Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes

Biopharmaceutics and Drug Disposition

Volumn , Issue , 2015, Pages 622-635

  Dai, Peimin ^a,b   Luo, Feifei ^b   Wang, Ying ^a,b   Jiang, Huangyu ^b   Wang, Liping ^a,c   Zhang, Guiyu ^b   Zhu, Lijun ^b   Hu, Ming ^b,d   Wang, Xinchun ^c   Lu, Linlin ^b   Liu, Zhongqiu ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c SHIHEZI UNIVERSITY   (China)

^d UNIVERSITY OF HOUSTON   (United States)

Author keywords

enzyme kinetics; flavonoids; glucuronidation; in vitro incubation

Indexed keywords

ACACETIN; DRUG METABOLITE; GLUCOSIDE; GLUCURONOSYLTRANSFERASE 1A8; TILIANIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOG; DRUG DETERMINATION; DRUG GLUCURONIDATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME KINETICS; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; INTESTINAL MICROSOME; LIVER MICROSOME; MALE; MICROSOME; NONHUMAN; RAT; SEX DIFFERENCE; SPECIES DIFFERENCE; SUBSTRATE CONCENTRATION; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84973594796     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1989     Document Type: Article

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