Phase II metabolism of hesperetin by individual UDP- glucuronosyltransferases and sulfotransferases and rat and human tissue samples

Drug Metabolism and Disposition

Volumn 38, Issue 4, 2010, Pages 617-625

  Brand, Walter ^a,b   Boersma, Marelle G ^a   Bik, Hanneke ^a   Hoek van Den Hil, Elisabeth F ^a   Vervoort, Jacques ^c   Barron, Denis ^b   Meinl, Walter ^d   Glatt, Hansruedi ^d   Williamson, Gary ^b,e   Van Bladeren, Peter J ^a,b   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c Biqualys   (Netherlands)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^e UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; HESPERETIN; HESPERETIN 3' O GLUCURONIDE; HESPERETIN 3' O SULFATE; HESPERETIN 7 O GLUCURONIDE; HESPERETIN 7 O SULFATE; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A2; SULFOTRANSFERASE 1A3; SULFOTRANSFERASE 1B1; SULFOTRANSFERASE 1C2; SULFOTRANSFERASE 1C3; SULFOTRANSFERASE 1C4; SULFOTRANSFERASE 1E1; SULFOTRANSFERASE 2A1; SULFOTRANSFERASE 2B1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SULFONATION;

ANIMALS; BIOTRANSFORMATION; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; CYTOSOL; DNA, COMPLEMENTARY; GLUCOSIDES; GLUCURONOSYLTRANSFERASE; HESPERIDIN; HUMANS; INSECTS; INTESTINE, SMALL; KINETICS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SULFATES; SULFOTRANSFERASES; TRANSFECTION;

RATTUS;

EID: 77950221864     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.031047     Document Type: Article

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