardjo SA. 2009. Antioxidant phytochemicals and antioxidant capacity of biofortified carrots (Daucus carota L.) of various colors. J Agric Food Chem 57:4142-7.
124. Surles RL, Weng N, Simon PW, Tanumihardjo SA. 2004. Carotenoid profiles and consumer sensory evaluation of specialty carrots (Daucus carotaL.) of various colors. J Agric Food Chem 52:3417-21.
125. Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. 2000. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 293:230-36.
126. Tan HL, Thomas-Ahner JM, Grainger EM, Wan L, Francis DM, Schwartz SJ, Erdman JW Jr, Clinton SK. 2010. Tomato-based food products for prostate cancer prevention: what have we learned? Cancer Metastasis Rev 29:553-68.
127. Telang U, Ji Y, Morris ME. 2009. ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions. Biopharm Drug Dispos 30:335-44.
128. Tian Q, Rosselot RA, Schwartz SJ. 2005. Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, Brussels sprouts, and cauliflower by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem 343:93-9.
129. Tomlinson B, Hu M, Lee VW. 2008. In vivoassessment of herb-drug interactions: possible utility of a pharmacogenetic approach? Mol Nut Food Res 52:799-809.
130. Uesawa Y, Mohri K. 2006. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 58:1067-72.
131. Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. 2009. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmacol 68:194-200.
132. Van Den Bout-Van den Beukel CJ, Koopmans PP, Van Der Ven AJ, De Smet PA, Burger DM. 2006. Possible drug-metabolism interactions of medicinal herbs with antiretroviral agents. Drug Metab Rev 38:477-514.
133. VanWert AL, Gionfriddo MR, Sweet DH. 2010. Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 31:1-71.
134. Vasanthi HR, Mukherjee S, Das DK. 2009. Potential health benefits of broccoli-a chemico-biological overview. Mini Rev Med Chem 9:749-59.
135. Veeramachaneni S, Ausman LM, Choi SW, Russell RM, Wang XD. 2008. High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats. J Nutr 138:1329-35.
136. Velasco P, Francisco M, Moreno DA, Ferreres F, García-Viguera C, Cartea ME. 2011. Phytochemical fingerprinting of vegetable Brassica oleracea and Brassica napus by simultaneous identification of glucosinolates and phenolics. Phytochem Anal 22:144-52.
137. Vislocky LM, Fernandez ML. 2010. Biomedical effects of grape products. Nutr Rev 68:656-70.
138. Waliszewski KN, Blasco G. 2010. Nutraceutical properties of lycopen. Salud Publica Mex 52:254-65
139. Walter-Sack I, Klotz U. 1996. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokinet 31:47-64.
140. Wang H, Leung LK. 2010. The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells. Nutrition 26:1181-7.
141. Wang SY, Lin HS. 2000. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 48:140-6.
142. Watkins PB. 1992. Drug metabolism by cytochromes P450 in liver and small bowel. Gastrointerol. Clin North Am 21:511-26.
143. Wells PS, Holbrook AM, Crowther NR, Hirsh J. 1994. Interactions of warfarin with drugs and food. Ann Intern Med 121:676-83.
144. Whiley AW, Schaffer B. 2002. History, distribution and uses. In: Whiley AW, Schaffer B, Wolstenholme BN, editors. The avocado: botany, production, and uses. New York CABI Publishing. Chapter 1, p 1.
145. Wink M. 2008. Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr Drug Metab 9:996-1009.
146. World Health Organization. Diet, nutrition, and the prevalence of chronic diseases. Geneva, Switzerland World Health Organization; 2003. Contract Nr: WHO Technical Report Series Nr 916.
147. Xu C, Li CYL, Kong ANT. 2005. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 28:249-68.
148. Yadav M, Jain S, Bhardwaj A, Nagpal R, Puniya M, Tomar R, Singh V, Parkash O, Prasad GB, Marotta F, Yadav H. 2009. Biological and medicinal properties of grapes and their bioactive constituents: an update. J Med Food 12:473-84.
149. Yeh CT, Yen GC. 2005. Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics. Free Radic Res 39:893-904
150. Yoo HH, Lee M, Chung HJ, Lee SK, Kim DH. 2007. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem 55:7620-5.
151. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D. 2007. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51:675-83.
152. Zhang L, Zhang Y D, Strong J M, Reynolds K S, Huang S M. 2008. A regulatory viewpoint on transporter based drug interactions. Xenobiotica 38:709-24.
153. Zhou S, Lim LY, Chowbay B. 2004. Herbal modulation of P-glycoprotein. Drug Metab Rev 36:57-104.