Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice

Drug Metabolism and Disposition

Volumn 40, Issue 6, 2012, Pages 1216-1225

  Fu, Zidong Donna ^a   Csanaky, Iván L ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; AROMATIC HYDROCARBON RECEPTOR; BREAST CANCER RESISTANCE PROTEIN; CARBOXYLESTERASE; CATECHOL METHYLTRANSFERASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A11; CYTOCHROME P450 REDUCTASE; DRUG METABOLIZING ENZYME; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GLUCURONOSYLTRANSFERASE 1A1; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE P1; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 6; ORGANIC ANION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 1; SULFOTRANSFERASE 1A1;

3' PHOSPHOADENOSINE 5' PHOSPHOSULFATE SYNTHASE 1 GENE; 3' PHOSPHOADENOSINE 5' PHOSPHOSULFATE SYNTHASE 2 GENE; AGED; AGING; ALCOHOL DEHYDROGENASE 4 GENE; ALCOHOL DEHYDROGENASE 6B GENE; ALCOHOL DEHYDROGENASE 7 GENE; ALDEHYDE DEHYDROGENASE 1A1 GENE; ALDEHYDE DEHYDROGENASE 1A7 GENE; ALDEHYDE DEHYDROGENASE 2 GENE; ALDEHYDE DEHYDROGENASE 3A2 GENE; ALDEHYDE DEHYDROGENASE 4A1 GENE; ALDEHYDE DEHYDROGENASE 6A1 GENE; ALDEHYDE DEHYDROGENASE 7A1 GENE; ALDEHYDE DEHYDROGENASE 9A1 GENE; ANIMAL TISSUE; ARTICLE; ARYL HYDROCARBON RECEPTOR GENE; ATP BINDING CASSETTE A1 GENE; ATP BINDING CASSETTE G8 GENE; BREAST CANCER RESISTANCE PROTEIN GENE; CARBOXYLESTERASE 1C GENE; CARBOXYLESTERASE 1E GENE; CARBOXYLESTERASE 1F GENE; CARBOXYLESTERASE 2C GENE; CARBOXYLESTERASE 3A GENE; CATECHOL O METHYLTRANSFERASE GENE; CONSTITUTIVE ANDROSTANE RECEPTOR GENE; CONTROLLED STUDY; CYTOCHROME P450 1A1 GENE; CYTOCHROME P450 1A2 GENE; CYTOCHROME P450 2B10 GENE; CYTOCHROME P450 3A11 GENE; CYTOCHROME P450 4A14 GENE; CYTOCHROME P450 REDUCTASE GENE; DOWN REGULATION; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 GENE; ESTERASE D GENE; FEMALE; FLAVIN CONTAINING MONOOXYGENASE 2 GENE; FLAVIN CONTAINING MONOOXYGENASE 3 GENE; FLAVIN CONTAINING MONOOXYGENASE 4 GENE; FLAVIN CONTAINING MONOOXYGENASE 5 GENE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE A1 GENE; GLUTATHIONE TRANSFERASE M2 GENE; GLUTATHIONE TRANSFERASE M3 GENE; GLUTATHIONE TRANSFERASE M4 GENE; GLUTATHIONE TRANSFERASE M6 GENE; GLUTATHIONE TRANSFERASE P1 GENE; GLUTATHIONE TRANSFERASE P2 GENE; GLUTATHIONE TRANSFERASE T2 GENE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA GENE; LIFESPAN; LIVER; MALE; MICROSOMAL GLUTATHIONE TRANSFERASE 3 GENE; MOUSE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2 GENE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3 GENE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4 GENE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6 GENE; N ACETYLTRANSFERASE 1 GENE; NAD(P)H:QUINONE OXIDOREDUCTASE 1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANIC ANION TRANSPORTER 2 GENE; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1 GENE; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A4 GENE; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B2 GENE; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1 GENE; ORGANIC CATION TRANSPORTER 1 GENE; PRIORITY JOURNAL; SEX DIFFERENCE; SULFOTRANSFERASE 1A1 GENE; SULFOTRANSFERASE 1D1 GENE; SULFOTRANSFERASE 1E1 GENE; SULFOTRANSFERASE 2A1 GENE; SULFOTRANSFERASE 2A2 GENE; SULFOTRANSFERASE 3A1 GENE; SULFOTRANSFERASE 5A1 GENE; UDP GLUCOSE PYROPHOSPHORYLASE 2 GENE; UDP GLUCURONOSYLTRANSFERASE 1A1 GENE; UDP GLUCURONOSYLTRANSFERASE 1A6A GENE; UDP GLUCURONOSYLTRANSFERASE 2B1 GENE; UDP GLUCURONOSYLTRANSFERASE 2B35 GENE; UDP GLUCURONOSYLTRANSFERASE 2B36 GENE; UDP GLUCURONOSYLTRANSFERASE 3A1 GENE; UDP GLUCURONOSYLTRANSFERASE 3A2 GENE; UPREGULATION; XENOBIOTIC PROCESSING GENE;

AGING; ANIMALS; FEMALE; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED C57BL; PHARMACEUTICAL PREPARATIONS; RNA, MESSENGER; SEX CHARACTERISTICS;

MUS;

EID: 84862067321     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.044461     Document Type: Article

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