Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

Drug Metabolism and Disposition

Volumn 37, Issue 1, 2009, Pages 229-236

  Argikar, Upendra A ^a   Remmel, Rory P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMIC ACID; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A8; VALPROIC ACID;

AGED; AGING; ANTICONVULSANT THERAPY; ARTICLE; BINDING KINETICS; BIPOLAR DEPRESSION; CATALYSIS; DRUG CLEARANCE; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MIGRAINE; MOOD DISORDER; OXIDATIVE STRESS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; MICROSOMES, LIVER; MIDDLE AGED; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY; VALPROIC ACID;

EID: 58149469245     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022426     Document Type: Article

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